9e9072ed614f1eea598191f6d78511e7 pmc_30823672.pdf 17efe2e147b6e4d55b1c992be9677db0d4885463 pmc_30823672.pdf d7d7509643bc45aa53f1dbfd3d54605e4174cd4517433f9ebcb27d6fed5c36f7 pmc_30823672.pdf Title: Implication of Voltage-Gated Potassium Channels in Neoplastic Cell Proliferation Subject: Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development. Keywords: K+ channels; cancer; tumor progression; cell cycle; proliferation Author: Clara Serrano-Novillo, Jesusa Capera, Magalí Colomer-Molera, Enric Condom, Joan Carles Ferreres and Antonio Felipe Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Mar 1 10:05:05 2019 CET ModDate: Fri Mar 1 10:05:05 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2621213 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FIDNJB+URWPalladioL-Ital Type 1 Custom yes yes no 70 0 HAEEFI+URWPalladioL-Bold Type 1 Custom yes yes no 71 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 72 0 FNMHJS+URWPalladioL-Roma Type 1 Custom yes yes no 73 0 KORLVE+VnURWPalladioL Type 1 Custom yes yes no 74 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 80 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 97 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 98 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 99 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 134 0 VDWKPG+CMSY10 Type 1 Builtin yes yes no 135 0 GBGKFN+PalatinoLinotype TrueType WinAnsi yes yes no 167 0 GBGKIO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 168 0 GBGKJA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 169 0 GBGLAO+TimesNewRoman CID TrueType Identity-H yes yes yes 170 0 GBGNIC+TimesNewRoman,Italic TrueType WinAnsi yes yes no 296 0 GBGKFN+PalatinoLinotype TrueType WinAnsi yes yes no 297 0 GBGKIO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 298 0 GBGKJA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 299 0 GBGLAO+TimesNewRoman CID TrueType Identity-H yes yes yes 300 0 GBGKFN+PalatinoLinotype TrueType WinAnsi yes yes no 384 0 GBGKIO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 385 0 GBGKJA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 386 0 GBGLAO+TimesNewRoman CID TrueType Identity-H yes yes yes 387 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:51:27 CEST RepresentationInformation: pmc_30823672.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-16 03:48:08 CET Size: 2621213 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぐはぴちびびどふねぜ〴ぜ〰ぃとちののづぬび〺ぜ〴ぜ〰ぃぬちびびどてどっちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぐはぴちびびどふねぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: かぶぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰いづぬちべづつぜ〴ぜ〰げづっぴどてどづひぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰ぜ〵ぜ〰ぉいげぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぁ〭ごべばづぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰ぜ〵ぜ〰ぉぁぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きはつどてどづひ〯こどぬづのっづひぜ〴ぜ〰こふぢふのどぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: いづぬちべづつぜ〴ぜ〰げづっぴどてどづひぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰ぜ〵ぜ〰ぉいげぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぁ〭ごべばづぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰ぜ〵ぜ〰ぉぁぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きはつどてどづひ〯こどぬづのっづひぜ〴ぜ〰こふぢふのどぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁ〭ごべばづぜ〴ぜ〰ぃとちののづぬびぜ〴ぜ〰ぜ〵ぜ〰ぉぁぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きはつどてどづひ〯こどぬづのっづひぜ〴ぜ〰こふぢふのどぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きはつどてどづひ〯こどぬづのっづひぜ〴ぜ〰こふぢふのどぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: くぴとづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづでふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃべっぬづぜ〴ぜ〰ぐひはでひづびびどはのぜ〴ぜ〰ぢべぜ〴ぜ〰かぶぜ〴ぜ〰ぃとちののづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふつどのでぜ〴ぜ〰げづねちひにびぜ〴〩਼㰠⽓ 䝯呯 䐠⡴慢汥⹣慰瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: FIDNJB+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: FIDNJB+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QDCWHF+EURM10 FontSubset: true FirstChar: 11 LastChar: 12 FontDescriptor: FontName: QDCWHF+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: HAEEFI+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: HAEEFI+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VDWKPG+CMSY10 FontSubset: true FirstChar: 0 LastChar: 35 FontDescriptor: FontName: VDWKPG+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: WLENKM+VnURWPalladioL-Bold FontSubset: true FirstChar: 189 LastChar: 189 FontDescriptor: FontName: WLENKM+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FNMHJS+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 169 FontDescriptor: FontName: FNMHJS+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KORLVE+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: KORLVE+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 193, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 257, 660, 268, 674 Annotation: Subtype: Link Rect: 276, 647, 288, 660 Annotation: Subtype: Link Rect: 466, 520, 518, 539 Annotation: Subtype: Link Rect: 389, 198, 396, 207 ActionDest: 583 Annotation: Subtype: Link Rect: 364, 157, 371, 166 ActionDest: 583 Annotation: Subtype: Link Rect: 372, 157, 379, 166 ActionDest: 583 Annotation: Subtype: Link Rect: 201, 127, 386, 139 Annotation: Subtype: Link Rect: 309, 76, 316, 85 ActionDest: 583 Annotation: Subtype: Link Rect: 316, 76, 323, 85 ActionDest: 583 Annotation: Subtype: Link Rect: 164, 38, 255, 50 Annotation: Subtype: Link Rect: 399, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 461, 634, 468, 643 ActionDest: 583 Annotation: Subtype: Link Rect: 469, 634, 476, 643 ActionDest: 583 Annotation: Subtype: Link Rect: 298, 551, 305, 560 ActionDest: 583 Annotation: Subtype: Link Rect: 176, 429, 183, 439 ActionDest: 583 Annotation: Subtype: Link Rect: 184, 429, 191, 439 ActionDest: 583 Annotation: Subtype: Link Rect: 110, 373, 117, 385 ActionDest: 160 Annotation: Subtype: Link Rect: 458, 376, 465, 385 ActionDest: 583 Annotation: Subtype: Link Rect: 466, 375, 478, 385 ActionDest: 583 Annotation: Subtype: Link Rect: 212, 254, 224, 263 ActionDest: 583 Annotation: Subtype: Link Rect: 227, 254, 239, 263 ActionDest: 583 Annotation: Subtype: Link Rect: 198, 200, 210, 209 ActionDest: 583 Annotation: Subtype: Link Rect: 210, 200, 222, 209 ActionDest: 583 Annotation: Subtype: Link Rect: 297, 186, 309, 195 ActionDest: 583 Annotation: Subtype: Link Rect: 417, 159, 429, 168 ActionDest: 583 Annotation: Subtype: Link Rect: 199, 119, 211, 128 ActionDest: 624 Annotation: Subtype: Link Rect: 492, 92, 504, 101 ActionDest: 624 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 115, 326, 122, 335 ActionDest: 583 Annotation: Subtype: Link Rect: 122, 326, 129, 335 ActionDest: 583 Annotation: Subtype: Link Rect: 388, 280, 395, 292 ActionDest: 286 Annotation: Subtype: Link Rect: 148, 121, 160, 130 ActionDest: 624 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 314, 743, 326, 751 ActionDest: 624 Annotation: Subtype: Link Rect: 396, 729, 408, 738 ActionDest: 624 Annotation: Subtype: Link Rect: 408, 729, 420, 738 ActionDest: 624 Annotation: Subtype: Link Rect: 466, 715, 478, 724 ActionDest: 624 Annotation: Subtype: Link Rect: 478, 715, 490, 724 ActionDest: 624 Annotation: Subtype: Link Rect: 115, 661, 127, 670 ActionDest: 624 Annotation: Subtype: Link Rect: 127, 661, 139, 670 ActionDest: 624 Annotation: Subtype: Link Rect: 123, 634, 135, 643 ActionDest: 583 Annotation: Subtype: Link Rect: 136, 634, 148, 643 ActionDest: 624 Annotation: Subtype: Link Rect: 151, 634, 163, 643 ActionDest: 624 Annotation: Subtype: Link Rect: 449, 634, 461, 643 ActionDest: 583 Annotation: Subtype: Link Rect: 286, 607, 298, 616 ActionDest: 624 Annotation: Subtype: Link Rect: 298, 607, 310, 616 ActionDest: 624 Annotation: Subtype: Link Rect: 295, 580, 307, 589 ActionDest: 624 Annotation: Subtype: Link Rect: 308, 580, 320, 589 ActionDest: 624 Annotation: Subtype: Link Rect: 320, 580, 332, 589 ActionDest: 624 Annotation: Subtype: Link Rect: 307, 567, 319, 576 ActionDest: 624 Annotation: Subtype: Link Rect: 319, 567, 331, 576 ActionDest: 624 Annotation: Subtype: Link Rect: 454, 553, 466, 562 ActionDest: 624 Annotation: Subtype: Link Rect: 198, 540, 210, 549 ActionDest: 667 Annotation: Subtype: Link Rect: 270, 540, 282, 549 ActionDest: 667 Annotation: Subtype: Link Rect: 283, 540, 295, 549 ActionDest: 667 Annotation: Subtype: Link Rect: 163, 486, 175, 495 ActionDest: 667 Annotation: Subtype: Link Rect: 503, 459, 515, 468 ActionDest: 667 Annotation: Subtype: Link Rect: 350, 432, 362, 441 ActionDest: 624 Annotation: Subtype: Link Rect: 270, 405, 282, 414 ActionDest: 667 Annotation: Subtype: Link Rect: 283, 405, 294, 414 ActionDest: 667 Annotation: Subtype: Link Rect: 384, 378, 396, 387 ActionDest: 667 Annotation: Subtype: Link Rect: 399, 378, 411, 387 ActionDest: 667 Annotation: Subtype: Link Rect: 145, 310, 157, 319 ActionDest: 667 Annotation: Subtype: Link Rect: 411, 297, 423, 306 ActionDest: 583 Annotation: Subtype: Link Rect: 228, 283, 240, 292 ActionDest: 624 Annotation: Subtype: Link Rect: 330, 283, 342, 292 ActionDest: 667 Annotation: Subtype: Link Rect: 451, 283, 463, 292 ActionDest: 667 Annotation: Subtype: Link Rect: 215, 256, 227, 265 ActionDest: 667 Annotation: Subtype: Link Rect: 118, 242, 130, 252 ActionDest: 667 Annotation: Subtype: Link Rect: 369, 202, 381, 211 ActionDest: 667 Annotation: Subtype: Link Rect: 382, 202, 394, 211 ActionDest: 667 Annotation: Subtype: Link Rect: 216, 175, 228, 184 ActionDest: 667 Annotation: Subtype: Link Rect: 457, 121, 469, 130 ActionDest: 667 Annotation: Subtype: Link Rect: 469, 121, 481, 130 ActionDest: 667 Annotation: Subtype: Link Rect: 153, 80, 165, 89 ActionDest: 667 Annotation: Subtype: Link Rect: 376, 81, 388, 89 ActionDest: 624 Annotation: Subtype: Link Rect: 461, 80, 473, 89 ActionDest: 708 Annotation: Subtype: Link Rect: 474, 80, 485, 89 ActionDest: 708 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 167, 742, 179, 751 ActionDest: 708 Annotation: Subtype: Link Rect: 180, 742, 192, 751 ActionDest: 708 Annotation: Subtype: Link Rect: 283, 742, 295, 751 ActionDest: 708 Annotation: Subtype: Link Rect: 295, 742, 307, 751 ActionDest: 708 Annotation: Subtype: Link Rect: 191, 661, 203, 670 ActionDest: 708 Annotation: Subtype: Link Rect: 203, 661, 215, 670 ActionDest: 708 Annotation: Subtype: Link Rect: 216, 661, 228, 670 ActionDest: 708 Annotation: Subtype: Link Rect: 111, 371, 118, 383 ActionDest: 286 Annotation: Subtype: Link Rect: 264, 306, 276, 315 ActionDest: 708 Annotation: Subtype: Link Rect: 384, 279, 396, 288 ActionDest: 708 Annotation: Subtype: Link Rect: 399, 279, 411, 288 ActionDest: 708 Annotation: Subtype: Link Rect: 417, 252, 429, 261 ActionDest: 708 Annotation: Subtype: Link Rect: 468, 239, 480, 248 ActionDest: 708 Annotation: Subtype: Link Rect: 103, 198, 115, 207 ActionDest: 708 Annotation: Subtype: Link Rect: 115, 198, 127, 207 ActionDest: 708 Annotation: Subtype: Link Rect: 442, 75, 454, 83 ActionDest: 708 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 190, 729, 202, 738 ActionDest: 667 Annotation: Subtype: Link Rect: 355, 702, 366, 711 ActionDest: 708 Annotation: Subtype: Link Rect: 436, 565, 448, 574 ActionDest: 624 Annotation: Subtype: Link Rect: 448, 565, 460, 574 ActionDest: 748 Annotation: Subtype: Link Rect: 463, 565, 475, 574 ActionDest: 748 Annotation: Subtype: Link Rect: 439, 538, 451, 547 ActionDest: 748 Annotation: Subtype: Link Rect: 451, 538, 463, 547 ActionDest: 748 Annotation: Subtype: Link Rect: 464, 538, 476, 547 ActionDest: 748 Annotation: Subtype: Link Rect: 409, 497, 421, 506 ActionDest: 748 Annotation: Subtype: Link Rect: 424, 497, 435, 506 ActionDest: 748 Annotation: Subtype: Link Rect: 233, 438, 240, 450 ActionDest: 375 Annotation: Subtype: Link Rect: 437, 292, 449, 301 ActionDest: 748 Annotation: Subtype: Link Rect: 449, 292, 461, 301 ActionDest: 748 Annotation: Subtype: Link Rect: 358, 279, 370, 288 ActionDest: 748 Annotation: Subtype: Link Rect: 368, 225, 380, 234 ActionDest: 748 Annotation: Subtype: Link Rect: 380, 225, 392, 234 ActionDest: 748 Annotation: Subtype: Link Rect: 269, 157, 281, 166 ActionDest: 748 Page: Sequence: 7 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 196, 702, 208, 711 ActionDest: 748 Annotation: Subtype: Link Rect: 110, 661, 122, 670 ActionDest: 748 Annotation: Subtype: Link Rect: 123, 661, 135, 670 ActionDest: 748 Annotation: Subtype: Link Rect: 503, 607, 515, 616 ActionDest: 748 Annotation: Subtype: Link Rect: 248, 553, 260, 562 ActionDest: 791 Annotation: Subtype: Link Rect: 107, 499, 119, 508 ActionDest: 667 Annotation: Subtype: Link Rect: 260, 486, 272, 495 ActionDest: 791 Annotation: Subtype: Link Rect: 353, 445, 365, 454 ActionDest: 791 Annotation: Subtype: Link Rect: 253, 364, 265, 373 ActionDest: 791 Annotation: Subtype: Link Rect: 415, 351, 427, 360 ActionDest: 791 Annotation: Subtype: Link Rect: 211, 297, 223, 306 ActionDest: 791 Annotation: Subtype: Link Rect: 448, 242, 460, 252 ActionDest: 624 Annotation: Subtype: Link Rect: 351, 161, 368, 171 ActionDest: 791 Annotation: Subtype: Link Rect: 268, 121, 285, 130 ActionDest: 791 Annotation: Subtype: Link Rect: 489, 107, 506, 117 ActionDest: 791 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 498, 688, 515, 697 ActionDest: 791 Annotation: Subtype: Link Rect: 218, 661, 235, 670 ActionDest: 791 Annotation: Subtype: Link Rect: 498, 648, 515, 657 ActionDest: 791 Annotation: Subtype: Link Rect: 236, 548, 243, 560 ActionDest: 542 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 723, 465, 733, 472 ActionDest: 624 Annotation: Subtype: Link Rect: 734, 465, 744, 472 ActionDest: 624 Annotation: Subtype: Link Rect: 722, 448, 732, 455 ActionDest: 583 Annotation: Subtype: Link Rect: 731, 448, 745, 455 ActionDest: 791 Annotation: Subtype: Link Rect: 719, 431, 729, 438 ActionDest: 583 Annotation: Subtype: Link Rect: 728, 431, 738, 438 ActionDest: 624 Annotation: Subtype: Link Rect: 737, 431, 747, 438 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 419, 738, 426 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 406, 738, 413 ActionDest: 583 Annotation: Subtype: Link Rect: 728, 389, 738, 396 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 372, 738, 379 ActionDest: 583 Annotation: Subtype: Link Rect: 728, 359, 738, 366 ActionDest: 583 Annotation: Subtype: Link Rect: 727, 347, 740, 354 ActionDest: 791 Annotation: Subtype: Link Rect: 727, 330, 740, 337 ActionDest: 791 Annotation: Subtype: Link Rect: 720, 308, 734, 315 ActionDest: 791 Annotation: Subtype: Link Rect: 733, 308, 746, 315 ActionDest: 791 Annotation: Subtype: Link Rect: 728, 291, 738, 298 ActionDest: 624 Annotation: Subtype: Link Rect: 727, 279, 740, 286 ActionDest: 791 Annotation: Subtype: Link Rect: 728, 266, 738, 273 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 253, 738, 260 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 236, 738, 243 ActionDest: 624 Annotation: Subtype: Link Rect: 727, 219, 740, 226 ActionDest: 791 Annotation: Subtype: Link Rect: 728, 207, 738, 214 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 190, 738, 197 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 173, 738, 180 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 160, 738, 167 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 147, 738, 154 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 135, 738, 142 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 122, 738, 129 ActionDest: 624 Annotation: Subtype: Link Rect: 724, 105, 734, 112 ActionDest: 667 Annotation: Subtype: Link Rect: 733, 105, 743, 112 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 84, 738, 91 ActionDest: 624 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 728, 465, 738, 472 ActionDest: 583 Annotation: Subtype: Link Rect: 728, 448, 738, 455 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 431, 738, 438 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 414, 738, 421 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 393, 738, 400 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 376, 738, 383 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 363, 738, 370 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 346, 738, 353 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 329, 738, 336 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 317, 738, 324 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 304, 738, 311 ActionDest: 708 Annotation: Subtype: Link Rect: 724, 291, 734, 298 ActionDest: 667 Annotation: Subtype: Link Rect: 733, 291, 743, 298 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 274, 738, 281 ActionDest: 708 Annotation: Subtype: Link Rect: 724, 257, 734, 264 ActionDest: 708 Annotation: Subtype: Link Rect: 733, 257, 743, 264 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 240, 738, 247 ActionDest: 708 Annotation: Subtype: Link Rect: 724, 219, 734, 226 ActionDest: 708 Annotation: Subtype: Link Rect: 733, 219, 743, 226 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 202, 738, 209 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 189, 738, 196 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 172, 738, 179 ActionDest: 667 Annotation: Subtype: Link Rect: 728, 155, 738, 162 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 143, 738, 150 ActionDest: 708 Annotation: Subtype: Link Rect: 728, 126, 738, 133 ActionDest: 624 Annotation: Subtype: Link Rect: 728, 108, 738, 116 ActionDest: 748 Annotation: Subtype: Link Rect: 728, 96, 738, 103 ActionDest: 748 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 248, 586, 286, 597 Annotation: Subtype: Link Rect: 292, 586, 328, 597 Annotation: Subtype: Link Rect: 288, 547, 326, 558 Annotation: Subtype: Link Rect: 332, 547, 368, 558 Annotation: Subtype: Link Rect: 480, 509, 516, 520 Annotation: Subtype: Link Rect: 100, 497, 136, 507 Annotation: Subtype: Link Rect: 436, 470, 473, 481 Annotation: Subtype: Link Rect: 480, 470, 516, 481 Annotation: Subtype: Link Rect: 405, 458, 443, 468 Annotation: Subtype: Link Rect: 449, 458, 485, 468 Annotation: Subtype: Link Rect: 323, 432, 361, 442 Annotation: Subtype: Link Rect: 367, 432, 403, 442 Annotation: Subtype: Link Rect: 145, 406, 182, 416 Annotation: Subtype: Link Rect: 188, 406, 224, 416 Annotation: Subtype: Link Rect: 100, 367, 137, 378 Annotation: Subtype: Link Rect: 143, 367, 179, 378 Annotation: Subtype: Link Rect: 154, 342, 191, 352 Annotation: Subtype: Link Rect: 197, 342, 233, 352 Annotation: Subtype: Link Rect: 479, 328, 516, 339 Annotation: Subtype: Link Rect: 100, 316, 136, 326 Annotation: Subtype: Link Rect: 416, 289, 453, 300 Annotation: Subtype: Link Rect: 479, 277, 516, 287 Annotation: Subtype: Link Rect: 100, 264, 136, 274 Annotation: Subtype: Link Rect: 359, 225, 397, 236 Annotation: Subtype: Link Rect: 403, 225, 439, 236 Annotation: Subtype: Link Rect: 231, 187, 269, 197 Annotation: Subtype: Link Rect: 275, 187, 311, 197 Annotation: Subtype: Link Rect: 410, 160, 447, 171 Annotation: Subtype: Link Rect: 453, 160, 489, 171 Annotation: Subtype: Link Rect: 437, 134, 474, 145 Annotation: Subtype: Link Rect: 481, 134, 516, 145 Annotation: Subtype: Link Rect: 136, 96, 173, 106 Annotation: Subtype: Link Rect: 180, 96, 216, 106 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 162, 728, 200, 738 Annotation: Subtype: Link Rect: 206, 728, 242, 738 Annotation: Subtype: Link Rect: 242, 689, 280, 699 Annotation: Subtype: Link Rect: 286, 689, 322, 699 Annotation: Subtype: Link Rect: 100, 638, 137, 648 Annotation: Subtype: Link Rect: 143, 638, 179, 648 Annotation: Subtype: Link Rect: 307, 598, 344, 609 Annotation: Subtype: Link Rect: 350, 598, 386, 609 Annotation: Subtype: Link Rect: 228, 547, 266, 557 Annotation: Subtype: Link Rect: 272, 547, 308, 557 Annotation: Subtype: Link Rect: 267, 508, 305, 519 Annotation: Subtype: Link Rect: 311, 508, 347, 519 Annotation: Subtype: Link Rect: 378, 470, 415, 480 Annotation: Subtype: Link Rect: 421, 470, 457, 480 Annotation: Subtype: Link Rect: 171, 431, 209, 441 Annotation: Subtype: Link Rect: 215, 431, 251, 441 Annotation: Subtype: Link Rect: 330, 404, 368, 415 Annotation: Subtype: Link Rect: 153, 366, 191, 377 Annotation: Subtype: Link Rect: 197, 366, 233, 377 Annotation: Subtype: Link Rect: 118, 328, 156, 338 Annotation: Subtype: Link Rect: 162, 328, 198, 338 Annotation: Subtype: Link Rect: 163, 289, 200, 299 Annotation: Subtype: Link Rect: 207, 289, 243, 299 Annotation: Subtype: Link Rect: 100, 250, 137, 260 Annotation: Subtype: Link Rect: 143, 250, 179, 260 Annotation: Subtype: Link Rect: 270, 212, 307, 222 Annotation: Subtype: Link Rect: 313, 212, 349, 222 Annotation: Subtype: Link Rect: 385, 185, 422, 196 Annotation: Subtype: Link Rect: 429, 185, 465, 196 Annotation: Subtype: Link Rect: 277, 146, 314, 157 Annotation: Subtype: Link Rect: 320, 146, 356, 157 Annotation: Subtype: Link Rect: 280, 107, 317, 118 Annotation: Subtype: Link Rect: 324, 107, 360, 118 Annotation: Subtype: Link Rect: 412, 82, 450, 93 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 100, 715, 136, 725 Annotation: Subtype: Link Rect: 338, 676, 375, 686 Annotation: Subtype: Link Rect: 381, 676, 417, 686 Annotation: Subtype: Link Rect: 365, 637, 403, 648 Annotation: Subtype: Link Rect: 409, 637, 445, 648 Annotation: Subtype: Link Rect: 100, 599, 137, 609 Annotation: Subtype: Link Rect: 143, 599, 179, 609 Annotation: Subtype: Link Rect: 323, 572, 360, 583 Annotation: Subtype: Link Rect: 366, 572, 402, 583 Annotation: Subtype: Link Rect: 181, 547, 218, 557 Annotation: Subtype: Link Rect: 224, 547, 261, 557 Annotation: Subtype: Link Rect: 411, 508, 448, 519 Annotation: Subtype: Link Rect: 455, 508, 491, 519 Annotation: Subtype: Link Rect: 336, 470, 374, 480 Annotation: Subtype: Link Rect: 380, 470, 416, 480 Annotation: Subtype: Link Rect: 293, 431, 330, 441 Annotation: Subtype: Link Rect: 336, 431, 372, 441 Annotation: Subtype: Link Rect: 378, 392, 416, 402 Annotation: Subtype: Link Rect: 422, 392, 458, 402 Annotation: Subtype: Link Rect: 277, 366, 315, 377 Annotation: Subtype: Link Rect: 321, 366, 357, 377 Annotation: Subtype: Link Rect: 360, 327, 398, 338 Annotation: Subtype: Link Rect: 404, 327, 440, 338 Annotation: Subtype: Link Rect: 357, 288, 394, 299 Annotation: Subtype: Link Rect: 400, 288, 436, 299 Annotation: Subtype: Link Rect: 232, 249, 269, 260 Annotation: Subtype: Link Rect: 275, 249, 311, 260 Annotation: Subtype: Link Rect: 286, 211, 324, 222 Annotation: Subtype: Link Rect: 330, 211, 366, 222 Annotation: Subtype: Link Rect: 100, 173, 137, 183 Annotation: Subtype: Link Rect: 143, 173, 179, 183 Annotation: Subtype: Link Rect: 344, 146, 382, 157 Annotation: Subtype: Link Rect: 388, 146, 424, 157 Annotation: Subtype: Link Rect: 480, 120, 516, 131 Annotation: Subtype: Link Rect: 100, 108, 136, 118 Annotation: Subtype: Link Rect: 249, 82, 286, 93 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 233, 715, 271, 725 Annotation: Subtype: Link Rect: 277, 715, 313, 725 Annotation: Subtype: Link Rect: 167, 676, 205, 686 Annotation: Subtype: Link Rect: 211, 676, 247, 686 Annotation: Subtype: Link Rect: 238, 638, 276, 648 Annotation: Subtype: Link Rect: 282, 638, 318, 648 Annotation: Subtype: Link Rect: 346, 612, 384, 622 Annotation: Subtype: Link Rect: 390, 612, 426, 622 Annotation: Subtype: Link Rect: 423, 586, 461, 596 Annotation: Subtype: Link Rect: 467, 586, 503, 596 Annotation: Subtype: Link Rect: 438, 559, 475, 570 Annotation: Subtype: Link Rect: 481, 559, 516, 570 Annotation: Subtype: Link Rect: 247, 521, 284, 532 Annotation: Subtype: Link Rect: 290, 521, 326, 532 Annotation: Subtype: Link Rect: 478, 482, 516, 493 Annotation: Subtype: Link Rect: 100, 470, 136, 480 Annotation: Subtype: Link Rect: 437, 443, 474, 454 Annotation: Subtype: Link Rect: 481, 443, 516, 454 Annotation: Subtype: Link Rect: 136, 405, 173, 415 Annotation: Subtype: Link Rect: 180, 405, 216, 415 Annotation: Subtype: Link Rect: 149, 366, 187, 377 Annotation: Subtype: Link Rect: 193, 366, 229, 377 Annotation: Subtype: Link Rect: 264, 315, 302, 325 Annotation: Subtype: Link Rect: 308, 315, 344, 325 Annotation: Subtype: Link Rect: 413, 288, 450, 299 Annotation: Subtype: Link Rect: 457, 288, 493, 299 Annotation: Subtype: Link Rect: 438, 249, 475, 260 Annotation: Subtype: Link Rect: 481, 249, 516, 260 Annotation: Subtype: Link Rect: 438, 224, 475, 235 Annotation: Subtype: Link Rect: 481, 224, 516, 235 Annotation: Subtype: Link Rect: 384, 199, 421, 209 Annotation: Subtype: Link Rect: 427, 199, 463, 209 Annotation: Subtype: Link Rect: 412, 159, 449, 170 Annotation: Subtype: Link Rect: 456, 159, 492, 170 Annotation: Subtype: Link Rect: 135, 134, 173, 144 Annotation: Subtype: Link Rect: 179, 134, 215, 144 Annotation: Subtype: Link Rect: 176, 95, 212, 105 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 372, 714, 409, 725 Annotation: Subtype: Link Rect: 390, 675, 428, 686 Annotation: Subtype: Link Rect: 434, 675, 470, 686 Annotation: Subtype: Link Rect: 100, 625, 137, 635 Annotation: Subtype: Link Rect: 143, 625, 179, 635 Annotation: Subtype: Link Rect: 478, 598, 516, 609 Annotation: Subtype: Link Rect: 100, 586, 136, 596 Annotation: Subtype: Link Rect: 335, 547, 373, 557 Annotation: Subtype: Link Rect: 379, 547, 415, 557 Annotation: Subtype: Link Rect: 379, 521, 417, 532 Annotation: Subtype: Link Rect: 423, 521, 459, 532 Annotation: Subtype: Link Rect: 210, 483, 247, 493 Annotation: Subtype: Link Rect: 253, 483, 289, 493 Annotation: Subtype: Link Rect: 162, 431, 200, 441 Annotation: Subtype: Link Rect: 206, 431, 242, 441 Annotation: Subtype: Link Rect: 351, 391, 389, 402 Annotation: Subtype: Link Rect: 395, 391, 431, 402 Annotation: Subtype: Link Rect: 436, 353, 472, 364 Annotation: Subtype: Link Rect: 136, 328, 172, 338 Annotation: Subtype: Link Rect: 223, 302, 261, 312 Annotation: Subtype: Link Rect: 370, 275, 408, 286 Annotation: Subtype: Link Rect: 414, 275, 450, 286 Annotation: Subtype: Link Rect: 381, 250, 418, 260 Annotation: Subtype: Link Rect: 424, 250, 460, 260 Annotation: Subtype: Link Rect: 100, 224, 137, 235 Annotation: Subtype: Link Rect: 143, 224, 179, 235 Annotation: Subtype: Link Rect: 158, 186, 195, 196 Annotation: Subtype: Link Rect: 202, 186, 238, 196 Annotation: Subtype: Link Rect: 427, 146, 464, 157 Annotation: Subtype: Link Rect: 470, 146, 506, 157 Annotation: Subtype: Link Rect: 344, 107, 382, 118 Annotation: Subtype: Link Rect: 388, 107, 424, 118 Annotation: Subtype: Link Rect: 136, 69, 173, 80 Annotation: Subtype: Link Rect: 180, 69, 216, 80 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 277, 727, 315, 738 Annotation: Subtype: Link Rect: 479, 701, 516, 712 Annotation: Subtype: Link Rect: 100, 689, 136, 699 Annotation: Subtype: Link Rect: 404, 663, 441, 674 Annotation: Subtype: Link Rect: 447, 663, 483, 674 Annotation: Subtype: Link Rect: 208, 611, 246, 622 Annotation: Subtype: Link Rect: 252, 611, 288, 622 Annotation: Subtype: Link Rect: 100, 573, 137, 583 Annotation: Subtype: Link Rect: 143, 573, 179, 583 Annotation: Subtype: Link Rect: 230, 546, 268, 557 Annotation: Subtype: Link Rect: 274, 546, 310, 557 Annotation: Subtype: Link Rect: 415, 508, 452, 519 Annotation: Subtype: Link Rect: 458, 508, 494, 519 Annotation: Subtype: Link Rect: 100, 470, 136, 480 Annotation: Subtype: Link Rect: 100, 418, 137, 428 Annotation: Subtype: Link Rect: 143, 418, 179, 428 Annotation: Subtype: Link Rect: 368, 379, 406, 390 Annotation: Subtype: Link Rect: 412, 379, 448, 390 Annotation: Subtype: Link Rect: 405, 354, 443, 364 Annotation: Subtype: Link Rect: 449, 354, 485, 364 Annotation: Subtype: Link Rect: 360, 314, 397, 325 Annotation: Subtype: Link Rect: 404, 314, 440, 325 Annotation: Subtype: Link Rect: 411, 288, 448, 299 Annotation: Subtype: Link Rect: 455, 288, 491, 299 Annotation: Subtype: Link Rect: 248, 249, 286, 260 Annotation: Subtype: Link Rect: 292, 249, 328, 260 Annotation: Subtype: Link Rect: 219, 224, 256, 235 Annotation: Subtype: Link Rect: 229, 198, 267, 209 Annotation: Subtype: Link Rect: 273, 198, 309, 209 Annotation: Subtype: Link Rect: 260, 159, 298, 170 Annotation: Subtype: Link Rect: 304, 159, 340, 170 Annotation: Subtype: Link Rect: 430, 133, 467, 144 Annotation: Subtype: Link Rect: 473, 133, 509, 144 Annotation: Subtype: Link Rect: 76, 91, 166, 122 Annotation: Subtype: Link Rect: 234, 85, 424, 96 Checksum: 184a4030 Type: CRC32 Checksum: 9e9072ed614f1eea598191f6d78511e7 Type: MD5 Checksum: 17efe2e147b6e4d55b1c992be9677db0d4885463 Type: SHA-1