ff2feac31307d75262becaccfd784eb0 pmc_30845683.pdf 242e9cfce95e179fac65e8641c5de021fdaf8cb7 pmc_30845683.pdf f8b9dfd9df3c38f161160e502e8143bba3d5125c03493f760b1f41fc17b59d2b pmc_30845683.pdf Title: Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications Subject: Hydrogels (HG) have recognized benefits as drug delivery platforms for biomedical applications. Their high sensitivity to sterilization processes is however one of the greatest challenges regarding their clinical translation. Concerning infection diseases, prevention of post-operatory related infections is crucial to ensure appropriate patient recovery and good clinical outcomes. Silver nanoparticles (AgNPs) have shown good antimicrobial properties but sustained release at the right place is required. Thus, we produced and characterized thermo-sensitive HG based on Pluronic® F127 loaded with AgNPs (HG-AgNPs) and their integrity and functionality after sterilization by dry-heat and autoclave methods were carefully assessed. The quality attributes of HG-AgNPs were seriously affected by dry-heat methods but not by autoclaving methods, which allowed to ensure the required sterility. Also, direct sterilization of the final HG-AgNPs product proved more effective than of the raw material, allowing simpler production procedures in non-sterile conditions. The mechanical properties were assessed in post mortem rat models and the HG-AgNPs were tested for its antimicrobial properties in vitro using extremely drug-resistant (XDR) clinical strains. The produced HG-AgNPs prove to be versatile, easy produced and cost-effective products, with activity against XDR strains and an adequate gelation time and spreadability features and optimal for in situ biomedical applications. Keywords: hydrogels; poloxamer; silver nanoparticles; sterilization; anti-bacterial agents; XDR strains; post-operative infections; chirurgic applications Author: Diana Rafael, Fernanda Andrade, Francesc Martinez-Trucharte, Jana Basas, Joaquín Seras-Franzoso, Marta Palau, Xavier Gomis, Marc Pérez-Burgos, Alberto Blanco, Alba López-Fernández, Roberto Vélez, Ibane Abasolo, Màrius Aguirre, Joan Gavaldà and Simó Schwartz Jr. Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Mar 6 08:48:15 2019 CET ModDate: Wed Mar 6 08:48:15 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4057102 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XYQWJT+URWPalladioL-Ital Type 1 Custom yes yes no 109 0 ZPWXFK+URWPalladioL-Bold Type 1 Custom yes 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DNPOLA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 369 0 DNPOMC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 370 0 DOAADN+TimesNewRoman CID TrueType Identity-H yes yes yes 395 0 DOAANL+Arial CID TrueType Identity-H yes yes yes 396 0 DOAHAG+Arial,Bold CID TrueType Identity-H yes yes yes 397 0 DNPOHP+PalatinoLinotype TrueType WinAnsi yes yes no 398 0 DNPOLA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 399 0 DNPOMC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 400 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:50:53 CEST RepresentationInformation: pmc_30845683.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:26:09 CET Size: 4057102 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰えべつひはでづぬぜ〴ぜ〰こべのぴとづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰えべつひはでづぬぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰えべつひはでづぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴ぜ〰えべつひはでづぬぜ〴ぜ〰きちのどばふぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁでぎぐびぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: えべつひはでづぬぜ〴ぜ〰こべのぴとづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰えべつひはでづぬぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰えべつひはでづぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴ぜ〰えべつひはでづぬぜ〴ぜ〰きちのどばふぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁでぎぐびぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: えべつひはでづぬぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰えべつひはでづぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴ぜ〰えべつひはでづぬぜ〴ぜ〰きちのどばふぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁでぎぐびぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: えべつひはでづぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴ぜ〰えべつひはでづぬぜ〴ぜ〰きちのどばふぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁでぎぐびぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴ぜ〰えべつひはでづぬぜ〴ぜ〰きちのどばふぬちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぁでぎぐびぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁでぎぐびぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴ぜ〰ぢべぜ〴ぜ〰ぐひづびぴはぜ〴ぜ〰あぬふづぜ㈵㙜〰ぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きどのどねちぬぜ〴ぜ〰ぉのとどぢどぴはひべぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴ぜ〰ぜ〵ぜ〰きぉぃぜ〵ㅜ〰ぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴづのびどぶづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰ぜ〵ぜ〰じいげぜ〵ㅜ〰ぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えべつひはでづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぇづぬちぴどはのぜ〴ぜ〰ごどねづぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ちのつぜ〴ぜ〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぬべねづひぜ〴ぜ〰ちのつぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬぶづひぜ〴ぜ〰ぎちのはばちひぴどっぬづびぜ〴ぜ〰ぐひはつふっぴどはの〬ぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごとづどひぜ〴ぜ〰ぉのっはひばはひちぴどはのぜ〴ぜ〰どのぴはぜ〴ぜ〰〲〰ぜ〴㕜〰ぜ〴ぜ〰ぷ〯ぶぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰こぴづひどぬどぺづつぜ〴ぜ〰ざづひびふびぜ〴ぜ〰ぎはの〭こぴづひどぬどぺづつぜ〴ぜ〰えぇぜ〴ぜ〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸱ Children: Item: Title: こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えべつひはでづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぇづぬちぴどはのぜ〴ぜ〰ごどねづぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ちのつぜ〴ぜ〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぬべねづひぜ〴ぜ〰ちのつぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬぶづひぜ〴ぜ〰ぎちのはばちひぴどっぬづびぜ〴ぜ〰ぐひはつふっぴどはの〬ぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごとづどひぜ〴ぜ〰ぉのっはひばはひちぴどはのぜ〴ぜ〰どのぴはぜ〴ぜ〰〲〰ぜ〴㕜〰ぜ〴ぜ〰ぷ〯ぶぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰こぴづひどぬどぺづつぜ〴ぜ〰ざづひびふびぜ〴ぜ〰ぎはの〭こぴづひどぬどぺづつぜ〴ぜ〰えぇぜ〴ぜ〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸱ Item: Title: ぇづぬちぴどはのぜ〴ぜ〰ごどねづぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ちのつぜ〴ぜ〰ぐはびぴぜ〴ぜ〰きはひぴづねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぬべねづひぜ〴ぜ〰ちのつぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬぶづひぜ〴ぜ〰ぎちのはばちひぴどっぬづびぜ〴ぜ〰ぐひはつふっぴどはの〬ぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごとづどひぜ〴ぜ〰ぉのっはひばはひちぴどはのぜ〴ぜ〰どのぴはぜ〴ぜ〰〲〰ぜ〴㕜〰ぜ〴ぜ〰ぷ〯ぶぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰こぴづひどぬどぺづつぜ〴ぜ〰ざづひびふびぜ〴ぜ〰ぎはの〭こぴづひどぬどぺづつぜ〴ぜ〰えぇぜ〴ぜ〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸱ Item: Title: ごとづぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰こぴづひどぬどぺちぴどはのぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぬべねづひぜ〴ぜ〰ちのつぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰こどぬぶづひぜ〴ぜ〰ぎちのはばちひぴどっぬづびぜ〴ぜ〰ぐひはつふっぴどはの〬ぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごとづどひぜ〴ぜ〰ぉのっはひばはひちぴどはのぜ〴ぜ〰どのぴはぜ〴ぜ〰〲〰ぜ〴㕜〰ぜ〴ぜ〰ぷ〯ぶぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰こぴづひどぬどぺづつぜ〴ぜ〰ざづひびふびぜ〴ぜ〰ぎはの〭こぴづひどぬどぺづつぜ〴ぜ〰えぇぜ〴ぜ〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸱ Item: Title: こどぬぶづひぜ〴ぜ〰ぎちのはばちひぴどっぬづびぜ〴ぜ〰ぐひはつふっぴどはの〬ぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごとづどひぜ〴ぜ〰ぉのっはひばはひちぴどはのぜ〴ぜ〰どのぴはぜ〴ぜ〰〲〰ぜ〴㕜〰ぜ〴ぜ〰ぷ〯ぶぜ〴ぜ〰えぇぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰こぴづひどぬどぺづつぜ〴ぜ〰ざづひびふびぜ〴ぜ〰ぎはの〭こぴづひどぬどぺづつぜ〴ぜ〰えぇぜ〴ぜ〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸱ Item: Title: こぴづひどぬどぺづつぜ〴ぜ〰ざづひびふびぜ〴ぜ〰ぎはの〭こぴづひどぬどぺづつぜ〴ぜ〰えぇぜ〴ぜ〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸱ Children: Item: Title: ぅててどっちっべぜ〴ぜ〰どのぜ〴ぜ〰ちぜ〴ぜ〰ぃはのぶづのぴどはのちぬぜ〴ぜ〰がちぢはひちぴはひべぜ〴ぜ〰こぴひちどの〺ぜ〴ぜ〰こぴちばとべぬはっはっっふびぜ〴ぜ〰ぁふひづふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸵⸲ Item: Title: こふびっづばぴどぢどぬどぴべぜ〴ぜ〰ごづびぴぜ〴ぜ〰どのぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぅへぴひづねづぬべぜ〴ぜ〰いひふで〭げづびどびぴちのぴぜ〴ぜ〰こぴひちどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: 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