5c419b9766e90c9c3dd7956b1ad279a2 pmc_30846695.pdf c1b6545009066a9edcf13d636d00d1dfbae184a2 pmc_30846695.pdf b01ad13600126256d66236cb683240ab493fa804811c7be83f354665c5f81f4e pmc_30846695.pdf Title: Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis Subject: Nature Communications, doi:10.1038/s41467-019-08858-y Keywords: Author: Iria Carballo-Carbajal Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Feb 27 04:44:50 2019 CET ModDate: Wed Feb 27 11:56:05 2019 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 6441962 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KILPOD+AdvOTea1a7398 Type 1C WinAnsi yes yes no 103 0 KILPOE+AdvOTea1a7398+20 Type 1C 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR80' cannot be found Offset: 5943459 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR81' cannot be found Offset: 5943459 MIMEtype: application/pdf PDFMetadata: Objects: 1149 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Brain tyrosinase overexpression implicates age-„dependent neuromelanin production in’Parkinson’s disease pathogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Age-dependent NM formation in tyrosinase-overexpressing rats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Progressive PD-like neurodegeneration in NM-producing rats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: PD-like inclusion formation in NM-producing rats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: aSyn is dispensable for NM-linked PD pathology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: General proteostasis failure in NM-producing cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Modulation of NM levels and pathology in NM-producing rats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Viral vector production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Surgical procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Transduction efficiency Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Brain processing for histological analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Masson-Fontana and hematoxylin-eosin stainings Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Magnetic resonance imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Intracellular NM quantifications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Stereological cell counting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Quantification of neuropathological parameters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Optical densitometry analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Cylinder behavioral test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: In vivo microdialysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Tissular levels of DA and metabolites Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: UPLC-MS/MS analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Human post-mortem brain tissue Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Endogenous brain tyrosinase gene expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: TR5TY6 neuroblastoma cell line Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Immunoblot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Optical microscopy for NM Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: aSyn-proximity ligation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Mitochondrial respiration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Intracellular protein degradation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Ubiquitin-proteasome system activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: TFEB-induced lysosomal exocytosis (dot blot) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Cell metabolic activity and ROS production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Transmission electron microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Info: Title: Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis Author: Iria Carballo-Carbajal Subject: Nature Communications, doi:10.1038/s41467-019-08858-y Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Wed Feb 27 05:14:50 CET 2019 ModDate: Wed Feb 27 11:56:05 CET 2019 ID: 0xd13e0a57ef0bcb25afd0c5f3b8d1ad6d, 0x5354a895061c61d4ec7ff369aa7de727 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2001 ImageHeight: 532 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: 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Springer US Nature Communications, doi:10.1038/s41467-019-08858-y 10.1038/s41467-019-08858-y http://dx.doi.org/10.1038/s41467-019-08858-y journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-08858-y springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-08858-y springer.com springerlink.com Springer 2019-02-27T11:56:05+01:00 2019-02-27T09:14:50+05:30 2019-02-27T11:56:05+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:f2bdb8e1-0165-4133-b6fb-d9d599818591 uuid:df23e9a9-0328-46d9-9e46-99407f917e00 default 1 converted uuid:78e9516b-8779-4333-a010-fefa88726975 converted to PDF/A-2b pdfToolbox 2019-02-27T09:15:38+05:30 2 B Iria Carballo-Carbajal http://orcid.org/0000-0002-4403-8006 Ariadna Laguna http://orcid.org/0000-0002-9732-6677 Jordi Romero-Giménez http://orcid.org/0000-0002-8459-9895 Marta Martinez-Vicente http://orcid.org/0000-0001-7053-2625 Annabelle Parent http://orcid.org/0000-0002-6195-812X Núria Peñuelas http://orcid.org/0000-0001-6443-9790 Albert Torra http://orcid.org/0000-0002-6852-7146 Andrea Ballabio http://orcid.org/0000-0003-1381-4604 Analía Bortolozzi http://orcid.org/0000-0002-2069-9192 Ellen Gelpi http://orcid.org/0000-0003-2948-4187 Miquel Vila http://orcid.org/0000-0002-1352-989X http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI 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