0813fa0c4c68c99d1612341fb3677277  Safer_by_design_flame_sprayed_silicon_dioxide.pdf
ff4eb2a7faee536eaf22fe349d3dafb8c5fc3d1d  Safer_by_design_flame_sprayed_silicon_dioxide.pdf
6094b98391191354d895750525bdf54523b8ae9301685ff0cb6dab5e49491805  Safer_by_design_flame_sprayed_silicon_dioxide.pdf

Title:           Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity
Subject:         Particle and Fibre Toxicology, 2019, doi:10.1186/s12989-019-0325-1
Keywords:        Silanol groups,Amorphous silica,Surface reactivity,Flame spray pyrolysis,Toxicity
Author:          Laura Rubio
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     Item: 
      Title: Abstract
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      Children: 
       Item: 
        Title: Background
        Destination: sectionASec1
       Item: 
        Title: Results
        Destination: sectionASec2
       Item: 
        Title: Conclusion
        Destination: sectionASec3
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Synthesis of SiO2 NPs
        Destination: sectionSec3
        Children: 
         Item: 
          Title: Enthalpy estimation for FSP-made SiO2 NPs
          Destination: sectionSec4
       Item: 
        Title: Physicochemical characterization of SiO2 NPs
        Destination: sectionSec5
        Children: 
         Item: 
          Title: Tem
          Destination: sectionSec6
         Item: 
          Title: Bet
          Destination: sectionSec7
         Item: 
          Title: Density
          Destination: sectionSec8
         Item: 
          Title: Silanol content
          Destination: sectionSec9
         Item: 
          Title: X-ray photoelectron spectroscopy
          Destination: sectionSec10
       Item: 
        Title: Suspension preparation, colloidal characterization and dosimetry analysis of SiO2 NPs for cellular studies
        Destination: sectionSec11
        Children: 
         Item: 
          Title: Suspension preparation and colloidal characterization
          Destination: sectionSec12
         Item: 
          Title: Fate and transport modeling for calculation of dose delivered to cells
          Destination: sectionSec13
       Item: 
        Title: Acellular ROS characterization of SiO2 NPs
        Destination: sectionSec14
        Children: 
         Item: 
          Title: Incubation of SiO2 NPs with Trolox
          Destination: sectionSec15
         Item: 
          Title: LC-ESI-MS/MS analysis
          Destination: sectionSec16
         Item: 
          Title: Fast reacting ROS and H2O2 quantitation
          Destination: sectionSec17
       Item: 
        Title: In-vitro cellular studies
        Destination: sectionSec18
        Children: 
         Item: 
          Title: Cell culture
          Destination: sectionSec19
         Item: 
          Title: Cellular treatment
          Destination: sectionSec20
         Item: 
          Title: Cellular membrane integrity
          Destination: sectionSec21
         Item: 
          Title: Assessment of cell viability
          Destination: sectionSec22
         Item: 
          Title: Measurement of intracellular reactive oxygen species
          Destination: sectionSec23
       Item: 
        Title: Cellular statistical analysis
        Destination: sectionSec24
     Item: 
      Title: Results
      Destination: sectionSec25
      Children: 
       Item: 
        Title: Physicochemical characterization of SiO2 NPs
        Destination: sectionSec26
       Item: 
        Title: Suspension preparation, colloidal characterization and dosimetry analysis of SiO2 NPs
        Destination: sectionSec27
       Item: 
        Title: Acellular ROS production
        Destination: sectionSec28
       Item: 
        Title: In vitro cellular toxicity
        Destination: sectionSec29
        Children: 
         Item: 
          Title: Silanol content plays a role in cell membrane integrity and viability
          Destination: sectionSec30
         Item: 
          Title: Intracellular ROS
          Destination: sectionSec31
     Item: 
      Title: Discussion
      Destination: sectionSec32
     Item: 
      Title: Conclusions
      Destination: sectionSec33
     Item: 
      Title: Supplementary information
      Destination: sectionSec34
     Item: 
      Title: Acknowledgments
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Authors information
      Destination: sectionFPar1
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar2
     Item: 
      Title: Consent for publication
      Destination: sectionFPar3
     Item: 
      Title: Competing interests
      Destination: sectionFPar4
     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
      Destination: ArtNote2
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    Subject: Particle and Fibre Toxicology, 2019, doi:10.1186/s12989-019-0325-1
    Keywords: Silanol groups,Amorphous silica,Surface reactivity,Flame spray pyrolysis,Toxicity
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