b26c5cac827d997f74247926e0e69c1a pmc_30815250.pdf 0fa02e53ca4a7715c37ae0c7ed25885d776db29c pmc_30815250.pdf c350dcbf5c41f7bf11e917147d3dfecbaad32fe1a813aaaea768a9043ffa9a92 pmc_30815250.pdf Producer: iText 4.2.0 by 1T3XT CreationDate: Fri Sep 20 11:30:05 2019 CEST ModDate: Fri Sep 20 11:30:05 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 29 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 4922033 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IDFGVN+HelveticaWorld-Regular CID TrueType Identity-H yes yes yes 69 0 PVPJYQ+HelveticaWorld-Bold CID TrueType Identity-H yes yes yes 70 0 QFKORI+HelveticaWorld-BoldItalic CID TrueType Identity-H yes yes yes 71 0 JOPKOZ+HelveticaWorld-Regular CID TrueType Identity-H yes yes yes 4 0 GFLLTM+HelveticaWorld-Italic CID TrueType Identity-H yes yes yes 72 0 Helvetica-Bold Type 1 WinAnsi no no no 73 0 RVRCZL+Helvetica-Bold Type 1C Custom yes yes yes 148 0 BSPFJR+Times-Italic Type 1C Custom yes yes yes 149 0 RVRCZL+Times-Roman Type 1C Custom yes yes yes 150 0 BSPFJR+Helvetica-Light Type 1C Custom yes yes yes 151 0 BSPFJR+Helvetica-Roman Type 1C Custom yes yes yes 152 0 BSPFJR+Helvetica-86HeavyItalic Type 1C WinAnsi yes yes no 153 0 BSPFJR+Helvetica-LightOblique Type 1C WinAnsi yes yes yes 154 0 BSPFJR+Helvetica-BoldItalic Type 1C Custom yes yes yes 206 0 BSPFJR+Helvetica-BoldOblique Type 1C WinAnsi yes yes yes 275 0 BSPFJR+Helvetica-Oblique Type 1C WinAnsi yes yes yes 205 0 BSPFJR+Symbol CID Type 0C Identity-H yes yes yes 353 0 ZLAJNM+HelveticaWorld-Regular CID TrueType Identity-H yes yes yes 690 0 BRKHGE+HelveticaWorld-Bold CID TrueType Identity-H yes yes yes 691 0 Helvetica-Bold Type 1 WinAnsi no no no 692 0 Helvetica Type 1 WinAnsi no no no 693 0 NNOBUF+HelveticaWorld-Italic CID TrueType Identity-H yes yes yes 694 0 WNHHCB+HelveticaWorld-BoldItalic CID TrueType Identity-H yes yes yes 722 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-09-21 02:38:00 CEST RepresentationInformation: pmc_30815250.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:01:34 CET Size: 4922033 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 818 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Producer: iText 4.2.0 by 1T3XT CreationDate: Fri Sep 20 11:30:05 CEST 2019 ModDate: Fri Sep 20 11:30:05 CEST 2019 ID: 0xfca1171f49b9c1f34764443b86cac012, 0xb3a022893f191d73961b14eaaae42d99 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png 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NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 9 ImageHeight: 17 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 9 ImageHeight: 17 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: CalRGB Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1645 ImageHeight: 1058 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2108 ImageHeight: 1504 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2043 ImageHeight: 2471 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1981 ImageHeight: 2534 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1447 ImageHeight: 2492 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 1 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: CalRGB Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 1 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: CalRGB Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 48 ImageHeight: 48 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 1 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: CalRGB Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3840 ImageHeight: 421 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2496 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3840 ImageHeight: 421 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type0: Font: BaseFont: BSPFJR+Symbol Encoding: Identity-H ToUnicode: true Font: BaseFont: ZLAJNM+HelveticaWorld-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: WNHHCB+HelveticaWorld-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: BRKHGE+HelveticaWorld-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: JOPKOZ+HelveticaWorld-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: IDFGVN+HelveticaWorld-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: PVPJYQ+HelveticaWorld-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: NNOBUF+HelveticaWorld-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: QFKORI+HelveticaWorld-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: GFLLTM+HelveticaWorld-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: Helvetica-Bold Encoding: WinAnsiEncoding Font: BaseFont: BSPFJR+Helvetica-Oblique FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: 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Helvetica-Bold Encoding: WinAnsiEncoding Font: BaseFont: BSPFJR+Times-Italic FontSubset: true FirstChar: 31 LastChar: 149 FontDescriptor: FontName: BSPFJR+Times-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -169, -217, 1010, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Helvetica Encoding: WinAnsiEncoding Font: BaseFont: RVRCZL+Times-Roman FontSubset: true FirstChar: 30 LastChar: 181 FontDescriptor: FontName: RVRCZL+Times-Roman Flags: Serif, Nonsymbolic FontBBox: -168, -218, 1000, 898 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BSPFJR+Helvetica-Light FontSubset: true FirstChar: 30 LastChar: 148 FontDescriptor: FontName: BSPFJR+Helvetica-Light Flags: Nonsymbolic FontBBox: -164, -250, 1000, 979 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BSPFJR+Helvetica-Roman FontSubset: true FirstChar: 29 LastChar: 246 FontDescriptor: FontName: BSPFJR+Helvetica-Roman Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BSPFJR+Helvetica-86HeavyItalic FontSubset: true FirstChar: 68 LastChar: 86 FontDescriptor: FontName: BSPFJR+Helvetica-86HeavyItalic Flags: Nonsymbolic FontBBox: -165, -228, 1139, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BSPFJR+Helvetica-LightOblique FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BSPFJR+Helvetica-LightOblique Flags: Nonsymbolic, Italic FontBBox: -372, -250, 1053, 979 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType0: Font: BaseFont: BSPFJR+Symbol CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BSPFJR+Symbol Flags: Serif, Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true CIDFontType2: Font: BaseFont: 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