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SinglePage PageMode: UseOutlines Outlines: Item: Title: Autonomous Neurodegeneration in Parkinson's Disease Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Generation and Characterization of iPSC-Derived Patient-Specific Astrocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Generation of vmDAns and Setup of Neuron-Astrocyte Co-culture System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Control vmDAns Show Morphological Signs of Neurodegeneration when Co-cultured with PD Astrocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Control vmDAns Accumulate α-syn when Co-cultured with PD Astrocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Control Astrocytes Partially Rescue Neurodegeneration of PD vmDAns Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Dysfunctional Chaperone-Mediated Autophagy and Progressive α-syn Accumulation in PD Astrocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Impaired Macroautophagy in PD Astrocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Restoration of α-syn Proteostasis in PD Astrocytes Alone and during Co-culture of Control Neurons with PD Astrocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Experimental Procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: iPSC-Derived Astrocyte Generation and Culture Destination: 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Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease Author: Angelique di Domenico Subject: Stem Cell Reports, 12 (2019) 213-229. doi:10.1016/j.stemcr.2018.12.011 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) ID: 0x997e8bc6e9465b64d2573fd14a7db81c, 0x049adbdad92f2c4a85450319bf2e331b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 68 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1734 ImageHeight: 1785 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2033 ImageHeight: 2279 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1965 ImageHeight: 2531 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Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MCCFKA+AdvPS4BD310 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: MCCFKA+AdvPS4BD310 Flags: Nonsymbolic FontBBox: 0, -208, 989, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MCBNGK+AdvPS8E91 FontSubset: true FirstChar: 67 LastChar: 116 FontDescriptor: FontName: MCBNGK+AdvPS8E91 Flags: Nonsymbolic FontBBox: -197, -239, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.stemcr.2018.12.011 Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease Angelique di Domenico Giulia Carola Carles Calatayud Meritxell Pons-Espinal Juan Pablo Muñoz Yvonne Richaud-Patin Irene Fernandez-Carasa Marta Gut Armida Faella Janani Parameswaran Jordi Soriano Isidro Ferrer Eduardo Tolosa Antonio Zorzano Ana Maria Cuervo Angel Raya Antonella Consiglio iPSC Parkinson's disease non-cell-autonomous astrocytes α-synuclein LRRK2 CRISPR/Cas9 disease modeling autophagy neurodegeneration Stem Cell Reports, 12 (2019) 213-229. doi:10.1016/j.stemcr.2018.12.011 ElsevierCompany. journal Stem Cell Reports © 2018 The Authors. 2213-6711 12 2 12 February 2019 2019-02-12 213-229 213 229 10.1016/j.stemcr.2018.12.011 https://doi.org/10.1016/j.stemcr.2018.12.011 2010-04-23 true 10.1016/j.stemcr.2018.12.011 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.stemcr.2018.12.011 noindex 2010-04-23 true 5th February 2019 sciencedirect.com elsevier.com Elsevier 2019-02-05T23:29:26+05:30 2019-02-05T23:29:26+05:30 True 5th February 2019 Acrobat Distiller 8.1.0 (Windows) uuid:28b93cfa-9d4f-431b-86da-41c202548586 uuid:9006772a-83c7-4f52-8be3-4e3a658c553c http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 213 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 164, 625, 169, 635 Destination: 862 Annotation: Subtype: Link Rect: 171, 625, 175, 635 Destination: 862 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