4a6e6b3bcce7aae75ccadadf940d68f4  253371.pdf
ef8d9521ba1271d7208ef4e607bea1e9f6db8cb8  253371.pdf
408bd09e8fb1b28f624ee962e100da3d5fd68db53e388642ca9579393fec8f3e  253371.pdf

Title:          Extension of the European Medicines Agency (EMA) approval of trifluridine/tipiracil for gastric cancer
Subject:        ESMO Open, (2019) e000591. doi:10.1136/esmoopen-2019-000591
Author:         Maria Alsina
Creator:        Elsevier
Producer:       Acrobat Distiller 7.0.5 pour Macintosh
CreationDate:   Sat Nov 21 08:42:41 2020 CET
ModDate:        Sat Jan 30 03:05:15 2021 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          2
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      233120 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OXPJTV+BookAntiqua-Bold              CID TrueType      Identity-H       yes yes yes    147  0
ADJBBJ+MinionPro-Regular             Type 1C           Custom           yes yes yes    150  0
BAIYTV+HelveticaNeueLTStd-BdCn       Type 1C           WinAnsi          yes yes yes    152  0
PBZPHT+HelveticaNeueLTStd-Bd         Type 1C           WinAnsi          yes yes yes    154  0
KRMLPD+HelveticaNeueLTStd-Roman      Type 1C           Custom           yes yes yes    157  0
FMZHXN+HelveticaLTStd-BoldCond       Type 1C           WinAnsi          yes yes yes    159  0
FGGWXN+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes    162  0
DDHKVR+HelveticaNeueLTStd-CnO        Type 1C           WinAnsi          yes yes yes    164  0
XVYLPD+NewBaskerville-Roman          Type 1C           WinAnsi          yes yes yes    166  0
VSZZNH+NewBaskerville-Italic         Type 1C           WinAnsi          yes yes yes    168  0
MULXRZ+BookAntiqua-Bold              TrueType          WinAnsi          yes yes yes    170  0
FGGWXN+HelveticaNeueLTStd-Cn         Type 1C           Custom           yes yes yes    179  0
DDHKVR+HelveticaNeueLTStd-CnO        Type 1C           WinAnsi          yes yes yes    180  0
BAIYTV+HelveticaNeueLTStd-BdCn       Type 1C           WinAnsi          yes yes yes    181  0
UTKTZJ+Symbol                        Type 1C           Custom           yes yes yes     64  0
SQLHXN+FrutigerLTStd-Bold            Type 1C           WinAnsi          yes yes yes     63  0
RMBBJP+HelveticaNeueLTStd-It         Type 1C           Custom           yes yes yes     65  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-12-17 02:30:44 CET
 RepresentationInformation: 253371.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-12-16 13:39:44 CET
  Size: 233120
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseThumbs
    Outlines: 
     Item: 
      Title: Extension of the European Medicines Agency (EMA) approval of trifluridine/tipiracil for gastric cancer
      Children: 
       Item: 
        Title: References
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 391
      ImageHeight: 109
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: OXPJTV+BookAntiqua-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: UTKTZJ+Symbol
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: UTKTZJ+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: RMBBJP+HelveticaNeueLTStd-It
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: RMBBJP+HelveticaNeueLTStd-It
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -214, 1106, 957
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FGGWXN+HelveticaNeueLTStd-Cn
      FontSubset: true
      FirstChar: 29
      LastChar: 242
      FontDescriptor: 
       FontName: FGGWXN+HelveticaNeueLTStd-Cn
       Flags: Nonsymbolic
       FontBBox: -164, -212, 1000, 932
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DDHKVR+HelveticaNeueLTStd-CnO
      FontSubset: true
      FirstChar: 32
      LastChar: 112
      FontDescriptor: 
       FontName: DDHKVR+HelveticaNeueLTStd-CnO
       Flags: Nonsymbolic, Italic
       FontBBox: -171, -272, 1068, 932
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: XVYLPD+NewBaskerville-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: XVYLPD+NewBaskerville-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -205, -272, 1207, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ADJBBJ+MinionPro-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: ADJBBJ+MinionPro-Regular
       Flags: Serif, Symbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VSZZNH+NewBaskerville-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: VSZZNH+NewBaskerville-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -138, -274, 1347, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BAIYTV+HelveticaNeueLTStd-BdCn
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: BAIYTV+HelveticaNeueLTStd-BdCn
       Flags: Nonsymbolic
       FontBBox: -164, -224, 1066, 961
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: PBZPHT+HelveticaNeueLTStd-Bd
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: PBZPHT+HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: KRMLPD+HelveticaNeueLTStd-Roman
      FontSubset: true
      FirstChar: 31
      LastChar: 150
      FontDescriptor: 
       FontName: KRMLPD+HelveticaNeueLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1076, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FMZHXN+HelveticaLTStd-BoldCond
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: FMZHXN+HelveticaLTStd-BoldCond
       Flags: Nonsymbolic
       FontBBox: -169, -250, 1091, 991
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SQLHXN+FrutigerLTStd-Bold
      FontSubset: true
      FirstChar: 67
      LastChar: 83
      FontDescriptor: 
       FontName: SQLHXN+FrutigerLTStd-Bold
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 935
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: MULXRZ+BookAntiqua-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: MULXRZ+BookAntiqua-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -134, -337, 1193, 1021
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: OXPJTV+BookAntiqua-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: OXPJTV+BookAntiqua-Bold
       Flags: Serif, Symbolic
       FontBBox: -134, -337, 1193, 1021
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.4-c006 80.159825, 2016/09/16-03:31:08        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:prism_1__1_="http://prismstandard.org/namespaces/basic/3.0/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <pdf:Producer>Acrobat Distiller 7.0.5 pour Macintosh</pdf:Producer>
         <pdf:Trapped>Unknown</pdf:Trapped>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2021-01-30T07:35:15+05:30</xmp:ModifyDate>
         <xmp:CreateDate>2020-11-21T13:12:41+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2021-01-30T07:35:15+05:30</xmp:MetadataDate>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1136/esmoopen-2019-000591</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Masson SAS</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">ESMO Open, (2019) e000591. doi:10.1136/esmoopen-2019-000591</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Maria Alsina</rdf:li>
               <rdf:li>Elizabeth C. Smyth</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>gastric cancer</rdf:li>
               <rdf:li>gastro-oesophageal junction cancer</rdf:li>
               <rdf:li>trifluridine/tipiracil</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Extension of the European Medicines Agency (EMA) approval of trifluridine/tipiracil for gastric cancer</rdf:li>
            </rdf:Alt>
         </dc:title>
         <xmpRights:Marked>True</xmpRights:Marked>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <prism_1__1_:url>https://doi.org/10.1136/esmoopen-2019-000591</prism_1__1_:url>
         <prism_1__1_:doi>10.1136/esmoopen-2019-000591</prism_1__1_:doi>
         <prism_1__1_:startingPage>e000591</prism_1__1_:startingPage>
         <prism_1__1_:pageRange>e000591</prism_1__1_:pageRange>
         <prism_1__1_:coverDisplayDate>2019</prism_1__1_:coverDisplayDate>
         <prism_1__1_:number>5</prism_1__1_:number>
         <prism_1__1_:volume>4</prism_1__1_:volume>
         <prism_1__1_:issn>2059-7029</prism_1__1_:issn>
         <prism_1__1_:copyright>2019 © THE AUTHORS. Published by Elsevier Limited on behalf of European Society for Medical Oncology.</prism_1__1_:copyright>
         <prism_1__1_:publicationName>ESMO Open</prism_1__1_:publicationName>
         <prism_1__1_:aggregationType>journal</prism_1__1_:aggregationType>
         <crossmark:DOI>10.1136/esmoopen-2019-000591</crossmark:DOI>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <w8arlmwmOztaNyPmGmd6Nz8NNytqPlt-Py.yGnguQnPj-n9v.z9-Mo9ePnMeKotiSn96Tma/>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:doi>10.1136/esmoopen-2019-000591</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:3454ef7b-4106-4e80-9d6f-9329e6cf4291</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:15aaeee8-27a7-42c8-95fd-9245c8dac445</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 474, 38, 539, 18
      Annotation: 
       Subtype: Link
       Rect: 38, 34, 63, 18
      Annotation: 
       Subtype: Link
       Rect: 40, 706, 139, 662
      Annotation: 
       Subtype: Link
       Rect: 212, 648, 221, 635
      Annotation: 
       Subtype: Link
       Rect: 252, 367, 255, 355
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 246, 257, 249, 246
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 245, 136, 254, 124
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 551, 453, 554, 441
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 551, 428, 554, 416
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 503, 331, 512, 319
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 455, 306, 458, 294
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 413, 99, 422, 87
       ActionDest: 1
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 125, 746, 128, 734
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 76, 321, 80, 309
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 159, 139, 166, 127
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 281, 115, 288, 103
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 447, 674, 451, 662
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 321, 426, 463, 416
      Annotation: 
       Subtype: Link
       Rect: 345, 398, 461, 389
      Annotation: 
       Subtype: Link
       Rect: 409, 335, 466, 326
      Annotation: 
       Subtype: Link
       Rect: 523, 318, 539, 309
      Annotation: 
       Subtype: Link
       Rect: 322, 309, 342, 301
      Annotation: 
       Subtype: Link
       Rect: 382, 292, 425, 284
      Annotation: 
       Subtype: Link
       Rect: 497, 275, 542, 267
      Annotation: 
       Subtype: Link
       Rect: 392, 241, 436, 233
      Annotation: 
       Subtype: Link
       Rect: 349, 216, 384, 207
      Annotation: 
       Subtype: Link
       Rect: 440, 182, 476, 173
      Annotation: 
       Subtype: Link
       Rect: 531, 156, 554, 148
      Annotation: 
       Subtype: Link
       Rect: 322, 148, 342, 139
      Annotation: 
       Subtype: Link
       Rect: 502, 122, 517, 114
      Annotation: 
       Subtype: Link
       Rect: 322, 88, 378, 80
  Checksum: 8418b730
   Type: CRC32
  Checksum: 4a6e6b3bcce7aae75ccadadf940d68f4
   Type: MD5
  Checksum: ef8d9521ba1271d7208ef4e607bea1e9f6db8cb8
   Type: SHA-1