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systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways Destination: title_link Children: Item: Title: Results Destination: A1 Children: Item: Title: Twenty-seven signals independently associated with SSc Destination: B1 Item: Title: Fine-mapping of SSc-associated loci in a Bayesian framework Destination: B2 Item: Title: Functional annotation of SNPs from credible sets Destination: B3 Item: Title: H3K27ac HiChIP in T’cells expands and refines target genes Destination: B4 Item: Title: Chromatin interaction analyses in other relevant cell types Destination: B5 Item: Title: Candidate genes prioritized by DEPICT Destination: B6 Item: Title: Tissue-specific enrichment of SSc loci in epigenetic marks Destination: B7 Item: Title: Specific patterns of associations for the main SSc subtypes Destination: B8 Item: Title: Drug target enrichment analysis Destination: B9 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: Study cohorts and GWAS quality control Destination: B10 Item: Title: PC analysis and identification of outliers Destination: B11 Item: Title: Imputation Destination: B12 Item: Title: Genome-wide association analysis Destination: B13 Item: Title: Stratified analysis in clinical and serological SSc subtypes Destination: B14 Item: Title: Permutation analysis for subphenotype hits Destination: B15 Item: Title: Stepwise conditional analysis in SSc-associated loci Destination: B16 Item: Title: Fine-mapping of SSc-associated loci in a Bayesian framework Destination: B17 Item: Title: Functional annotation of SNPs from credible sets Destination: B18 Item: Title: H3K27ac HiChIP analysis in human CD4+ T’cells Destination: B19 Item: Title: Promoter capture Hi-C analysis Destination: B20 Item: Title: Enrichment of SSc loci in epigenetic marks and cell types Destination: B21 Item: Title: Drug-target gene enrichment analysis Destination: B22 Item: Title: Reporting summary Destination: 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true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: AOEDFF+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AOEECJ+AdvOT1ef757c0+20 FontSubset: true FirstChar: 145 LastChar: 151 FontDescriptor: FontName: AOEECJ+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-12760-y GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways Elena López-Isac Marialbert Acosta-Herrera Martin Kerick Shervin Assassi Ansuman T. Satpathy Jeffrey Granja Maxwell R. Mumbach Lorenzo Beretta Carmen P. Simeón Patricia Carreira Norberto Ortego-Centeno Ivan Castellvi Lara Bossini-Castillo F. David Carmona Gisela Orozco Nicolas Hunzelmann Jörg H. W. Distler Andre Franke Claudio Lunardi Gianluca Moroncini Armando Gabrielli Jeska de Vries-Bouwstra Cisca Wijmenga Bobby P. C. Koeleman Annika Nordin Leonid Padyukov Anna-Maria Hoffmann-Vold Benedicte Lie R. Ríos J. L. Callejas J. A. Vargas-Hitos R. García-Portales M. T. Camps A. Fernández-Nebro M. F. González-Escribano F. J. García-Hernández M. J. Castillo M. A. Aguirre I. Gómez-Gracia B. Fernández-Gutiérrez L. Rodríguez-Rodríguez P. García de la Peña E. Vicente J. L. Andreu M Fernández de Castro F. J. López-Longo L. Martínez Fonollosa A. Guillén G. Espinosa C. Tolosa A. Pros M. Rodríguez-Carballeira F. J. Narváez M. Rubio-Rivas Ortiz-Santamaría A. B. Madroñero M. A. González-Gay B. Díaz L. Trapiella A. Sousa M. V. Egurbide P. Fanlo-Mateo L. Sáez-Comet F. Díaz Hernández E. Beltrán J. A. Román-Ivorra E. Grau J. J. Alegre-Sancho M. Freire F. J. Blanco-García N. Oreiro T. Witte A. Kreuter G. Riemekasten P. Airó C. Magro A. E. Voskuyl M. C. Vonk R. Hesselstrand Susanna Proudman Wendy Stevens Mandana Nikpour J. Zochling J. Sahhar J. Roddy P. Nash K. Tymms M. Rischmueller S. Lester Timothy Vyse Ariane L. Herrick Jane Worthington Christopher P. Denton Yannick Allanore Matthew A. Brown Timothy R. D. J. Radstake Carmen Fonseca Howard Y. Chang Maureen D. Mayes Javier Martin Springer US Nature Communications, doi:10.1038/s41467-019-12760-y 10.1038/s41467-019-12760-y http://dx.doi.org/10.1038/s41467-019-12760-y journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-12760-y springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-12760-y springer.com springerlink.com Springer 2019-10-25T13:04:15+02:00 2019-10-24T23:10:32+05:30 2019-10-25T13:04:15+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:08dc3f8e-4650-4bca-a734-21b8159788bf uuid:e3ce93f5-e2b4-4701-aafb-d3da98af319e default 1 converted uuid:7e6fdbd0-41c3-4329-bf3e-9ca091e1e41b converted to PDF/A-2b pdfToolbox 2019-10-24T23:11:51+05:30 2 B Ansuman T. Satpathy http://orcid.org/0000-0002-5167-537X F. 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