b901ae1e069a2c500acd2f8613e27923 286305.pdf fc80f1ba428fdc9eee291601c55b434ad52f8a5d 286305.pdf b52aa97836c9b7bddbc54e04957f6db19b9a32e476de58d9d09b41a71e105ccf 286305.pdf Title: Safinamide in Clinical Practice: A Spanish Multicenter Cohort Study Subject: Background: Safinamide is an approved drug for the treatment of motor fluctuations of Parkinson’s Disease (PD) patients with a potential benefit on non-motor symptoms (NMS). Methods: A retrospective multicenter cohort study was conducted, in which the clinical effect of safinamide on both motor and NMS was assessed by the Clinical Global Impression of Change scale. Furthermore, we assessed the appearance of adverse events (AEs) and its effect on dyskinesia, that were also recorded in non-fluctuating PD patients and in those previously treated with rasagiline. Results: We included 213 PD patients who received safinamide in addition to their regular levodopa therapy. Thirty-five withdrew prematurely from safinamide, mainly because of AEs. Out of 178, clinical improvement on motor and NMS was found in 76.4% and 26.2%, respectively. A total of 44 reported AEs of mild intensity. We did not find a difference concerning the clinical benefit or AEs when comparing either patients who had or had not been taking Monoamine Oxidase B Inhibitor (MAOB-I) previously or between patients with and without motor complications. Conclusions: Safinamide is an effective and safe add-on to levodopa drug for PD patients. Moreover, safinamide could elicit an additional clinical improvement in PD patients previously treated with other MAOB-I and in non- fluctuating patients with suboptimal motor control. Keywords: Parkinson’s Disease; Safinamide; Adverse drug event; Dyskinesia; Drug-Induced; Motor complications Author: Gloria Martí-Andrés, Rayco Jiménez-Bolaños, José Matias Arbelo-González, Javier Pagonabarraga, Carmen Duran-Herrera, Rafael Valenti-Azcarate and Mª Rosario Luquin Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Oct 11 12:43:27 2019 CEST ModDate: Fri Oct 11 12:43:27 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 271506 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XRKCNA+URWPalladioL-Ital Type 1 Custom yes yes no 77 0 IRVRCL+URWPalladioL-Bold Type 1 Custom yes yes no 78 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 79 0 STUXEX+URWPalladioL-Roma Type 1 Custom yes yes no 80 0 RYQMUY+VnURWPalladioL Type 1 Custom yes yes no 81 0 FATHTC+Rpxr Type 1 Builtin yes yes no 82 0 SLUQMQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 87 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 104 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 105 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 106 0 TGMEOR+Rpcxr Type 1 Builtin yes yes no 133 0 CKBPVA+EURM10 Type 1 Builtin yes yes no 134 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 163 0 PHSWUJ+Rpxb Type 1 Builtin yes yes no 164 0 LGZKLX+Rpxi Type 1 Builtin yes yes no 170 0 RDFBCX+Pxsy Type 1 Builtin yes yes no 185 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes no 251 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-19 02:40:25 CET RepresentationInformation: 286305.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-18 10:00:04 CET Size: 271506 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはの〠 Item: Title: きちぴづひどちぬび〠ちのつ〠きづぴとはつび〠 Children: Item: Title: こぴふつべ〠いづびどでの〠ちのつ〠ぐはばふぬちぴどはの〠 Item: Title: こぴちぴどびぴどっちぬ〠ぁのちぬべびどび〠 Item: Title: げづびふぬぴび〠 Children: Item: Title: こふぢなづっぴび〠 Item: Title: ぅててどっちっべ〠 Item: Title: ごはぬづひちぢどぬどぴべ〠ちのつ〠こちてづぴべ〠 Item: Title: ぐひづぶどはふび〠ごひづちぴねづのぴ〠ぷどぴと〠きぁくあ〭ぉ〠〨〜きぁくあ〭ぉ〝〠ぶび〮〠〜のは〠きぁくあ〭ぉ〝〩〠 Item: Title: ぐちぴどづのぴび〠ぷどぴと〠はひ〠ぷどぴとはふぴ〠きはぴはひ〠ぃはねばぬどっちぴどはのび〠〨ぎは〠きぃ〠ぶび〮〠きぃ〩〠 Item: Title: いどびっふびびどはの〠 Item: Title: ぃはのっぬふびどはのび〠 Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PHSWUJ+Rpxb FontSubset: true FirstChar: 47 LastChar: 61 FontDescriptor: FontName: PHSWUJ+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: TGMEOR+Rpcxr FontSubset: true FirstChar: 169 LastChar: 174 FontDescriptor: FontName: TGMEOR+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: CKBPVA+EURM10 FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: CKBPVA+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: LGZKLX+Rpxi FontSubset: true FirstChar: 14 LastChar: 14 FontDescriptor: FontName: LGZKLX+Rpxi Flags: Symbolic FontBBox: -162, -280, 856, 733 FontFile: true Font: BaseFont: XRKCNA+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 148 FontDescriptor: FontName: XRKCNA+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IRVRCL+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: IRVRCL+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IOJCNK+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 189 FontDescriptor: FontName: IOJCNK+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: STUXEX+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: STUXEX+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RYQMUY+VnURWPalladioL FontSubset: true FirstChar: 189 LastChar: 189 FontDescriptor: FontName: RYQMUY+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FATHTC+Rpxr FontSubset: true FirstChar: 11 LastChar: 61 FontDescriptor: FontName: FATHTC+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: RDFBCX+Pxsy FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: RDFBCX+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: SYVAVM+VnURWPalladioL-Italic FontSubset: true FirstChar: 226 LastChar: 226 FontDescriptor: FontName: SYVAVM+VnURWPalladioL-Italic Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 214, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 182, 660, 193, 674 Annotation: Subtype: Link Rect: 178, 647, 189, 660 Annotation: Subtype: Link Rect: 431, 647, 442, 660 Annotation: Subtype: Link Rect: 466, 482, 518, 501 Annotation: Subtype: Link Rect: 176, 119, 183, 129 ActionDest: 248 Annotation: Subtype: Link Rect: 166, 38, 252, 50 Annotation: Subtype: Link Rect: 403, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 247, 702, 254, 711 ActionDest: 248 Annotation: Subtype: Link Rect: 255, 702, 262, 711 ActionDest: 248 Annotation: Subtype: Link Rect: 143, 621, 150, 630 ActionDest: 248 Annotation: Subtype: Link Rect: 211, 607, 218, 617 ActionDest: 248 Annotation: Subtype: Link Rect: 219, 607, 226, 617 ActionDest: 248 Annotation: Subtype: Link Rect: 229, 607, 236, 617 ActionDest: 248 Annotation: Subtype: Link Rect: 427, 445, 434, 454 ActionDest: 248 Annotation: Subtype: Link Rect: 437, 445, 449, 454 ActionDest: 248 Annotation: Subtype: Link Rect: 386, 418, 398, 427 ActionDest: 248 Annotation: Subtype: Link Rect: 401, 418, 413, 427 ActionDest: 271 Annotation: Subtype: Link Rect: 461, 378, 473, 387 ActionDest: 271 Annotation: Subtype: Link Rect: 474, 378, 486, 387 ActionDest: 271 Annotation: Subtype: Link Rect: 482, 244, 494, 253 ActionDest: 271 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 439, 212, 446, 224 ActionDest: 160 Annotation: Subtype: Link Rect: 358, 172, 373, 184 ActionDest: 175 Annotation: Subtype: Link Rect: 413, 145, 420, 157 ActionDest: 160 Page: Sequence: 4 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 156, 726, 163, 738 ActionDest: 160 Annotation: Subtype: Link Rect: 103, 659, 110, 671 ActionDest: 166 Annotation: Subtype: Link Rect: 508, 551, 515, 562 ActionDest: 160 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 502, 497, 509, 508 ActionDest: 175 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 359, 707, 366, 719 ActionDest: 181 Annotation: Subtype: Link Rect: 508, 278, 515, 289 ActionDest: 204 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 139, 375, 146, 385 ActionDest: 248 Annotation: Subtype: Link Rect: 149, 376, 161, 385 ActionDest: 248 Annotation: Subtype: Link Rect: 161, 375, 173, 385 ActionDest: 271 Annotation: Subtype: Link Rect: 173, 376, 185, 385 ActionDest: 271 Annotation: Subtype: Link Rect: 186, 375, 198, 385 ActionDest: 271 Annotation: Subtype: Link Rect: 198, 375, 210, 385 ActionDest: 271 Annotation: Subtype: Link Rect: 99, 321, 106, 331 ActionDest: 248 Annotation: Subtype: Link Rect: 106, 321, 118, 331 ActionDest: 271 Annotation: Subtype: Link Rect: 119, 321, 131, 331 ActionDest: 271 Annotation: Subtype: Link Rect: 141, 267, 153, 277 ActionDest: 271 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 157, 729, 169, 738 ActionDest: 271 Annotation: Subtype: Link Rect: 170, 729, 182, 738 ActionDest: 271 Annotation: Subtype: Link Rect: 182, 729, 194, 738 ActionDest: 271 Annotation: Subtype: Link Rect: 450, 702, 457, 711 ActionDest: 248 Annotation: Subtype: Link Rect: 460, 702, 472, 711 ActionDest: 248 Annotation: Subtype: Link Rect: 478, 634, 490, 644 ActionDest: 248 Annotation: Subtype: Link Rect: 491, 634, 503, 644 ActionDest: 271 Annotation: Subtype: Link Rect: 503, 634, 515, 644 ActionDest: 271 Annotation: Subtype: Link Rect: 105, 567, 117, 576 ActionDest: 271 Annotation: Subtype: Link Rect: 447, 418, 459, 427 ActionDest: 271 Annotation: Subtype: Link Rect: 320, 310, 332, 319 ActionDest: 271 Annotation: Subtype: Link Rect: 336, 297, 348, 306 ActionDest: 271 Annotation: Subtype: Link Rect: 428, 189, 440, 198 ActionDest: 271 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 357, 433, 394, 444 Annotation: Subtype: Link Rect: 401, 433, 437, 444 Annotation: Subtype: Link Rect: 438, 420, 475, 431 Annotation: Subtype: Link Rect: 481, 420, 516, 431 Annotation: Subtype: Link Rect: 375, 407, 412, 418 Annotation: Subtype: Link Rect: 369, 382, 406, 393 Annotation: Subtype: Link Rect: 413, 382, 449, 393 Annotation: Subtype: Link Rect: 340, 356, 378, 367 Annotation: Subtype: Link Rect: 384, 356, 420, 367 Annotation: Subtype: Link Rect: 208, 331, 246, 341 Annotation: Subtype: Link Rect: 311, 292, 349, 302 Annotation: Subtype: Link Rect: 172, 253, 210, 263 Annotation: Subtype: Link Rect: 323, 215, 361, 225 Annotation: Subtype: Link Rect: 371, 176, 409, 186 Annotation: Subtype: Link Rect: 168, 137, 205, 147 Annotation: Subtype: Link Rect: 211, 137, 247, 147 Annotation: Subtype: Link Rect: 392, 110, 429, 121 Annotation: Subtype: Link Rect: 436, 110, 472, 121 Annotation: Subtype: Link Rect: 423, 85, 461, 96 Annotation: Subtype: Link Rect: 467, 85, 503, 96 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 297, 714, 334, 725 Annotation: Subtype: Link Rect: 388, 688, 425, 699 Annotation: Subtype: Link Rect: 410, 663, 448, 673 Annotation: Subtype: Link Rect: 100, 599, 137, 609 Annotation: Subtype: Link Rect: 300, 559, 338, 570 Annotation: Subtype: Link Rect: 462, 533, 499, 544 Annotation: Subtype: Link Rect: 445, 508, 483, 519 Annotation: Subtype: Link Rect: 292, 469, 330, 480 Annotation: Subtype: Link Rect: 336, 469, 372, 480 Annotation: Subtype: Link Rect: 228, 431, 265, 441 Annotation: Subtype: Link Rect: 271, 431, 308, 441 Annotation: Subtype: Link Rect: 395, 391, 433, 402 Annotation: Subtype: Link Rect: 439, 391, 475, 402 Annotation: Subtype: Link Rect: 76, 349, 166, 380 Annotation: Subtype: Link Rect: 234, 344, 407, 355 Checksum: 5e17003b Type: CRC32 Checksum: b901ae1e069a2c500acd2f8613e27923 Type: MD5 Checksum: fc80f1ba428fdc9eee291601c55b434ad52f8a5d Type: SHA-1 Checksum: b52aa97836c9b7bddbc54e04957f6db19b9a32e476de58d9d09b41a71e105ccf Type: SHA-256