0e29e3da07fd607f27974f5898f003f7 253259.pdf 189c0205d5d0b5a7049cc04384bbeff9f61e5717 253259.pdf b716360d73ef41c42c44fc8b032286e683f20984e79323f103038c48b056bcc7 253259.pdf Title: Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis Subject: There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon- (IFN) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN- at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Keywords: inflammation; fatty acids; cell membranes Author: Jananee Muralidharan, Christopher Papandreou, Aleix Sala-Vila, Nuria Rosique-Esteban, Montserrat Fitó, Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Emilio Ros, Cristina Razquín, Olga Castañer, Jordi Salas-Salvadó and Monica Bulló Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.17 CreationDate: Thu Mar 7 14:35:16 2019 CET ModDate: Thu Mar 7 14:35:16 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 258441 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XMZGLC+URWPalladioL-Ital Type 1 Custom yes yes no 86 0 RIXCXK+URWPalladioL-Bold Type 1 Custom yes yes no 87 0 PRJKGQ+VnURWPalladioL-Bold Type 1 Custom yes yes no 88 0 TUHMRE+URWPalladioL-Roma Type 1 Custom yes yes no 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