524f6bae8c02419c35ea0cd98d75d7c7 pmc_30987329.pdf 5b3ff6c53f630ca43236bbd29fff68fe3f83a329 pmc_30987329.pdf 30125cf41ec2f1f1bfef28d4acefc52c2fe0aeb719c5771730b09243a4695d56 pmc_30987329.pdf Title: Distinct Dopamine D2 Receptor Antagonists Differentially Impact D2 Receptor Oligomerization Subject: Dopamine D2 receptors (D2R) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor homodimers might lead to a better understanding of the critical role played by these complexes in physiological and pathological conditions. Whereas agonist addition has shown to prolong the D2R dimer lifetime and increase the level of dimer formation, the possible influence of D2R antagonists on dimerization has remained rather unexplored. Here, using a live-cell reporter assay based on the functional complementation of a split Nanoluciferase, a panel of six D2R antagonists were screened for their ability to modulate the level of D2LR dimer formation. Incubation with the D2R antagonist spiperone decreased the level of D2LR dimer formation significantly by 40–60% in real-time and after long-term (16 h) incubations. The fact that dimer formation of the well-studied A2a–D2LR dimer was not altered following incubation with spiperone supports the specificity of this observation. Other D2R antagonists, such as clozapine, risperidone, and droperidol did not significantly evoke this dissociation event. Furthermore, molecular modeling reveals that spiperone presents specific Tyr1995.48 and Phe3906.52 conformations, compared to clozapine, which may determine D2R homodimerization. Keywords: G protein-coupled receptor (GPCR); dimerization; oligomerization; protein complementation assay; NanoLuc binary technology (NanoBiT); dopamine D2 receptor Author: Elise Wouters, Adrián Ricarte Marín, James Andrew Rupert Dalton, Jesús Giraldo and Christophe Stove Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Apr 4 11:28:51 2019 CEST ModDate: Thu Apr 4 11:28:51 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3137746 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HKYRKC+URWPalladioL-Ital Type 1 Custom yes yes no 147 0 ZAJXXO+URWPalladioL-Bold Type 1 Custom yes yes no 148 0 JGBJTI+VnURWPalladioL-Bold Type 1 Custom yes yes no 149 0 AXQTCM+URWPalladioL-Roma Type 1 Custom yes yes no 150 0 LWJOET+VnURWPalladioL 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IHGURL+EURM7 Type 1 Builtin yes yes no 613 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-19 06:16:04 CET RepresentationInformation: pmc_30987329.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-03 03:43:41 CEST Size: 3137746 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐとちひねちっはぬはでどっちぬぜ〴ぜ〰ぐひはばづひぴどづびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰い〲がげぜ〴ぜ〰うふびどはのぜ〴ぜ〰ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ごちひでづぴどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰いはばちねどのづぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰ふびどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎちのはあどごぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのぴちではのどびぴ〭いづばづのつづのぴぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰がづぶづぬぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰うはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Children: Item: Title: ぐとちひねちっはぬはでどっちぬぜ〴ぜ〰ぐひはばづひぴどづびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰い〲がげぜ〴ぜ〰うふびどはのぜ〴ぜ〰ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ごちひでづぴどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰いはばちねどのづぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰ふびどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎちのはあどごぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのぴちではのどびぴ〭いづばづのつづのぴぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰がづぶづぬぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰うはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Item: Title: ごちひでづぴどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰いはばちねどのづぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰ふびどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎちのはあどごぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのぴちではのどびぴ〭いづばづのつづのぴぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰がづぶづぬぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰うはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Item: Title: ぁのぴちではのどびぴ〭いづばづのつづのぴぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰がづぶづぬぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰うはひねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Children: Item: Title: ことはひぴ〭ごづひねぜ〴ぜ〰ぅててづっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸲ Item: Title: がはので〭ごづひねぜ〴ぜ〰ぅててづっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸳ Item: Title: こっひづづのどのでぜ〴ぜ〰はてぜ〴ぜ〰ちぜ〴ぜ〰あひはちつづひぜ〴ぜ〰ぐちのづぬぜ〴ぜ〰はてぜ〴ぜ〰い〲げぜ〴ぜ〰ぬどでちのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ざちぬどつちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどばづひはのづ〭きはつふぬちぴどのでぜ〴ぜ〰ぃちばちっどぴべぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰ぁっとどづぶづぜ〴ぜ〰こぴちぢぬづぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぐはびづびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰つふひどのでぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっびぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰こづぬづっぴぜ〴ぜ〰てはひぜ〴ぜ〰いどててづひづのぴぜ〴ぜ〰こどつづっとちどのぜ〴ぜ〰ぃはのてはひねちぴどはのびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰ごき〵ぜ〴ぜ〰ちのつぜ〴ぜ〰ごき〶ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぁひはねちぴどっぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴ぜ〰こぴちぢどぬどぺづぜ〴ぜ〰い〲げぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰きはつづぬぜ〴ぜ〰ぉのぴづひてちっづぜ〴ぜ〰つふひどのでぜ〴ぜ〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰い〲がげぜ〴ぜ〰くぬどではねづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ざちぬどつちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどばづひはのづ〭きはつふぬちぴどのでぜ〴ぜ〰ぃちばちっどぴべぜ〴ぜ〰はのぜ〴ぜ〰ぴとづぜ〴ぜ〰い〲がげぜ〴ぜ〰えはねはつどねづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰ぁっとどづぶづぜ〴ぜ〰こぴちぢぬづぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぐはびづびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰つふひどのでぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっびぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰こづぬづっぴぜ〴ぜ〰てはひぜ〴ぜ〰いどててづひづのぴぜ〴ぜ〰こどつづっとちどのぜ〴ぜ〰ぃはのてはひねちぴどはのびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰ごき〵ぜ〴ぜ〰ちのつぜ〴ぜ〰ごき〶ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぁひはねちぴどっぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴ぜ〰こぴちぢどぬどぺづぜ〴ぜ〰い〲げぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰きはつづぬぜ〴ぜ〰ぉのぴづひてちっづぜ〴ぜ〰つふひどのでぜ〴ぜ〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰い〲がげぜ〴ぜ〰くぬどではねづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰ぁっとどづぶづぜ〴ぜ〰こぴちぢぬづぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぐはびづびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰つふひどのでぜ〴ぜ〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっびぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰こづぬづっぴぜ〴ぜ〰てはひぜ〴ぜ〰いどててづひづのぴぜ〴ぜ〰こどつづっとちどのぜ〴ぜ〰ぃはのてはひねちぴどはのびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰ごき〵ぜ〴ぜ〰ちのつぜ〴ぜ〰ごき〶ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぁひはねちぴどっぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴ぜ〰こぴちぢどぬどぺづぜ〴ぜ〰い〲げぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰きはつづぬぜ〴ぜ〰ぉのぴづひてちっづぜ〴ぜ〰つふひどのでぜ〴ぜ〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰い〲がげぜ〴ぜ〰くぬどではねづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こばどばづひはのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬはぺちばどのづぜ〴ぜ〰こづぬづっぴぜ〴ぜ〰てはひぜ〴ぜ〰いどててづひづのぴぜ〴ぜ〰こどつづっとちどのぜ〴ぜ〰ぃはのてはひねちぴどはのびぜ〴ぜ〰どのぜ〴ぜ〰い〲げぜ〴ぜ〰ごき〵ぜ〴ぜ〰ちのつぜ〴ぜ〰ごき〶ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰ぁひはねちぴどっぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴ぜ〰こぴちぢどぬどぺづぜ〴ぜ〰い〲げぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰きはつづぬぜ〴ぜ〰ぉのぴづひてちっづぜ〴ぜ〰つふひどのでぜ〴ぜ〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰い〲がげぜ〴ぜ〰くぬどではねづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁひはねちぴどっぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴ぜ〰こぴちぢどぬどぺづぜ〴ぜ〰い〲げぜ〴ぜ〰えはねはつどねづひぜ〴ぜ〰きはつづぬぜ〴ぜ〰ぉのぴづひてちっづぜ〴ぜ〰つふひどのでぜ〴ぜ〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰い〲がげぜ〴ぜ〰くぬどではねづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: い〲がげぜ〴ぜ〰くぬどではねづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとづねどっちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰げづちでづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃぬはのどのでぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰いはばちねどのづぜ〴ぜ〰い〲げぜ〴ぜ〰どのぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎちのはあどごぜ㈵㙜〰ぜ〴ぜ〰ばぬちびねどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸱ Children: Item: Title: ぃとづねどっちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰げづちでづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃぬはのどのでぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰いはばちねどのづぜ〴ぜ〰い〲げぜ〴ぜ〰どのぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎちのはあどごぜ㈵㙜〰ぜ〴ぜ〰ばぬちびねどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸱ Item: Title: ぃぬはのどのでぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰いはばちねどのづぜ〴ぜ〰い〲げぜ〴ぜ〰どのぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎちのはあどごぜ㈵㙜〰ぜ〴ぜ〰ばぬちびねどつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸱ Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸱ Children: Item: Title: ぅへばひづびびどはのぜ〴ぜ〰どのぜ〴ぜ〰えぅか〲〹〳ごぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸲ Item: Title: ぃづぬぬぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴ぜ〰てはひぜ〴ぜ〰いどねづひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰えぅか〲〹〳ごぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰こふびばづのびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸳ Item: Title: ぃづぬぬぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴ぜ〰てはひぜ〴ぜ〰いどねづひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぁつとづひづのぴぜ〴ぜ〰えぅか〲〹〳ごぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸴⸳⸴ Item: Title: うぬふはひづびっづのっづぜ〴ぜ〰ぎはひねちぬどぺちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰こどでのちぬ〭ごは〭ぎはどびづぜ〴ぜ〰げちぴどはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぎちのはあどごぜ㈵㙜〰〭あちびづつぜ〴ぜ〰ざちぬどつちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰うふのっぴどはのちぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰がふねどのづびっづのぴぜ〴ぜ〰うふびどはのぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰ぢべぜ〴ぜ〰ねどのど〭ぇどぜ〴ぜ〰ぐひはぴづどの〭きづつどちぴづつぜ〴ぜ〰こどでのちぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰いづぴづっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰いどねづひびぜ〴ぜ〰ぢべぜ〴ぜ〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはねばふぴちぴどはのちぬぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっぜ〴ぜ〰ぜ〵ぜ〰きいぜ〵ㅜ〰ぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぎちのはあどごぜ㈵㙜〰〭あちびづつぜ〴ぜ〰ざちぬどつちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰うふのっぴどはのちぬどぴべぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰がふねどのづびっづのぴぜ〴ぜ〰うふびどはのぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰ぢべぜ〴ぜ〰ねどのど〭ぇどぜ〴ぜ〰ぐひはぴづどの〭きづつどちぴづつぜ〴ぜ〰こどでのちぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰いづぴづっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰いどねづひびぜ〴ぜ〰ぢべぜ〴ぜ〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはねばふぴちぴどはのちぬぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっぜ〴ぜ〰ぜ〵ぜ〰きいぜ〵ㅜ〰ぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: いづぴづっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰い〲がげぜ〴ぜ〰いどねづひびぜ〴ぜ〰ぢべぜ〴ぜ〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはねばふぴちぴどはのちぬぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっぜ〴ぜ〰ぜ〵ぜ〰きいぜ〵ㅜ〰ぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃはねばふぴちぴどはのちぬぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっぜ〴ぜ〰ぜ〵ぜ〰きいぜ〵ㅜ〰ぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぃはねばふぴちぴどはのちぬぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰いべのちねどっぜ〴ぜ〰ぜ〵ぜ〰きいぜ〵ㅜ〰ぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: きはぬづっふぬちひぜ〴ぜ〰いべのちねどっぜ〴ぜ〰ぜ〵ぜ〰きいぜ〵ㅜ〰ぜ〴ぜ〰こどねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: きいぜ〴ぜ〰こどねふぬちぴどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: HKYRKC+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 174 FontDescriptor: FontName: HKYRKC+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: 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