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Statistical analysis Destination: Section3 Item: Title: 3 Results Destination: Section4 Children: Item: Title: 3.1 Study population Destination: Section5 Item: Title: 3.2 PrCa detection rates after 3 yr of screening and PPV of biopsy Destination: Section6 Item: Title: 3.3 Cancer characteristics Destination: Section7 Item: Title: 4 Discussion Destination: Section8 Children: Item: Title: 4.1 Limitations Destination: Section9 Item: Title: 5 Conclusions Destination: Section10 Item: Title: Appendix A Supplementary data Destination: SectionApp11 Item: Title: References Destination: Section12 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode FilterPipeline: CCITTFaxDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 296 ImageHeight: 371 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 120 ImageHeight: 120 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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LHBBGP+AdvOTf2586c63.I+20 Flags: Nonsymbolic FontBBox: -48, -211, 887, 789 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHBBFP+AdvOTf2586c63.I FontSubset: true FirstChar: 38 LastChar: 248 FontDescriptor: FontName: LHBBFP+AdvOTf2586c63.I Flags: Serif, Nonsymbolic FontBBox: -141, -232, 1053, 972 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHBAKM+AdvOT1be73566.BI FontSubset: true FirstChar: 47 LastChar: 117 FontDescriptor: FontName: LHBAKM+AdvOT1be73566.BI Flags: Nonsymbolic FontBBox: -175, -248, 1120, 998 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHBBKP+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: LHBBKP+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf 10.1016/j.eururo.2019.08.019 Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers Elizabeth C. Page Elizabeth K. Bancroft Mark N. Brook Melissa Assel Mona Hassan Al Battat Sarah Thomas Natalie Taylor Anthony Chamberlain Jennifer Pope Holly Ni Raghallaigh D. Gareth Evans Jeanette Rothwell Lovise Maehle Eli Marie Grindedal Paul James Lyon Mascarenhas Joanne McKinley Lucy Side Tessy Thomas Christi van Asperen Hans Vasen Lambertus A. Kiemeney Janneke Ringelberg Thomas Dyrsø Jensen Palle J.S. Osther Brian T. Helfand Elena Genova Rogier A. Oldenburg Cezary Cybulski Dominika Wokolorczyk Kai-Ren Ong Camilla Huber Jimmy Lam Louise Taylor Monica Salinas Lidia Feliubadaló Jan C. Oosterwijk Wendy van Zelst-Stams Jackie Cook Derek J. Rosario Susan Domchek Jacquelyn Powers Saundra Buys Karen O'Toole Margreet G.E.M. Ausems Rita K. Schmutzler Kerstin Rhiem Louise Izatt Vishakha Tripathi Manuel R. Teixeira Marta Cardoso William D. Foulkes Armen Aprikian Heleen van Randeraad Rosemarie Davidson Mark Longmuir Mariëlle W.G. Ruijs Apollonia T.J.M. Helderman van den Enden Muriel Adank Rachel Williams Lesley Andrews Declan G. Murphy Dorothy Halliday Lisa Walker Annelie Liljegren Stefan Carlsson Ashraf Azzabi Irene Jobson Catherine Morton Kylie Shackleton Katie Snape Helen Hanson Marion Harris Marc Tischkowitz Amy Taylor Judy Kirk Rachel Susman Rakefet Chen-Shtoyerman Allan Spigelman Nicholas Pachter Munaza Ahmed Teresa Ramon y Cajal Janez Zgajnar Carole Brewer Neus Gadea Angela F. Brady Theo van Os David Gallagher Oskar Johannsson Alan Donaldson Julian Barwell Nicola Nicolai Eitan Friedman Elias Obeid Lynn Greenhalgh Vedang Murthy Lucia Copakova Sibel Saya John McGrath Peter Cooke Karina Rønlund Kate Richardson Alex Henderson Soo H. Teo Banu Arun Karin Kast Alexander Dias Neil K. Aaronson Audrey Ardern-Jones Chris H. Bangma Elena Castro David Dearnaley Diana M. Eccles Karen Tricker Jorunn Eyfjord Alison Falconer Christopher Foster Henrik Gronberg Freddie C. Hamdy Vigdis Stefansdottir Vincent Khoo Geoffrey J. Lindeman Jan Lubinski Karol Axcrona Christos Mikropoulos Anita Mitra Clare Moynihan Gadi Rennert Mohnish Suri Penny Wilson Tim Dudderidge The IMPACT Study Collaborators‡ Judith Offman Zsofia Kote-Jarai Andrew Vickers Hans Lilja Rosalind A. Eeles European Urology, 76 (2019) 831-842. doi:10.1016/j.eururo.2019.08.019 The Authors BRCA1 BRCA2 Prostate-specific-antigen Prostate cancer Targeted prostate screening journal European Urology © 2019 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. 0302-2838 76 6 December 2019 831-842 831 842 10.1016/j.eururo.2019.08.019 https://doi.org/10.1016/j.eururo.2019.08.019 2010-04-23 true 10.1016/j.eururo.2019.08.019 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.eururo.2019.08.019 2010-04-23 true sciencedirect.com elsevier.com noindex sciencedirect.com elsevier.com Elsevier 2019-11-08T01:52:12+05:30 2019-11-08T05:50:10+05:30 2019-11-08T05:50:10+05:30 True Acrobat Distiller 10.0.0 (Windows) BRCA1; BRCA2; Prostate-specific-antigen; Prostate cancer; Targeted prostate screening uuid:9f504f13-e526-452b-8d6e-c61015f17135 uuid:db0f7221-8c4f-4d01-9d0f-2c9a764bd27e http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 831 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 143, 541, 150, 552 Destination: 1 Annotation: Subtype: Link Rect: 150, 536, 272, 547 Destination: 455 Annotation: Subtype: Link Rect: 272, 541, 279, 552 Destination: 1 Annotation: 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