aff1916cf31744b3b9ac814f87bcadde 253302.pdf ea025cda836e5d7ec52898c01a1a96da48639261 253302.pdf a6892172b52d4483f2a9471c81907e56f4adc35748918bf9e5df86fe3766652b 253302.pdf Title: The New Era for Reno-Cardiovascular Treatment in Type 2 Diabetes Subject: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease in the developed world. Until 2016, the only treatment that was clearly demonstrated to delay the DKD was the renin-angiotensin system blockade, either by angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. However, this strategy only partially covered the DKD progression. Thus, new strategies for reno-cardiovascular protection in type 2 diabetic patients are urgently needed. In the last few years, hypoglycaemic drugs, such as sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists, demonstrated a cardioprotective effect, mainly in terms of decreasing hospitalization for heart failure and cardiovascular death in type 2 diabetic patients. In addition, these drugs also demonstrated a clear renoprotective effect by delaying DKD progression and decreasing albuminuria. Another hypoglycaemic drug class, dipeptidyl peptidase 4 inhibitors, has been approved for its use in patients with advanced chronic kidney disease, avoiding, in part, the need for insulinization in this group of DKD patients. Studies in diabetic and non-diabetic experimental models suggest that these drugs may exert their reno-cardiovascular protective effect by glucose and non-glucose dependent mechanisms. This review focuses on newly demonstrated strategies that have shown reno-cardiovascular benefits in type 2 diabetes and that may change diabetes management algorithms. Keywords: diabetes; diabetic kidney disease; reno-cardiovascular protection; sodium-glucose co-transporter 2 inhibitors; glucagon-like peptide-1 receptor agonists; dipeptidyl peptidase 4 inhibitors Author: Clara García-Carro, Ander Vergara, Irene Agraz, Conxita Jacobs-Cachá, Eugenia Espinel, Daniel Seron and María José Soler Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Jun 17 11:32:22 2019 CEST ModDate: Mon Jun 17 11:32:22 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1133385 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZIPXHW+URWPalladioL-Ital Type 1 Custom yes yes no 68 0 WQPFWH+URWPalladioL-Bold Type 1 Custom yes yes no 69 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 70 0 QTLELQ+Pxbsy Type 1 Builtin 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