80ed17e5c7b68d26283b5bbb6a95a7e2 285830.pdf 8aba3c6ba331cd8ae0526b2c9545b939258e9c68 285830.pdf c91091f297d41b0c7a721d79b2ea4e1fa32c7f18814b64deed757ae260b44156 285830.pdf Title: Acute Effect of a Single Dose of Tomato Sofrito on Plasmatic Inflammatory Biomarkers in Healthy Men Subject: Sofrito is a Mediterranean tomato-based sauce that typically also contains olive oil, onion, and garlic. The preparation of sofrito modifies the bioactive compounds (carotenoids and polyphenols) in the ingredients to more bioavailable forms, promoting cis-lycopene formation and polyphenol bioaccessibility. To evaluate the health benefits of this cooking technique, the effect of consuming an acute dose of sofrito on the inflammatory status was studied. In a clinical trial, 22 healthy male subjects consumed a single dose of sofrito (240 g/70 kg) after three days without ingesting any tomato products and following a low-antioxidant diet the day before the intervention. Plasma carotenoids and total polyphenol excretion (TPE) were evaluated, as well as the inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL-6), interleukin 1 (IL-1) and tumor necrosis factor- (TNF-). After the sofrito intake, a significant decrease in CRP (p = 0.010) and TNF- (p = 0.011) was observed, but only TNF- was inversely correlated with an increase in TPE and plasma -carotene (not the major carotenoid, lycopene). The positive health effects of this tomato-based product may be attributed not only to lycopene, but to the bioactive compounds of all the ingredients. Keywords: carotenoids; polyphenols; TNF-; CRP; lycopene; -carotene; bioavailability; Mediterranean; onion; extra virgin olive oil Author: Sara Hurtado-Barroso, Miriam Martínez-Huélamo, Jose Fernando Rinaldi de Alvarenga, Paola Quifer-Rada, Anna Vallverdú-Queralt, Silvia Pérez-Fernández and Rosa M. 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