62ce4448d64d5c98e2be7a4abf67fd0d pmc_31065058.pdf 188c42f78f0063a667a10895a36401ffc9ef9dd6 pmc_31065058.pdf 8e705b6a725cbebcd8ea7b44451df01197e8299549c08c68ce8961b8f8f81fdd pmc_31065058.pdf Creator: Adobe InDesign CS6 (Windows) Producer: Adobe PDF Library 10.0.1; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Sat Oct 12 11:48:07 2019 CEST ModDate: Wed Oct 16 16:43:06 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1232628 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PSXNXO+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 56 0 URNBUE+Corbel-Bold CID TrueType Identity-H yes yes yes 55 0 OXBPLK+Corbel-BoldItalic2 Type 1C WinAnsi yes yes yes 48 0 EuclidSymbol-BoldItalic Type 1C Custom yes no yes 57 0 CUQDOK+Corbel-Bold2 Type 1C WinAnsi yes yes yes 50 0 MinionPro-Regular Type 1C Custom yes no yes 47 0 CHSYMF+Corbel2 Type 1C WinAnsi yes yes yes 53 0 IJSMIC+Corbel CID TrueType Identity-H yes yes yes 51 0 MyriadPro-It Type 1C WinAnsi yes no yes 59 0 AWERVS+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 440 0 CHSYMF+Corbel2 Type 1C WinAnsi yes yes yes 506 0 EuclidSymbol Type 1C Custom yes no yes 49 0 MinionPro-It Type 1C Custom yes no yes 52 0 EuclidSymbol-Italic Type 1C Custom yes no yes 54 0 EuclidSymbol-Bold Type 1C Custom yes no yes 58 0 CHSYMF+Corbel2 Type 1C WinAnsi yes yes yes 328 0 CHSYMF+Corbel2 Type 1C WinAnsi yes yes yes 336 0 MinionPro-Bold Type 1C WinAnsi yes no yes 132 0 ZTKIHU+STIXGeneral-Regular Type 1C Custom yes yes yes 295 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:44:30 CEST RepresentationInformation: pmc_31065058.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 04:12:32 CEST Size: 1232628 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: Table 1. Genetic loci with significant and suggestive associations with DLB at meta-analysis Stage 1 and Stage 2. CHR:BP: Chromosome and Base pair location based on Build 37, Assembly Hg19. Allele (min/maj): Minor:40' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd:Figure 1. Manhattan plot of Stage 1 meta-analysis. Manhattan plot of meta-analysis of Cohorts 1 and 2 for genome-wide association with Dementia with Lewy Body (DLB). Genome-wide significant associations to DLB (threshold P⁜琀㰠㔠휠㄀ヾBሀ㣾＀ 愀爀攀 昀漀㨀㐀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛ㄹ㘮ㄱ㠠㐵㐮㜶㌠㈰〮㐳㠠㐴㈮㘲㉝⽈⽎⽁值㰯丠ㄲ㈠〠刾㸾㸊敮摯扪਱ㄲ‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :47' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: Table 1. Genetic loci with significant and suggestive associations with DLB at meta-analysis Stage 1 and Stage 2. CHR:BP: Chromosome and Base pair location based on Build 37, Assembly Hg19. Allele (min/maj): Mino:48' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: Table 1. Genetic loci with significant and suggestive associations with DLB at meta-analysis Stage 1 and Stage 2. CHR:BP: Chromosome and Base pair location based on Build 37, Assembly Hg19. Allele (min/maj): Min:50' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :51' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: Table 1. Genetic loci with significant and suggestive associations with DLB at meta-analysis Stage 1 and Stage 2. CHR:BP: Chromosome and Base pair location based on Build 37, Assembly Hg19. Allele (min/maj): Mi:53' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 21. Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of genetic associations with FUMA. Nat Commun 8, 1826, https://doi.org/10.1038/s41467-017-01261-5 (2017). :54' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :56' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :57' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :61' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :63' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :66' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 12. Bras, J. et al. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human molecular genetics 23, 6139–6146, https://doi.org/10.1093/hmg/ddu334 (2014). :72' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 12. Bras, J. et al. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human molecular genetics 23, 6139–6146, https://doi.org/10.1093/hmg/ddu334 (2014). :74' cannot be found Offset: 757860 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43458.indd: 13. Guerreiro, R. et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet Neurology 17, 64–74 (2018). :77' cannot be found Offset: 757860 MIMEtype: application/pdf PDFMetadata: Objects: 510 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study Children: Item: Title: Methods Children: Item: Title: Participants. Item: Title: Genotyping. Item: Title: Association analysis. Item: Title: Functional mapping and annotation (FUMA) of GWAS. Item: Title: Ethics committee approval. Item: Title: Results Item: Title: Discussion Item: Title: Acknowledgements Item: Title: Figure 1 Manhattan plot of Stage 1 meta-analysis. Item: Title: Table 1 Genetic loci with significant and suggestive associations with DLB at meta-analysis Stage 1 and Stage 2. 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