e294e655a4509ed0b447ff3d6a60b715 285783.pdf 1076629a76e3bb12a3c87274ed232253404077e5 285783.pdf d728e01b4d8be02913b9e555030760a87e92c9e294eb537eb09af005ff898e45 285783.pdf Title: Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation Subject: Biology of Blood and Marrow Transplantation, 25 (2019) 1022-1030. doi:10.1016/j.bbmt.2019.01.012 Keywords: Cytomegalovirus DNAemia; Cytomegalovirus infection; Cytomegalovirus disease; Preemptive antiviral therapy; Sirolimus; Mechanistic target of rapamycin inhibitor; Allogeneic hematopoietic stem cells transplantation; Quantitative PCR; Sirolimus exposure; Time-to-event analysis; PK/PD Author: Beatriz Guglieri-Lopez Creator: Elsevier Producer: Acrobat Distiller 10.1.16 (Windows) CreationDate: Fri Apr 19 14:57:34 2019 CEST ModDate: Fri Apr 19 14:58:13 2019 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 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for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation Destination: Head1 Children: Item: Title: INTRODUCTION Destination: Head2 Item: Title: METHODS Destination: Head3 Children: Item: Title: Patients Destination: Head4 Item: Title: Conditioning Regimen and GVHD Prophylaxis Destination: Head5 Item: Title: Sirolimus and Tacrolimus Blood Concentration Monitoring, Management, and Technical Considerations Destination: Head6 Item: Title: CMV DNA Monitoring and Load Quantitation Destination: Head7 Item: Title: Preemptive Anti-CMV Therapy and Definitions Destination: Head8 Item: Title: Statistical Methods Destination: Head9 Item: Title: Nonparametric and Semiparametric Analyses Destination: Head10 Item: Title: Parametric Analysis Destination: Head11 Children: Item: Title: Development of the Baseline Model Destination: Head12 Item: Title: Development of the Covariate Model Destination: Head13 Item: Title: RESULTS Destination: Head14 Children: Item: Title: Patient Characteristics Destination: Head15 Item: Title: CMV-DNAemia-RAT and CMV Disease Characteristics Destination: Head16 Item: Title: Risk Factors for CMV DNAemia Necessitating Preemptive Antiviral Therapy Destination: Head17 Children: Item: Title: Nonparametric and Semiparametric Analyses Destination: Head18 Item: Title: Parametric Analyses Destination: Head19 Item: Title: NRM, Relapse, and Survival Destination: Head20 Item: Title: DISCUSSION Destination: Head21 Item: Title: ACKNOWLEDGMENTS Destination: Head22 Item: Title: REFERENCES Destination: Head23 Info: Title: Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation Author: Beatriz Guglieri-Lopez Subject: Biology of Blood and Marrow Transplantation, 25 (2019) 1022-1030. doi:10.1016/j.bbmt.2019.01.012 Keywords: Cytomegalovirus DNAemia; Cytomegalovirus infection; Cytomegalovirus disease; 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Biology of Blood and Marrow Transplantation, 25 (2019) 1022-1030. doi:10.1016/j.bbmt.2019.01.012 Cytomegalovirus DNAemia Cytomegalovirus infection Cytomegalovirus disease Preemptive antiviral therapy Sirolimus Mechanistic target of rapamycin inhibitor Allogeneic hematopoietic stem cells transplantation Quantitative PCR Sirolimus exposure Time-to-event analysis PK/PD Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation Beatriz Guglieri-Lopez Alejandro Perez-Pitarch Irene Garcia-Cadenas Estela Gimenez Pere Barba Nuria Rabella Juan Carlos Hernandez-Boluda Laura Fox David Valcarcel Albert Esquirol Rafael Ferriols-Lisart Jorge Sierra Carlos Solano David Navarro Rodrigo Martino José Luis Piñana uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:ad97a3e4-9299-4dfd-9e21-233575a7fa32 journal © 2019 American Society for Blood and Marrow Transplantation. 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