15dbd35dab3ed1e6298ad785221a6553  285224.pdf
abdb7ccdc8ae91afb6a8e1cc81f5d296ac68e6c4  285224.pdf
d4853379a674e01ddf0a5620f551c40d3112da2cd69c7314b62502b47db46ef7  285224.pdf

Title:          SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
Subject:        Clinical and Translational Oncology, https://doi.org/10.1007/s12094-018-02001-x
Keywords:       Bladder cancer,Cystectomy,Chemotherapy,Immune checkpoint inhibitors
Author:         A. González del Alba 
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows)
CreationDate:   Tue Dec 18 02:34:16 2018 CET
ModDate:        Fri Jan 11 10:41:15 2019 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      841757 bytes
Optimized:      yes
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    386  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    381  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes    382  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes    383  0
UNNDXJ+STIX-Regular                  Type 1C           Custom           yes yes yes    384  0
DQRKOS+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    406  0
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes   1085  0
Springnew-Regular                    Type 1C           WinAnsi          yes no  yes    415  0
STIX-Italic                          Type 1C           Custom           yes no  yes    162  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes    164  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-11-28 02:42:21 CET
 RepresentationInformation: 285224.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-11-27 11:40:52 CET
  Size: 841757
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1181
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Methodology
       Item: 
        Title: Molecular biology and classification
        Children: 
         Item: 
          Title: mRNA expression-based molecular subtypes
       Item: 
        Title: Clinical prognostic factors
        Children: 
         Item: 
          Title: Recommendations
       Item: 
        Title: Neoadjuvant and adjuvant treatment
        Children: 
         Item: 
          Title: Neoadjuvant treatment
          Children: 
           Item: 
            Title: Recommendations
         Item: 
          Title: Adjuvant treatment
          Children: 
           Item: 
            Title: Recommendations
       Item: 
        Title: Bladder-sparing treatments
        Children: 
         Item: 
          Title: Recommendations
       Item: 
        Title: Treatment of locally advanced or metastatic bladder cancer
        Children: 
         Item: 
          Title: First-line therapy for fit patients
          Children: 
           Item: 
            Title: Recommendations
         Item: 
          Title: First-line therapy for unfit patients
          Children: 
           Item: 
            Title: Recommendations
         Item: 
          Title: Second-line therapy
          Children: 
           Item: 
            Title: Recommendations
       Item: 
        Title: Treatment after failure to respond to immune checkpoint inhibitors
        Children: 
         Item: 
          Title: Recommendations
       Item: 
        Title: New drugs in research
       Item: 
        Title: References
   Info: 
    Title: SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)
    Author: A. González del Alba 
    Subject: Clinical and Translational Oncology, https://doi.org/10.1007/s12094-018-02001-x
    Keywords: Bladder cancer,Cystectomy,Chemotherapy,Immune checkpoint inhibitors
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows)
    CreationDate: Tue Dec 18 03:04:16 CET 2018
    ModDate: Fri Jan 11 11:11:15 CET 2019
   ID: 0xb032f990e05a0b40af9136a5c2a940b9, 0x445489ca885c274386acca30f2cd1653
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 2
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 4
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 62
      ImageHeight: 7
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 105
      ImageHeight: 97
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 50
      ImageHeight: 17
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 50
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 50
      ImageHeight: 72
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 50
      ImageHeight: 13
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 50
      ImageHeight: 8
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 50
      ImageHeight: 14
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 23
      ImageHeight: 9
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: UNNDXJ+STIX-Regular
      FontSubset: true
      FirstChar: 24
      LastChar: 248
      FontDescriptor: 
       FontName: UNNDXJ+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 32
      LastChar: 169
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -159, -250, 1161, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DQRKOS+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DQRKOS+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1115, 963
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
            xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <xmp:CreateDate>2018-12-18T07:04:16+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2019-01-11T15:11:15+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2019-01-11T15:11:15+05:30</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows)</pdf:Producer>
         <pdf:Keywords>Bladder cancer,Cystectomy,Chemotherapy,Immune checkpoint inhibitors</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s12094-018-02001-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer International Publishing</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Clinical and Translational Oncology, https://doi.org/10.1007/s12094-018-02001-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Bladder cancer</rdf:li>
               <rdf:li>Cystectomy</rdf:li>
               <rdf:li>Chemotherapy</rdf:li>
               <rdf:li>Immune checkpoint inhibitors</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">SEOM clinical guideline for treatment of muscle-invasive and metastatic urothelial bladder cancer (2018)</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>A. González del Alba </rdf:li>
               <rdf:li>G. De Velasco </rdf:li>
               <rdf:li>N. Lainez </rdf:li>
               <rdf:li>P. Maroto </rdf:li>
               <rdf:li>R. Morales-Barrera </rdf:li>
               <rdf:li>J. Muñoz-Langa </rdf:li>
               <rdf:li>B. Pérez-Valderrama </rdf:li>
               <rdf:li>L. Basterretxea </rdf:li>
               <rdf:li>C. Caballero </rdf:li>
               <rdf:li>S. Vazquez </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s12094-018-02001-x</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s12094-018-02001-x</prism:url>
         <prism:doi>10.1007/s12094-018-02001-x</prism:doi>
         <prism:issn>1699-3055</prism:issn>
         <prism:volume>21</prism:volume>
         <prism:number>1</prism:number>
         <prism:startingPage>64</prism:startingPage>
         <prism:endingPage>74</prism:endingPage>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Clinical and Translational Oncology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s12094-018-02001-x</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:afa28fa4-45ca-4f53-8068-0f2879cc35dd</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b0117994-62d1-45f4-84b3-ccd9d816fcce</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:17e860a3-2d6e-4a78-bf0d-4c3261a68d45</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-01-11T15:10:29+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:29626167-1a58-49e2-8461-24da6fde5dc0</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-01-11T15:11:15+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>A. González del Alba</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6570-009X</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 64
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 634, 153, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 153, 279, 158, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 253, 179, 258, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 414, 266, 419, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 331, 141, 336, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 485, 721, 546, 695
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 65
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 459, 59, 444
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 199, 247, 205, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 344, 511, 349, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 515, 498, 520, 483
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 525, 498, 530, 483
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 359, 473, 364, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 506, 348, 516, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 490, 261, 500, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 487, 236, 497, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 389, 186, 399, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 533, 173, 538, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
     Thumb: true
    Page: 
     Label: 66
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 144, 424, 155, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 122, 286, 132, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 130, 261, 140, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 214, 161, 225, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 110, 136, 120, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 125, 136, 135, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 361, 699, 371, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 380, 674, 390, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 309, 611, 319, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 407, 436, 418, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 423, 436, 433, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 464, 299, 474, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 469, 249, 479, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 484, 249, 494, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 381, 211, 391, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 396, 211, 406, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 444, 161, 454, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 459, 161, 469, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 487, 136, 497, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 502, 136, 512, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 528, 99, 538, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
     Thumb: true
    Page: 
     Label: 67
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 736, 166, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 273, 711, 283, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 148, 374, 158, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 193, 336, 203, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 118, 286, 128, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 135, 199, 145, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 273, 124, 283, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 228, 86, 238, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 309, 386, 319, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 410, 324, 420, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 500, 286, 511, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
     Thumb: true
    Page: 
     Label: 68
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 116, 711, 126, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 72, 661, 82, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 93, 574, 103, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 202, 524, 212, 509
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 54, 136, 64, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 258, 124, 268, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 423, 561, 433, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 528, 486, 538, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 522, 249, 533, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 524, 174, 534, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 391, 161, 402, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
     Thumb: true
    Page: 
     Label: 69
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 257, 586, 267, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 54, 499, 64, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 69, 499, 79, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 171, 261, 181, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 125, 236, 135, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 72, 111, 82, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 492, 574, 502, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 527, 486, 537, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 378, 399, 389, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 454, 249, 464, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
     Thumb: true
    Page: 
     Label: 70
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 151, 647, 161, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 167, 647, 177, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 183, 647, 193, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 198, 647, 208, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 275, 585, 285, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 54, 485, 64, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 194, 147, 205, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 199, 122, 209, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 309, 486, 320, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 528, 249, 538, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 117
     Thumb: true
    Page: 
     Label: 71
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 222, 289, 209
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 212, 145, 199
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 85, 86, 205, 73
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 666, 542, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 506, 586, 544, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 576, 395, 563
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 72
     Sequence: 9
     Thumb: true
    Page: 
     Label: 73
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 119, 386, 287, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 115, 336, 289, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 326, 93, 313
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 436, 544, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 426, 400, 413
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 316, 544, 303
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 306, 452, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 141, 160, 153, 148
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 74
     Sequence: 11
     Thumb: true
  Checksum: f268b2e5
   Type: CRC32
  Checksum: 15dbd35dab3ed1e6298ad785221a6553
   Type: MD5
  Checksum: abdb7ccdc8ae91afb6a8e1cc81f5d296ac68e6c4
   Type: SHA-1