66755d113eacd54137a7f0f9986644c7 1-s2.0-S2211034818305145-main.pdf 0637af8df3b2752c16c304c443906a1d0434ede9 1-s2.0-S2211034818305145-main.pdf 99a43ed9b816cf4b31f3d1cd5e288b21b1dc8824f771301a195a1cd986e0acae 1-s2.0-S2211034818305145-main.pdf Title: Safety of cladribine tablets in the treatment of patients with multiple sclerosis_ An integrated analysis Subject: Multiple Sclerosis and Related Disorders, 29 (2019) 157-167. doi:10.1016/j.msard.2018.11.021 Keywords: Cladribine tablets; Safety; Tolerability; Risk_benefit; Combined analysis; Author: Stuart Cook Creator: Elsevier CreationDate: Wed Mar 13 12:35:42 2019 CET ModDate: Wed Mar 13 12:35:42 2019 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1140327 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RPSWUL+CharisSIL CID Type 0C Identity-H yes yes yes 597 0 CULGZI+Calibri CID TrueType Identity-H yes yes yes 592 0 PNFPSO+CharisSIL Type 1C Custom yes yes yes 576 0 RVKHCE+UniversLTStd Type 1C Custom yes yes yes 577 0 ZBNEBA+STIXGeneral-Regular Type 1C Custom yes yes yes 578 0 NPDGMV+CharisSIL-Italic Type 1C Custom yes yes yes 586 0 BRQZZR+CharisSIL-Italic CID Type 0C Identity-H yes yes yes 268 0 JDTTWH+CharisSIL-Bold Type 1C Custom yes yes yes 263 0 LTRAGM+CharisSIL-BoldItalic Type 1C Custom yes yes yes 276 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-28 02:32:18 CEST RepresentationInformation: 1-s2.0-S2211034818305145-main.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-27 18:53:30 CEST Size: 1140327 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 660 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Safety of cladribine tablets in the treatment of patients with multiple sclerosis: An integrated analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Monotherapy Oral cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: All Exposed cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Adverse events of special interest (AESI) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Summary of adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Effects of cladribine tablets on lymphocyte counts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Summary of infections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Infections during periods of grade 3 or 4 lymphopenia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Malignancy risk Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: Comparison with external reference populations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Risk of malignancies over time Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Comparison of overall experience for cladribine and other disease modifying drugs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Role of the funding source Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Conflict of interest statements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Safety of cladribine tablets in the treatment of patients with multiple sclerosis_ An integrated analysis Author: Stuart Cook Subject: Multiple Sclerosis and Related Disorders, 29 (2019) 157-167. doi:10.1016/j.msard.2018.11.021 Keywords: Cladribine tablets; Safety; Tolerability; Risk_benefit; Combined analysis; Creator: Elsevier CreationDate: Wed Mar 13 12:35:42 CET 2019 ModDate: Wed Mar 13 12:35:42 CET 2019 ID: 0xcce2fcc24a973b9a8404b0b0a708000c, 0x024ad7e4c2d05f4788b6061cfea59291 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 247 ImageHeight: 272 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: CULGZI+Calibri Encoding: Identity-H ToUnicode: true Font: BaseFont: RPSWUL+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: BRQZZR+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: PNFPSO+CharisSIL FontSubset: true FirstChar: 1 LastChar: 101 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FontDescriptor: FontName: BRQZZR+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true CIDFontType2: Font: BaseFont: CULGZI+Calibri CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CULGZI+Calibri Flags: Nonsymbolic FontBBox: -476, -194, 1214, 952 FontFile2: true XMP: application/pdf doi:10.1016/j.msard.2018.11.021 Safety of cladribine tablets in the treatment of patients with multiple sclerosis_ An integrated analysis Stuart Cook Thomas Leist Giancarlo Comi Xavier Montalban Gavin Giovannoni Axel Nolting Christine Hicking Andrew Galazka Elke Sylvester Cladribine tablets Safety Tolerability Risk_benefit Combined analysis Elsevier B.V. Multiple Sclerosis and Related Disorders, 29 (2019) 157-167. doi:10.1016/j.msard.2018.11.021 journal Multiple Sclerosis and Related Disorders © 2018 The Authors. 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