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Producer: Aspose.Pdf for .NET 10.1.0 PDF Creator http://www.pdf-tools.com; modified using iTextSharp™ 5.4.0 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Feb 28 23:20:52 2019 CET ModDate: Sun Mar 17 13:01:02 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 599.98 x 799.99 pts Page rot: 0 File size: 2157505 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular2 CID Type 0C Identity-H yes no yes 29 0 GLIFKJ+MinionProIt Type 1C WinAnsi yes yes no 30 0 GLIFKK+Minion-Black Type 1C WinAnsi yes yes no 31 0 GLIFOK+MinionProBold Type 1C WinAnsi yes yes no 32 0 GLIGBJ+MinionProRegular Type 1C WinAnsi yes yes no 33 0 GLIGBK+MinionProRegular2 Type 1C Custom yes yes yes 34 0 GLIGCL+MinionProRegular3 Type 1C WinAnsi yes yes no 35 0 WUERCX+MinionPro-Regular CID TrueType Identity-H yes yes yes 1 0 GLIGEL+MinionMath Italic Type 1C Custom yes yes yes 144 0 GLIGEM+MinionMath-Regular Type 1C WinAnsi yes yes no 145 0 GLIGGN+MinionProIt2 Type 1C Custom yes yes yes 262 0 GLIGGO+MinionScUnic Type 1C WinAnsi yes yes no 263 0 GLIGHP+MinionMath Italic2 Type 1C WinAnsi yes yes no 264 0 GLIHOK+MinionMath-Regular2 Type 1C Custom yes yes yes 282 0 MinionPro-Regular22 Type 1C WinAnsi yes no no 283 0 GLIHIL+MinionMath-Regular-Graphic Type 1C Custom yes yes yes 284 0 GLJBIP+Minion-Black2 Type 1C WinAnsi yes yes no 642 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-22 02:34:06 CET RepresentationInformation: 286555.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-21 11:24:12 CET Size: 2157505 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 782 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Association of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus Erythematosus Destination: maintitle Item: Title: 1. Introduction Destination: section1 Item: Title: 2. Material and Methods Destination: section2 Children: Item: Title: 2.1. Study Subjects and Sample Collection Destination: section3 Item: Title: 2.2. Staining of Peripheral Blood Mononuclear Cells and Whole Blood Cells Destination: section4 Item: Title: 2.3. Flow Cytometry Analysis of Surface Markers and IL-10 Production Destination: section5 Item: Title: 2.4. Quantification of Anti-dsDNA, Complement C3, Albumin/Creatinine, Hematuria, IgG, IgM, and IgA Destination: section6 Item: Title: 2.5. Determination of IL-10 and sCD40L Destination: section7 Item: Title: 2.6. Statistics Destination: section8 Item: Title: 3. Results Destination: section9 Children: Item: Title: 3.1. Circulating Lymphocytes with Bound Platelets in SLE Patients Destination: section10 Item: Title: 3.2. Association of B Lymphocytes with Bound Platelets with the Levels of Immunoglobulin and Platelet Activation Destination: section11 Item: Title: 3.3. Different Binding of Platelet to Preswitched Memory B Lymphocytes in SLE Patients Destination: section12 Item: Title: 3.4. Phenotype of B Lymphocytes with Bound Platelets in HD and SLE Patients Destination: section13 Item: Title: 3.5. IL-10 Production by B Lymphocytes with and without Bound Platelets Destination: section14 Item: Title: 3.6. Relationship between Lymphocytes with Bound Platelets and Clinical Features Destination: section15 Item: Title: 4. Discussion Destination: section16 Item: Title: 5. Conclusions Destination: section17 Item: Title: Abbreviations Destination: section18 Item: Title: Data Availability Destination: section19 Item: Title: Conflicts of Interest Destination: section20 Item: Title: Authors’ Contributions Destination: section21 Item: Title: Acknowledgments Destination: section22 Info: Title: HDMIN_2473164 1..12 Creator: Aspose Ltd. 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WUERCX+MinionPro-Regular Flags: Nonsymbolic FontBBox: -289, -360, 1684, 917 FontFile2: true XMP: application/pdfAssociation of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus ErythematosusZamora, CarlosToniolo, ElideDiaz-Torné, CesarCantó, ElisabetMagallares, BertaOrtiz, Ma AngelsPerea, LidiaCorominas, HectorVidal, SilviaSystemic lupus erythematosus (SLE) is an autoimmune disease associated with the polyclonal activation of B lymphocytes and the production of autoantibodies that cause immune complex-related inflammation. Immunological factors derived from platelets modulate B cell function in SLE disease. However, platelets do not only modify the immune system by soluble factors. The binding of platelets to lymphocytes can modulate immune response. Thus, we speculate that the binding of platelets to lymphocytes in SLE patients may play a role in abnormal B lymphocyte response and the pathogenesis of SLE. We observed that levels of lymphocytes with bound platelets were higher in SLE patients than in healthy donors (HD). In SLE patients, the percentage of B lymphocytes with bound platelets positively correlated with plasmatic levels of IgG, IgA, IL-10, and soluble CD40L and negatively correlated with IgM levels, though not in HD. Preswitched memory B lymphocytes were the subpopulation with more bound platelets. Lymphocytes with bound platelets from both HD and SLE patients had major levels of CD86 and BAFFR and a greater production of IL-10 than lymphocytes without bound platelets. However, only B lymphocytes with bound platelets from SLE patients had increased levels of IgG and IgA on their surface. SLE patients with a suggestive renal manifestation had the highest levels of B and T lymphocytes with bound platelets. These results suggest that the binding of platelets to lymphocytes plays a role in SLE disease and that controlling this binding may be a promising therapeutic approach.Mediators of InflammationHindawi2019/03/03Research articledoi:10.1155/2019/2473164en Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 163, 537, 173, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 434, 523, 444, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 169, 185, 179 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 190, 169, 195, 179 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 234, 146, 239, 156 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 245, 146, 249, 156 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 90, 135, 95, 145 Flags: Print AppearanceDictionary: true Destination: 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