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Title:          Neuroprotection mediated by cystatin C-loaded extracellular vesicles
Subject:        Scientific Reports, doi:10.1038/s41598-019-47524-7
Keywords:       
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     Item: 
      Title: Neuroprotection mediated by cystatin C-loaded extracellular vesicles
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: In vitro loading of EVs with CysC. 
         Item: 
          Title: Uptake of exogenous CysC in association with EVs by recipient cells. 
         Item: 
          Title: EVs containing CysC protect primary cortical SMC and primary neurons from nutrition deprivation. 
         Item: 
          Title: Regulation of EV secretion by CysC. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Mice. 
         Item: 
          Title: Primary cultures of cortical neurons and cortical smooth muscle cells. 
         Item: 
          Title: EV isolation from culture media. 
         Item: 
          Title: EV isolation from mouse brains. 
         Item: 
          Title: Immuno-electron microscopy (immuno-EM). 
         Item: 
          Title: Acetylcholine esterase activity assay. 
         Item: 
          Title: Nanoparticle tracking analysis. 
         Item: 
          Title: Western blot analysis. 
         Item: 
          Title: Immunocytochemistry with isolated EVs. 
         Item: 
          Title: Cellular protection assay. 
         Item: 
          Title: Statistical analyses. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Loading of EVs with CysC.
       Item: 
        Title: Figure 2 Endocytic uptake of EVs by SMC isolated from CysCko mice.
       Item: 
        Title: Figure 3 EVs containing CysC protect primary cortical SMC and primary cortical neurons isolated from CysCko mice.
       Item: 
        Title: Figure 4 CysC regulates the level of EV secretion.
       Item: 
        Title: Figure 5 CysC enhances EV levels in the brain extracellular space of CysC transgenic mice but does not specifically regulate ESCRT-dependent exosome secretion.
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
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