2de41240c524f56e69ca075e8727e7d2 NIHM_a2019v139n2p412.pdf 6573b826dcb64c2dd787c215095d1fb69c241d17 NIHM_a2019v139n2p412.pdf 26f6cbbca93a51b5f26e820652ac3f2e65c1055575a36f97291e84df5e3d494b NIHM_a2019v139n2p412.pdf Title: PAR2 Pepducin-Based Suppression of Inflammation and Itch in Atopic Dermatitis Models Author: Travis P. Barr, Chris Garzia, Srijoy Guha, Elizabeth K. Fletcher, Nga Nguyen, Adam J. Wieschhaus, Lluis Ferrer, Lidija Covic, Athan Kuliopulos Creator: AH XSL Formatter V6.3 R1 for Linux64 : 6.3.1.23495 (2016/02/03 14:39JST) Producer: Antenna House PDF Output Library 6.3.752 (Linux64) CreationDate: Tue Nov 5 20:24:04 2019 CET ModDate: Tue Nov 5 20:24:04 2019 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1241053 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Times-Roman Type 1 Custom no no yes 11 0 Helvetica-Bold Type 1 Standard no no no 13 0 Helvetica Type 1 Standard no no no 16 0 BSJYJF+Code2000 CID TrueType Identity-H yes yes yes 32 0 Times-Bold Type 1 Standard no no no 279 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:57:11 CEST RepresentationInformation: NIHM_a2019v139n2p412.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-26 13:24:41 CEST Size: 1241053 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 65 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: INTRODUCTION Item: Title: RESULTS Children: Item: Title: PZ-235 inhibits PAR2-calcium responses and K10 differentiation marker in human keratinocytes Item: Title: PZ-235 suppresses PAR2-driven expression of proinflammatory mediators in keratinocytes and mast cells Item: Title: PZ-235 reduces ear and epidermal thickening induced by oxazolone and dust mites in mice Item: Title: Delayed PZ-235 treatment mitigates skin lesion thickness in DNFB-induced chronic dermatitis Item: Title: PZ-235 inhibits skin crusting and ex vivo mouse neutrophil migration to PAR2 agonists Item: Title: PZ-235 reduces the severity of dust mite-induced atopic dermatitis lesions in filaggrin-deficient mice Item: Title: PZ-235 reduces itching evoked by mast cell degranulation and dust mites in mice Item: Title: DISCUSSION Item: Title: MATERIALS AND METHODS Children: Item: Title: Animal models Item: Title: Cell-based assays Item: Title: Statistical analyses Item: Title: References Item: Title: Figure 1. Item: Title: Figure 2. Item: Title: Figure 3. Item: Title: Figure 4. Item: Title: Figure 5. 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