48d4eac265499ecc6d60ad5f6901074d 253250.pdf 6452e2182151f0b13e3361795756e85416d2c2ed 253250.pdf 8a7299b2424ee7a9ce4fe1fe28c978393c0ef4a9d370646cc938285b51a0f280 253250.pdf Title: Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy Subject: Nature Communications, doi:10.1038/s41467-019-08548-9 Keywords: Author: María Cristina Estañ Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Feb 6 09:46:03 2019 CET ModDate: Mon Feb 11 18:03:34 2019 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 11077251 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JHDCOE+AdvOTea1a7398 Type 1C WinAnsi yes yes no 61 0 JHDCOF+AdvOTea1a7398+fb Type 1C Custom yes yes yes 131 0 JHDCOG+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 132 0 JHDEGO+AdvOTcb88df00 Type 1C WinAnsi yes yes no 63 0 Arial-BoldMT Type 1C WinAnsi yes no no 845 0 JHDELO+AdvOTf23bb480 Type 1C WinAnsi yes yes no 846 0 JHDENP+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 68 0 JHDELP+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 847 0 JHDFCP+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 62 0 JHDFDA+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 64 0 JHDFFD+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 65 0 JHDFCO+AdvOT125c650c Type 1C WinAnsi yes yes no 66 0 JHDFFE+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 67 0 JHDFEB+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 69 0 JHDFEC+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 70 0 JHDFGE+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 71 0 JHFDDP+Helvetica Type 1C WinAnsi yes yes no 90 0 ArialMT Type 1C WinAnsi yes no no 91 0 JHFDDO+Helvetica-Bold Type 1C WinAnsi yes yes no 92 0 JHGBEL+AdvTTab7e17fd Type 1C WinAnsi yes yes no 133 0 JHGBEM+AdvTTab7e17fd+22 Type 1C Custom yes yes no 134 0 JHGBGM+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 135 0 JHGBGN+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 136 0 JHHLDP+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 177 0 JHHNHD+Helvetica-Oblique Type 1C WinAnsi yes yes no 201 0 JHHPFI+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 260 0 JHJCAG+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 309 0 JHJCAH+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 310 0 SymbolMT Type 1C Custom yes no yes 346 0 Symbol Type 1C WinAnsi yes no no 347 0 Helvetica2 Type 1C WinAnsi yes no no 419 0 JHOJHC+AdvTT7b515deb Type 1C WinAnsi yes yes no 475 0 JHOOHG+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 546 0 JHONPI+AdvOTcb88df00+fb Type 1C Custom yes yes yes 547 0 JHOOLF+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 599 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-07-12 02:36:59 CEST RepresentationInformation: 253250.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-07-11 13:51:37 CEST Size: 11077251 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Fig10' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR49' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR58' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR59' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found Offset: 10755194 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR63' cannot be found Offset: 10755194 MIMEtype: application/pdf PDFMetadata: Objects: 934 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Clinical evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Muscular pathology of patients from family 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: FXR1 exon-15 is mutated in patients with recessive congenital myopathy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: DelACAG P82,84 variants localize to cytoplasmic granules Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Myf5-dependent inactivation of Fxr1 is lethal in mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Mice with exon-15 mutations display myopathic phenotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Bone mineral density is decreased in delACAG mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Multicore myopathy in mice carrying exon-15 mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Expression and localization of P82,84 in exon-15 mutants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: DelACAG granules contain polyA-mRNA but differ from SGs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Mutant iso-e variants assemble into delACAG granules in HeLa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Expression profiling of delACAG skeletal muscle Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Human samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Genetic analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Directed mutagenesis, plasmids and transfections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Transgenic mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Histopathology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Electron microscopy of mouse tissue and differentiated myotubes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Immunogold labeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Magnetic resonance imaging (MRI) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Dual-energy x-ray absorptiometry (DXA) and X-rays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Functional performance tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Immunoblotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Isolation of EDL fibers and confocal microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: RNA-FISH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Transcriptomics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: qRT-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Image and statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Info: Title: Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy Author: María Cristina Estañ Subject: Nature Communications, doi:10.1038/s41467-019-08548-9 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Feb 06 10:16:03 CET 2019 ModDate: Mon Feb 11 18:03:34 CET 2019 ID: 0xabbb3fc4aa07edab343c95b09d4d8a9f, 0xd98dfe95f4aff7b1565ee0a42b21900a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1713 ImageHeight: 676 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1713 ImageHeight: 410 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 501 ImageHeight: 315 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 372 ImageHeight: 328 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 911 ImageHeight: 706 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 450 ImageHeight: 418 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 151 ImageHeight: 696 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 270 ImageHeight: 329 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 450 ImageHeight: 417 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 450 ImageHeight: 417 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 749 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 539 ImageHeight: 329 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 749 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 599 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 450 ImageHeight: 418 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 450 ImageHeight: 417 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 151 ImageHeight: 695 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 450 ImageHeight: 418 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 270 ImageHeight: 330 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 538 ImageHeight: 330 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 5 ImageHeight: 5 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 751 ImageHeight: 539 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 794 ImageHeight: 429 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 824 ImageHeight: 529 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1329 ImageHeight: 1075 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1343 ImageHeight: 875 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 982 ImageHeight: 426 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1547 ImageHeight: 1233 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1691 ImageHeight: 1235 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1406 ImageHeight: 589 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1499 ImageHeight: 1750 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1458 ImageHeight: 846 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1458 ImageHeight: 431 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1468 ImageHeight: 2096 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 501 ImageHeight: 915 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 320 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 320 ImageHeight: 307 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 517 ImageHeight: 1010 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 320 ImageHeight: 314 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 319 ImageHeight: 121 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: JHDFDA+AdvOT7d6df7ab.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JHDFDA+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDFFD+AdvOTb65e897d.B FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: JHDFFD+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDFCO+AdvOT125c650c FontSubset: true FirstChar: 70 LastChar: 70 FontDescriptor: FontName: JHDFCO+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDCOF+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JHDCOF+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHDFFE+AdvOT45bf69de.BI FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: JHDFFE+AdvOT45bf69de.BI Flags: Nonsymbolic FontBBox: -135, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDENP+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: JHDENP+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDCOG+AdvOT9bd21c25.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JHDCOG+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHHPFI+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: JHHPFI+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHDFEB+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JHDFEB+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHGBEL+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: JHGBEL+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDFEC+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JHDFEC+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHGBEM+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: JHGBEM+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JHDFGE+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHDFGE+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHGBGM+AdvOTea1a7398+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JHGBGM+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHGBGN+AdvOT8608a8d1 FontSubset: true FirstChar: 181 LastChar: 181 FontDescriptor: FontName: JHGBGN+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHHNHD+Helvetica-Oblique FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JHHNHD+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDELO+AdvOTf23bb480 FontSubset: true FirstChar: 40 LastChar: 250 FontDescriptor: FontName: JHDELO+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDELP+AdvOTf23bb480+20 FontSubset: true FirstChar: 146 LastChar: 148 FontDescriptor: FontName: JHDELP+AdvOTf23bb480+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOOLF+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: JHOOLF+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHFDDP+Helvetica FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: JHFDDP+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: SymbolMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ArialMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Symbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Symbol Flags: Nonsymbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOJHC+AdvTT7b515deb FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: JHOJHC+AdvTT7b515deb Flags: Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHFDDO+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 105 FontDescriptor: FontName: JHFDDO+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOOHG+AdvOT7d6df7ab.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHOOHG+AdvOT7d6df7ab.I+03 Flags: Symbolic FontBBox: -62, -270, 906, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica2 FirstChar: 32 LastChar: 119 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHONPI+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHONPI+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHHLDP+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHHLDP+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHJCAG+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHJCAG+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHJCAH+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JHJCAH+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHDCOE+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 250 FontDescriptor: FontName: JHDCOE+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDFCP+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 243 FontDescriptor: FontName: JHDFCP+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHDEGO+AdvOTcb88df00 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JHDEGO+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-08548-9 Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy María Cristina Estañ Elisa Fernández-Núñez Maha S. Zaki María Isabel Esteban Sandra Donkervoort Cynthia Hawkins José A. Caparros-Martin Dimah Saade Ying Hu Véronique Bolduc Katherine Ru-Yui Chao Julián Nevado Ana Lamuedra Raquel Largo Gabriel Herrero-Beaumont Javier Regadera Concepción Hernandez-Chico Eduardo F. Tizzano Victor Martinez-Glez Jaime J. Carvajal Ruiting Zong David L. Nelson Ghada A. Otaify Samia Temtamy Mona Aglan Mahmoud Issa Carsten G. Bönnemann Pablo Lapunzina Grace Yoon Victor L. Ruiz-Perez Springer US Nature Communications, doi:10.1038/s41467-019-08548-9 10.1038/s41467-019-08548-9 http://dx.doi.org/10.1038/s41467-019-08548-9 journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-08548-9 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-08548-9 springer.com springerlink.com Springer 2019-02-11T18:03:34+01:00 2019-02-06T14:16:03+05:30 2019-02-11T18:03:34+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:f3c0fede-c9c9-4291-9f68-87abbe2d4646 uuid:1147fd45-034e-414b-b67c-25663d84f9dd default 1 converted uuid:92450fbc-ab4f-4326-afdf-39de6dd59c1c converted to PDF/A-2b pdfToolbox 2019-02-06T14:17:54+05:30 2 B Raquel Largo http://orcid.org/0000-0001-6525-2944 Gabriel Herrero-Beaumont http://orcid.org/0000-0002-3241-991X Victor Martinez-Glez http://orcid.org/0000-0002-4680-881X Mahmoud Issa http://orcid.org/0000-0002-3899-2821 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 372, 507, 373, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 507, 373, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 381, 507, 382, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 507, 382, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 382, 507, 384, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 517, 507, 518, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 517, 507, 518, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 526, 507, 527, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 516, 507, 527, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 527, 507, 529, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 489, 491, 490, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 489, 491, 490, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 498, 491, 499, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 491, 499, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 491, 502, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 111, 459, 112, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 111, 459, 112, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 459, 121, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 459, 121, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 121, 459, 124, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 84, 43, 164, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 243, 43, 299, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 158, 663, 161, 670 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 165, 663, 169, 670 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 71, 621, 74, 629 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 76, 621, 80, 629 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 73, 579, 77, 587 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 81, 579, 84, 587 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 65, 558, 68, 566 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 71, 516, 78, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 171, 495, 178, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 495, 187, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 258, 454, 262, 461 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 264, 454, 267, 461 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 269, 454, 273, 461 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 282, 422, 289, 430 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 391, 176, 398 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 178, 391, 185, 398 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 171, 370, 175, 377 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 268, 126, 273, 135 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 276, 63, 281, 73 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 407, 581, 411, 590 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 453, 518, 458, 528 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 475, 318, 482, 325 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 324, 262, 328, 271 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 364, 136, 369, 146 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 325, 74, 329, 83 Flags: Print AppearanceDictionary: true Destination: 141 Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 66, 515, 70, 525 Flags: Print AppearanceDictionary: true Destination: 141 Annotation: Subtype: Link Rect: 244, 449, 251, 457 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 376, 127, 384 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 273, 334, 280, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 334, 289, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 118, 279, 123, 288 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 480, 452, 484, 462 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 518, 432, 523, 441 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 525, 411, 529, 420 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 396, 337, 400, 347 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 454, 247, 458, 257 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 385, 226, 389, 236 Flags: Print AppearanceDictionary: true Destination: 206 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 253, 130, 257, 139 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 508, 57, 513, 66 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 391, 115, 396, 125 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 188, 536, 192, 546 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 62, 432, 67, 441 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 169, 330, 172, 338 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 174, 330, 181, 338 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 330, 190, 338 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 142, 181, 146, 190 Flags: Print AppearanceDictionary: true Destination: 335 Annotation: Subtype: Link Rect: 173, 128, 178, 138 Flags: Print AppearanceDictionary: true Destination: 335 Annotation: Subtype: Link Rect: 130, 76, 135, 85 Flags: Print AppearanceDictionary: true Destination: 358 Annotation: Subtype: Link Rect: 208, 55, 213, 64 Flags: Print AppearanceDictionary: true Destination: 358 Annotation: Subtype: Link Rect: 378, 515, 383, 525 Flags: Print AppearanceDictionary: true Destination: 358 Annotation: Subtype: Link Rect: 413, 484, 417, 493 Flags: Print AppearanceDictionary: true Destination: 358 Annotation: Subtype: Link Rect: 543, 452, 547, 462 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 516, 297, 524, 305 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 471, 284, 475, 293 Flags: Print AppearanceDictionary: true Destination: 389 Annotation: Subtype: Link Rect: 417, 245, 424, 253 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 519, 235, 526, 242 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 527, 235, 535, 242 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 330, 203, 337, 211 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 339, 203, 346, 211 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 423, 99, 430, 106 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 99, 439, 106 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 482, 78, 489, 85 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 323, 43, 328, 53 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 492, 67, 500, 74 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 266, 463, 271, 472 Flags: Print AppearanceDictionary: true Destination: 424 Annotation: Subtype: Link Rect: 147, 178, 156, 188 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 127, 95, 136, 104 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 53, 96, 62 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 324, 473, 333, 483 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 411, 435, 418, 442 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 461, 421, 470, 431 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 539, 348, 548, 357 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 526, 257, 533, 265 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 537, 222, 546, 232 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 383, 46, 391, 54 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 121, 566, 125, 574 Flags: Print AppearanceDictionary: true Destination: 358 Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 488, 98, 496, 106 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 317, 171, 324, 179 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 326, 171, 333, 179 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 462, 150, 469, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 471, 150, 478, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 480, 150, 487, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 443, 129, 450, 137 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 406, 77, 414, 85 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 423, 46, 430, 53 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 434, 46, 441, 53 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 86, 301, 94, 309 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 68, 270, 75, 277 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 77, 270, 84, 277 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 195, 259, 203, 267 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 150, 207, 157, 214 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 414, 301, 421, 309 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 370, 291, 378, 298 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 396, 207, 404, 214 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 336, 186, 343, 194 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 94, 435, 101 Flags: Print AppearanceDictionary: true Destination: 101 Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 247, 96, 252, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 46, 51, 158, 59 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 209, 54, 215, 60 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 164, 45, 170, 51 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 206, 45, 212, 51 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 413, 111, 466, 118 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 119, 101, 125, 107 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 89, 226, 97 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 61, 75, 66, 81 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 160, 73, 247, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 129, 56, 259, 63 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 217, 47, 291, 55 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 106, 332, 114 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 275, 552, 281, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 181, 118, 187, 124 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 267, 118, 273, 124 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 374, 45, 379, 51 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 57, 617, 63, 623 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 162, 592, 168, 598 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 564, 285, 571 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 555, 205, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 64, 357, 70, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 81, 348, 84, 354 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 64, 306, 70, 312 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 58, 206, 63, 212 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 509, 627, 515, 633 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 395, 453, 401, 459 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 394, 445, 400, 451 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 324, 419, 330, 425 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 345, 411, 351, 417 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 357, 402, 363, 408 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 354, 394, 360, 400 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 458, 368, 464, 374 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 19 Annotations: Annotation: Subtype: Link Rect: 88, 405, 91, 410 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 92, 405, 95, 410 Flags: Print AppearanceDictionary: true Destination: 556 Annotation: Subtype: Link Rect: 96, 405, 101, 410 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 102, 405, 108, 410 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 405, 242, 410 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 468, 707, 551, 714 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 514, 701, 519, 706 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 463, 518, 551, 525 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 509, 338, 516 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 475, 538, 482 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 466, 371, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 295, 551, 302 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 286, 346, 293 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 373, 23, 488, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 2ef253c0 Type: CRC32 Checksum: 48d4eac265499ecc6d60ad5f6901074d Type: MD5 Checksum: 6452e2182151f0b13e3361795756e85416d2c2ed Type: SHA-1