d376b1e86ac90253cf6ed07a8c7c095d pmc_30999586.pdf b15a35ef50a6fc6dd31ae79773d039fe61bca80e pmc_30999586.pdf bebcc37b91dbb471e66d6c5b9e65e17b55040386480e465640c85507fdfdffb8 pmc_30999586.pdf Title: QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy Subject: We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid QT78 in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer’s disease therapy. We have found that QT78 is less toxic than tacrine at high concentrations (from 100 M to 1 mM), less potent than tacrine as a ChE inhibitor, but shows selective BuChE inhibition (IC50 (hAChE) = 22.0 1.3 M; IC50 (hBuChE) = 6.79 0.33 M). Moreover, QT78 showed effective and strong neuroprotection against diverse toxic stimuli, such as rotenone plus oligomycin-A or okadaic acid, of biological significance for Alzheimer’s disease. Keywords: Alzheimer’s disease; cholinesterase inhibitor; hepatotoxicity; molecular modeling; neuroprotection; quinoxalines; quinoxalinetacrines; tacrine Author: Eva Ramos, Alejandra Palomino-Antolín, Manuela Bartolini, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, Abdelouahid Samadi, Carol V. Cortina, Mourad Chioua, Javier Egea, Alejandro Romero and José Marco-Contelles Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Apr 17 09:57:41 2019 CEST ModDate: Wed Apr 17 09:57:41 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3471799 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RSFTBE+URWPalladioL-Ital Type 1 Custom yes yes no 84 0 KUIMRX+URWPalladioL-Bold Type 1 Custom yes yes no 85 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 86 0 JRTNVH+URWPalladioL-Roma Type 1 Custom yes yes no 87 0 OPZDHV+VnURWPalladioL Type 1 Custom yes yes no 88 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 89 0 ODYBLU+EURM10 Type 1 Builtin yes yes no 90 0 DFIRNB+Pxsy Type 1 Builtin yes yes no 91 0 PUSVWS+TimesNewRomanPS-BoldItalicMT 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TrueType Identity-H yes no yes 377 0 CIDFont+F3 CID TrueType Identity-H yes no yes 378 0 CIDFont+F7 CID TrueType Identity-H yes no yes 379 0 MOADQM+URWPalladioL-BoldItal Type 1 Custom yes yes no 463 0 PIJANT+Arial-BoldMT CID TrueType Identity-H yes yes yes 466 0 CIDFont+F3 CID TrueType Identity-H yes no yes 467 0 CIDFont+F5 CID TrueType Identity-H yes no yes 468 0 CIDFont+F6 CID TrueType Identity-H yes no yes 469 0 CIDFont+F4 CID TrueType Identity-H yes no yes 470 0 YWGLGW+Rpxi Type 1 Builtin yes yes no 557 0 ZVKNIW+Rpcxr Type 1 Builtin yes yes no 559 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 563 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 564 0 Times New Roman TrueType WinAnsi no no no 565 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 566 0 ABCDEE+Palatino Linotype,BoldItalic TrueType WinAnsi yes yes no 567 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 568 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:46:43 CEST RepresentationInformation: pmc_30999586.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:20:04 CET Size: 3471799 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴ぜ〰ちのつぜ〴ぜ〰いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとづねどびぴひべぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰こどぬどっはぜ〴ぜ〰ぐひづつどっぴどはのぜ〴ぜ〰こべびぴづねびぜ〴ぜ〰てはひぜ〴ぜ〰ごはへどっはぬはでべぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴちぢはぬどびねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴ぜ〰ちのつぜ〴ぜ〰ごちっひどのづぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁぃとぅぜ〴ぜ〰ちのつぜ〴ぜ〰あふぃとぅぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぃとづねどびぴひべぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰こどぬどっはぜ〴ぜ〰ぐひづつどっぴどはのぜ〴ぜ〰こべびぴづねびぜ〴ぜ〰てはひぜ〴ぜ〰ごはへどっはぬはでべぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴちぢはぬどびねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴ぜ〰ちのつぜ〴ぜ〰ごちっひどのづぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁぃとぅぜ〴ぜ〰ちのつぜ〴ぜ〰あふぃとぅぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: こべのぴとづびどびぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰こどぬどっはぜ〴ぜ〰ぐひづつどっぴどはのぜ〴ぜ〰こべびぴづねびぜ〴ぜ〰てはひぜ〴ぜ〰ごはへどっはぬはでべぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴちぢはぬどびねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴ぜ〰ちのつぜ〴ぜ〰ごちっひどのづぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁぃとぅぜ〴ぜ〰ちのつぜ〴ぜ〰あふぃとぅぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのぜ〴ぜ〰こどぬどっはぜ〴ぜ〰ぐひづつどっぴどはのぜ〴ぜ〰こべびぴづねびぜ〴ぜ〰てはひぜ〴ぜ〰ごはへどっはぬはでべぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴちぢはぬどびねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴ぜ〰ちのつぜ〴ぜ〰ごちっひどのづぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁぃとぅぜ〴ぜ〰ちのつぜ〴ぜ〰あふぃとぅぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのぜ〴ぜ〰ざどぴひはぜ〴ぜ〰ごはへどっどぴべぜ〴ぜ〰はてぜ〴ぜ〰けご〷〸ぜ〴ぜ〰ちのつぜ〴ぜ〰ごちっひどのづぜ〴ぜ〰どのぜ〴ぜ〰えづばぇ〲ぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁぃとぅぜ〴ぜ〰ちのつぜ〴ぜ〰あふぃとぅぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰えふねちのぜ〴ぜ〰ぁぃとぅぜ〴ぜ〰ちのつぜ〴ぜ〰あふぃとぅぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きはぬづっふぬちひぜ〴ぜ〰きはつづぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぎづふひはばひはぴづっぴどはのぜ〴ぜ〰こぴふつどづびぜ〴ぜ〰どのぜ〴ぜ〰えふねちのぜ〴ぜ〰ぎづふひはぢぬちびぴはねちぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: XIRVNA+EURB10 FontSubset: true FirstChar: 22 LastChar: 22 FontDescriptor: FontName: XIRVNA+EURB10 Flags: Symbolic FontBBox: -30, -247, 1178, 723 FontFile: true Font: BaseFont: RSFTBE+URWPalladioL-Ital FontSubset: true FirstChar: 46 LastChar: 122 FontDescriptor: FontName: RSFTBE+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KUIMRX+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: KUIMRX+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YSPQJI+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 189 FontDescriptor: FontName: YSPQJI+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true 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