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Title:          Plasma lipid profiles discriminate bacterial from viral infection in febrile children
Subject:        Scientific Reports, doi:10.1038/s41598-019-53721-1
Keywords:       
Author:         Xinzhu Wang
Creator:        Springer
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     Item: 
      Title: Plasma lipid profiles discriminate bacterial from viral infection in febrile children
      Children: 
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study population and sampling. 
         Item: 
          Title: Lipidomic analysis. 
         Item: 
          Title: Spectral and statistical analysis. 
         Item: 
          Title: Metabolite annotation. 
         Item: 
          Title: Single feature ROC curve analysis. 
         Item: 
          Title: Feature selection. 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patient characteristics. 
         Item: 
          Title: Plasma lipidome can differentiate bacterial from viral infection. 
         Item: 
          Title: Lipid changes were not the same in the bacterial and viral infected groups. 
         Item: 
          Title: Evaluation of diagnostic potential of metabolic biomarkers. 
       Item: 
        Title: Discussion
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Principal components analysis (PCA) of lipidomics dataset.
       Item: 
        Title: Figure 2 The scatter plot of the cross-validated score vectors showing the clustering of definitive bacterial infected samples (green dots) from definitive viral infected samples (blue dots).
       Item: 
        Title: Figure 3 Manhattan-style plot of the 3891 lipid features detected by lipid-positive mode UPLC-MS with 40 features showing a significant association with infection type (as determined by model S-plot) highlighted and annotated.
       Item: 
        Title: Figure 4 Receiver operator characteristic (ROC) analysis based on single lipids.
       Item: 
        Title: Figure 5 Receiver operator characteristic (ROC) analysis based on 3-lipid signature.
       Item: 
        Title: Figure 6 Boxplots comparing the Disease Risk Score (DRS) for definitive bacterial and definitive viral samples.
       Item: 
        Title: Table 1 Metabolic features changed in bacterial and viral group.
       Item: 
        Title: Table 2 Demographic and clinical patient characteristic.
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               <rdf:li>A. M. van Wermeskerken</rdf:li>
               <rdf:li>W. A. Verwijs</rdf:li>
               <rdf:li>T. F. W. Wolfs</rdf:li>
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               <rdf:li>Christoph Aebi</rdf:li>
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               <rdf:li>Christoph Aebi</rdf:li>
               <rdf:li>Eric Giannoni</rdf:li>
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               <rdf:li>Sara Bernhard-Stirnemann</rdf:li>
               <rdf:li>Anita Niederer-Loher</rdf:li>
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               <rdf:li>Paul Hasters</rdf:li>
               <rdf:li>Christa Relly</rdf:li>
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               <rdf:li>Hannah Frederick</rdf:li>
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               <rdf:li>Joanne Johnston</rdf:li>
               <rdf:li>Rhian Kenwright</rdf:li>
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               <rdf:li>Fatou Secka</rdf:li>
               <rdf:li>Kalifa Bojang</rdf:li>
               <rdf:li>Isatou Sarr</rdf:li>
               <rdf:li>Ngange Kebbeh</rdf:li>
               <rdf:li>Gibbi Sey</rdf:li>
               <rdf:li>Momodou</rdf:li>
               <rdf:li>Saidy khan</rdf:li>
               <rdf:li>Fatoumata Cole</rdf:li>
               <rdf:li>Gilleh Thomas</rdf:li>
               <rdf:li>Martin Antonio</rdf:li>
               <rdf:li>Daniela S. Klobassa</rdf:li>
               <rdf:li>Alexander Binder</rdf:li>
               <rdf:li>Nina A. Schweintzger</rdf:li>
               <rdf:li>Manfred Sagmeister</rdf:li>
               <rdf:li>Hinrich Baumgart</rdf:li>
               <rdf:li>Markus Baumgartner</rdf:li>
               <rdf:li>Uta Behrends</rdf:li>
               <rdf:li>Ariane Biebl</rdf:li>
               <rdf:li>Robert Birnbacher</rdf:li>
               <rdf:li>Jan-Gerd Blanke</rdf:li>
               <rdf:li>Carsten Boelke</rdf:li>
               <rdf:li>Kai Breuling</rdf:li>
               <rdf:li>Jamp#x000FC;rgen Brunner</rdf:li>
               <rdf:li>Maria Buller</rdf:li>
               <rdf:li>Peter Dahlem</rdf:li>
               <rdf:li>Beate Dietrich</rdf:li>
               <rdf:li>Ernst Eber</rdf:li>
               <rdf:li>Johannes Elias</rdf:li>
               <rdf:li>Josef Emhofer</rdf:li>
               <rdf:li>Rosa Etschmaier</rdf:li>
               <rdf:li>Sebastian Farr</rdf:li>
               <rdf:li>Ylenia Girtler</rdf:li>
               <rdf:li>Irina Grigorow</rdf:li>
               <rdf:li>Konrad Heimann</rdf:li>
               <rdf:li>Ulrike Ihm</rdf:li>
               <rdf:li>Zdenek Jaros</rdf:li>
               <rdf:li>Hermann Kalhoff</rdf:li>
               <rdf:li>Wilhelm Kaulfersch</rdf:li>
               <rdf:li>Christoph Kemen</rdf:li>
               <rdf:li>Nina Klocker</rdf:li>
               <rdf:li>Bernhard Kamp#x000F6;ster</rdf:li>
               <rdf:li>Benno Kohlmaier</rdf:li>
               <rdf:li>Eleni Komini</rdf:li>
               <rdf:li>Lydia Kramer</rdf:li>
               <rdf:li>Antje Neubert</rdf:li>
               <rdf:li>Daniel Ortner</rdf:li>
               <rdf:li>Lydia Pescollderungg</rdf:li>
               <rdf:li>Klaus Pfurtscheller</rdf:li>
               <rdf:li>Karl Reiter</rdf:li>
               <rdf:li>Goran Ristic</rdf:li>
               <rdf:li>Siegfried Ramp#x000F6;dl</rdf:li>
               <rdf:li>Andrea Sellner</rdf:li>
               <rdf:li>Astrid Sonnleitner</rdf:li>
               <rdf:li>Matthias Sperl</rdf:li>
               <rdf:li>Wolfgang Stelzl</rdf:li>
               <rdf:li>Holger Till</rdf:li>
               <rdf:li>Andreas Trobisch</rdf:li>
               <rdf:li>Anne Vierzig</rdf:li>
               <rdf:li>Ulrich Vogel</rdf:li>
               <rdf:li>Christina Weingarten</rdf:li>
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               <rdf:li>Andreas Wimmer</rdf:li>
               <rdf:li>Uwe Wintergerst</rdf:li>
               <rdf:li>Daniel Wamp#x000FC;ller</rdf:li>
               <rdf:li>Andrew Zaunschirm</rdf:li>
               <rdf:li>Ieva Ziuraite</rdf:li>
               <rdf:li>Veslava amp#x0017D;ukovskaja</rdf:li>
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Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
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Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
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SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
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