d88ebc668210dee47e379cf61d7d5820 Bertucci_et_al_2019_AEM.00895-19.pdf 72618e1c644ce74f013900e16e4cc094eaf3cd4d Bertucci_et_al_2019_AEM.00895-19.pdf 7dc8fe7de5cdc27f28684169c52e1662022a5e1a6361f528f56789f0890a7bb2 Bertucci_et_al_2019_AEM.00895-19.pdf Title: Carbohydrate Hydrolytic Potential and Redundancy of an Anaerobic Digestion Microbiome Exposed to Acidosis, as Uncovered by Metagenomics Subject: Appl Environ Microbiol 2019.85:e00895-19 Keywords: recombinant-protein production, Bacteroidetes, molecular biology, polysaccharides, biotechnology, enzymes Author: Marie Bertucci, Magdalena Calusinska, Xavier Goux, Corinne Rouland-Lefèvre, Boris Untereiner, Pau Ferrer, Patrick A. Gerin, Philippe Delfosse Creator: XPP Producer: Adobe LiveCycle PDF Generator; modified using iText 5.0.3 (c) 1T3XT BVBA CreationDate: Tue Jul 2 10:22:09 2019 CEST ModDate: Mon Oct 17 16:09:12 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 585 x 783 pts Page rot: 0 File size: 2501809 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LNDPGN+MyriadPro-It Type 1C Custom yes yes yes 58 0 LNEFON+MyriadMM-Bold Type 1C WinAnsi yes yes no 57 0 LNEEGE+ArialMT-Light Type 1C WinAnsi yes yes no 423 0 LNEFCM+Minion-Regular Type 1C WinAnsi yes yes no 424 0 MyriadPro-Light Type 1C WinAnsi yes no no 425 0 LNDHOE+MyriadPro-Semibold Type 1C Custom yes yes yes 426 0 LNDJDN+ArialMT-Bold Type 1C WinAnsi yes yes no 427 0 LNDKGC+MyriadMM-Light Type 1C WinAnsi yes yes no 428 0 LNDLFK+MyriadPro-Light Type 1C Custom yes yes yes 429 0 LNDLOI+MyriadPro-Bold Type 1C Custom yes yes yes 59 0 LNDNMM+MyriadPro-Regular Type 1C Custom yes yes yes 60 0 Times-Roman Type 1 WinAnsi no no no 2 0 LNEHBO+Universal-GreekwithMathPi Type 1C Custom yes yes no 113 0 LNLEHI+MathematicalPi-One Type 1C Custom yes yes no 146 0 LNMKLP+MyriadPro-BoldIt Type 1C Custom yes yes yes 158 0 LOEDHI+OurOwn-CJS Type 1C Custom yes yes yes 249 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-10-19 02:36:34 CEST RepresentationInformation: Bertucci_et_al_2019_AEM.00895-19.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-10-17 16:10:25 CEST Size: 2501809 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: RESULTS Destination: 1 Children: Item: Title: Functional redundancy of hydrolytic metabolism under changing environmental conditions in AD reactors. Destination: 1 Item: Title: Bacteroidetes may be favored in some anaerobic digesters owing to its polysaccharide hydrolytic potential as reflected by higher CAZy diversity and genomic content. Destination: 1 Item: Title: The diversity of CAZyme-coding genes in MAG15 might explain the metagenomic abundance of this species. Destination: 1 Item: Title: Biochemical assays confirm predicted CAZy activities of six heterologously expressed proteins present in PUL219. Destination: 1 Item: Title: DISCUSSION Destination: 1 Children: Item: Title: Functional redundancy of AD microbiome. Destination: 1 Item: Title: Diversity of CAZymes. Destination: 1 Item: Title: Bacteroidetes and their PULs. Destination: 1 Item: Title: MATERIALS AND METHODS Destination: 1 Children: Item: Title: Sampling, metagenomics, and data processing. Destination: 1 Item: Title: CAZyme-coding gene heterologous expression in E. coli. Destination: 1 Item: Title: Signal peptide predication and activity assays. Destination: 1 Item: Title: Data availability. Destination: 1 Item: Title: SUPPLEMENTAL MATERIAL Destination: 1 Item: Title: ACKNOWLEDGMENTS Destination: 1 Item: Title: REFERENCES Destination: 1 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 148 ImageHeight: 148 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 915 ImageHeight: 140 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2093 ImageHeight: 1810 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2090 ImageHeight: 1458 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2093 ImageHeight: 1171 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1931 ImageHeight: 1200 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2090 ImageHeight: 1884 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: LNEEGE+ArialMT-Light FontSubset: true FirstChar: 42 LastChar: 42 FontDescriptor: FontName: LNEEGE+ArialMT-Light Flags: Nonsymbolic FontBBox: -212, -210, 1006, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LNEFCM+Minion-Regular FontSubset: true FirstChar: 99 LastChar: 115 FontDescriptor: FontName: LNEFCM+Minion-Regular Flags: Serif, Nonsymbolic FontBBox: -141, -250, 1104, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Light FirstChar: 32 LastChar: 121 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LNDHOE+MyriadPro-Semibold FontSubset: true FirstChar: 44 LastChar: 232 FontDescriptor: FontName: LNDHOE+MyriadPro-Semibold Flags: Symbolic FontBBox: -71, -250, 1198, 889 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LNDJDN+ArialMT-Bold FontSubset: true FirstChar: 42 LastChar: 42 FontDescriptor: FontName: LNDJDN+ArialMT-Bold Flags: Nonsymbolic, ForceBold FontBBox: -167, -210, 1006, 939 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LNDKGC+MyriadMM-Light FontSubset: true FirstChar: 97 LastChar: 99 FontDescriptor: FontName: LNDKGC+MyriadMM-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 823 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LNDLFK+MyriadPro-Light FontSubset: true FirstChar: 44 LastChar: 242 FontDescriptor: FontName: LNDLFK+MyriadPro-Light Flags: Symbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LNEHBO+Universal-GreekwithMathPi FontSubset: true FirstChar: 2 LastChar: 7 FontDescriptor: FontName: LNEHBO+Universal-GreekwithMathPi Flags: Symbolic FontBBox: -30, -240, 1012, 815 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: LNLEHI+MathematicalPi-One FontSubset: true FirstChar: 2 LastChar: 5 FontDescriptor: FontName: LNLEHI+MathematicalPi-One Flags: Symbolic FontBBox: -30, -210, 1000, 779 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: LNEFON+MyriadMM-Bold FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: LNEFON+MyriadMM-Bold Flags: Nonsymbolic, ForceBold FontBBox: -40, -250, 1256, 851 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LOEDHI+OurOwn-CJS FontSubset: true FirstChar: 161 LastChar: 161 FontDescriptor: FontName: LOEDHI+OurOwn-CJS Flags: Serif, Symbolic FontBBox: -7, -285, 1003, 840 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LNDPGN+MyriadPro-It FontSubset: true FirstChar: 45 LastChar: 148 FontDescriptor: FontName: LNDPGN+MyriadPro-It Flags: Symbolic, Italic FontBBox: -112, -250, 1090, 873 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LNDLOI+MyriadPro-Bold FontSubset: true FirstChar: 44 LastChar: 148 FontDescriptor: FontName: LNDLOI+MyriadPro-Bold Flags: Symbolic, ForceBold FontBBox: -92, -250, 1256, 897 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LNDNMM+MyriadPro-Regular FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: LNDNMM+MyriadPro-Regular Flags: Symbolic FontBBox: -46, -250, 1126, 881 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LNMKLP+MyriadPro-BoldIt FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: LNMKLP+MyriadPro-BoldIt Flags: Symbolic, Italic, ForceBold FontBBox: -96, -250, 1225, 889 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 475, 227, 527, 236 Annotation: Subtype: Link Rect: 407, 218, 466, 227 Annotation: Subtype: Link Rect: 425, 178, 522, 187 Annotation: Subtype: Link Rect: 407, 169, 465, 178 Annotation: Subtype: Link Rect: 439, 149, 521, 158 Annotation: Subtype: Link Rect: 513, 695, 552, 730 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 187, 686, 194, 698 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 144, 602, 151, 614 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 195, 566, 201, 578 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 206, 566, 213, 578 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 89, 506, 95, 518 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 303, 494, 309, 506 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 312, 494, 318, 506 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 52, 446, 58, 458 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 62, 446, 68, 458 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 290, 434, 296, 446 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 195, 338, 202, 350 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 194, 302, 201, 314 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 348, 182, 359, 194 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 250, 170, 256, 182 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 259, 170, 270, 182 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 268, 170, 275, 182 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 273, 170, 284, 182 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 351, 146, 362, 158 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 360, 146, 366, 158 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 364, 146, 376, 158 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 167, 98, 178, 110 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 181, 98, 192, 110 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 330, 98, 341, 110 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 343, 98, 355, 110 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 204, 62, 215, 74 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 217, 62, 228, 74 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 245, 710, 256, 722 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 253, 674, 264, 686 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 253, 650, 264, 662 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 262, 650, 269, 662 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 267, 650, 278, 662 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 214, 614, 225, 626 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 149, 590, 160, 602 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 256, 362, 263, 374 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 275, 302, 298, 314 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 64, 278, 70, 290 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 222, 254, 233, 266 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 211, 218, 222, 230 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 222, 194, 233, 206 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 77, 158, 106, 170 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 177, 122, 205, 134 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 216, 122, 223, 134 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 76, 98, 87, 110 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 194, 74, 205, 86 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 74, 122, 101, 134 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 118, 122, 124, 134 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 342, 110, 364, 122 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 49, 98, 56, 110 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 149, 242, 177, 254 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 305, 194, 334, 206 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 78, 158, 106, 170 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 347, 98, 376, 110 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 206, 50, 217, 62 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 132, 254, 160, 266 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 365, 194, 380, 206 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 49, 182, 61, 194 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 145, 62, 172, 74 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 188, 62, 196, 74 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 347, 254, 376, 266 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 90, 194, 101, 206 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 365, 158, 380, 170 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 49, 146, 61, 158 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 137, 134, 149, 146 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 157, 98, 186, 110 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 262, 710, 290, 722 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 74, 638, 103, 650 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 206, 518, 235, 530 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 165, 398, 194, 410 Flags: Print Destination: 97 Annotation: Subtype: Link Rect: 62, 374, 90, 386 Flags: Print Destination: 97 Annotation: Subtype: Link Rect: 314, 230, 325, 242 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 88, 194, 116, 206 Flags: Print Destination: 97 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 52, 50, 58, 62 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 502, 32, 542, 42 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 134, 673, 162, 685 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 174, 673, 182, 685 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 189, 673, 195, 685 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 353, 649, 376, 661 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 275, 637, 286, 649 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 274, 612, 297, 624 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 326, 539, 349, 551 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 225, 515, 231, 527 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 247, 502, 253, 514 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 268, 490, 279, 502 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 353, 405, 380, 417 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 66, 392, 73, 404 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 158, 356, 170, 368 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 326, 258, 337, 270 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 185, 221, 212, 233 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 233, 184, 261, 196 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 102, 123, 113, 135 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 195, 50, 206, 62 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 210, 50, 221, 62 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 329, 698, 340, 710 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 343, 698, 355, 710 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 129, 637, 140, 649 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 266, 612, 278, 624 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 288, 576, 300, 588 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 303, 551, 333, 563 Flags: Print Destination: 93 Annotation: Subtype: Link Rect: 198, 490, 209, 502 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 81, 453, 93, 465 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 94, 453, 106, 465 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 107, 453, 119, 465 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 159, 416, 188, 428 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 152, 392, 164, 404 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 70, 282, 81, 294 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 346, 270, 375, 282 Flags: Print Destination: 94 Annotation: Subtype: Link Rect: 232, 233, 244, 245 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 99, 221, 110, 233 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 193, 123, 204, 135 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 140, 99, 151, 111 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 345, 62, 376, 74 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 169, 50, 197, 62 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 217, 50, 224, 62 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 230, 686, 242, 698 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 275, 662, 286, 674 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 190, 650, 218, 662 Flags: Print Destination: 95 Annotation: Subtype: Link Rect: 137, 578, 149, 590 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 213, 494, 243, 506 Flags: Print Destination: 97 Annotation: Subtype: Link Rect: 250, 494, 261, 506 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 265, 494, 276, 506 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 52, 470, 63, 482 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 326, 470, 337, 482 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 115, 446, 144, 458 Flags: Print Destination: 97 Annotation: Subtype: Link Rect: 308, 386, 319, 398 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 323, 386, 334, 398 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 266, 362, 277, 374 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 291, 338, 303, 350 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 95, 290, 106, 302 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 52, 266, 63, 278 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 310, 218, 321, 230 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 325, 218, 337, 230 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 73, 194, 84, 206 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 81, 158, 105, 170 Flags: Print Destination: 97 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 265, 710, 276, 722 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 135, 602, 141, 612 Flags: Print Destination: 245 Annotation: Subtype: Link Rect: 133, 592, 153, 602 Flags: Print Destination: 92 Annotation: Subtype: Link Rect: 264, 573, 273, 583 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 89, 545, 99, 555 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 307, 545, 317, 555 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 231, 535, 241, 545 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 170, 526, 179, 536 Flags: Print Destination: 246 Annotation: Subtype: Link Rect: 264, 526, 333, 536 Annotation: Subtype: Link Rect: 279, 507, 288, 517 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 236, 488, 246, 498 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 218, 478, 228, 488 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 301, 469, 311, 479 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 220, 326, 230, 336 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 232, 326, 242, 336 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 94, 174, 216, 184 Annotation: Subtype: Link Rect: 224, 174, 234, 184 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 151, 117, 160, 127 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 162, 117, 172, 127 Flags: Print Destination: 247 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 309, 626, 378, 636 Annotation: Subtype: Link Rect: 271, 528, 380, 540 Annotation: Subtype: Link Rect: 49, 516, 88, 528 Annotation: Subtype: Link Rect: 239, 268, 291, 278 Annotation: Subtype: Link Rect: 62, 259, 169, 269 Annotation: Subtype: Link Rect: 266, 222, 291, 232 Annotation: Subtype: Link Rect: 62, 213, 176, 223 Annotation: Subtype: Link Rect: 127, 159, 273, 169 Annotation: Subtype: Link Rect: 115, 123, 252, 133 Annotation: Subtype: Link Rect: 198, 105, 291, 115 Annotation: Subtype: Link Rect: 62, 96, 102, 106 Annotation: Subtype: Link Rect: 320, 313, 457, 323 Annotation: Subtype: Link Rect: 499, 286, 549, 296 Annotation: Subtype: Link Rect: 320, 277, 403, 287 Annotation: Subtype: Link Rect: 470, 240, 549, 250 Annotation: Subtype: Link Rect: 320, 231, 389, 241 Annotation: Subtype: Link Rect: 320, 186, 450, 196 Annotation: Subtype: Link Rect: 320, 150, 461, 160 Annotation: Subtype: Link Rect: 514, 105, 549, 115 Annotation: Subtype: Link Rect: 320, 96, 411, 106 Annotation: Subtype: Link Rect: 491, 69, 549, 79 Annotation: Subtype: Link Rect: 320, 60, 395, 70 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 241, 693, 291, 703 Annotation: Subtype: Link Rect: 62, 684, 136, 694 Annotation: Subtype: Link Rect: 107, 648, 234, 658 Annotation: Subtype: Link Rect: 99, 621, 214, 631 Annotation: Subtype: Link Rect: 143, 585, 272, 595 Annotation: Subtype: Link Rect: 126, 558, 273, 568 Annotation: Subtype: Link Rect: 204, 530, 291, 540 Annotation: Subtype: Link Rect: 62, 521, 106, 531 Annotation: Subtype: Link Rect: 125, 485, 278, 495 Annotation: Subtype: Link Rect: 116, 440, 231, 450 Annotation: Subtype: Link Rect: 109, 395, 241, 405 Annotation: Subtype: Link Rect: 266, 367, 291, 377 Annotation: Subtype: Link Rect: 62, 358, 176, 368 Annotation: Subtype: Link Rect: 129, 322, 260, 332 Annotation: Subtype: Link Rect: 62, 286, 198, 296 Annotation: Subtype: Link Rect: 266, 259, 291, 269 Annotation: Subtype: Link Rect: 62, 250, 172, 260 Annotation: Subtype: Link Rect: 167, 204, 284, 214 Annotation: Subtype: Link Rect: 134, 168, 271, 178 Annotation: Subtype: Link Rect: 128, 141, 240, 151 Annotation: Subtype: Link Rect: 233, 114, 291, 124 Annotation: Subtype: Link Rect: 62, 105, 143, 115 Annotation: Subtype: Link Rect: 201, 78, 291, 88 Annotation: Subtype: Link Rect: 62, 69, 91, 79 Annotation: Subtype: Link Rect: 439, 712, 549, 722 Annotation: Subtype: Link Rect: 320, 702, 344, 712 Annotation: Subtype: Link Rect: 436, 666, 549, 676 Annotation: Subtype: Link Rect: 320, 657, 350, 667 Annotation: Subtype: Link Rect: 364, 621, 501, 631 Annotation: Subtype: Link Rect: 491, 594, 549, 604 Annotation: Subtype: Link Rect: 320, 585, 418, 595 Annotation: Subtype: Link Rect: 470, 558, 549, 568 Annotation: Subtype: Link Rect: 320, 548, 389, 558 Annotation: Subtype: Link Rect: 355, 512, 488, 522 Annotation: Subtype: Link Rect: 441, 494, 549, 504 Annotation: Subtype: Link Rect: 320, 485, 344, 495 Annotation: Subtype: Link Rect: 320, 449, 464, 459 Annotation: Subtype: Link Rect: 402, 422, 516, 432 Annotation: Subtype: Link Rect: 366, 376, 489, 386 Annotation: Subtype: Link Rect: 491, 349, 549, 359 Annotation: Subtype: Link Rect: 320, 340, 396, 350 Annotation: Subtype: Link Rect: 320, 295, 450, 305 Annotation: Subtype: Link Rect: 341, 231, 478, 241 Annotation: Subtype: Link Rect: 345, 186, 482, 196 Annotation: Subtype: Link Rect: 491, 168, 549, 178 Annotation: Subtype: Link Rect: 320, 159, 384, 169 Annotation: Subtype: Link Rect: 394, 123, 525, 133 Annotation: Subtype: Link Rect: 491, 87, 549, 97 Annotation: Subtype: Link Rect: 320, 78, 401, 88 Annotation: Subtype: Link Rect: 369, 51, 500, 61 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 233, 694, 291, 704 Annotation: Subtype: Link Rect: 62, 685, 163, 695 Annotation: Subtype: Link Rect: 98, 640, 207, 650 Annotation: Subtype: Link Rect: 256, 622, 291, 632 Annotation: Subtype: Link Rect: 62, 613, 173, 623 Annotation: Subtype: Link Rect: 130, 577, 269, 587 Annotation: Subtype: Link Rect: 122, 541, 248, 551 Annotation: Subtype: Link Rect: 214, 514, 291, 524 Annotation: Subtype: Link Rect: 62, 505, 111, 515 Annotation: Subtype: Link Rect: 266, 469, 291, 479 Annotation: Subtype: Link Rect: 62, 460, 169, 470 Annotation: Subtype: Link Rect: 118, 433, 262, 443 Annotation: Subtype: Link Rect: 256, 406, 291, 416 Annotation: Subtype: Link Rect: 62, 397, 187, 407 Annotation: Subtype: Link Rect: 131, 334, 243, 344 Annotation: Subtype: Link Rect: 130, 298, 261, 308 Annotation: Subtype: Link Rect: 212, 262, 291, 272 Annotation: Subtype: Link Rect: 62, 253, 119, 263 Annotation: Subtype: Link Rect: 320, 702, 450, 712 Annotation: Subtype: Link Rect: 524, 656, 549, 666 Annotation: Subtype: Link Rect: 320, 647, 427, 657 Annotation: Subtype: Link Rect: 341, 620, 467, 630 Annotation: Subtype: Link Rect: 423, 592, 543, 602 Annotation: Subtype: Link Rect: 456, 565, 549, 575 Annotation: Subtype: Link Rect: 320, 556, 364, 566 Annotation: Subtype: Link Rect: 491, 528, 549, 538 Annotation: Subtype: Link Rect: 320, 519, 381, 529 Annotation: Subtype: Link Rect: 491, 491, 549, 501 Annotation: Subtype: Link Rect: 320, 482, 410, 492 Annotation: Subtype: Link Rect: 403, 436, 518, 446 Annotation: Subtype: Link Rect: 439, 409, 549, 419 Annotation: Subtype: Link Rect: 320, 400, 344, 410 Annotation: Subtype: Link Rect: 364, 372, 512, 382 Annotation: Subtype: Link Rect: 404, 345, 517, 355 Annotation: Subtype: Link Rect: 472, 281, 549, 291 Annotation: Subtype: Link Rect: 320, 271, 392, 281 Annotation: Subtype: Link Rect: 371, 217, 497, 227 Annotation: Subtype: Link Rect: 499, 32, 538, 42 Checksum: b74392b3 Type: CRC32 Checksum: d88ebc668210dee47e379cf61d7d5820 Type: MD5 Checksum: 72618e1c644ce74f013900e16e4cc094eaf3cd4d Type: SHA-1