7524bfdbdae950e51266a86afd083ced 253405.pdf b4a9617d8e2f4d4bb17e729cfb6a6a5746a7163f 253405.pdf fe047fc5931610c1fdb6d1e961975538ee1a0245319fe1226c720db182d8ec27 253405.pdf Title: MRI/Photoluminescence Dual-Modal Imaging Magnetic PLGA Nanocapsules for Theranostics Subject: Developing multifunctional and biocompatible drug delivery nanoplatforms that integrate high drug loads and multiple imaging modalities avoiding cross-interferences is extremely challenging. Here we report on the successful chemical reaction of the high quantum yield biodegradable and photoluminescent polyester (BPLP) with the poly(lactic-co-glycolic acid) (PLGA) polymer to fabricate biocompatible photoluminescent nanocapsules (NCs). Furthermore, we transform the PLGA-BPLP NCs into a magnetic resonance (MR)/photoluminescence dual-modal imaging theranostic platform by incorporating superparamagnetic iron oxide nanoparticles (SPIONs) into the polymeric shell. In vitro phantoms confirmed the excellent MRI-r2 relaxivity values of the NCs whilst the cellular uptake of these NCs was clearly observed by fluorescence optical imaging. Besides, the NCs (mean size ~270 nm) were loaded with ~1 wt% of a model protein (BSA) and their PEGylation provided a more hydrophilic surface. The NCs show biocompatibility in vitro, as hCMEC/D3 endothelial cells viability was not affected for particle concentration up to 500 g/mL. Interestingly, NCs decorated with SPIONs can be exploited for magnetic guiding and retention. Keywords: PLGA nanocapsules; magnetic resonance imaging; photoluminescence; drug delivery systems; magnetic targeting; multimodal imaging; theranostics Author: Yajie Zhang, Miguel García-Gabilondo, Anna Rosell and Anna Roig Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Sat Dec 21 12:25:07 2019 CET ModDate: Sat Dec 21 12:25:07 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4809595 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LALMDK+URWPalladioL-Ital Type 1 Custom yes yes no 131 0 QPPHSI+URWPalladioL-Bold Type 1 Custom yes yes no 132 0 MFIGJL+Rpxb Type 1 Builtin yes yes no 133 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 134 0 WXLNMF+URWPalladioL-Roma Type 1 Custom yes yes no 135 0 OXNQRR+VnURWPalladioL Type 1 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Identity-H yes yes yes 442 0 MGAPDH+PalatinoLinotype TrueType WinAnsi yes yes no 443 0 MGAPJH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 444 0 MGAPJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 445 0 MGBAHF+TimesNewRoman CID TrueType Identity-H yes yes yes 446 0 MGAPDG+PalatinoLinotype CID TrueType Identity-H yes yes yes 485 0 MGAPDH+PalatinoLinotype TrueType WinAnsi yes yes no 486 0 MGAPJH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 487 0 MGAPJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 488 0 MGBAHF+TimesNewRoman CID TrueType Identity-H yes yes yes 489 0 MGAPDG+PalatinoLinotype CID TrueType Identity-H yes yes yes 515 0 MGAPDH+PalatinoLinotype TrueType WinAnsi yes yes no 516 0 MGAPJH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 517 0 MGAPJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 518 0 MGBAHF+TimesNewRoman CID TrueType Identity-H yes yes yes 519 0 MGAPDG+PalatinoLinotype CID TrueType Identity-H yes yes yes 554 0 MGAPDH+PalatinoLinotype TrueType WinAnsi yes yes no 555 0 MGAPJH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 556 0 MGAPJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 557 0 MGBAHF+TimesNewRoman CID TrueType Identity-H yes yes yes 558 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-14 02:27:58 CEST RepresentationInformation: 253405.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-06-13 10:57:46 CEST Size: 4809595 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぅへばづひどねづのぴちぬぜ〴ぜ〰こづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぃはばはぬべねづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰くぬづどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはちぴづつぜ〴ぜ〰こぐぉくぎびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのっちばびふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰あこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐ〬ぜ〴ぜ〰こぐぉくぎび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Children: Item: Title: こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぃはばはぬべねづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰くぬづどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはちぴづつぜ〴ぜ〰こぐぉくぎびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのっちばびふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰あこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐ〬ぜ〴ぜ〰こぐぉくぎび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Item: Title: こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰くぬづどっぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぃはちぴづつぜ〴ぜ〰こぐぉくぎびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのっちばびふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰あこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐ〬ぜ〴ぜ〰こぐぉくぎび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Item: Title: うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのっちばびふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰あこぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐ〬ぜ〴ぜ〰こぐぉくぎび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Item: Title: ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐ〬ぜ〴ぜ〰こぐぉくぎび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Children: Item: Title: ぁぢびはひばぴどはのぜ〴ぜ〰こばづっぴひはびっはばどづびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぬべねづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸲ Item: Title: こどぺづぜ〴ぜ〰いどびぴひどぢふぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰いどびばづひびづぜ〴ぜ〰こぴちぢどぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸳ Item: Title: ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸴ Item: Title: きちでのづぴはねづぴひべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸵ Item: Title: うぬふはひづびっづのっづぜ〴ぜ〰ぐひはばづひぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰きげぉぜ〴ぜ〰ぐとちのぴはねびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰くぢびづひぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰あこぁぜ〴ぜ〰がはちつどのでぜ〴ぜ〰どのぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰げづぬづちびづぜ〴ぜ〰かどのづぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きげぉぜ〴ぜ〰ぐとちのぴはねびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰くぢびづひぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰あこぁぜ〴ぜ〰がはちつどのでぜ〴ぜ〰どのぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰げづぬづちびづぜ〴ぜ〰かどのづぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰くぢびづひぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰あこぁぜ〴ぜ〰がはちつどのでぜ〴ぜ〰どのぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰げづぬづちびづぜ〴ぜ〰かどのづぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰くぢびづひぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃづぬぬふぬちひぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰あこぁぜ〴ぜ〰がはちつどのでぜ〴ぜ〰どのぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰げづぬづちびづぜ〴ぜ〰かどのづぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: あこぁぜ〴ぜ〰がはちつどのでぜ〴ぜ〰どのぜ〴ぜ〰ぎぃびぜ〴ぜ〰ちのつぜ〴ぜ〰げづぬづちびづぜ〴ぜ〰かどのづぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴ぜ〰ちのつぜ〴ぜ〰いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐとはぴはぬふねどのづびっづのぴぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぃはばはぬべねづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃはねぢどのどのでぜ〴ぜ〰くぴとづひぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰きはどづぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぉねちでどのでぜ〴ぜ〰ぐづひてはひねちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きちでのづぴどっぜ〴ぜ〰ぐとはぴはぬふねどのづびっづのぴぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ぎぃびぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰がはちつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰げづぬづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぐとはぴはぬふねどのづびっづのぴぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぃはばはぬべねづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃはねぢどのどのでぜ〴ぜ〰くぴとづひぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰きはどづぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぉねちでどのでぜ〴ぜ〰ぐづひてはひねちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きちでのづぴどっぜ〴ぜ〰ぐとはぴはぬふねどのづびっづのぴぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ぎぃびぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰がはちつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰げづぬづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: うちぢひどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐがぇぁ〭あぐがぐぜ〴ぜ〰ぎぃびぜ〴ぜ〰ぃはねぢどのどのでぜ〴ぜ〰くぴとづひぜ〴ぜ〰うふのっぴどはのちぬぜ〴ぜ〰きはどづぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぉねちでどのでぜ〴ぜ〰ぐづひてはひねちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きちでのづぴどっぜ〴ぜ〰ぐとはぴはぬふねどのづびっづのぴぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ぎぃびぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰がはちつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰げづぬづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉねちでどのでぜ〴ぜ〰ぐづひてはひねちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きちでのづぴどっぜ〴ぜ〰ぐとはぴはぬふねどのづびっづのぴぜ〴ぜ〰ぎぃびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ぎぃびぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰がはちつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰げづぬづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ちてぴづひぜ〴ぜ〰ぎぃびぜ〴ぜ〰さばぴちにづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰がはちつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰げづぬづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぐひはぴづどのぜ〴ぜ〰がはちつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰げづぬづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NKZFAM+Rpxsc FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: NKZFAM+Rpxsc Flags: Symbolic FontBBox: -37, -172, 852, 718 FontFile: true Font: BaseFont: HHMDGK+Pxsy FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: HHMDGK+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: LALMDK+URWPalladioL-Ital FontSubset: true 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