d5d812ab5cc329eab7fae9abb293762e 285797.pdf 68f8990da8add6dd6574f49b3be3100061152ed1 285797.pdf 0b16d0e788712e417c3b843b788784723a1b933b6e5765c347d03410714a3356 285797.pdf Title: Poorer Quality of Life and Treatment Satisfaction is Associated with Diabetic Retinopathy in Patients with Type 1 Diabetes without Other Advanced Late Complications Subject: Diabetic retinopathy (DR) may potentially cause vision loss and affect the patient’s quality of life (QoL) and treatment satisfaction (TS). Using specific tools, we aimed to assess the impact of DR and clinical factors on the QoL and TS in patients with type 1 diabetes. This was a cross-sectional, two-centre study. A sample of 102 patients with DR and 140 non-DR patients were compared. The Audit of Diabetes-Dependent Quality of Life (ADDQoL-19) and Diabetes Treatment Satisfaction Questionnaire (DTSQ-s) were administered. Data analysis included bivariate and multivariable analysis. Patients with DR showed a poorer perception of present QoL (p = 0.039), work life (p = 0.037), dependence (p = 0.010), and had a lower average weighted impact (AWI) score (p = 0.045). The multivariable analysis showed that DR was associated with a lower present QoL (p = 0.040), work life (p = 0.036) and dependence (p = 0.016). With regards to TS, DR was associated with a higher perceived frequency of hypoglycaemia (p = 0.019). In patients with type 1 diabetes, the presence of DR is associated with a poorer perception of their QoL. With regard to TS, these subjects also show a higher perceived frequency of hypoglycaemia. Keywords: diabetic retinopathy; type 1 diabetes; quality of life; treatment satisfaction; patient-reported outcomes Author: Minerva Granado-Casas, Esmeralda Castelblanco, Anna Ramírez-Morros, Mariona Martín, Nuria Alcubierre, Montserrat Martínez-Alonso, Xavier Valldeperas, Alicia Traveset, Esther Rubinat, Ana Lucas-Martin, Marta Hernández, Núria Alonso and Didac Mauricio Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Mar 18 11:38:10 2019 CET ModDate: Mon Mar 18 11:38:10 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 272855 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KHLOCZ+URWPalladioL-Ital Type 1 Custom yes yes no 78 0 CRLADW+URWPalladioL-Bold Type 1 Custom yes yes no 79 0 JGBJTI+VnURWPalladioL-Bold Type 1 Custom yes yes no 80 0 JCTPHL+URWPalladioL-Roma Type 1 Custom yes yes no 81 0 YQOTQA+VnURWPalladioL Type 1 Custom yes yes no 82 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 87 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 88 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 107 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 108 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 109 0 JDUPKS+CMSY10 Type 1 Builtin yes yes no 204 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 215 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 223 0 ZYYJXI+EURB10 Type 1 Builtin yes yes no 248 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-08 02:35:44 CET RepresentationInformation: 285797.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-07 13:56:23 CET Size: 272855 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの〠 Item: Title: きちぴづひどちぬび〠ちのつ〠きづぴとはつび〠 Children: Item: Title: ぃぬどのどっちぬ〠ざちひどちぢぬづび〠 Item: Title: けふちぬどぴべ〠はて〠がどてづ〠 Item: Title: ごひづちぴねづのぴ〠こちぴどびてちっぴどはの〠 Item: Title: こちねばぬづ〠こどぺづ〠 Item: Title: こぴちぴどびぴどっちぬ〠きづぴとはつび〠 Item: Title: げづびふぬぴび〠 Children: Item: Title: いどちぢづぴづび〭げづぬちぴづつ〠けふちぬどぴべ〠はて〠がどてづ〠 Item: Title: ごひづちぴねづのぴ〠こちぴどびてちっぴどはの〠 Item: Title: いどびっふびびどはの〠 Item: Title: ぃはのっぬふびどはのび〠 Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: JGBJTI+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 243 FontDescriptor: FontName: JGBJTI+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JCTPHL+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: JCTPHL+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YQOTQA+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 243 FontDescriptor: FontName: YQOTQA+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZYYJXI+EURB10 FontSubset: true FirstChar: 12 LastChar: 12 FontDescriptor: FontName: ZYYJXI+EURB10 Flags: Symbolic FontBBox: -30, -247, 1178, 723 FontFile: true Font: BaseFont: JDUPKS+CMSY10 FontSubset: true FirstChar: 0 LastChar: 6 FontDescriptor: FontName: JDUPKS+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: KHLOCZ+URWPalladioL-Ital FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: KHLOCZ+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CRLADW+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: CRLADW+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LWLIVD+EURM10 FontSubset: true FirstChar: 12 LastChar: 12 FontDescriptor: FontName: LWLIVD+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 217, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 199, 621, 210, 633 Annotation: Subtype: Link Rect: 229, 594, 240, 606 Annotation: Subtype: Link Rect: 430, 594, 441, 606 Annotation: Subtype: Link Rect: 274, 582, 285, 593 Annotation: Subtype: Link Rect: 466, 309, 518, 328 Annotation: Subtype: Link Rect: 176, 38, 249, 50 Annotation: Subtype: Link Rect: 413, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 508, 723, 515, 732 ActionDest: 300 Annotation: Subtype: Link Rect: 196, 696, 203, 705 ActionDest: 300 Annotation: Subtype: Link Rect: 383, 682, 390, 691 ActionDest: 300 Annotation: Subtype: Link Rect: 96, 642, 103, 651 ActionDest: 300 Annotation: Subtype: Link Rect: 345, 628, 351, 637 ActionDest: 300 Annotation: Subtype: Link Rect: 154, 588, 161, 597 ActionDest: 300 Annotation: Subtype: Link Rect: 161, 588, 168, 597 ActionDest: 300 Annotation: Subtype: Link Rect: 341, 574, 348, 583 ActionDest: 300 Annotation: Subtype: Link Rect: 493, 561, 500, 570 ActionDest: 300 Annotation: Subtype: Link Rect: 503, 561, 515, 570 ActionDest: 328 Annotation: Subtype: Link Rect: 142, 520, 154, 529 ActionDest: 328 Annotation: Subtype: Link Rect: 127, 493, 139, 502 ActionDest: 328 Annotation: Subtype: Link Rect: 143, 493, 154, 502 ActionDest: 355 Annotation: Subtype: Link Rect: 265, 466, 277, 475 ActionDest: 328 Annotation: Subtype: Link Rect: 115, 412, 127, 421 ActionDest: 328 Annotation: Subtype: Link Rect: 127, 412, 139, 421 ActionDest: 328 Annotation: Subtype: Link Rect: 140, 412, 151, 421 ActionDest: 328 Annotation: Subtype: Link Rect: 464, 399, 476, 408 ActionDest: 328 Annotation: Subtype: Link Rect: 477, 399, 489, 408 ActionDest: 355 Annotation: Subtype: Link Rect: 114, 358, 126, 367 ActionDest: 355 Annotation: Subtype: Link Rect: 126, 358, 138, 367 ActionDest: 355 Annotation: Subtype: Link Rect: 428, 345, 440, 354 ActionDest: 328 Annotation: Subtype: Link Rect: 440, 345, 452, 354 ActionDest: 328 Annotation: Subtype: Link Rect: 278, 277, 290, 286 ActionDest: 328 Annotation: Subtype: Link Rect: 176, 237, 188, 246 ActionDest: 328 Annotation: Subtype: Link Rect: 189, 237, 201, 246 ActionDest: 328 Annotation: Subtype: Link Rect: 413, 196, 420, 205 ActionDest: 300 Annotation: Subtype: Link Rect: 131, 155, 138, 165 ActionDest: 300 Annotation: Subtype: Link Rect: 139, 155, 146, 165 ActionDest: 328 Annotation: Subtype: Link Rect: 146, 155, 158, 165 ActionDest: 355 Annotation: Subtype: Link Rect: 255, 115, 267, 124 ActionDest: 355 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 198, 578, 210, 587 ActionDest: 355 Annotation: Subtype: Link Rect: 294, 538, 306, 547 ActionDest: 355 Annotation: Subtype: Link Rect: 285, 348, 297, 357 ActionDest: 355 Annotation: Subtype: Link Rect: 206, 103, 218, 112 ActionDest: 355 Annotation: Subtype: Link Rect: 218, 103, 230, 112 ActionDest: 355 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 420, 729, 431, 738 ActionDest: 355 Annotation: Subtype: Link Rect: 365, 659, 376, 668 ActionDest: 355 Annotation: Subtype: Link Rect: 380, 659, 392, 668 ActionDest: 355 Annotation: Subtype: Link Rect: 409, 538, 416, 547 ActionDest: 300 Annotation: Subtype: Link Rect: 491, 481, 503, 490 ActionDest: 355 Annotation: Subtype: Link Rect: 503, 481, 515, 490 ActionDest: 355 Annotation: Subtype: Link Rect: 209, 331, 216, 340 ActionDest: 300 Annotation: Subtype: Link Rect: 172, 263, 184, 272 ActionDest: 355 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 440, 661, 452, 670 ActionDest: 355 Annotation: Subtype: Link Rect: 451, 616, 457, 628 ActionDest: 211 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 157, 707, 164, 719 ActionDest: 220 Annotation: Subtype: Link Rect: 201, 639, 208, 651 ActionDest: 245 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 508, 504, 515, 516 ActionDest: 220 Annotation: Subtype: Link Rect: 388, 436, 395, 448 ActionDest: 245 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 265, 702, 276, 711 ActionDest: 328 Annotation: Subtype: Link Rect: 373, 634, 385, 643 ActionDest: 328 Annotation: Subtype: Link Rect: 274, 607, 286, 616 ActionDest: 328 Annotation: Subtype: Link Rect: 286, 607, 298, 616 ActionDest: 328 Annotation: Subtype: Link Rect: 299, 607, 311, 616 ActionDest: 328 Annotation: Subtype: Link Rect: 383, 607, 395, 616 ActionDest: 328 Annotation: Subtype: Link Rect: 329, 526, 341, 535 ActionDest: 328 Annotation: Subtype: Link Rect: 454, 513, 466, 522 ActionDest: 355 Annotation: Subtype: Link Rect: 329, 418, 341, 427 ActionDest: 355 Annotation: Subtype: Link Rect: 147, 391, 159, 400 ActionDest: 355 Annotation: Subtype: Link Rect: 160, 391, 172, 400 ActionDest: 355 Annotation: Subtype: Link Rect: 157, 351, 164, 360 ActionDest: 300 Annotation: Subtype: Link Rect: 148, 324, 155, 333 ActionDest: 328 Annotation: Subtype: Link Rect: 440, 283, 452, 292 ActionDest: 328 Annotation: Subtype: Link Rect: 452, 283, 464, 292 ActionDest: 328 Annotation: Subtype: Link Rect: 503, 229, 515, 238 ActionDest: 328 Annotation: Subtype: Link Rect: 251, 175, 262, 184 ActionDest: 355 Annotation: Subtype: Link Rect: 331, 175, 343, 184 ActionDest: 328 Annotation: Subtype: Link Rect: 97, 121, 104, 130 ActionDest: 328 Annotation: Subtype: Link Rect: 104, 121, 116, 130 ActionDest: 328 Annotation: Subtype: Link Rect: 117, 121, 129, 130 ActionDest: 355 Annotation: Subtype: Link Rect: 129, 121, 141, 130 ActionDest: 366 Annotation: Subtype: Link Rect: 503, 108, 515, 117 ActionDest: 328 Annotation: Subtype: Link Rect: 496, 80, 503, 89 ActionDest: 300 Annotation: Subtype: Link Rect: 503, 81, 515, 89 ActionDest: 355 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 503, 702, 515, 711 ActionDest: 366 Annotation: Subtype: Link Rect: 362, 634, 369, 643 ActionDest: 300 Annotation: Subtype: Link Rect: 370, 634, 377, 643 ActionDest: 328 Annotation: Subtype: Link Rect: 377, 634, 389, 643 ActionDest: 366 Annotation: Subtype: Link Rect: 400, 580, 407, 589 ActionDest: 300 Annotation: Subtype: Link Rect: 171, 526, 178, 535 ActionDest: 300 Annotation: Subtype: Link Rect: 178, 526, 190, 535 ActionDest: 355 Annotation: Subtype: Link Rect: 117, 513, 124, 522 ActionDest: 328 Annotation: Subtype: Link Rect: 125, 513, 137, 522 ActionDest: 366 Annotation: Subtype: Link Rect: 178, 80, 185, 89 ActionDest: 300 Annotation: Subtype: Link Rect: 188, 81, 195, 89 ActionDest: 300 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 330, 588, 518, 599 Annotation: Subtype: Link Rect: 394, 344, 519, 355 Annotation: Subtype: Link Rect: 97, 331, 393, 342 Annotation: Subtype: Link Rect: 100, 306, 137, 316 Annotation: Subtype: Link Rect: 143, 306, 179, 316 Annotation: Subtype: Link Rect: 100, 255, 137, 265 Annotation: Subtype: Link Rect: 143, 255, 179, 265 Annotation: Subtype: Link Rect: 318, 229, 355, 239 Annotation: Subtype: Link Rect: 475, 215, 513, 226 Annotation: Subtype: Link Rect: 100, 177, 137, 187 Annotation: Subtype: Link Rect: 143, 177, 179, 187 Annotation: Subtype: Link Rect: 436, 150, 472, 161 Annotation: Subtype: Link Rect: 100, 100, 137, 110 Annotation: Subtype: Link Rect: 143, 100, 179, 110 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 429, 714, 467, 725 Annotation: Subtype: Link Rect: 181, 663, 218, 674 Annotation: Subtype: Link Rect: 475, 637, 512, 648 Annotation: Subtype: Link Rect: 316, 598, 354, 609 Annotation: Subtype: Link Rect: 360, 598, 396, 609 Annotation: Subtype: Link Rect: 480, 559, 516, 570 Annotation: Subtype: Link Rect: 471, 533, 508, 544 Annotation: Subtype: Link Rect: 163, 508, 200, 519 Annotation: Subtype: Link Rect: 368, 469, 405, 480 Annotation: Subtype: Link Rect: 412, 469, 448, 480 Annotation: Subtype: Link Rect: 100, 431, 137, 441 Annotation: Subtype: Link Rect: 143, 431, 179, 441 Annotation: Subtype: Link Rect: 100, 392, 137, 402 Annotation: Subtype: Link Rect: 143, 392, 179, 402 Annotation: Subtype: Link Rect: 100, 354, 137, 364 Annotation: Subtype: Link Rect: 99, 263, 136, 273 Annotation: Subtype: Link Rect: 328, 224, 365, 235 Annotation: Subtype: Link Rect: 372, 224, 408, 235 Annotation: Subtype: Link Rect: 288, 185, 325, 196 Annotation: Subtype: Link Rect: 331, 185, 367, 196 Annotation: Subtype: Link Rect: 335, 159, 373, 170 Annotation: Subtype: Link Rect: 379, 159, 415, 170 Annotation: Subtype: Link Rect: 181, 121, 218, 131 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 167, 702, 205, 712 Annotation: Subtype: Link Rect: 390, 675, 428, 686 Annotation: Subtype: Link Rect: 249, 638, 286, 648 Annotation: Subtype: Link Rect: 276, 611, 314, 622 Annotation: Subtype: Link Rect: 360, 572, 397, 583 Annotation: Subtype: Link Rect: 299, 547, 337, 557 Annotation: Subtype: Link Rect: 288, 508, 325, 519 Annotation: Subtype: Link Rect: 332, 508, 368, 519 Annotation: Subtype: Link Rect: 400, 469, 437, 480 Annotation: Subtype: Link Rect: 250, 444, 287, 454 Annotation: Subtype: Link Rect: 341, 366, 379, 377 Annotation: Subtype: Link Rect: 158, 328, 195, 338 Annotation: Subtype: Link Rect: 363, 288, 401, 299 Annotation: Subtype: Link Rect: 407, 288, 443, 299 Annotation: Subtype: Link Rect: 481, 224, 516, 235 Annotation: Subtype: Link Rect: 454, 211, 519, 222 Annotation: Subtype: Link Rect: 97, 198, 141, 209 Annotation: Subtype: Link Rect: 408, 159, 445, 170 Annotation: Subtype: Link Rect: 452, 159, 488, 170 Annotation: Subtype: Link Rect: 376, 133, 414, 144 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 339, 727, 377, 738 Annotation: Subtype: Link Rect: 331, 701, 369, 712 Annotation: Subtype: Link Rect: 76, 659, 166, 690 Annotation: Subtype: Link Rect: 234, 653, 424, 665 Checksum: 97ac1ca2 Type: CRC32 Checksum: d5d812ab5cc329eab7fae9abb293762e Type: MD5 Checksum: 68f8990da8add6dd6574f49b3be3100061152ed1 Type: SHA-1 Checksum: 0b16d0e788712e417c3b843b788784723a1b933b6e5765c347d03410714a3356 Type: SHA-256