89d11b45d156960ef8fb8391d979e67c 285847.pdf 032ece88656c4dc13e9cbad980e3374db4a721cb 285847.pdf 69ef7f2a36db6afb1e33a7a18b59acfb8b659ffe90b9abdcfd61d02152e5b833 285847.pdf Title: Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort Keywords: EMIF-AD, Alzheimer’s disease, Dementia, Amyloid, Tau, CSF, Brain volume measurements, Cognitive function measurements, Metabolomics, Biomarkers Author: Min Kim, Stuart Snowden, Tommi Suvitaival, Ashfaq Ali, David J. Merkler, Tahmina Ahmad, Sarah Westwood, Alison Baird, Petroula Proitsi, Alejo Nevado-Holgado, Abdul Hye, Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Charlotte Teunissen, Mara ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen De Roeck, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Isabel Sala, Alberto Lléo, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni B. Frisoni, José L. Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Frederik Barkhof, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter J. Visser, Simon Lovestone, Cristina Legido-Quigley Creator: AH XSL Formatter V6.3 R1 for Linux64 : 6.3.1.23495 (2016/02/03 14:39JST) Producer: Antenna House PDF Output Library 6.3.752 (Linux64) CreationDate: Tue Nov 12 20:21:29 2019 CET ModDate: Tue Nov 12 20:21:29 2019 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1010396 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Times-Roman Type 1 Custom no no yes 11 0 Helvetica-Bold Type 1 Custom no no yes 13 0 Helvetica-Oblique Type 1 Standard no no no 15 0 Helvetica Type 1 Custom no no yes 42 0 SHFQDD+Code2000 CID TrueType Identity-H yes yes yes 68 0 Times-Bold Type 1 Standard no no no 456 0 Times-BoldItalic Type 1 Standard no no no 574 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-14 02:37:12 CET RepresentationInformation: 285847.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-13 12:22:22 CET Size: 1010396 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 70 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: Background Item: Title: Methods Children: Item: Title: Subjects Item: Title: Clinical and cognitive data Item: Title: Metabolomics data acquisition and treatment Item: Title: Statistical analyses Item: Title: Results Children: Item: Title: Demographic and cognitive comparisons Item: Title: Association of blood metabolites with measures of amyloid and tau in CSF Item: Title: Association of blood panel with cognition, ROD, and diagnosis Item: Title: Associations of blood panel with brain structural measures Item: Title: Predictive models of clinical diagnosis Item: Title: Network analysis Item: Title: Discussion Children: Item: Title: PFAMs and AD Item: Title: References Item: Title: Fig. 1. Item: Title: Fig. 2. Item: Title: Fig. 3. Item: Title: Fig. 4. Item: Title: Table 1 Item: Title: Table 2 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 152 ImageHeight: 152 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1200 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2096 ImageHeight: 996 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2096 ImageHeight: 975 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2096 ImageHeight: 1592 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: SHFQDD+Code2000 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: Times-Bold Font: BaseFont: Helvetica FirstChar: 32 LastChar: 133 FontDescriptor: FontName: Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-Roman FirstChar: 32 LastChar: 138 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Bold FirstChar: 32 LastChar: 128 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-BoldItalic Font: BaseFont: Helvetica-Oblique CIDFontType2: Font: BaseFont: SHFQDD+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SHFQDD+Code2000 Flags: Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 294, 136, 455, 144 LastModified: D:20191112142129-05'00' Annotation: Subtype: Link Rect: 274, 85, 407, 93 LastModified: D:20191112142129-05'00' Page: Sequence: 2 Page: Sequence: 3 Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Page: Sequence: 7 Page: Sequence: 8 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Page: Sequence: 12 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Page: Sequence: 20 Page: Sequence: 21 Page: Sequence: 22 Checksum: cd2f0700 Type: CRC32 Checksum: 89d11b45d156960ef8fb8391d979e67c Type: MD5 Checksum: 032ece88656c4dc13e9cbad980e3374db4a721cb Type: SHA-1 Checksum: 69ef7f2a36db6afb1e33a7a18b59acfb8b659ffe90b9abdcfd61d02152e5b833 Type: SHA-256