d42f613489e5bd64e7fa1d8b63452e7b 285227.pdf 5d2c2de8d1e2d38769f0071b0c0d6fc4322748a1 285227.pdf 95246324fd8583a27795f962fe67ca6e3c826e57dc62e42ff8e8dd4694d9e491 285227.pdf Title: Cross-Talk between Lipoproteins and Inflammation: The Role of Microvesicles Subject: Atherothrombosis is the principal underlying cause of cardiovascular disease (CVD). Microvesicles (MV) are small blebs originated by an outward budding at the cell plasma membranes, which are released in normal conditions. However, MV release is increased in pathophysiologic conditions such as CVD. Low density lipoprotein (LDL) and MV contribute to atherothrombosis onset and progression by promoting inflammation and leukocyte recruitment to injured endothelium, as well as by increasing thrombosis and plaque vulnerability. Moreover, (oxidized)LDL induces MV release and vice-versa, perpetuating endothelium injury leading to CVD progression. Therefore, MV and lipoproteins exhibit common features, which should be considered in the interpretation of their respective roles in the pathophysiology of CVD. Understanding the pathways implicated in this process will aid in developing novel therapeutic approaches against atherothrombosis. Keywords: microvesicles; inflammation; lipoproteins; LDL cholesterol; microparticles; cardiovascular disease; platelets; endothelial cells; leukocytes; atherothrombosis Author: Gemma Chiva-Blanch and Lina Badimon Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Nov 22 10:09:50 2019 CET ModDate: Fri Nov 22 10:09:50 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 888202 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BPUQZY+URWPalladioL-Ital Type 1 Custom yes yes no 61 0 GQOQWV+URWPalladioL-Bold Type 1 Custom yes yes no 62 0 ETFWBQ+URWPalladioL-Roma Type 1 Custom yes yes no 63 0 SVVJCD+Rpxr Type 1 Builtin yes yes no 64 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 69 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C 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