f8e5590cf90bf0af26b7544f4fc5316e pmc_30971925.pdf 8dd0931e043f74df56b289884630eda091b7be57 pmc_30971925.pdf d2e9e2ae4df807788b59fa90f8fdef973fac64d01683fe234d5e551f60a5e500 pmc_30971925.pdf Title: Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated Subject: We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with persistent neuropathic pain. Keywords: analgesia, depression, Nrf2 transcription factor, delta opioid receptors, oxidative stress, chronic pain, UFP-512 Author: Olga Pol Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri Mar 22 13:28:36 2019 CET ModDate: Sat Mar 23 07:45:42 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2881358 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BEQTNC+MinionPro-Regular Type 1 Custom yes yes no 27 0 RERYCG+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 28 0 DAFDKB+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 29 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 34 0 VCMJLD+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 35 0 MDXCTP+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 36 0 WLQBWP+MTGU Type 1 Builtin yes 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Nociceptive Behavioral Tests Item: Title: Depression-Like Behavior Test Item: Title: Western Blot Analysis Item: Title: Experimental Procedure Item: Title: Drugs Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Effects of UFP-512 on Mechanical Allodynia and Thermal Hyperalgesia Induced by Inflammatory Pain Item: Title: Effects of UFP-512 on the Mechanical Allodynia, Thermal Hyperalgesia, and Thermal Allodynia Induced by Sciatic Nerve Injury Item: Title: Reversal of the Antinociceptive Effects of UFP-512 in Animals With Inflammatory or Neuropathic Pain Item: Title: Effect of UFP-512 on the Expression of Nrf2, HO-1, NQO1, and NOS2 in the Spinal Cords of Animals With Inflammatory Pain Item: Title: Effect of UFP-512 on the Expression of Nrf2, HO-1, NQO1, and NOS2 in the Spinal Cords of Animals With Neuropathic Pain Item: Title: Effect of UFP-512 on the Expression of PI3K, p-Akt, DOR, p-JNK, and p-ERK1/2 in the Spinal Cords of Animals With Inflammatory Pain Item: Title: Effect of UFP-512 on the Expression of PI3K, p-Akt, DOR, p-JNK, and p-ERK1/2 in the Spinal Cords of Animals With Neuropathic Pain Item: Title: Effects of the Coadministration of SFN on the Antinociceptive Actions of UFP-512 in Animals With Inflammatory or Neuropathic Pain Item: Title: The Effects of UFP-512 on the Depressive-Like Behaviors Associated With Neuropathic Pain Item: Title: Discussion Item: Title: Conclusion Item: Title: Data Availability Item: Title: Author Contributions Item: Title: Funding Item: Title: References Info: Author: Olga Pol Subject: We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), whic栀 愀氀猀漀 愀挀琀椀瘀愀琀攀猀 渀甀挀氀攀愀爀 昀愀挀琀漀爀 攀爀礀琀栀爀漀椀搀 ㈀ⴀ爀攀氀愀琀攀搀 昀愀挀琀漀爀 ㈀ 一爀昀㈀Ⰰ 愀氀氀攀瘀椀愀琀攀搀 挀栀爀漀渀椀挀 椀渀昀氀愀洀洀愀琀漀爀礀 愀渀搀⼀漀爀 渀攀甀爀漀瀀愀琀栀椀挀 瀀愀椀渀 愀湜ഀ搀 椀渀栀椀戀椀琀攀搀 琀栀攀 搀攀瀀爀攀猀猀椀瘀攀ⴀ氀椀欀攀 戀攀栀愀瘀椀漀爀猀 愀猀猀漀挀椀愀琀攀搀 眀椀琀栀 瀀攀爀猀椀猀琀攀渀琀 渀攀甀爀漀瀀愀琀栀椀挀 瀀愀椀渀⸩⽔楴汥⡔牥慴浥湴⁗楴栠瑨攠䑥汴愠佰楯楤⁁杯湩獴⁕䙐ⴵㄲ⁁汬敶楡瑥猠䍨牯湩挠䥮晬慭浡瑯特⁡湤⁎敵牯灡瑨楣⁐慩渺⁍散桡湩獭猠䥭灬楣慴敤 Keywords: analgesia, 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Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associated with persistent neuropathic pain. 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