916084f21c6b1a096ad1e6b12d4fe013 286304.pdf 64b919824a6e801a9d16f231ef9b9dadeb4384bf 286304.pdf 458af12f70172ebfd64f6e970e59ce8fedbc8d5c385fe0e4cc2353f12ca20c77 286304.pdf Title: The Diabetes Unmet Need with basal insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal insulin in a real-world setting Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Apr 29 15:47:12 2019 CEST ModDate: Mon Apr 29 15:47:12 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 608983 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ADJFPA+AdvTTfac587ca.B Type 1C WinAnsi yes yes no 167 0 ADJFPB+AdvTT6071803a.B Type 1C WinAnsi yes yes no 168 0 ADJGDA+AdvTTa9c1b374 Type 1C WinAnsi yes yes no 169 0 ADJGDB+AdvTTeb5f0e55.I Type 1C WinAnsi yes yes no 170 0 ADJGDC+AdvTTa9c1b374+20 Type 1C WinAnsi yes yes no 171 0 ADJGHC+AdvTTa9c1b374+22 Type 1C Custom yes yes yes 48 0 ADJHAP+AdvTT6071803a.B+20 Type 1C WinAnsi yes yes no 49 0 ADJHBP+AdvTT9c438aa4.BI Type 1C WinAnsi yes yes no 19 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-19 02:40:27 CET RepresentationInformation: 286304.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-18 09:04:22 CET Size: 608983 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 184 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal ... Destination: atl_DOM_13673_ Children: Item: Title: 1 INTRODUCTION Destination: HeadingDOM_13673dom13673-sec-0005 Item: Title: 2 MATERIALS AND METHODS Destination: HeadingDOM_13673dom13673-sec-0006 Children: Item: Title: 2.1 Study design and participants Destination: HeadingDOM_13673dom13673-sec-0007 Item: Title: 2.2 HbA1c targets Destination: HeadingDOM_13673dom13673-sec-0008 Item: Title: 2.3 Defining participants at low or high risk of hypoglycaemia complications Destination: HeadingDOM_13673dom13673-sec-0009 Item: Title: 2.4 Objectives and endpoints Destination: HeadingDOM_13673dom13673-sec-0010 Item: Title: 2.5 Data analysis and statistics Destination: HeadingDOM_13673dom13673-sec-0011 Item: Title: 3 RESULTS Destination: HeadingDOM_13673dom13673-sec-0012 Children: Item: Title: 3.1 Study population and baseline characteristics Destination: HeadingDOM_13673dom13673-sec-0013 Children: Item: Title: 3.1.1 Study population Destination: HeadingDOM_13673dom13673-sec-0014 Item: Title: 3.1.2 Baseline characteristics Destination: HeadingDOM_13673dom13673-sec-0015 Item: Title: 3.2 Individualized HbA1c target Destination: HeadingDOM_13673dom13673-sec-0016 Item: Title: 3.3 Insulin treatment and weight Destination: HeadingDOM_13673dom13673-sec-0017 Item: Title: 3.4 Achievement of HbA1c target at 12weeks Destination: HeadingDOM_13673dom13673-sec-0018 Item: Title: 3.5 Self-reported hypoglycaemia Destination: HeadingDOM_13673dom13673-sec-0019 Item: Title: 3.6 HbA1c target achievement at 12weeks - multivariate model Destination: HeadingDOM_13673dom13673-sec-0020 Item: Title: 3.7 Predictive factors for treatment failure - multivariate model Destination: HeadingDOM_13673dom13673-sec-0021 Item: Title: 4 DISCUSSION Destination: HeadingDOM_13673dom13673-sec-0022 Item: Title: 4 ACKNOWLEDGMENTS Destination: HeadingDOM_13673dom13673-sec-0023 Children: Item: Title: 4 Conflict of interest Destination: HeadingDOM_13673dom13673-sec-0024 Item: Title: Author contributions Destination: HeadingDOM_13673dom13673-sec-0025 Item: Title: REFERENCES Destination: HeadingDOM_13673dom13673-bibl-00011 Info: Title: The Diabetes Unmet Need with basal insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal insulin in a real-world setting Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Apr 29 16:17:12 CEST 2019 ModDate: Mon Apr 29 16:17:12 CEST 2019 ID: 0xbee5370ecc2692bd2206fb54ddf113aa, 0x5a0bb5fbee121045bd1f1b0166e292a0 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ADJGHC+AdvTTa9c1b374+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: ADJGHC+AdvTTa9c1b374+22 Flags: Symbolic FontBBox: 0, -166, 677, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ADJHAP+AdvTT6071803a.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: ADJHAP+AdvTT6071803a.B+20 Flags: Nonsymbolic FontBBox: -250, -229, 1218, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ADJHBP+AdvTT9c438aa4.BI FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: ADJHBP+AdvTT9c438aa4.BI Flags: Nonsymbolic FontBBox: -83, -177, 1010, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ADJFPA+AdvTTfac587ca.B FontSubset: true FirstChar: 49 LastChar: 84 FontDescriptor: FontName: ADJFPA+AdvTTfac587ca.B Flags: Nonsymbolic FontBBox: -72, -177, 1062, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ADJFPB+AdvTT6071803a.B FontSubset: true FirstChar: 37 LastChar: 124 FontDescriptor: FontName: ADJFPB+AdvTT6071803a.B Flags: Nonsymbolic FontBBox: -52, -177, 1041, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ADJGDA+AdvTTa9c1b374 FontSubset: true FirstChar: 37 LastChar: 177 FontDescriptor: FontName: ADJGDA+AdvTTa9c1b374 Flags: Nonsymbolic FontBBox: -41, -177, 1010, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ADJGDB+AdvTTeb5f0e55.I FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: ADJGDB+AdvTTeb5f0e55.I Flags: Nonsymbolic FontBBox: -83, -177, 989, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ADJGDC+AdvTTa9c1b374+20 FontSubset: true FirstChar: 129 LastChar: 151 FontDescriptor: FontName: ADJGDC+AdvTTa9c1b374+20 Flags: Nonsymbolic FontBBox: -239, -218, 1166, 937 FontFile3: true Encoding: WinAnsiEncoding XMP: VoR 10.1111/dom.13673 10.1111/dom.13673 10.1111/(ISSN)1463-1326 3 The Diabetes Unmet Need with basal insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal insulin in a real-world setting Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 181, 579, 189, 587 Annotation: Subtype: Link Rect: 317, 579, 325, 587 Annotation: Subtype: Link Rect: 65, 194, 178, 201 Annotation: Subtype: Link Rect: 205, 50, 382, 57 Annotation: Subtype: Link Rect: 409, 18, 518, 25 Thumb: true Page: Label: 2 Thumb: true Page: Label: 3 Thumb: true Page: Label: 4 Thumb: true Page: Label: 5 Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 367, 519, 376, 527 Annotation: Subtype: Link Rect: 378, 517, 521, 525 Annotation: Subtype: Link Rect: 358, 505, 367, 514 Annotation: Subtype: Link Rect: 369, 504, 511, 511 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 396, 268, 523, 276 Thumb: true Checksum: 57ea114a Type: CRC32 Checksum: 916084f21c6b1a096ad1e6b12d4fe013 Type: MD5 Checksum: 64b919824a6e801a9d16f231ef9b9dadeb4384bf Type: SHA-1 Checksum: 458af12f70172ebfd64f6e970e59ce8fedbc8d5c385fe0e4cc2353f12ca20c77 Type: SHA-256