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Title:          Xenofree generation of limbal stem cells for ocular surface advanced cell therapy
Subject:        Stem Cell Research & Therapy, 2019, doi:10.1186/s13287-019-1501-9
Keywords:       Cultured limbal stem cells transplantation,XSHEM,CnT07,Processed lipoaspirate cells,3T3,Clinical grade,Limbal stem cells deficiency
Author:         Nuria Nieto-Nicolau
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        Title: Methods
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       Item: 
        Title: Results
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       Item: 
        Title: Conclusions
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     Item: 
      Title: Background
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     Item: 
      Title: Materials and methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Cell culture of feeder layers
        Destination: sectionSec3
       Item: 
        Title: Human LSC and corneal epithelial cells
        Destination: sectionSec4
       Item: 
        Title: Colony-forming assay (CFA) and doubling population time (DPT)
        Destination: sectionSec5
       Item: 
        Title: Immunofluorescence (IF)
        Destination: sectionSec6
       Item: 
        Title: mRNA extraction and quantitative polymerase chain reaction (qPCR) analysis
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       Item: 
        Title: ELISA assay
        Destination: sectionSec8
       Item: 
        Title: Metabolic assay
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        Title: Viability calculation
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        Title: Statistical analysis
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      Title: Results
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       Item: 
        Title: XSHEM produced cells with LSC morphology and higher viability
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       Item: 
        Title: LSC in XSHEM and in CnT07 were positive for p63 and negative for corneal differentiation markers
        Destination: sectionSec14
       Item: 
        Title: PLA increased the clonogenicity and growth of LSC
        Destination: sectionSec15
       Item: 
        Title: LSC-PLA expressed more IL-6 and SDF-1 than LSC-3T3
        Destination: sectionSec16
       Item: 
        Title: Both PLA and 3T3 feeder generated cells with LSC characteristics
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     Item: 
      Title: Discussion
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     Item: 
      Title: Conclusions
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     Item: 
      Title: Supplementary information
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     Item: 
      Title: Abbreviations
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     Item: 
      Title: Acknowledgements
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     Item: 
      Title: Authors’ contributions
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     Item: 
      Title: Funding
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     Item: 
      Title: Availability of data and materials
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      Title: Ethics approval and consent to participate
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     Item: 
      Title: Consent for publication
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     Item: 
      Title: Competing interests
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     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
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     Item: 
      Title: Publisher’s Note
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    Author: Nuria Nieto-Nicolau
    Subject: Stem Cell Research & Therapy, 2019, doi:10.1186/s13287-019-1501-9
    Keywords: Cultured limbal stem cells transplantation,XSHEM,CnT07,Processed lipoaspirate cells,3T3,Clinical grade,Limbal stem cells deficiency
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                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
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                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
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                                    <pdfaField:valueType>URI</pdfaField:valueType>
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                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
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                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
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                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
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                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
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                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
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                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
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                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
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                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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