dcb80f1f11f6ea16a82ff11230c5bfa5 pmc_30892987.pdf 96956eb58ba8f85417e280476f46e22986955549 pmc_30892987.pdf ee0c2453ddbe8d1979347bc56bc3427eb509f475afde14f91d13355f2222f805 pmc_30892987.pdf Title: Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E–Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study Author: Eric Van Cutsem, Sanne Huijberts, Axel Grothey, Rona Yaeger, Pieter-Jan Cuyle, Elena Elez, Marwan Fakih, Clara Montagut, Marc Peeters, Takayuki Yoshino, Harpreet Wasan, Jayesh Desai, Fortunato Ciardiello, Ashwin Gollerkeri, Janna Christy-Bittel, Kati Maharry, Victor Sandor, Jan H.M. Schellens, Scott Kopetz, Josep Tabernero Creator: AH XSL Formatter V6.6 MR7 for Linux64 : 6.6.9.39847 (2019-07-29T09:58+09) Producer: Antenna House PDF Output Library 6.6.1477 (Linux64) CreationDate: Mon Jul 20 18:35:27 2020 CEST ModDate: Mon Jul 20 18:35:27 2020 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 428627 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Times-Roman Type 1 Custom no no yes 11 0 Helvetica-Bold Type 1 Custom no no yes 13 0 Helvetica-BoldOblique Type 1 Standard no no no 14 0 Helvetica Type 1 Custom no no yes 17 0 Times-Bold Type 1 Standard no no no 54 0 Times-BoldItalic Type 1 Standard no no no 506 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:49:50 CEST RepresentationInformation: pmc_30892987.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-27 03:48:21 CEST Size: 428627 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 127 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: INTRODUCTION Item: Title: PATIENTS AND METHODS Children: Item: Title: Study Procedures Item: Title: Outcome Measures Item: Title: Statistical Methods Children: Item: Title: Study population. Item: Title: End points. Item: Title: Statistical analysis. Item: Title: RESULTS Children: Item: Title: Patient Disposition and Characteristics Item: Title: Safety Children: Item: Title: DLTs. Item: Title: AEs. Item: Title: Drug discontinuations as a result of AEs. Item: Title: Efficacy Children: Item: Title: Overall response. Item: Title: Time to response. Item: Title: DOR. Item: Title: PFS and OS. Item: Title: DISCUSSION Item: Title: References Item: Title: FIG 1. Item: Title: FIG 2. Item: Title: FIG 3. Item: Title: TABLE 1. Item: Title: TABLE 2. Item: Title: TABLE 3. Item: Title: TABLE 4. Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 152 ImageHeight: 152 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1273 ImageHeight: 1273 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1606 ImageHeight: 1813 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1773 ImageHeight: 605 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: Helvetica FirstChar: 32 LastChar: 133 FontDescriptor: FontName: Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-Bold Font: BaseFont: Times-BoldItalic Font: BaseFont: Times-Roman FirstChar: 32 LastChar: 167 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Bold FirstChar: 32 LastChar: 129 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-BoldOblique Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: http://creativecommons.org/licenses/by-nc-nd/4.0/ Rect: 337, 323, 498, 331 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: https://doi.org/10.1200/JCO.18.02459 Rect: 471, 94, 518, 102 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: 10.1200/JCO.18.02459 Rect: 90, 85, 164, 93 LastModified: D:20200720113527-05'00' Page: Sequence: 2 Annotations: Annotation: Subtype: Link Contents: ClinicalTrials.gov Rect: 111, 569, 183, 579 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: NCT02928224 Rect: 227, 569, 287, 579 LastModified: D:20200720113527-05'00' Page: Sequence: 3 Annotations: Annotation: Subtype: Link Contents: ClinicalTrials.gov Rect: 280, 210, 352, 220 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: NCT02928224 Rect: 397, 210, 457, 220 LastModified: D:20200720113527-05'00' Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Page: Sequence: 7 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Contents: ClinicalTrials.gov Rect: 244, 178, 316, 188 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: NCT01909453 Rect: 360, 178, 420, 188 LastModified: D:20200720113527-05'00' Page: Sequence: 9 Annotations: Annotation: Subtype: Link Contents: ClinicalTrials.gov Rect: 150, 486, 222, 496 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: NCT03693170 Rect: 266, 486, 326, 496 LastModified: D:20200720113527-05'00' Page: Sequence: 10 Annotations: Annotation: Subtype: Link Contents: https://packageinserts.bms.com/pi/pi_opdivo.pdf Rect: 299, 266, 474, 275 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf Rect: 251, 253, 470, 262 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: keytruda_pi.pdf Rect: 165, 242, 222, 251 LastModified: D:20200720113527-05'00' Page: Sequence: 11 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Contents: http://www.arraybiopharma.com/documents/Braftovi_Prescribing_information.pdf Rect: 288, 651, 449, 660 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: Braftovi_Prescribing_information.pdf Rect: 165, 640, 301, 649 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: http://www.arraybiopharma.com/documents/Mektovi_Prescribing_information.pdf Rect: 288, 627, 450, 636 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: Mektovi_Prescribing_information.pdf Rect: 165, 616, 302, 625 LastModified: D:20200720113527-05'00' Annotation: Subtype: Link Contents: http://pi.lilly.com/us/erbitux-uspi.pdf Rect: 251, 557, 384, 566 LastModified: D:20200720113527-05'00' Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Checksum: a0af384d Type: CRC32 Checksum: dcb80f1f11f6ea16a82ff11230c5bfa5 Type: MD5 Checksum: 96956eb58ba8f85417e280476f46e22986955549 Type: SHA-1