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Producer: Aspose.Pdf for .NET 10.1.0 PDF Creator http://www.pdf-tools.com; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Feb 23 09:30:27 2019 CET ModDate: Mon Mar 11 10:39:02 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 600.04 x 800.05 pts Page rot: 0 File size: 1213237 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular2 CID Type 0C Identity-H yes no yes 25 0 MQIFZO+MinionPro-It Type 1C Custom yes yes yes 26 0 KLZDYB+MinionStd-Black Type 1C Custom yes yes yes 27 0 TGPGFO+MinionPro-Regular22 Type 1C Custom yes yes yes 28 0 YJEOCR+MinionMathSymbols Type 1C Builtin yes yes yes 29 0 HXEXZQ+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 WMOAAD+MinionMath-Regular Type 1C Custom yes yes yes 98 0 OOPDYB+Minion-RegularSC Type 1C Custom yes yes yes 225 0 MinionPro-Regular22 Type 1C WinAnsi yes no no 234 0 ONMPDH+MinionPro-It2 Type 1C WinAnsi yes yes no 235 0 IKIULG+minionMathItalic Type 1C Builtin yes yes yes 397 0 ONNIHJ+MinionPro-Regular3 Type 1C Custom yes yes yes 437 0 ONNIHK+MinionPro-It3 Type 1C Custom yes yes yes 438 0 MinionPro-Regular22 Type 1C WinAnsi yes no no 449 0 ONMPDH+MinionPro-It2 Type 1C WinAnsi yes yes no 450 0 XTTGAT+MinionPro-Bold Type 1C Custom yes yes yes 484 0 MinionPro-Regular22 Type 1C WinAnsi yes no no 492 0 ONNIHK+MinionPro-It3 Type 1C Custom yes yes yes 493 0 ONPDCK+MinionPro-Regular4 Type 1C WinAnsi yes yes no 511 0 ONMPDH+MinionPro-It2 Type 1C WinAnsi yes yes no 512 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-20 02:48:18 CET RepresentationInformation: 286431.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-19 13:27:42 CET Size: 1213237 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 652 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Language: en Info: Creator: Aspose Ltd. Producer: Aspose.Pdf for .NET 10.1.0 PDF Creator http://www.pdf-tools.com; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Feb 23 09:30:27 CET 2019 ModDate: Mon Mar 11 10:39:02 CET 2019 ID: 0x0043706d43c426b8c4467871856f4f3f, 0xfe44dc57bc03989a1dd12dc35be6a660 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: HXEXZQ+MinionPro-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: MinionPro-Regular2 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: OOPDYB+Minion-RegularSC FontSubset: true FirstChar: 1 LastChar: 14 FontDescriptor: FontName: OOPDYB+Minion-RegularSC Flags: Nonsymbolic, SmallCap FontBBox: -141, -250, 1104, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WMOAAD+MinionMath-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: WMOAAD+MinionMath-Regular Flags: Nonsymbolic FontBBox: -1196, -2876, 2350, 3473 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XTTGAT+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 13 FontDescriptor: FontName: XTTGAT+MinionPro-Bold Flags: Nonsymbolic, ForceBold FontBBox: -318, -360, 1684, 917 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MQIFZO+MinionPro-It FontSubset: true FirstChar: 1 LastChar: 74 FontDescriptor: FontName: MQIFZO+MinionPro-It Flags: Nonsymbolic, Italic FontBBox: -201, -360, 1684, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KLZDYB+MinionStd-Black FontSubset: true FirstChar: 1 LastChar: 59 FontDescriptor: FontName: KLZDYB+MinionStd-Black Flags: Nonsymbolic, ForceBold FontBBox: -173, -250, 1120, 827 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TGPGFO+MinionPro-Regular22 FontSubset: true FirstChar: 1 LastChar: 93 FontDescriptor: FontName: TGPGFO+MinionPro-Regular22 Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YJEOCR+MinionMathSymbols FontSubset: true FirstChar: 1 LastChar: 153 FontDescriptor: FontName: YJEOCR+MinionMathSymbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IKIULG+minionMathItalic FontSubset: true FirstChar: 1 LastChar: 132 FontDescriptor: FontName: IKIULG+minionMathItalic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType0: Font: BaseFont: MinionPro-Regular2 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MinionPro-Regular2 Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true CIDFontType2: Font: BaseFont: HXEXZQ+MinionPro-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HXEXZQ+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfLeukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-AnalysisSimancas-Racines, DanielArevalo-Rodriguez, IngridUrrutia, GerardBuitrago-Garcia, DianaNúñez-González, SolangeMartínez-Zapata, María JoséMadrid, EvaBonfill, XavierHidalgo-Ottolenghi, RicardoBackground. Leukocytes contained in the allogeneic packed red blood cell (PRBC) are the cause of certain adverse reactions associated with blood transfusion. Leukoreduction consists of eliminating leukocytes in all blood products below the established safety levels for any patient type. In this systematic review, we appraise the clinical effectiveness of allogeneic leukodepleted (LD) PRBC transfusion for preventing infections and death in patients undergoing major cardiovascular surgical procedures. Methods. We searched randomized controlled trials (RCT), enrolling patients undergoing a major cardiovascular surgical procedure and transfused with LD-PRBC. Data were extracted, and risk of bias was assessed according to Cochrane guidelines. In addition, trial sequential analysis (TSA) was used to assess the need of conducting additional trials. Quality of the evidence was assessed using the GRADE approach. Results. Seven studies met the eligibility criteria. Quality of the evidence was rated as moderate for both outcomes. The risk ratio for death from any cause comparing the LD-PRBC versus non-LD-PRBC group was 0.69 (CI 95% = 0.53 to 0.90; I2 = 0%). The risk ratio for infection in the same comparison groups was 0.77 (CI 95% = 0.66 to 0.91; I2 = 0%). TSA showed a conclusive result in this outcome. Conclusions. We found evidence that supports the routine use of leukodepletion in patients undergoing a major cardiovascular surgical procedure requiring PRBC transfusion to prevent death and infection. In the case of infection, the evidence should be considered sufficient and conclusive and hence indicated that further trials would not be required.Cardiology Research and PracticeHindawi2019/02/25Research articledoi:10.1155/2019/7543917en Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 331, 395, 440, 404 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 78, 66, 82, 76 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Rect: 216, 537, 227, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 342, 523, 352, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 147, 509, 157, 519 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 337, 549, 347 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 327, 157, 336 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 337, 549, 347 Flags: Print 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