5521127958d0f2c953ea28a9d8df4002 286570.pdf dee5bddfaf238d2c96b5c858dea73bc1b6a8528d 286570.pdf 92978d2858c4d64ac19cc5bcab741b7ef3c7a3bdae93e042692f215845315d5e 286570.pdf Title: Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR Subject: Scientific Reports, doi:10.1038/s41598-019-48592-5 Keywords: Author: Lorena Vigamp#x000F3;n Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 14 00:17:29 2019 CEST ModDate: Thu Aug 15 14:29:17 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2024284 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MOQLUK+Corbel-Bold CID TrueType Identity-H yes yes yes 49 0 QPVVTC+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 563 0 MinionPro-Regular Type 1C Custom yes no yes 27 0 JIVEEQ+STIXGeneral-Regular Type 1C Custom yes yes yes 206 0 HXIFQR+Corbel-Bold2 Type 1C WinAnsi yes yes yes 28 0 EuclidSymbol Type 1C Custom yes no yes 30 0 EuclidSymbol-Bold Type 1C Custom yes no yes 29 0 HUHCRG+Corbel2 Type 1C WinAnsi yes yes yes 31 0 XMJESO+Corbel CID TrueType Identity-H yes yes yes 32 0 MyriadPro-It Type 1C WinAnsi yes no yes 33 0 MinionPro-Bold Type 1C WinAnsi yes no yes 26 0 MinionPro-It Type 1C Custom yes no yes 180 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-09 02:35:04 CET RepresentationInformation: 286570.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-08 10:02:52 CET Size: 2024284 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 656 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR Children: Item: Title: Results Children: Item: Title: Patient characteristics at baseline. Item: Title: Potency and breadth of neutralizing antibodies against HCV chimeric viruses. Item: Title: Correlation analysis among HCV-nAb titers against chimeric viruses. Item: Title: Correlation among clinical data and HCV-nAb titers. Item: Title: Discussion Children: Item: Title: Limitations of the study. Item: Title: Conclusions Item: Title: Patients and Methods Children: Item: Title: Study subjects. Item: Title: HCV genotyping. Item: Title: E1 and E2 sequencing and phylogenetic analysis. Item: Title: Cells and viruses. Item: Title: HCV neutralization assay. Item: Title: Production of HCV-E2 (H77) and quantitative enzyme-linked immunoassay. Item: Title: Statistical analysis. Item: Title: Acknowledgements Item: Title: Figure 1 Summary of the neutralization potency of HCV antibodies against recombinant viruses in HIV/HCV-coinfected patients, at baseline and 24 weeks after sustained virological response. Item: Title: Figure 2 Impact of HCV clearance on HCV-nAb titers in HIV/HCV-coinfected patients who achieved sustained virological response. Item: Title: Figure 3 Summary of relevant correlation coefficients (r > 0. Item: Title: Table 1 Epidemiological and clinical characteristics at baseline of the HIV/HCV-coinfected patients included in the study. Item: Title: Table 2 Characteristics of the antiviral therapy in HIV/HCV-coinfected patients included in the study during the follow-up. Info: Title: Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR Author: Lorena Vigamp#x000F3;n Subject: Scientific Reports, doi:10.1038/s41598-019-48592-5 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Aug 14 00:47:29 CEST 2019 ModDate: Thu Aug 15 14:29:17 CEST 2019 ID: 0xe8f56aef905f04ed5765af83bded6fbb, 0xd873100f06d4dee3d5113b2d6e8be99a Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1900 ImageHeight: 1095 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1650 ImageHeight: 765 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1650 ImageHeight: 1151 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: XMJESO+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: MOQLUK+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: QPVVTC+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: QPVVTC+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HXIFQR+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HXIFQR+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1101, 960 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JIVEEQ+STIXGeneral-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: JIVEEQ+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HUHCRG+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: HUHCRG+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: XMJESO+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XMJESO+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: MOQLUK+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MOQLUK+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-019-48592-5 Springer US Scientific Reports, doi:10.1038/s41598-019-48592-5 Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR Lorena Vigamp#x000F3;n Sonia Vamp#x000E1;zquez-Moramp#x000F3;n Juan Berenguer Juan Gonzamp#x000E1;lez-Garcamp#x000ED;a Ma amp#x000C1;ngeles Jimamp#x000E9;nez-Sousa Josep M. Guardiola Manuel Crespo Ignacio Los Santos Miguel A. Wichmann Ana Carrero Maramp#x000ED;a Belamp#x000E9;n Yamp#x000E9;lamos Juliamp#x000E1;n Gamp#x000F3;mez Salvador Resino Isidoro Martamp#x000ED;nez P. Miralles J. C. Lamp#x000F3;pez F. Parras B. Padilla T. Aldamiz-Echevarramp#x000ED;a F. Tejerina C. Damp#x000ED;ez L. Pamp#x000E9;rez-Latorre C. Fanciulli I. Gutiamp#x000E9;rrez M. Ramamp#x000ED;rez S. Carretero J. M. Bellamp#x000F3;n J. Bermejo V. Hontaamp#x000F1;amp#x000F3;n J. R. Arribas M. L. Montes I. Bernardino J. F. Pascual F. Zamora J. M. Peamp#x000F1;a F. Arnalich M. Damp#x000ED;az P. Domingo J. Sanz M. J. Bustinduy J. A. Iribarren F. Rodramp#x000ED;guez-Arrondo E Van den Eynde M. Pamp#x000E9;rez E. Ribera J. L. Casado F. Dronda A. Moreno M. J. Pamp#x000E9;rez-Elamp#x000ED;as M. A. Sanfrutos S. Moreno C. Quereda A. Arranz E. Casas J. de Miguel S. Schroeder J. Vergas M. J. Tamp#x000E9;llez D. Vinuesa L. Muamp#x000F1;oz J. Hernamp#x000E1;ndez-Quero A. Ferrer M. J. Galindo L. 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