1307117bd6f195d86faef09ed900b50e  pmc_30982767.pdf
4305b53ef76db399302be9119363b37442de8acb  pmc_30982767.pdf
9c8ae46f6fbdf71023cc22ef13a2dc4f65ceffcdc814cad7ce83c801397fe4f8  pmc_30982767.pdf

Title:          APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm
Creator:        Elsevier
Producer:       Acrobat Distiller 11.0 (Windows)
CreationDate:   Thu May 23 17:46:36 2019 CEST
ModDate:        Thu May 23 17:51:16 2019 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      2705296 bytes
Optimized:      yes
PDF version:    1.7

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LHFEFL+AdvTT5235d5a9                 Type 1C           WinAnsi          yes yes no     727  0
LHFEFM+AdvTT5235d5a9+20              Type 1C           Custom           yes yes yes    728  0
LHFEFN+AdvTT94c8263f.I               Type 1C           WinAnsi          yes yes no     729  0
LHFEFO+AdvTT0f485e03                 Type 1C           WinAnsi          yes yes no     715  0
LHFEGP+AdvTT5235d5a9+fb              Type 1C           Custom           yes yes yes    730  0
LHFEHA+AdvTT28000ce1.B               Type 1C           WinAnsi          yes yes no     731  0
LHFEKP+AdvTTc8c83e50                 Type 1C           WinAnsi          yes yes no     732  0
LHFEMC+AdvTT6b11a639.I               Type 1C           WinAnsi          yes yes no      25  0
LHFENC+AdvTT94c8263f.I+20            Type 1C           WinAnsi          yes yes no     434  0
LHFEMA+AdvTT5235d5a9+22              Type 1C           Custom           yes yes yes    435  0
LHFEMB+AdvTT47a11158.B               Type 1C           WinAnsi          yes yes no      26  0
LHFEOD+AdvTT5235d5a9+03              Type 1C           Custom           yes yes yes    436  0
LHFEOE+AdvTT454a7a89                 Type 1C           WinAnsi          yes yes no     437  0
LHFEOF+AdvTT5235d5a9+01              Type 1C           MacRoman         yes yes no      44  0
LHFGEN+AdvTT94c8263f.I+fb            Type 1C           Custom           yes yes yes     77  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-08-10 12:47:02 CEST
 RepresentationInformation: pmc_30982767.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-07-06 04:13:12 CEST
  Size: 2705296
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn0005' cannot be found
   Offset: 2684367
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn0005' cannot be found
   Offset: 2684367
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn0005' cannot be found
   Offset: 2684367
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'url2' cannot be found
   Offset: 2684367
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'url3' cannot be found
   Offset: 2684367
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 783
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: APOA1 oxidation is associated to dysfunctional high-„density lipoproteins in human abdominal aortic aneurysm
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
       Item: 
        Title: 2. Material and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
        Children: 
         Item: 
          Title: 2.1. Data statement
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
         Item: 
          Title: 2.2. Tissue and tissue-conditioned medium
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
         Item: 
          Title: 2.3. HDL isolation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
       Item: 
        Title: Evidence before this study
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: Added value of this study
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: Implications of all the available evidence
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
        Children: 
         Item: 
          Title: 2.4. Plasmas
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: 2.5. Proteomics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
          Children: 
           Item: 
            Title: 2.5.1. Sample preparation
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
           Item: 
            Title: 2.5.2. LC-MS analysis
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
           Item: 
            Title: 2.5.3. Database search
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
           Item: 
            Title: 2.5.4. Comet-PTM
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
           Item: 
            Title: 2.5.5. SHIFTS
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
           Item: 
            Title: 2.5.6. Annotation of modifications
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
           Item: 
            Title: 2.5.7. Peptide quantification and statistical analysis
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
         Item: 
          Title: 2.6. Immunohistochemistry
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: 2.7. Lipoprotein oxidation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: 2.8. Cholesterol efflux analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: 2.9. Statistics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
        Children: 
         Item: 
          Title: 3.1. Characterization of PTMs of HDL-like particles recovered from AAA tissue highlights APOA1 oxidation
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: 3.2. Incubation of plasmatic HDL with AAA tissue-conditioned medium produces APOA1 oxidation and impacts HDL functionality
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
         Item: 
          Title: 3.3. Increased oxidized Trp50 and Trp108 of APOA1 in HDL incubated with PMN-conditioned medium and in plasma of patients with AAA
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
        Children: 
         Item: 
          Title: 4.1. Limitations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
       Item: 
        Title: Funding
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
       Item: 
        Title: Declaration of interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
       Item: 
        Title: Author contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
       Item: 
        Title: Appendix A. Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
   Info: 
    Title: APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm
    Creator: Elsevier
    Producer: Acrobat Distiller 11.0 (Windows)
    CreationDate: Thu May 23 18:16:36 CEST 2019
    ModDate: Thu May 23 18:21:16 CEST 2019
   ID: 0x41a8dcbcd6183be60da25a124fe0e4a2, 0x93ffaa34a54b87c436da7877781a4b30
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 689
      ImageHeight: 178
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 272
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1679
      ImageHeight: 2770
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1825
      ImageHeight: 2770
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1034
      ImageHeight: 556
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1752
      ImageHeight: 2770
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LHFEFO+AdvTT0f485e03
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: LHFEFO+AdvTT0f485e03
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEOF+AdvTT5235d5a9+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: LHFEOF+AdvTT5235d5a9+01
       Flags: Serif, Nonsymbolic
       FontBBox: -114, -302, 1260, 1145
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: LHFGEN+AdvTT94c8263f.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: LHFGEN+AdvTT94c8263f.I+fb
       Flags: Symbolic
       FontBBox: -114, -291, 1406, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LHFENC+AdvTT94c8263f.I+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: LHFENC+AdvTT94c8263f.I+20
       Flags: Nonsymbolic
       FontBBox: -875, -270, 1333, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEMA+AdvTT5235d5a9+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: LHFEMA+AdvTT5235d5a9+22
       Flags: Symbolic
       FontBBox: -135, -208, 1125, 1041
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LHFEOD+AdvTT5235d5a9+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: LHFEOD+AdvTT5235d5a9+03
       Flags: Symbolic
       FontBBox: -843, -291, 1062, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LHFEOE+AdvTT454a7a89
      FontSubset: true
      FirstChar: 78
      LastChar: 98
      FontDescriptor: 
       FontName: LHFEOE+AdvTT454a7a89
       Flags: Nonsymbolic
       FontBBox: -52, -208, 968, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEFL+AdvTT5235d5a9
      FontSubset: true
      FirstChar: 34
      LastChar: 252
      FontDescriptor: 
       FontName: LHFEFL+AdvTT5235d5a9
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEFM+AdvTT5235d5a9+20
      FontSubset: true
      FirstChar: 1
      LastChar: 142
      FontDescriptor: 
       FontName: LHFEFM+AdvTT5235d5a9+20
       Flags: Symbolic
       FontBBox: -875, -270, 1312, 979
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LHFEFN+AdvTT94c8263f.I
      FontSubset: true
      FirstChar: 39
      LastChar: 243
      FontDescriptor: 
       FontName: LHFEFN+AdvTT94c8263f.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEMC+AdvTT6b11a639.I
      FontSubset: true
      FirstChar: 65
      LastChar: 121
      FontDescriptor: 
       FontName: LHFEMC+AdvTT6b11a639.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 1083, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEGP+AdvTT5235d5a9+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: LHFEGP+AdvTT5235d5a9+fb
       Flags: Symbolic
       FontBBox: 9, -291, 1333, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LHFEMB+AdvTT47a11158.B
      FontSubset: true
      FirstChar: 82
      LastChar: 120
      FontDescriptor: 
       FontName: LHFEMB+AdvTT47a11158.B
       Flags: Nonsymbolic
       FontBBox: -41, -250, 968, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEHA+AdvTT28000ce1.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: LHFEHA+AdvTT28000ce1.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LHFEKP+AdvTTc8c83e50
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: LHFEKP+AdvTTc8c83e50
       Flags: Nonsymbolic
       FontBBox: -10, -250, 968, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
xmlns:xap="http://ns.adobe.com/xap/1.0/"
xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
xmlns:crossmark="http://crossref.org/crossmark/1.0/">
<rdf:Description rdf:about="">
<dc:format>application/pdf</dc:format>
<dc:title>APOA1 oxidation is associated to dysfunctional high-density lipoproteins in human abdominal aortic aneurysm</dc:title>
<dc:creator>
<rdf:Seq>
<rdf:li>Diego Martínez-López</rdf:li>
<rdf:li>Emilio Camafeita</rdf:li>
<rdf:li>Lídia Cedó</rdf:li>
<rdf:li>Raquel Roldan-Montero</rdf:li>
<rdf:li>Inmaculada Jorge</rdf:li>
<rdf:li>Fernando García-Marqués</rdf:li>
<rdf:li>María Gómez-Serrano</rdf:li>
<rdf:li>Elena Bonzon-Kulichenko</rdf:li>
<rdf:li>Francisco Blanco-Vaca</rdf:li>
<rdf:li>Luis Miguel Blanco-Colio</rdf:li>
<rdf:li>Jean-Baptiste Michel</rdf:li>
<rdf:li>Joan Carles Escola-Gil</rdf:li>
<rdf:li>Jesús Vázquez</rdf:li>
<rdf:li>Jose Luis Martin-Ventura</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:subject>
<rdf:Bag>
<rdf:li>Abdominal aortic aneurysm</rdf:li>
<rdf:li>HDL</rdf:li>
<rdf:li>Oxidative stress</rdf:li>
<rdf:li>Proteomics</rdf:li>
<rdf:li>Cholesterol efflux</rdf:li>
<rdf:li>Biomarkers</rdf:li>
</rdf:Bag>
</dc:subject>
<dc:description>EBioMedicine, 43 (2019) 43-53. doi:10.1016/j.ebiom.2019.04.012</dc:description>
<prism:aggregationType>journal</prism:aggregationType>
<prism:publicationName>EBioMedicine</prism:publicationName>
<prism:copyright></prism:copyright>
<dc:publisher>Elsevier B.V.</dc:publisher>
<prism:issn>2352-3964</prism:issn>
<prism:volume>43</prism:volume>
<prism:issueIdentifier>C</prism:issueIdentifier>
<prism:coverDisplayDate>May 2019</prism:coverDisplayDate>
<prism:coverDate>2019-05</prism:coverDate>
<prism:pageRange>43-53</prism:pageRange>
<prism:startingPage>43</prism:startingPage>
<prism:endingPage>53</prism:endingPage>
<prism:doi>10.1016/j.ebiom.2019.04.012</prism:doi>
<prism:url>https://doi.org/10.1016/j.ebiom.2019.04.012</prism:url>
<dc:identifier>doi:10.1016/j.ebiom.2019.04.012</dc:identifier>
<crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
<crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
<crossmark:DOI>10.1016/j.ebiom.2019.04.012</crossmark:DOI>
<crossmark:CrossMarkDomains>
<rdf:Seq>
<rdf:li>elsevier.com</rdf:li>
<rdf:li>sciencedirect.com</rdf:li>
</rdf:Seq>
</crossmark:CrossMarkDomains>
<jav:journal_article_version>VoR</jav:journal_article_version>
<pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
<pdfx:doi>10.1016/j.ebiom.2019.04.012</pdfx:doi>
<pdfx:robots>noindex</pdfx:robots>
<pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
<pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
<pdfx:CrossMarkDomains>
<rdf:Seq>
<rdf:li>elsevier.com</rdf:li>
<rdf:li>sciencedirect.com</rdf:li>
</rdf:Seq>
</pdfx:CrossMarkDomains>
<xap:CreatorTool>Elsevier</xap:CreatorTool>
<xapRights:Marked>True</xapRights:Marked>
</rdf:Description>
<rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/"><pdf:Keywords>Abdominal aortic aneurysm;  HDL;  Oxidative stress;  Proteomics;  Cholesterol efflux;  Biomarkers</pdf:Keywords></rdf:Description></rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 43
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 505, 602, 533, 630
      Annotation: 
       Subtype: Link
       Rect: 149, 577, 153, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 240, 577, 245, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 246, 577, 250, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 307, 577, 310, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 431, 577, 435, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 524, 577, 529, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 531, 577, 535, 588
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 167, 564, 172, 575
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 283, 564, 288, 575
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 417, 564, 421, 575
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 533, 564, 537, 575
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 161, 551, 165, 562
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 167, 551, 171, 562
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 275, 551, 280, 562
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 389, 551, 393, 562
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 394, 548, 407, 558
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 409, 551, 413, 562
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 111, 539, 115, 549
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 117, 539, 121, 549
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 123, 534, 133, 546
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 134, 539, 139, 549
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 264, 539, 268, 549
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 269, 539, 273, 549
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 275, 534, 280, 546
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 282, 539, 286, 549
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 541, 230, 561, 238
      Annotation: 
       Subtype: Link
       Rect: 418, 221, 556, 228
      Annotation: 
       Subtype: Link
       Rect: 390, 136, 395, 144
       Destination: 144
      Annotation: 
       Subtype: Link
       Rect: 552, 94, 556, 102
       Destination: 144
      Annotation: 
       Subtype: Link
       Rect: 257, 749, 346, 755
      Annotation: 
       Subtype: Link
       Rect: 103, 101, 159, 108
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 207, 101, 256, 108
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 42, 93, 85, 99
      Annotation: 
       Subtype: Link
       Rect: 395, 674, 560, 717
      Annotation: 
       Subtype: Link
       Rect: 42, 56, 167, 63
      Annotation: 
       Subtype: Link
       Rect: 386, 48, 530, 54
      Annotation: 
       Subtype: Link
       Rect: 269, 721, 318, 729
      Annotation: 
       Subtype: Link
       Rect: 236, 666, 345, 674
    Page: 
     Label: 44
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 156, 110, 161, 118
       Destination: 144
      Annotation: 
       Subtype: Link
       Rect: 266, 79, 280, 87
       Destination: 144
      Annotation: 
       Subtype: Link
       Rect: 114, 58, 133, 66
       Destination: 144
      Annotation: 
       Subtype: Link
       Rect: 304, 717, 326, 725
       Destination: 144
      Annotation: 
       Subtype: Link
       Rect: 304, 686, 313, 694
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 315, 686, 323, 694
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 391, 675, 399, 683
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 401, 675, 410, 683
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 511, 644, 520, 652
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 454, 581, 463, 589
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 465, 581, 474, 589
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 448, 560, 457, 568
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 391, 539, 400, 547
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 504, 497, 513, 505
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 515, 497, 524, 505
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 444, 477, 453, 484
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 343, 466, 352, 474
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 398, 435, 407, 443
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 476, 131, 485, 139
       Destination: 223
    Page: 
     Label: 45
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 675, 116, 683
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 258, 487, 267, 495
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 46, 381, 71, 389
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 372, 184, 382, 192
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 383, 184, 393, 192
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 492, 121, 501, 129
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 345, 100, 354, 108
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 518, 48, 527, 56
       Destination: 223
    Page: 
     Label: 46
     Sequence: 4
    Page: 
     Label: 47
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 644, 156, 652
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 277, 623, 286, 631
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 215, 508, 224, 516
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 167, 382, 176, 390
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 178, 382, 187, 390
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 189, 382, 197, 390
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 149, 361, 158, 369
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 103, 330, 112, 338
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 237, 309, 246, 317
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 72, 205, 81, 212
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 340, 633, 349, 641
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 496, 550, 505, 558
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 546, 393, 555, 401
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 386, 225, 405, 233
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 437, 215, 455, 223
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 442, 205, 460, 212
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 314, 184, 333, 192
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 379, 163, 399, 171
       Destination: 54
    Page: 
     Label: 48
     Sequence: 6
    Page: 
     Label: 49
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 717, 98, 725
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 133, 696, 153, 704
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 247, 686, 266, 694
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 243, 644, 261, 652
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 255, 612, 274, 620
       Destination: 54
      Annotation: 
       Subtype: Link
       Rect: 45, 369, 64, 377
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 239, 348, 258, 356
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 202, 338, 220, 346
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 162, 296, 180, 304
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 227, 243, 246, 251
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 113, 160, 133, 168
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 341, 463, 359, 471
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 427, 369, 436, 377
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 438, 369, 447, 377
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 475, 359, 484, 367
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 486, 359, 495, 367
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 371, 285, 390, 293
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 460, 233, 479, 241
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 385, 212, 394, 220
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 502, 91, 517, 97
       Destination: 54
    Page: 
     Label: 50
     Sequence: 8
    Page: 
     Label: 51
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 64, 717, 82, 725
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 257, 686, 283, 694
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 233, 665, 259, 673
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 192, 644, 217, 652
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 181, 267, 190, 275
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 192, 267, 200, 275
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 184, 184, 193, 192
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 94, 131, 102, 139
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 548, 487, 557, 495
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 377, 435, 386, 443
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 443, 403, 452, 411
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 427, 341, 435, 349
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 441, 142, 450, 150
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 452, 142, 461, 150
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 458, 609, 461, 616
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 509, 609, 511, 616
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 552, 609, 555, 616
       Destination: 122
    Page: 
     Label: 52
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 207, 696, 216, 704
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 165, 675, 174, 683
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 120, 654, 129, 662
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 131, 654, 140, 662
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 104, 612, 113, 620
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 110, 341, 119, 348
       Destination: 223
      Annotation: 
       Subtype: Link
       Rect: 513, 359, 552, 367
      Annotation: 
       Subtype: Link
       Rect: 301, 349, 419, 357
      Annotation: 
       Subtype: Link
       Rect: 316, 311, 552, 317
      Annotation: 
       Subtype: Link
       Rect: 316, 303, 342, 309
      Annotation: 
       Subtype: Link
       Rect: 316, 295, 552, 301
      Annotation: 
       Subtype: Link
       Rect: 316, 287, 552, 293
      Annotation: 
       Subtype: Link
       Rect: 316, 279, 405, 285
      Annotation: 
       Subtype: Link
       Rect: 448, 255, 552, 262
      Annotation: 
       Subtype: Link
       Rect: 316, 247, 335, 254
      Annotation: 
       Subtype: Link
       Rect: 316, 239, 552, 246
      Annotation: 
       Subtype: Link
       Rect: 316, 231, 552, 238
      Annotation: 
       Subtype: Link
       Rect: 316, 223, 351, 230
      Annotation: 
       Subtype: Link
       Rect: 316, 215, 552, 222
      Annotation: 
       Subtype: Link
       Rect: 316, 207, 552, 214
      Annotation: 
       Subtype: Link
       Rect: 316, 199, 357, 206
      Annotation: 
       Subtype: Link
       Rect: 316, 191, 552, 198
      Annotation: 
       Subtype: Link
       Rect: 316, 183, 552, 190
      Annotation: 
       Subtype: Link
       Rect: 316, 175, 348, 182
      Annotation: 
       Subtype: Link
       Rect: 316, 168, 552, 174
      Annotation: 
       Subtype: Link
       Rect: 316, 160, 552, 166
      Annotation: 
       Subtype: Link
       Rect: 316, 152, 474, 158
      Annotation: 
       Subtype: Link
       Rect: 316, 144, 552, 150
      Annotation: 
       Subtype: Link
       Rect: 316, 136, 552, 142
      Annotation: 
       Subtype: Link
       Rect: 316, 128, 439, 134
      Annotation: 
       Subtype: Link
       Rect: 316, 120, 552, 126
      Annotation: 
       Subtype: Link
       Rect: 316, 112, 552, 118
      Annotation: 
       Subtype: Link
       Rect: 316, 104, 416, 110
      Annotation: 
       Subtype: Link
       Rect: 316, 96, 552, 102
      Annotation: 
       Subtype: Link
       Rect: 316, 88, 552, 94
      Annotation: 
       Subtype: Link
       Rect: 316, 80, 507, 86
      Annotation: 
       Subtype: Link
       Rect: 316, 72, 552, 78
      Annotation: 
       Subtype: Link
       Rect: 316, 64, 508, 70
      Annotation: 
       Subtype: Link
       Rect: 316, 56, 552, 62
      Annotation: 
       Subtype: Link
       Rect: 316, 48, 552, 54
    Page: 
     Label: 53
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 730, 293, 737
      Annotation: 
       Subtype: Link
       Rect: 57, 722, 264, 729
      Annotation: 
       Subtype: Link
       Rect: 57, 715, 293, 721
      Annotation: 
       Subtype: Link
       Rect: 57, 707, 293, 713
      Annotation: 
       Subtype: Link
       Rect: 57, 699, 264, 705
      Annotation: 
       Subtype: Link
       Rect: 57, 691, 293, 697
      Annotation: 
       Subtype: Link
       Rect: 57, 683, 293, 689
      Annotation: 
       Subtype: Link
       Rect: 57, 675, 80, 681
      Annotation: 
       Subtype: Link
       Rect: 57, 667, 293, 673
      Annotation: 
       Subtype: Link
       Rect: 57, 659, 293, 665
      Annotation: 
       Subtype: Link
       Rect: 57, 651, 200, 657
      Annotation: 
       Subtype: Link
       Rect: 57, 643, 293, 649
      Annotation: 
       Subtype: Link
       Rect: 57, 635, 293, 641
      Annotation: 
       Subtype: Link
       Rect: 57, 627, 293, 633
      Annotation: 
       Subtype: Link
       Rect: 57, 619, 92, 625
      Annotation: 
       Subtype: Link
       Rect: 57, 611, 293, 617
      Annotation: 
       Subtype: Link
       Rect: 57, 603, 293, 609
      Annotation: 
       Subtype: Link
       Rect: 57, 595, 247, 601
      Annotation: 
       Subtype: Link
       Rect: 57, 587, 293, 593
      Annotation: 
       Subtype: Link
       Rect: 57, 579, 293, 585
      Annotation: 
       Subtype: Link
       Rect: 57, 571, 293, 577
      Annotation: 
       Subtype: Link
       Rect: 57, 563, 173, 569
      Annotation: 
       Subtype: Link
       Rect: 57, 555, 293, 561
      Annotation: 
       Subtype: Link
       Rect: 57, 547, 293, 554
      Annotation: 
       Subtype: Link
       Rect: 57, 539, 206, 546
      Annotation: 
       Subtype: Link
       Rect: 57, 531, 293, 538
      Annotation: 
       Subtype: Link
       Rect: 57, 523, 293, 530
      Annotation: 
       Subtype: Link
       Rect: 57, 515, 184, 522
      Annotation: 
       Subtype: Link
       Rect: 57, 507, 293, 514
      Annotation: 
       Subtype: Link
       Rect: 57, 499, 293, 506
      Annotation: 
       Subtype: Link
       Rect: 57, 491, 245, 498
      Annotation: 
       Subtype: Link
       Rect: 57, 483, 293, 490
      Annotation: 
       Subtype: Link
       Rect: 57, 475, 293, 482
      Annotation: 
       Subtype: Link
       Rect: 57, 467, 293, 474
      Annotation: 
       Subtype: Link
       Rect: 57, 459, 118, 466
      Annotation: 
       Subtype: Link
       Rect: 57, 451, 293, 458
      Annotation: 
       Subtype: Link
       Rect: 57, 444, 293, 450
      Annotation: 
       Subtype: Link
       Rect: 57, 436, 293, 442
      Annotation: 
       Subtype: Link
       Rect: 57, 428, 293, 434
      Annotation: 
       Subtype: Link
       Rect: 57, 420, 293, 426
      Annotation: 
       Subtype: Link
       Rect: 57, 412, 293, 418
      Annotation: 
       Subtype: Link
       Rect: 57, 404, 113, 410
      Annotation: 
       Subtype: Link
       Rect: 57, 396, 293, 402
      Annotation: 
       Subtype: Link
       Rect: 57, 388, 293, 394
      Annotation: 
       Subtype: Link
       Rect: 57, 380, 293, 386
      Annotation: 
       Subtype: Link
       Rect: 57, 372, 83, 378
      Annotation: 
       Subtype: Link
       Rect: 57, 364, 293, 370
      Annotation: 
       Subtype: Link
       Rect: 57, 356, 293, 362
      Annotation: 
       Subtype: Link
       Rect: 57, 348, 132, 354
      Annotation: 
       Subtype: Link
       Rect: 57, 340, 293, 346
      Annotation: 
       Subtype: Link
       Rect: 57, 332, 293, 338
      Annotation: 
       Subtype: Link
       Rect: 57, 324, 233, 330
      Annotation: 
       Subtype: Link
       Rect: 325, 730, 561, 737
      Annotation: 
       Subtype: Link
       Rect: 325, 722, 561, 729
      Annotation: 
       Subtype: Link
       Rect: 325, 715, 561, 721
      Annotation: 
       Subtype: Link
       Rect: 325, 707, 561, 713
      Annotation: 
       Subtype: Link
       Rect: 325, 699, 401, 705
      Annotation: 
       Subtype: Link
       Rect: 325, 691, 561, 697
      Annotation: 
       Subtype: Link
       Rect: 325, 683, 433, 689
      Annotation: 
       Subtype: Link
       Rect: 325, 675, 561, 681
      Annotation: 
       Subtype: Link
       Rect: 325, 667, 561, 673
      Annotation: 
       Subtype: Link
       Rect: 325, 659, 351, 665
      Annotation: 
       Subtype: Link
       Rect: 325, 651, 561, 657
      Annotation: 
       Subtype: Link
       Rect: 325, 643, 561, 649
      Annotation: 
       Subtype: Link
       Rect: 325, 635, 516, 641
      Annotation: 
       Subtype: Link
       Rect: 325, 627, 561, 633
      Annotation: 
       Subtype: Link
       Rect: 325, 619, 520, 625
      Annotation: 
       Subtype: Link
       Rect: 325, 611, 561, 617
      Annotation: 
       Subtype: Link
       Rect: 325, 603, 561, 609
      Annotation: 
       Subtype: Link
       Rect: 325, 595, 497, 601
      Annotation: 
       Subtype: Link
       Rect: 325, 587, 561, 593
      Annotation: 
       Subtype: Link
       Rect: 325, 579, 561, 585
      Annotation: 
       Subtype: Link
       Rect: 325, 571, 561, 577
      Annotation: 
       Subtype: Link
       Rect: 325, 563, 351, 569
      Annotation: 
       Subtype: Link
       Rect: 325, 555, 561, 561
      Annotation: 
       Subtype: Link
       Rect: 325, 547, 561, 554
      Annotation: 
       Subtype: Link
       Rect: 325, 539, 561, 546
      Annotation: 
       Subtype: Link
       Rect: 325, 531, 465, 538
      Annotation: 
       Subtype: Link
       Rect: 325, 523, 561, 530
      Annotation: 
       Subtype: Link
       Rect: 325, 515, 561, 522
      Annotation: 
       Subtype: Link
       Rect: 325, 507, 495, 514
      Annotation: 
       Subtype: Link
       Rect: 325, 499, 561, 506
      Annotation: 
       Subtype: Link
       Rect: 325, 491, 561, 498
      Annotation: 
       Subtype: Link
       Rect: 325, 483, 396, 490
      Annotation: 
       Subtype: Link
       Rect: 325, 475, 561, 482
      Annotation: 
       Subtype: Link
       Rect: 325, 467, 552, 474
      Annotation: 
       Subtype: Link
       Rect: 325, 459, 561, 466
      Annotation: 
       Subtype: Link
       Rect: 325, 451, 561, 458
      Annotation: 
       Subtype: Link
       Rect: 325, 444, 561, 450
      Annotation: 
       Subtype: Link
       Rect: 325, 436, 424, 442
      Annotation: 
       Subtype: Link
       Rect: 325, 428, 561, 434
      Annotation: 
       Subtype: Link
       Rect: 325, 420, 561, 426
      Annotation: 
       Subtype: Link
       Rect: 325, 412, 561, 418
      Annotation: 
       Subtype: Link
       Rect: 325, 404, 409, 410
      Annotation: 
       Subtype: Link
       Rect: 325, 396, 561, 402
      Annotation: 
       Subtype: Link
       Rect: 325, 388, 561, 394
      Annotation: 
       Subtype: Link
       Rect: 325, 380, 490, 386
      Annotation: 
       Subtype: Link
       Rect: 325, 372, 561, 378
      Annotation: 
       Subtype: Link
       Rect: 325, 364, 561, 370
      Annotation: 
       Subtype: Link
       Rect: 325, 356, 351, 362
      Annotation: 
       Subtype: Link
       Rect: 325, 348, 561, 354
      Annotation: 
       Subtype: Link
       Rect: 325, 340, 561, 346
      Annotation: 
       Subtype: Link
       Rect: 325, 332, 516, 338
  Checksum: c00b6fad
   Type: CRC32
  Checksum: 1307117bd6f195d86faef09ed900b50e
   Type: MD5
  Checksum: 4305b53ef76db399302be9119363b37442de8acb
   Type: SHA-1