d90efae0bcc7c1ea89a3d5c120f43f64 285843.pdf a9b898b9d8941a1e399a2c8bc081f3589c979d7b 285843.pdf 25ef9cd95dfba062416e712b8aedef291d7935b262a39d4b26d03a5f49e9780b 285843.pdf Title: Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome Subject: Journal of the American College of Cardiology, 74 (2019) 1167-1176. doi:10.1016/j.jacc.2019.03.013 Author: J. Wouter Jukema MD PhD Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 14th August 2019 ModDate: Wed Aug 14 17:06:42 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 576 x 773.972 pts Page rot: 0 File size: 331926 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FNDKFE+AdvPSSym Type 1C WinAnsi yes yes no 625 0 FNDKAK+AdvOT5b669f61 Type 1C WinAnsi yes yes no 590 0 FNDKAL+AdvOTa2a4c9ce Type 1C WinAnsi yes yes no 593 0 FNDKAM+AdvOTe81213fa Type 1C WinAnsi yes yes no 595 0 FNDKAN+AdvP4C4E74 Type 1C Custom yes yes yes 603 0 FNDKBO+AdvOT2986fa51 Type 1C WinAnsi yes yes no 605 0 FNDKBP+AdvOT2986fa51+20 Type 1C WinAnsi yes yes no 607 0 FNDKCA+AdvOT2986fa51+fb Type 1C Custom yes yes yes 597 0 FNDKCB+AdvOTe81213fa+20 Type 1C WinAnsi yes yes no 615 0 FNDKCC+AdvOT61751f86 Type 1C WinAnsi yes yes no 618 0 FNDKDD+AdvOT8e266094.B Type 1C WinAnsi yes yes no 621 0 FNDKDE+AdvOT8e266094.B+20 Type 1C WinAnsi yes yes no 623 0 FNDKFF+AdvOT78d326c7 Type 1C WinAnsi yes yes no 335 0 FNDKFG+AdvOTe81213fa+fb Type 1C Custom yes yes yes 333 0 FNDKGH+AdvOT1a97e067.I Type 1C WinAnsi yes yes no 355 0 FNDKGI+AdvOT1a97e067.I+20 Type 1C WinAnsi yes yes no 358 0 FNDKGJ+AdvOT8f503d4a Type 1C WinAnsi yes yes no 339 0 FNDKGK+AdvOTc3f2c111.B Type 1C WinAnsi yes yes no 342 0 FNDKGL+AdvOTc3f2c111.B+fb Type 1C Custom yes yes yes 352 0 FNDKHL+AdvOTd9ad3ae4.I Type 1C WinAnsi yes yes no 353 0 FNDKHM+AdvOT61751f86+20 Type 1C WinAnsi yes yes no 363 0 FNDKJM+AdvOTe60b6cd3.B Type 1C WinAnsi yes yes no 371 0 FNDKJN+AdvP4C4E51 Type 1C WinAnsi yes yes no 374 0 FNDKJO+AdvOT8817665d Type 1C WinAnsi yes yes no 370 0 FNDKMO+GuardianTextSans-Medium Type 1C WinAnsi yes yes no 383 0 FNDKMP+GuardianTextSans-Bold Type 1C WinAnsi yes yes no 386 0 FNDKOA+AdvOTc3f2c111.B+20 Type 1C WinAnsi yes yes no 389 0 FNDLBP+AdvOTf2345705 Type 1C WinAnsi yes yes no 401 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-14 02:37:17 CET RepresentationInformation: 285843.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-13 11:11:27 CET Size: 331926 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Improperly formed date ID: PDF-HUL-133 Offset: 321593 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 677 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome Destination: titlink1 Children: Item: Title: Methods Destination: flink1 Children: Item: Title: Categories of polyvascular disease Destination: slink1 Item: Title: Endpoints Destination: slink2 Item: Title: Statistical considerations Destination: slink3 Item: Title: Results Destination: flink2 Children: Item: Title: Baseline characteristics Destination: slink4 Item: Title: LDL-C lowering Destination: slink5 Item: Title: Primary MACE endpoint and all-cause death Destination: slink6 Item: Title: Safety outcomes Destination: slink7 Item: Title: Discussion Destination: flink3 Children: Item: Title: Study limitations Destination: slink8 Item: Title: Conclusions Destination: flink4 Item: Title: Acknowledgments Destination: acklink1 Item: Title: References Destination: blink2 Info: Title: Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome Author: J. 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Wouter Jukema MD PhD Michael Szarek PhD Laurien E. Zijlstra MD H. Asita de Silva MBBS DPhil Deepak L. Bhatt MD MPH Vera A. Bittner MD MSPH Rafael Diaz MD Jay M. Edelberg MD PhD Shaun G. Goodman MD MSc Corinne Hanotin MD Robert A. Harrington MD Yuri Karpov MD Angèle Moryusef MD Robert Pordy MD Juan C. Prieto MD Matthew T. Roe MD MHS Harvey D. White DSc Andreas M. Zeiher MD Gregory G. Schwartz MD PhD P. Gabriel Steg MD ODYSSEY OUTCOMES Committees and Investigators‡ acute coronary syndrome alirocumab cerebrovascular disease death major adverse cardiac events peripheral artery disease Journal of the American College of Cardiology, 74 (2019) 1167-1176. doi:10.1016/j.jacc.2019.03.013 Elsevier journal Journal of the American College of Cardiology © 2019 The Authors. 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