12215a5808d77b46d2facde57ccb1145 pmc_30909403.pdf 6f8793e4456c6b0252d8dcb05ce434619b33f637 pmc_30909403.pdf 33add687f8b694aee0988f2cbc1b949b57aa2fee7dad057efd2284f2eb46f02f pmc_30909403.pdf Title: Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination Subject: A highly enantioselective catalytic method for the synthesis of quaternary -fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions. Keywords: europium; fluorination; enantioselectivity; pybox; keto ester Author: Albert Granados, Pau Sarró and Adelina Vallribera Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Mar 22 08:03:34 2019 CET ModDate: Fri Mar 22 08:03:34 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2076552 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VWYFPH+URWPalladioL-Ital Type 1 Custom yes yes no 68 0 YMYUMR+URWPalladioL-Bold Type 1 Custom yes yes no 69 0 SOZKOC+VnURWPalladioL-Bold Type 1 Custom yes yes no 70 0 OUURRB+URWPalladioL-Roma Type 1 Custom yes yes no 71 0 MWHIBA+VnURWPalladioL Type 1 Custom yes yes no 72 0 XPNXUH+EURM10 Type 1 Builtin yes yes no 73 0 PUSVWS+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 78 0 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