fc67ff406807bd4fb30ad304ac3b4dd7 pmc_30814939.pdf 48a0e2e1ebdfa5a165d6e7e43346a3a7b818d3d0 pmc_30814939.pdf 1b5696fd9cc7b68f30d2e2495a670eb777503792e6bad46ce000ed3ad3b3f797 pmc_30814939.pdf Title: Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Age- and Task-Selective Manner in C57BL/6 Mice but Can Be Modulated by Neonatal Handling Subject: Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. Keywords: neonatal hypoxic ischemic injury, neonatal handling, sensory stimulation, animal model, sex, gender medicine, behavior, cognition Author: Lydia Giménez-Llort Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Mon Feb 11 11:16:29 2019 CET ModDate: Mon Feb 11 11:17:18 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 4826857 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MBBUAQ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 1020 0 GYOUJM+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 1021 0 YQLHNJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 1022 0 IZKYJV+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 1023 0 KNRPAY+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 1024 0 NXPOGW+MinionPro-Regular Type 1 Custom yes yes no 671 0 OJWPOY+MTSYN Type 1 Builtin yes yes no 679 0 AEAOYD+MinionPro-It Type 1 Custom yes yes no 683 0 YWHUFT+MinionPro-Bold Type 1 Custom yes yes no 678 0 GGENON+RMTMI Type 1 Builtin yes yes no 690 0 JYDOCF+MTGU Type 1 Builtin yes yes no 693 0 YOGWBG+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 694 0 TTDZXE+MTSY Type 1 Builtin yes yes no 697 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-19 06:17:14 CET RepresentationInformation: pmc_30814939.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-03 03:44:46 CEST Size: 4826857 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1220 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive I洀瀀愀椀爀洀攀渀琀 椀渀 愀 匀攀砀ⴀⰀ 䄀最攀ⴀ 愀渀搀 吀愀猀欀ⴀ匀攀氀攀挀琀椀瘀攀 䴀愀渀渀攀爀 椀渀 䌀㔀㜀䈀䰀⼀㘀 䴀椀挀攀 戀甀琀 䌀愀渀 䈀攀 䴀漀搀甀氀愀琀攀搀 戀礀 一攀漀渀愀琀愀氀 䠀愀渀搀氀椀渀朩൥湤潢樍㄰㤸‰扪഼㰯䐨剅䙅剅乃䕓⸱ Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Animals Item: Title: Experimental Design Item: Title: Hypoxia/Ischemia Item: Title: Handling Item: Title: Behavioral and Functional Assessments Item: Title: Body Weight (BW) Item: Title: Sensorimotor Functions (SMT) Item: Title: Cylinder Test (CYT) Item: Title: Spontaneous Motor Activity Test (ACT) Item: Title: Corner Test (CT) and Open Field Test (OF) Item: Title: Dark–Light Box Test (DLB) Item: Title: T-Maze Test (TM) Item: Title: Morris Water Maze (MWM) Children: Item: Title: Cue Learning With a Visible Platform Item: Title: Place Learning With a Hidden Platform Item: Title: Removal Item: Title: Analyses Item: Title: Neuropathological Analysis Item: Title: Statistics Item: Title: RESULTS Children: Item: Title: Short and Long Effects of HI and Their Counteraction by Handling Children: Item: Title: Neuropathological Analysis Item: Title: Somatic Development (Primary Screening) Children: Item: Title: Body Weight (BW) PND23–PND70–PND90 Item: Title: Sensorimotor Functions and Motor Activity (Secondary Screening) Children: Item: Title: Sensorimotor Functions (SMT)-PND23-PND70 Item: Title: Cylinder Test (CYT)—PND23 Item: Title: Spontaneous Motor Activity Test (ACT)–PND23 Item: Title: Non-Cognitive and Cognitive Functions (Tertiary Screening)–PND70–PND90 Children: Item: Title: Corner Test (CT) and Open Field (OF) Item: Title: Dark-Light Box Test (DLB) Item: Title: T-Maze Test (TM) Item: Title: Morris Water Maze (MWM) Item: Title: Correlations Analysis Item: Title: DISCUSSION Item: Title: ETHICS STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: REFERENCES Info: Title: Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Age- and Task-Selective Manner in C57BL/6 Mice but Can Be Modulated by Neonatal Handling Author: Lydia Giménez-Llort Subject: Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. 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