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Introduction Destination: flink1 Item: Title: 2. Methods Destination: flink2 Children: Item: Title: 2.1. Study population Destination: slink1 Item: Title: 2.2. Discovery phase assays Destination: slink2 Item: Title: 2.3. Replication phase assays Destination: slink3 Item: Title: 2.4. Statistical analysis Destination: slink4 Children: Item: Title: 2.4.1. Individual analytes Destination: tlink1 Item: Title: 2.4.2. Identification of optimal analyte sets Destination: tlink2 Item: Title: 2.4.3. Markers of disease progression Destination: tlink3 Item: Title: 3. Results Destination: flink3 Children: Item: Title: 3.1. Individual analytes differ between discovery set groups Destination: slink5 Item: Title: 3.2. Developing models to differentiate groups Destination: slink6 Children: Item: Title: 3.2.1. AD from CTL Destination: tlink4 Item: Title: 3.2.2. AD from MCI Destination: tlink5 Item: Title: 3.2.3. MCI from CTL Destination: tlink6 Item: Title: 3.2.4. MCI progressors from nonprogressors Destination: tlink7 Item: Title: 4. Discussion Destination: flink4 Item: Title: Acknowledgments Destination: ablink1 Item: Title: References Destination: blink2 Info: Title: Inflammatory biomarkers in Alzheimer's disease plasma Author: Angharad R. Morgan Subject: Alzheimer's & Dementia, 15 (2019) 776-787. doi:10.1016/j.jalz.2019.03.007 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Jun 03 20:53:11 CEST 2019 ModDate: Mon Jun 03 20:53:49 CEST 2019 ID: 0x8d4ae09ac9ffcf542afc0781255f694e, 0xb921278683234b4c9bef68f7dd0104c9 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1943 ImageHeight: 2365 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 631 ImageHeight: 1896 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1794 ImageHeight: 1282 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GBNCGI+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GBNCGI+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: GBNCEF+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 128 FontDescriptor: FontName: GBNCEF+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GBNCEG+AdvP41CBCA FontSubset: true FirstChar: 49 LastChar: 49 FontDescriptor: FontName: GBNCEG+AdvP41CBCA Flags: Nonsymbolic FontBBox: -20, -229, 927, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBNCKH+AdvPSA88B FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: GBNCKH+AdvPSA88B Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBNCKI+AdvOTd877c31c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GBNCKI+AdvOTd877c31c+03 Flags: Symbolic FontBBox: 24, -10, 407, 460 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GBNCLK+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: GBNCLK+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBNCFG+AdvPSA88C FontSubset: true FirstChar: 30 LastChar: 146 FontDescriptor: FontName: GBNCFG+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GBNCED+AdvPSA88A FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: GBNCED+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: GBNCFH+AdvPS586B FontSubset: true FirstChar: 44 LastChar: 54 FontDescriptor: FontName: GBNCFH+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBNCEE+AdvP4C4E74 FontSubset: true FirstChar: 121 LastChar: 121 FontDescriptor: FontName: GBNCEE+AdvP4C4E74 Flags: Nonsymbolic FontBBox: -20, -958, 1114, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBNCKJ+AdvP3F4C13 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: GBNCKJ+AdvP3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.jalz.2019.03.007 Inflammatory biomarkers in Alzheimer's disease plasma Angharad R. Morgan Samuel Touchard Claire Leckey Caroline O'Hagan Alejo J. Nevado-Holgado Frederik Barkhof Lars Bertram Olivier Blin Isabelle Bos Valerija Dobricic Sebastiaan Engelborghs Giovanni Frisoni Lutz Frölich Silvey Gabel Peter Johannsen Petronella Kettunen Iwona Kłoszewska Cristina Legido-Quigley Alberto Lleó Pablo Martinez-Lage Patrizia Mecocci Karen Meersmans José Luis Molinuevo Gwendoline Peyratout Julius Popp Jill Richardson Isabel Sala Philip Scheltens Johannes Streffer Hikka Soininen Mikel Tainta-Cuezva Charlotte Teunissen Magda Tsolaki Rik Vandenberghe Pieter Jelle Visser Stephanie Vos Lars-Olof Wahlund Anders Wallin Sarah Westwood Henrik Zetterberg Simon Lovestone B. Paul Morgan Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease Edward T. Bullmore Junaid Bhatti Samuel J. Chamberlain Marta M. Correia Anna L. Crofts Amber Dickinson Andrew C. Foster Manfred G. Kitzbichler Clare Knight Mary-Ellen Lynall Christina Maurice Ciara O'Donnell Linda J. Pointon Peter St George Hyslop Lorinda Turner Petra Vertes Barry Widmer Guy B. Williams B. Paul Morgan Claire A. Leckey Angharad R. Morgan Caroline O'Hagan Samuel Touchard Jonathan Cavanagh Catherine Deith Scott Farmer John McClean Alison McColl Andrew McPherson Paul Scouller Murray Sutherland H.W.G.M. Boddeke Jill C. Richardson Shahid Khan Phil Murphy Christine A. Parker Jai Patel Declan Jones Peter de Boer John Kemp Wayne C. Drevets Jeffrey S. Nye Gayle Wittenberg John Isaac Anindya Bhattacharya Nick Carruthers Hartmuth Kolb Carmine M. Pariante Federico Turkheimer Gareth J. Barker Heidi Byrom Diana Cash Annamaria Cattaneo Antony Gee Caitlin Hastings Nicole Mariani Anna McLaughlin Valeria Mondelli Maria Nettis Naghmeh Nikkheslat Karen Randall Hannah Sheridan Camilla Simmons Nisha Singh Victoria Van Loo Marta Vicente-Rodriguez Tobias C. Wood Courtney Worrell Zuzanna Zajkowska Niels Plath Jan Egebjerg Hans Eriksson Francois Gastambide Karen Husted Adams Ross Jeggo Christian Thomsen Jan Torleif Pederson Brian Campbell Thomas Möller Bob Nelson Stevin Zorn Jason O'Connor Mary Jane Attenburrow Alison Baird Jithen Benjamin Stuart Clare Philip Cowen I-Shu (Dante) Huang Samuel Hurley Helen Jones Simon Lovestone Francisca Mada Alejo Nevado-Holgado Akintayo Oladejo Elena Ribe Katy Smith Anviti Vyas Zoe Hughes Rita Balice-Gordon James Duerr Justin R. Piro Jonathan Sporn V. Hugh Perry Madeleine Cleal Gemma Fryatt Diego Gomez-Nicola Renzo Mancuso Richard Reynolds Neil A. Harrison Mara Cercignani Charlotte L. Clarke Elizabeth Hoskins Charmaine Kohn Rosemary Murray Lauren Wilcock Dominika Wlazly Howard Mount NIMA Consortium† Alzheimer's disease Biomarker Plasma Inflammation Complement Alzheimer's & Dementia, 15 (2019) 776-787. doi:10.1016/j.jalz.2019.03.007 Elsevier Inc. journal Alzheimer's & Dementia © 2019 The Authors. 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539, 365 Annotation: Subtype: Link Rect: 317, 347, 539, 355 Annotation: Subtype: Link Rect: 317, 337, 539, 345 Annotation: Subtype: Link Rect: 317, 327, 368, 335 Annotation: Subtype: Link Rect: 317, 317, 539, 325 Annotation: Subtype: Link Rect: 317, 307, 539, 315 Annotation: Subtype: Link Rect: 317, 297, 365, 305 Annotation: Subtype: Link Rect: 317, 287, 539, 295 Annotation: Subtype: Link Rect: 317, 277, 539, 285 Annotation: Subtype: Link Rect: 317, 267, 452, 275 Annotation: Subtype: Link Rect: 317, 257, 539, 265 Annotation: Subtype: Link Rect: 317, 247, 539, 255 Annotation: Subtype: Link Rect: 317, 237, 539, 245 Annotation: Subtype: Link Rect: 317, 227, 384, 235 Annotation: Subtype: Link Rect: 317, 217, 539, 225 Annotation: Subtype: Link Rect: 317, 207, 539, 215 Annotation: Subtype: Link Rect: 317, 197, 539, 205 Annotation: Subtype: Link Rect: 317, 187, 355, 195 Annotation: Subtype: Link Rect: 317, 178, 539, 186 Annotation: Subtype: Link Rect: 317, 168, 539, 176 Annotation: Subtype: Link Rect: 317, 158, 522, 166 Annotation: Subtype: Link Rect: 317, 148, 539, 156 Annotation: Subtype: Link Rect: 317, 138, 410, 146 Annotation: Subtype: Link Rect: 317, 128, 539, 136 Annotation: Subtype: Link Rect: 317, 118, 539, 126 Annotation: Subtype: Link Rect: 317, 108, 365, 116 Annotation: Subtype: Link Rect: 317, 98, 539, 106 Annotation: Subtype: Link Rect: 317, 88, 539, 96 Annotation: Subtype: Link Rect: 317, 78, 487, 86 Annotation: Subtype: Link Rect: 317, 68, 539, 76 Annotation: Subtype: Link Rect: 317, 58, 539, 66 Annotation: Subtype: Link Rect: 317, 48, 525, 56 Page: Label: 787 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 54, 696, 79, 704 Annotation: Subtype: Link Rect: 85, 696, 276, 704 Annotation: Subtype: Link Rect: 54, 686, 276, 694 Annotation: Subtype: Link Rect: 54, 676, 276, 684 Annotation: Subtype: Link Rect: 54, 666, 254, 674 Annotation: Subtype: Link Rect: 317, 696, 539, 704 Annotation: Subtype: Link Rect: 317, 686, 537, 694 Annotation: Subtype: Link Rect: 317, 676, 539, 684 Annotation: Subtype: Link Rect: 317, 666, 441, 674 Checksum: fb407e2e Type: CRC32 Checksum: 8ff0929cab1dae9a48ff1eb0381c5a2c Type: MD5 Checksum: 4a2b1ecccff74564a779090bd8423a4f6657ca8f Type: SHA-1 Checksum: a22a040c5f74329f953717ed066f47e72b51ebc87c7e31a4c72d7ea48719254e Type: SHA-256