6697ffe6c73539c0ef601ef842726cad  286558.pdf
53879792ebbccf3cc0adbf27861f82ae742f2f03  286558.pdf
03bc8caadeeadaba6ee3e3eca21da905ce03f733159414e1d1a861ef845e0c16  286558.pdf

Title:          A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
Subject:        Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (2019) 933-938. doi:10.1016/j.trci.2019.11.001
Author:         Daniel Stamate
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Sat Dec 28 02:48:13 2019 CET
ModDate:        Sat Dec 28 02:48:47 2019 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      576 x 773.972 pts
Page rot:       0
File size:      749023 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LCLMFC+AdvPSA88A                     Type 1C           Custom           yes yes no     445  0
LCLMFD+AdvP4C4E59                    Type 1C           Custom           yes yes yes    450  0
LCLMGE+AdvPSA88C                     Type 1C           Custom           yes yes no     455  0
LCLMHE+AdvPSSym                      Type 1C           Custom           yes yes no     459  0
LCLMLE+AdvPSA88B                     Type 1C           WinAnsi          yes yes no     202  0
LCLMLF+AdvPS586B                     Type 1C           WinAnsi          yes yes no     203  0
LCLMMG+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no     208  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2023-12-22 02:34:05 CET
 RepresentationInformation: 286558.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-12-21 12:03:35 CET
  Size: 749023
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 502
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medica ...
      Destination: titlink1
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: flink1
       Item: 
        Title: 2. Methods
        Destination: flink2
       Item: 
        Title: 3. Results
        Destination: flink3
       Item: 
        Title: 4. Discussion
        Destination: flink4
       Item: 
        Title: Acknowledgments
        Destination: ablink1
       Item: 
        Title: References
        Destination: blink2
   Info: 
    Title: A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
    Author: Daniel Stamate
    Subject: Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (2019) 933-938. doi:10.1016/j.trci.2019.11.001
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Sat Dec 28 03:18:13 CET 2019
    ModDate: Sat Dec 28 03:18:47 CET 2019
   ID: 0xa5d3ac1459220d59b5b9b273035f21d6, 0x50f3b6e31b4dde49b41b4657d8eb9edc
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 251
      ImageHeight: 276
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: Separation
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 946
      ImageHeight: 955
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1495
      ImageHeight: 1192
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LCLMMG+AdvPS44A44B
      FontSubset: true
      FirstChar: 33
      LastChar: 33
      FontDescriptor: 
       FontName: LCLMMG+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LCLMFD+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 160
      FontDescriptor: 
       FontName: LCLMFD+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LCLMGE+AdvPSA88C
      FontSubset: true
      FirstChar: 25
      LastChar: 146
      FontDescriptor: 
       FontName: LCLMGE+AdvPSA88C
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -208, 1010, 781
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: LCLMLE+AdvPSA88B
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: LCLMLE+AdvPSA88B
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -208, 1000, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LCLMHE+AdvPSSym
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: LCLMHE+AdvPSSym
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: LCLMLF+AdvPS586B
      FontSubset: true
      FirstChar: 44
      LastChar: 53
      FontDescriptor: 
       FontName: LCLMLF+AdvPS586B
       Flags: Nonsymbolic
       FontBBox: -20, -229, 1010, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LCLMFC+AdvPSA88A
      FontSubset: true
      FirstChar: 30
      LastChar: 151
      FontDescriptor: 
       FontName: LCLMFC+AdvPSA88A
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -208, 1000, 781
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.trci.2019.11.001</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical&amp;#160;Information Framework for Alzheimer disease biomarker discovery cohort</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Daniel Stamate</rdf:li>
               <rdf:li>Min Kim</rdf:li>
               <rdf:li>Petroula Proitsi</rdf:li>
               <rdf:li>Sarah Westwood</rdf:li>
               <rdf:li>Alison Baird</rdf:li>
               <rdf:li>Alejo Nevado-Holgado</rdf:li>
               <rdf:li>Abdul Hye</rdf:li>
               <rdf:li>Isabelle Bos</rdf:li>
               <rdf:li>Stephanie J.B. Vos</rdf:li>
               <rdf:li>Rik Vandenberghe</rdf:li>
               <rdf:li>Charlotte E. Teunissen</rdf:li>
               <rdf:li>Mara Ten Kate</rdf:li>
               <rdf:li>Philip Scheltens</rdf:li>
               <rdf:li>Silvy Gabel</rdf:li>
               <rdf:li>Karen Meersmans</rdf:li>
               <rdf:li>Olivier Blin</rdf:li>
               <rdf:li>Jill Richardson</rdf:li>
               <rdf:li>Ellen De Roeck</rdf:li>
               <rdf:li>Sebastiaan Engelborghs</rdf:li>
               <rdf:li>Kristel Sleegers</rdf:li>
               <rdf:li>Régis Bordet</rdf:li>
               <rdf:li>Lorena Ramit</rdf:li>
               <rdf:li>Petronella Kettunen</rdf:li>
               <rdf:li>Magda Tsolaki</rdf:li>
               <rdf:li>Frans Verhey</rdf:li>
               <rdf:li>Daniel Alcolea</rdf:li>
               <rdf:li>Alberto Lléo</rdf:li>
               <rdf:li>Gwendoline Peyratout</rdf:li>
               <rdf:li>Mikel Tainta</rdf:li>
               <rdf:li>Peter Johannsen</rdf:li>
               <rdf:li>Yvonne Freund-Levi</rdf:li>
               <rdf:li>Lutz Frölich</rdf:li>
               <rdf:li>Valerija Dobricic</rdf:li>
               <rdf:li>Giovanni B. Frisoni</rdf:li>
               <rdf:li>José L. Molinuevo</rdf:li>
               <rdf:li>Anders Wallin</rdf:li>
               <rdf:li>Julius Popp</rdf:li>
               <rdf:li>Pablo Martinez-Lage</rdf:li>
               <rdf:li>Lars Bertram</rdf:li>
               <rdf:li>Kaj Blennow</rdf:li>
               <rdf:li>Henrik Zetterberg</rdf:li>
               <rdf:li>Johannes Streffer</rdf:li>
               <rdf:li>Pieter J. Visser</rdf:li>
               <rdf:li>Simon Lovestone</rdf:li>
               <rdf:li>Cristina Legido-Quigley</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>EMIF-AD</rdf:li>
               <rdf:li>Alzheimer's disease</rdf:li>
               <rdf:li>Metabolomics</rdf:li>
               <rdf:li>Biomarkers</rdf:li>
               <rdf:li>Machine-Learning</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions, 5 (2019) 933-938. doi:10.1016/j.trci.2019.11.001</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Inc.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions</prism:publicationName>
         <prism:copyright> © 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.</prism:copyright>
         <prism:issn>2352-8737</prism:issn>
         <prism:volume>5</prism:volume>
         <prism:coverDisplayDate>2019</prism:coverDisplayDate>
         <prism:pageRange>933-938</prism:pageRange>
         <prism:startingPage>933</prism:startingPage>
         <prism:endingPage>938</prism:endingPage>
         <prism:doi>10.1016/j.trci.2019.11.001</prism:doi>
         <prism:url>https://doi.org/10.1016/j.trci.2019.11.001</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.trci.2019.11.001</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.trci.2019.11.001</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2019-12-28T07:18:13+05:30</xap:CreateDate>
         <xap:ModifyDate>2019-12-28T07:18:47+05:30</xap:ModifyDate>
         <xap:MetadataDate>2019-12-28T07:18:47+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:0f21090e-a23d-4b26-8272-5b149bd63a6d</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:64c5ea57-9fa1-4106-ad3e-f5c728087aa7</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 933
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 116, 520, 120, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 123, 520, 128, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 130, 520, 134, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 188, 520, 193, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 280, 520, 284, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 377, 520, 380, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 453, 520, 456, 533
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 120, 505, 123, 518
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 188, 505, 192, 518
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 263, 505, 268, 518
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 270, 505, 275, 518
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 383, 505, 388, 518
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 492, 505, 497, 518
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 153, 490, 156, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 239, 490, 244, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 246, 490, 249, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 338, 490, 343, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 410, 490, 413, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 415, 490, 420, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 422, 490, 425, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 525, 490, 530, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 533, 490, 535, 503
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 139, 475, 147, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 232, 475, 237, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 327, 475, 332, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 334, 475, 339, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 342, 475, 346, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 478, 475, 483, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 485, 475, 490, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 492, 475, 496, 488
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 138, 460, 143, 473
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 145, 460, 149, 473
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 224, 460, 227, 473
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 306, 460, 311, 473
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 421, 460, 426, 473
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 511, 460, 518, 473
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 130, 446, 135, 458
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 221, 446, 226, 458
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 300, 446, 305, 458
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 428, 446, 433, 458
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 506, 446, 510, 458
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 164, 431, 173, 444
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 289, 431, 293, 444
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 295, 431, 305, 444
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 377, 431, 386, 444
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 482, 431, 492, 444
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 140, 416, 149, 429
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 151, 416, 157, 429
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 261, 416, 264, 429
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 267, 416, 276, 429
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 358, 416, 368, 429
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 435, 416, 440, 429
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 442, 416, 447, 429
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 76, 401, 80, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 156, 401, 166, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 168, 401, 174, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 250, 401, 259, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 262, 401, 267, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 368, 401, 377, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 380, 401, 385, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 388, 401, 403, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 405, 401, 415, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 512, 401, 522, 414
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 184, 386, 188, 399
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 191, 386, 196, 399
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 294, 386, 297, 399
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 300, 386, 309, 399
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 444, 386, 449, 399
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 451, 386, 461, 399
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 463, 380, 470, 393
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 101, 66, 213, 74
      Annotation: 
       Subtype: Link
       Rect: 107, 686, 150, 728
      Annotation: 
       Subtype: Link
       Rect: 36, 47, 168, 55
      Annotation: 
       Subtype: Link
       Rect: 64, 27, 224, 35
      Annotation: 
       Subtype: Link
       Rect: 140, 668, 175, 676
      Annotation: 
       Subtype: Link
       Rect: 140, 668, 435, 676
    Page: 
     Label: 934
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 299, 287, 467, 296
      Annotation: 
       Subtype: Link
       Rect: 108, 276, 122, 285
      Annotation: 
       Subtype: Link
       Rect: 40, 78, 55, 88
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 356, 217, 361, 227
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 363, 217, 368, 227
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 373, 157, 378, 167
       Destination: 61
    Page: 
     Label: 935
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 130, 551, 135, 561
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 138, 551, 143, 561
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 81, 515, 86, 525
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 184, 168, 189, 178
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 241, 120, 251, 130
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 96, 97, 106, 106
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 139, 85, 149, 95
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 151, 85, 161, 95
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 126, 73, 136, 83
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 40, 49, 50, 59
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 471, 651, 476, 661
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 438, 639, 443, 649
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 299, 519, 324, 529
       Destination: 13
      Annotation: 
       Subtype: Link
       Rect: 303, 460, 313, 469
       Destination: 61
    Page: 
     Label: 936
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 36, 575, 60, 585
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 142, 395, 152, 405
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 63, 371, 73, 381
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 303, 587, 313, 597
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 363, 551, 373, 561
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 501, 467, 506, 477
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 415, 419, 425, 429
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 370, 395, 380, 405
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 367, 371, 377, 381
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 180, 37, 188, 45
       Destination: 61
    Page: 
     Label: 937
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 235, 658, 245, 668
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 177, 622, 187, 632
       Destination: 61
      Annotation: 
       Subtype: Link
       Rect: 317, 74, 539, 82
      Annotation: 
       Subtype: Link
       Rect: 317, 64, 539, 72
      Annotation: 
       Subtype: Link
       Rect: 317, 54, 535, 62
    Page: 
     Label: 938
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 696, 276, 704
      Annotation: 
       Subtype: Link
       Rect: 54, 686, 276, 694
      Annotation: 
       Subtype: Link
       Rect: 54, 676, 264, 684
      Annotation: 
       Subtype: Link
       Rect: 54, 666, 276, 674
      Annotation: 
       Subtype: Link
       Rect: 54, 656, 276, 664
      Annotation: 
       Subtype: Link
       Rect: 54, 646, 220, 654
      Annotation: 
       Subtype: Link
       Rect: 54, 636, 276, 644
      Annotation: 
       Subtype: Link
       Rect: 54, 626, 276, 634
      Annotation: 
       Subtype: Link
       Rect: 54, 616, 276, 624
      Annotation: 
       Subtype: Link
       Rect: 54, 606, 113, 614
      Annotation: 
       Subtype: Link
       Rect: 54, 596, 276, 604
      Annotation: 
       Subtype: Link
       Rect: 54, 586, 156, 594
      Annotation: 
       Subtype: Link
       Rect: 54, 576, 276, 584
      Annotation: 
       Subtype: Link
       Rect: 54, 566, 276, 574
      Annotation: 
       Subtype: Link
       Rect: 54, 556, 106, 564
      Annotation: 
       Subtype: Link
       Rect: 54, 546, 276, 554
      Annotation: 
       Subtype: Link
       Rect: 54, 536, 276, 544
      Annotation: 
       Subtype: Link
       Rect: 54, 526, 276, 534
      Annotation: 
       Subtype: Link
       Rect: 54, 516, 276, 524
      Annotation: 
       Subtype: Link
       Rect: 54, 506, 172, 514
      Annotation: 
       Subtype: Link
       Rect: 54, 496, 276, 504
      Annotation: 
       Subtype: Link
       Rect: 54, 486, 276, 494
      Annotation: 
       Subtype: Link
       Rect: 54, 476, 274, 484
      Annotation: 
       Subtype: Link
       Rect: 54, 466, 276, 474
      Annotation: 
       Subtype: Link
       Rect: 54, 457, 256, 464
      Annotation: 
       Subtype: Link
       Rect: 54, 447, 267, 455
      Annotation: 
       Subtype: Link
       Rect: 54, 437, 276, 445
      Annotation: 
       Subtype: Link
       Rect: 54, 427, 276, 435
      Annotation: 
       Subtype: Link
       Rect: 54, 417, 276, 425
      Annotation: 
       Subtype: Link
       Rect: 54, 407, 110, 415
      Annotation: 
       Subtype: Link
       Rect: 54, 397, 276, 405
      Annotation: 
       Subtype: Link
       Rect: 54, 387, 213, 395
      Annotation: 
       Subtype: Link
       Rect: 54, 377, 276, 385
      Annotation: 
       Subtype: Link
       Rect: 54, 367, 70, 375
      Annotation: 
       Subtype: Link
       Rect: 317, 696, 539, 704
      Annotation: 
       Subtype: Link
       Rect: 317, 686, 539, 694
      Annotation: 
       Subtype: Link
       Rect: 317, 676, 468, 684
      Annotation: 
       Subtype: Link
       Rect: 317, 666, 539, 674
      Annotation: 
       Subtype: Link
       Rect: 317, 656, 539, 664
      Annotation: 
       Subtype: Link
       Rect: 317, 646, 539, 654
      Annotation: 
       Subtype: Link
       Rect: 317, 636, 411, 644
      Annotation: 
       Subtype: Link
       Rect: 317, 626, 539, 634
      Annotation: 
       Subtype: Link
       Rect: 317, 616, 539, 624
      Annotation: 
       Subtype: Link
       Rect: 317, 606, 539, 614
      Annotation: 
       Subtype: Link
       Rect: 317, 596, 488, 604
      Annotation: 
       Subtype: Link
       Rect: 317, 586, 539, 594
      Annotation: 
       Subtype: Link
       Rect: 317, 576, 539, 584
      Annotation: 
       Subtype: Link
       Rect: 317, 566, 539, 574
      Annotation: 
       Subtype: Link
       Rect: 317, 556, 373, 564
      Annotation: 
       Subtype: Link
       Rect: 317, 546, 539, 554
      Annotation: 
       Subtype: Link
       Rect: 317, 536, 539, 544
      Annotation: 
       Subtype: Link
       Rect: 317, 526, 539, 534
      Annotation: 
       Subtype: Link
       Rect: 317, 516, 420, 524
      Annotation: 
       Subtype: Link
       Rect: 317, 506, 539, 514
      Annotation: 
       Subtype: Link
       Rect: 317, 496, 539, 504
      Annotation: 
       Subtype: Link
       Rect: 317, 486, 539, 494
      Annotation: 
       Subtype: Link
       Rect: 317, 476, 417, 484
      Annotation: 
       Subtype: Link
       Rect: 317, 466, 539, 474
      Annotation: 
       Subtype: Link
       Rect: 317, 457, 539, 464
      Annotation: 
       Subtype: Link
       Rect: 317, 447, 462, 455
      Annotation: 
       Subtype: Link
       Rect: 317, 437, 539, 445
      Annotation: 
       Subtype: Link
       Rect: 317, 427, 539, 435
      Annotation: 
       Subtype: Link
       Rect: 317, 417, 539, 425
      Annotation: 
       Subtype: Link
       Rect: 317, 407, 365, 415
      Annotation: 
       Subtype: Link
       Rect: 317, 397, 539, 405
      Annotation: 
       Subtype: Link
       Rect: 317, 387, 539, 395
      Annotation: 
       Subtype: Link
       Rect: 317, 377, 539, 385
      Annotation: 
       Subtype: Link
       Rect: 317, 367, 355, 375
  Checksum: 8f1092f5
   Type: CRC32
  Checksum: 6697ffe6c73539c0ef601ef842726cad
   Type: MD5
  Checksum: 53879792ebbccf3cc0adbf27861f82ae742f2f03
   Type: SHA-1
  Checksum: 03bc8caadeeadaba6ee3e3eca21da905ce03f733159414e1d1a861ef845e0c16
   Type: SHA-256