50e047db97bbdfef1d70acb95fdd2e7a  286584.pdf
29443d32430856227b1c6269deab1188336d6c01  286584.pdf
b642b6a12ba451d8fd9e76e0c9e469f859577904a2a5c78b1f36ef1b3c6b9cae  286584.pdf

Title:          X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients
Subject:        Scientific Reports, doi:10.1038/s41598-019-48385-w
Keywords:       
Author:         Clara Xiol
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Sat Aug 10 09:31:24 2019 CEST
ModDate:        Tue Aug 13 12:10:44 2019 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1308566 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
YRVGPW+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     54  0
ZZBSDU+Corbel-BoldItalic             CID TrueType      Identity-H       yes yes yes    351  0
OPFWAQ+TimesNewRomanPSMT             Type 1C           WinAnsi          yes yes yes    352  0
MinionPro-It                         Type 1C           Custom           yes no  yes     59  0
CGPKTO+STIXGeneral-Regular           Type 1C           Custom           yes yes yes     55  0
VEPROU+Corbel-Bold2                  Type 1C           WinAnsi          yes yes yes     57  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     56  0
EPBMAR+Corbel2                       Type 1C           WinAnsi          yes yes yes     60  0
RBPVVK+Corbel                        CID TrueType      Identity-H       yes yes yes     62  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     63  0
EPBMAR+Corbel2                       Type 1C           WinAnsi          yes yes yes    398  0
EuclidSymbol                         Type 1C           Custom           yes no  yes     58  0
MinionPro-Bold                       Type 1C           WinAnsi          yes no  yes     61  0
MinionPro-BoldIt                     Type 1C           WinAnsi          yes no  yes     81  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-01-10 02:32:34 CET
 RepresentationInformation: 286584.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-01-09 13:31:50 CET
  Size: 1308566
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 402
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseThumbs
    Language: EN
    Outlines: 
     Item: 
      Title: X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Allele-specific X chromosome inactivation and XCI skewing in blood samples. 
         Item: 
          Title: Allele-specific X chromosome inactivation and XCI skewing in brain samples. 
         Item: 
          Title: Brain RNA analysis. 
       Item: 
        Title: Discussion
       Item: 
        Title: Materials and Methods
        Children: 
         Item: 
          Title: Sample material. 
         Item: 
          Title: Ethical approval and informed consent. 
         Item: 
          Title: HpaII and HinfI digestion. 
         Item: 
          Title: PCR amplification and fragment analysis. 
         Item: 
          Title: Brain RNA analysis. 
         Item: 
          Title: Patient phenotype evaluation and correlation analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Brain RNA Sanger Sequencing.
       Item: 
        Title: Figure 2 Brain RNA qRT-PCR analysis and comparison with XCI-AS assay results.
       Item: 
        Title: Table 1 Proportion of patients per mutation with a skewed XCI pattern according to at least one of the two techniques used for assessing XCI (XCI-AR and XCI-AS).
       Item: 
        Title: Table 2 Data of patients with skewed XCI according to at least one of the two assays.
       Item: 
        Title: Table 3 Data of patients P109 and P119 with the c.
   Info: 
    Title: X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients
    Author: Clara Xiol
    Subject: Scientific Reports, doi:10.1038/s41598-019-48385-w
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Sat Aug 10 10:01:24 CEST 2019
    ModDate: Tue Aug 13 12:10:44 CEST 2019
   ID: 0x8b381ad680766ae08e66879cc72b34cf, 0xab6a5a5f1e8b9c44b2421e3e37fb4d63
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1650
      ImageHeight: 1092
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1000
      ImageHeight: 688
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: YRVGPW+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: RBPVVK+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ZZBSDU+Corbel-BoldItalic
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: OPFWAQ+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: OPFWAQ+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-BoldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-BoldIt
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -230, -360, 1684, 1032
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: CGPKTO+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 30
      LastChar: 31
      FontDescriptor: 
       FontName: CGPKTO+STIXGeneral-Regular
       Flags: Serif, Symbolic
       FontBBox: -995, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VEPROU+Corbel-Bold2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: VEPROU+Corbel-Bold2
       Flags: Nonsymbolic
       FontBBox: -556, -239, 1155, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol
       Flags: Symbolic
       FontBBox: -166, -253, 1090, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EPBMAR+Corbel2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EPBMAR+Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: RBPVVK+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: RBPVVK+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: YRVGPW+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: YRVGPW+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
     Font: 
      BaseFont: ZZBSDU+Corbel-BoldItalic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZZBSDU+Corbel-BoldItalic
       Flags: Symbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41598-019-48385-w</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, doi:10.1038/s41598-019-48385-w</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Clara Xiol</rdf:li>
               <rdf:li>Silvia Vidal</rdf:li>
               <rdf:li>Ainhoa Pascual-Alonso</rdf:li>
               <rdf:li>Laura Blasco</rdf:li>
               <rdf:li>Namp#x000FA;ria Brandi</rdf:li>
               <rdf:li>Paola Pacheco</rdf:li>
               <rdf:li>Edgar Gerotina</rdf:li>
               <rdf:li>Mar Oamp#x02019;Callaghan</rdf:li>
               <rdf:li>Mercamp#x000E8; Pineda</rdf:li>
               <rdf:li>Judith Armstrong</rdf:li>
               <rdf:li>Francisco Javier Aguirre</rdf:li>
               <rdf:li>Montserrat Aleu</rdf:li>
               <rdf:li>Xamp#x000E8;nia Alonso</rdf:li>
               <rdf:li>Mercamp#x000E8; Alsius</rdf:li>
               <rdf:li>Maria Inmaculada Amoramp#x000F3;s</rdf:li>
               <rdf:li>Guillermo Antiamp#x000F1;olo</rdf:li>
               <rdf:li>Lourdes Aquino</rdf:li>
               <rdf:li>Carmen Arellano</rdf:li>
               <rdf:li>Gema Arriola</rdf:li>
               <rdf:li>Rosa Arteaga</rdf:li>
               <rdf:li>Neus Baena</rdf:li>
               <rdf:li>Montserrat Barcos</rdf:li>
               <rdf:li>Nuria Belzunces</rdf:li>
               <rdf:li>Susana Boronat</rdf:li>
               <rdf:li>Tomamp#x000E1;s Camacho</rdf:li>
               <rdf:li>Jaume Campistol</rdf:li>
               <rdf:li>Miguel del Campo</rdf:li>
               <rdf:li>Andrea Campo</rdf:li>
               <rdf:li>Ramon Cancho</rdf:li>
               <rdf:li>Ramon Candau</rdf:li>
               <rdf:li>Ignacio Canamp#x000F3;s</rdf:li>
               <rdf:li>Maramp#x000ED;a del Carmen Carrascosa</rdf:li>
               <rdf:li>Francisco Carratalamp#x000E1;-Marco</rdf:li>
               <rdf:li>Jovanamp#x000ED; Casano</rdf:li>
               <rdf:li>Pedro Castro</rdf:li>
               <rdf:li>Ana Cobo</rdf:li>
               <rdf:li>Jaime Colomer</rdf:li>
               <rdf:li>David Conejo</rdf:li>
               <rdf:li>Maria Josamp#x000E9; Corrales</rdf:li>
               <rdf:li>Rocamp#x000ED;o Cortamp#x000E9;s</rdf:li>
               <rdf:li>Gabriel Cruz</rdf:li>
               <rdf:li>Gamp#x000E1;bor Csamp#x000E1;nyi</rdf:li>
               <rdf:li>Maramp#x000ED;a Teresa de Santos</rdf:li>
               <rdf:li>Maramp#x000ED;a de Toledo</rdf:li>
               <rdf:li>Miguel Del Campo</rdf:li>
               <rdf:li>Mireia Del Toro</rdf:li>
               <rdf:li>Rosario Domingo</rdf:li>
               <rdf:li>Anna Duat</rdf:li>
               <rdf:li>Rosario Duque</rdf:li>
               <rdf:li>Ana Maramp#x000ED;a Esparza</rdf:li>
               <rdf:li>Rosa Fernamp#x000E1;ndez</rdf:li>
               <rdf:li>Maria Carme Fons</rdf:li>
               <rdf:li>Ana Fontalba</rdf:li>
               <rdf:li>Enrique Galamp#x000E1;n</rdf:li>
               <rdf:li>Pia Gallano</rdf:li>
               <rdf:li>Maramp#x000ED;a Josamp#x000E9; Gamundi</rdf:li>
               <rdf:li>Pedro Luis Garcamp#x000ED;a</rdf:li>
               <rdf:li>Maramp#x000ED;a del Mar Garcamp#x000ED;a</rdf:li>
               <rdf:li>Maramp#x000ED;a Garcamp#x000ED;a-Barcina</rdf:li>
               <rdf:li>Maramp#x000ED;a Jesamp#x000FA;s Garcia-Catalan</rdf:li>
               <rdf:li>amp#x000C1;ngels Garcamp#x000ED;a-Cazorla</rdf:li>
               <rdf:li>Sixto Garcamp#x000ED;a-Miamp#x000F1;aur</rdf:li>
               <rdf:li>Juan Jose Garcia-Peamp#x000F1;as</rdf:li>
               <rdf:li>Maramp#x000ED;a Teresa Garcamp#x000ED;a-Silva</rdf:li>
               <rdf:li>Rosa Gassio</rdf:li>
               <rdf:li>Esther Geamp#x000E1;n</rdf:li>
               <rdf:li>Belamp#x000E9;n Gil</rdf:li>
               <rdf:li>Sarenur Gamp#x000F6;kben</rdf:li>
               <rdf:li>Luis Gonzalez</rdf:li>
               <rdf:li>Veronica Gonzalez</rdf:li>
               <rdf:li>Julieta Gonzalez</rdf:li>
               <rdf:li>Gloria Gonzamp#x000E1;lez</rdf:li>
               <rdf:li>Encarna Guillamp#x000E9;n</rdf:li>
               <rdf:li>Miriam Guitart</rdf:li>
               <rdf:li>Montserrat Guitet</rdf:li>
               <rdf:li>Juan Manuel Gutierrez</rdf:li>
               <rdf:li>Eva Gutiamp#x000E9;rrez</rdf:li>
               <rdf:li>Jose Luamp#x000ED;s Herranz</rdf:li>
               <rdf:li>Gemma Iglesias</rdf:li>
               <rdf:li>Iva Karacic</rdf:li>
               <rdf:li>Carlos H. Lahoz</rdf:li>
               <rdf:li>Josamp#x000E9; Ignacio Lao</rdf:li>
               <rdf:li>Pablo Lapunzina</rdf:li>
               <rdf:li>Maramp#x000ED;a Jesamp#x000FA;s Lautre-Ecenarro</rdf:li>
               <rdf:li>Maramp#x000ED;a Dolores Lluch</rdf:li>
               <rdf:li>Laura Lamp#x000F3;pez</rdf:li>
               <rdf:li>Asunciamp#x000F3;n Lamp#x000F3;pez-Ariztegui</rdf:li>
               <rdf:li>Alfons Macaya</rdf:li>
               <rdf:li>Rosario Maramp#x000ED;n</rdf:li>
               <rdf:li>Charles M. Lourenamp#x000E7;o Marquez</rdf:li>
               <rdf:li>Elena Martamp#x000ED;n</rdf:li>
               <rdf:li>Beatriz Martamp#x000ED;nez</rdf:li>
               <rdf:li>Eduardo Martamp#x000ED;nez-Salcedo</rdf:li>
               <rdf:li>Maramp#x000ED;a Josamp#x000E9; Mas</rdf:li>
               <rdf:li>Gonzalo Mateo</rdf:li>
               <rdf:li>Pilar Mendez</rdf:li>
               <rdf:li>Amparo Morant Jimenez</rdf:li>
               <rdf:li>Sira Moreno</rdf:li>
               <rdf:li>Fernando Mulas</rdf:li>
               <rdf:li>Juan Narbona</rdf:li>
               <rdf:li>Andramp#x000E9;s Nascimento</rdf:li>
               <rdf:li>Manuel Nieto</rdf:li>
               <rdf:li>Tania Fabiola Nunes</rdf:li>
               <rdf:li>Namp#x000FA;ria Namp#x000FA;amp#x000F1;ez</rdf:li>
               <rdf:li>Maramp#x000ED;a Obamp#x000F3;n</rdf:li>
               <rdf:li>Ignacio Onsurbe</rdf:li>
               <rdf:li>Carlos Ignacio Ortez</rdf:li>
               <rdf:li>Emilio Orts</rdf:li>
               <rdf:li>Francisco Martinez</rdf:li>
               <rdf:li>Rafael Parrilla</rdf:li>
               <rdf:li>Samuel Ignacio Pascual</rdf:li>
               <rdf:li>Ana Patiamp#x000F1;o</rdf:li>
               <rdf:li>Maria Pamp#x000E9;rez-Poyato</rdf:li>
               <rdf:li>Belamp#x000E9;n Pamp#x000E9;rez-Dueamp#x000F1;as</rdf:li>
               <rdf:li>Pilar Pamp#x000F3;o</rdf:li>
               <rdf:li>Eliodoro Puche</rdf:li>
               <rdf:li>Feliciano Ramos</rdf:li>
               <rdf:li>Miquel Raspall</rdf:li>
               <rdf:li>Ana Roche</rdf:li>
               <rdf:li>Susana Roldan</rdf:li>
               <rdf:li>Jordi Rosell</rdf:li>
               <rdf:li>Cesar Ruiz</rdf:li>
               <rdf:li>Maramp#x000ED;a Luz Ruiz-Falcamp#x000F3;</rdf:li>
               <rdf:li>Maria Eugenia Russi</rdf:li>
               <rdf:li>Jordi Samarra</rdf:li>
               <rdf:li>Victoria San Antonio</rdf:li>
               <rdf:li>Ivan Sanchez</rdf:li>
               <rdf:li>Xavier Sanmartin</rdf:li>
               <rdf:li>Ana Sans</rdf:li>
               <rdf:li>Alfredo Santacana</rdf:li>
               <rdf:li>Sabine Scholl-Bamp#x000FC;rgi</rdf:li>
               <rdf:li>Nuria Serrano</rdf:li>
               <rdf:li>Mercedes Serrano</rdf:li>
               <rdf:li>Pilar Martin-Tamayo</rdf:li>
               <rdf:li>Adriamp#x000E1;n Tendero</rdf:li>
               <rdf:li>Jaime Torrents</rdf:li>
               <rdf:li>Diego Tortosa</rdf:li>
               <rdf:li>Emma Triviamp#x000F1;o</rdf:li>
               <rdf:li>Ledia Troncoso</rdf:li>
               <rdf:li>Eulamp#x000E0;lia Turamp#x000F3;n</rdf:li>
               <rdf:li>Pilar Vamp#x000E1;zquez</rdf:li>
               <rdf:li>Carlos Vamp#x000E1;zquez</rdf:li>
               <rdf:li>Ramamp#x000F3;n Velamp#x000E1;zquez</rdf:li>
               <rdf:li>Clara Ventura</rdf:li>
               <rdf:li>Alfonso Verdamp#x000FA;</rdf:li>
               <rdf:li>Anna Vernet</rdf:li>
               <rdf:li>M. Tomamp#x000E1;s Vila</rdf:li>
               <rdf:li>Cristina Villar</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41598-019-48385-w</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41598-019-48385-w</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>© 2019, The Author(s)</prism:copyright>
         <prism:issn>2045-2322</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41598-019-48385-w</pdfx:doi>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2019-08-13T12:10:44+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2019-08-10T13:01:24+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2019-08-13T12:10:44+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:a46acfd3-8f84-4d63-a1a4-7d8ba9970a9e</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:10fcb5f9-4a8d-485a-b30c-651f8978370a</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:2a0dc7af-863d-4954-b06a-2f068906a741</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-08-10T13:02:15+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 496, 380, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 259, 467, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 470, 259, 473, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 379, 249, 382, 237
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 260, 219, 263, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 325, 209, 328, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 329, 209, 332, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 199, 179, 201, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 203, 179, 206, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 496, 159, 499, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 500, 159, 506, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 518, 149, 521, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 549, 139, 552, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 502, 129, 507, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 510, 129, 516, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 181, 53, 315, 43
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 502, 347, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 348, 502, 354, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 355, 502, 361, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 228, 482, 233, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 188, 462, 194, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 195, 462, 201, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 203, 462, 208, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 170, 452, 175, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 177, 452, 182, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 184, 452, 189, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 203, 260, 209, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 210, 260, 216, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 281, 230, 285, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 471, 230, 476, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 478, 230, 483, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 360, 200, 365, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 199, 150, 203, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 180, 78, 184, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 261, 236, 265, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 260, 146, 275, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 436, 58, 441, 46
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 442, 58, 448, 46
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 253, 64, 259, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 260, 64, 266, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 263, 54, 268, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 525, 472, 531, 460
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 532, 472, 538, 460
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 426, 462, 432, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 471, 442, 477, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 173, 412, 179, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 357, 362, 363, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 364, 362, 370, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 371, 362, 377, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 375, 352, 381, 340
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 413, 342, 417, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 457, 313, 461, 299
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 547, 313, 551, 299
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 299, 303, 304, 289
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 373, 282, 377, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 452, 282, 457, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 412, 242, 418, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 429, 212, 434, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 436, 212, 441, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 438, 172, 443, 160
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 362, 162, 367, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 369, 162, 374, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 303, 152, 309, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 549, 62, 552, 50
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 714, 525, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 527, 714, 533, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 297, 674, 303, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 304, 674, 310, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 538, 564, 543, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 547, 564, 552, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 197, 534, 203, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 204, 534, 209, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 329, 464, 335, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 222, 394, 228, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 452, 384, 458, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 459, 384, 465, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 511, 364, 517, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 436, 55, 442, 43
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 164, 635, 169, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 547, 625, 552, 613
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 324, 595, 330, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 331, 595, 337, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 409, 545, 414, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 292, 417, 297, 405
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 413, 125, 531, 115
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 356, 283, 516, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 159, 504, 147
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 372, 16
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 75d288ad
   Type: CRC32
  Checksum: 50e047db97bbdfef1d70acb95fdd2e7a
   Type: MD5
  Checksum: 29443d32430856227b1c6269deab1188336d6c01
   Type: SHA-1
  Checksum: b642b6a12ba451d8fd9e76e0c9e469f859577904a2a5c78b1f36ef1b3c6b9cae
   Type: SHA-256