f6be18e37b14e38c63c053cb233040ed  pmc_31081014.pdf
0430697e9163fba9504890a844b33a3bc6a5d5c4  pmc_31081014.pdf
3a811166b3728a5becaa85ef29cba5e5138e11c5899ee0bf016f58be296bd9ee  pmc_31081014.pdf

Title:          
Subject:        
Keywords:       
Author:         
Creator:        XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.
Producer:       Acrobat Distiller 19.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version)
CreationDate:   Wed Jun 19 16:52:08 2019 CEST
ModDate:        Wed Jun 19 16:54:16 2019 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      612.284 x 790.866 pts
Page rot:       0
File size:      685383 bytes
Optimized:      no
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GFKCHF+TimesNewRomanMTStd            Type 1C           Custom           yes yes yes     43  0
GFKCHG+TimesNewRomanMTStd-Italic     Type 1C           Custom           yes yes yes     44  0
GFKCHH+TimesNewRomanMTStd-BoldIt     Type 1C           Custom           yes yes yes     45  0
GFKCHI+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      46  0
GFKCHJ+CMBSY10                       Type 1C           Custom           yes yes yes     47  0
GFKCLJ+Helvetica                     Type 1C           WinAnsi          yes yes no      48  0
GFKCLK+MTSYB                         Type 1C           Custom           yes yes yes     49  0
GFKCMK+RMTMI                         Type 1C           Custom           yes yes yes     50  0
GFKCML+MTSY                          Type 1C           Custom           yes yes yes     51  0
GFKCOL+CMSY10                        Type 1C           Custom           yes yes yes     52  0
GFKEGD+TimesNewRomanMTStd-Bold       Type 1C           Custom           yes yes yes    102  0
GFKENC+RMTMIB                        Type 1C           Custom           yes yes yes    153  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-11-19 06:14:02 CET
 RepresentationInformation: pmc_31081014.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-08-03 03:42:50 CEST
  Size: 685383
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: ISO PDF/A-1, Level B
  PDFMetadata: 
   Objects: 277
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseThumbs
   Info: 
    Title: 
    Author: 
    Subject: 
    Keywords: 
    Creator: XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.
    Producer: Acrobat Distiller 19.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version)
    CreationDate: Wed Jun 19 17:22:08 CEST 2019
    ModDate: Wed Jun 19 12:54:16 CEST 2019
   ID: 0xbda9d930d996c6015ff3b6f0483b3ae7, 0x210b91be34fb94b27e5973cd74fd546b
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1249
      ImageHeight: 3307
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1260
      ImageHeight: 1994
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: GFKCLJ+Helvetica
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: GFKCLJ+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GFKCLK+MTSYB
      FontSubset: true
      FirstChar: 138
      LastChar: 138
      FontDescriptor: 
       FontName: GFKCLK+MTSYB
       Flags: Symbolic, ForceBold
       FontBBox: -16, -935, 1043, 896
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCMK+RMTMI
      FontSubset: true
      FirstChar: 2
      LastChar: 62
      FontDescriptor: 
       FontName: GFKCMK+RMTMI
       Flags: Symbolic, Italic
       FontBBox: 0, -213, 987, 680
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCML+MTSY
      FontSubset: true
      FirstChar: 2
      LastChar: 215
      FontDescriptor: 
       FontName: GFKCML+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCOL+CMSY10
      FontSubset: true
      FirstChar: 129
      LastChar: 129
      FontDescriptor: 
       FontName: GFKCOL+CMSY10
       Flags: Symbolic, Italic
       FontBBox: -29, -960, 1116, 775
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKEGD+TimesNewRomanMTStd-Bold
      FontSubset: true
      FirstChar: 40
      LastChar: 144
      FontDescriptor: 
       FontName: GFKEGD+TimesNewRomanMTStd-Bold
       Flags: Serif, Symbolic, ForceBold
       FontBBox: -191, -241, 1065, 957
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKENC+RMTMIB
      FontSubset: true
      FirstChar: 47
      LastChar: 47
      FontDescriptor: 
       FontName: GFKENC+RMTMIB
       Flags: Symbolic, Italic, ForceBold
       FontBBox: 0, -208, 994, 706
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCHF+TimesNewRomanMTStd
      FontSubset: true
      FirstChar: 2
      LastChar: 180
      FontDescriptor: 
       FontName: GFKCHF+TimesNewRomanMTStd
       Flags: Serif, Symbolic
       FontBBox: -94, -241, 1006, 916
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCHG+TimesNewRomanMTStd-Italic
      FontSubset: true
      FirstChar: 2
      LastChar: 122
      FontDescriptor: 
       FontName: GFKCHG+TimesNewRomanMTStd-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -271, -246, 1100, 904
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCHH+TimesNewRomanMTStd-BoldIt
      FontSubset: true
      FirstChar: 46
      LastChar: 133
      FontDescriptor: 
       FontName: GFKCHH+TimesNewRomanMTStd-BoldIt
       Flags: Serif, Symbolic, Italic, ForceBold
       FontBBox: -266, -259, 1076, 942
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GFKCHI+Helvetica-Bold
      FontSubset: true
      FirstChar: 40
      LastChar: 180
      FontDescriptor: 
       FontName: GFKCHI+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GFKCHJ+CMBSY10
      FontSubset: true
      FirstChar: 129
      LastChar: 129
      FontDescriptor: 
       FontName: GFKCHJ+CMBSY10
       Flags: Symbolic, Italic, ForceBold
       FontBBox: -26, -940, 1332, 825
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
      dc:format="xml"
      dc:identifier="doi:10.1093/nar/gkz372"
      prism:aggregationType="journal"
      prism:publicationName="Nucleic Acids Research"
      prism:issn="1362-4962"
      prism:doi="10.1093/nar/gkz372"
      prism:url="http://dx.doi.org/10.1093/nar/gkz372"
      jav:journal_article_version="VoR"
      pdf:Producer="Acrobat Distiller 19.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version)"
      xmp:ModifyDate="2019-06-19T10:54:16-04:00"
      xmp:MetadataDate="2019-06-19T10:54:16-04:00">
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">iMKT: the integrative McDonald and Kreitman test</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li>Jesús Murga-Moreno</rdf:li>
          <rdf:li>Marta Coronado-Zamora</rdf:li>
          <rdf:li>Sergi Hervas</rdf:li>
          <rdf:li>Sònia Casillas</rdf:li>
          <rdf:li>Antonio Barbadilla</rdf:li>
        </rdf:Seq>
      </dc:creator>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Nucleic Acids Research</rdf:li>
        </rdf:Alt>
      </dc:description>
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Oxford University Press</rdf:li>
        </rdf:Bag>
      </dc:publisher>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 283
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 498, 674, 508, 688
      Annotation: 
       Subtype: Link
       Rect: 162, 658, 172, 673
      Annotation: 
       Subtype: Link
       Rect: 53, 282, 304, 309
      Annotation: 
       Subtype: Link
       Rect: 259, 180, 266, 193
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 251, 169, 258, 182
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 72, 114, 79, 127
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 429, 476, 435, 488
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 436, 476, 443, 488
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 531, 410, 538, 423
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 539, 410, 546, 423
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 431, 377, 438, 390
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 501, 344, 508, 357
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 504, 333, 511, 346
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 425, 322, 432, 335
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 363, 311, 375, 324
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 471, 268, 483, 280
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 484, 268, 496, 280
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 372, 257, 383, 269
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 321, 191, 328, 203
       Destination: 80
    Page: 
     Label: 284
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 522, 645, 534, 658
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 372, 634, 384, 647
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 515, 345, 527, 358
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 347, 181, 357, 192
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 354, 163, 360, 174
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 375, 55, 385, 66
       Destination: 84
    Page: 
     Label: 285
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 236, 562, 248, 574
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 249, 562, 261, 574
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 154, 551, 166, 563
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 275, 496, 287, 508
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 288, 496, 300, 508
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 220, 474, 232, 487
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 93, 441, 275, 454
      Annotation: 
       Subtype: Link
       Rect: 178, 358, 190, 370
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 113, 171, 124, 184
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 102, 149, 114, 162
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 99, 108, 111, 121
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 57, 86, 69, 99
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 404, 711, 415, 723
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 555, 711, 567, 723
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 552, 700, 564, 712
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 535, 667, 547, 680
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 363, 549, 370, 562
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 369, 420, 376, 433
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 377, 420, 389, 433
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 389, 420, 401, 433
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 417, 366, 429, 378
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 430, 366, 441, 378
       Destination: 83
    Page: 
     Label: 286
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 101, 466, 113, 479
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 77, 281, 89, 294
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 85, 128, 97, 141
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 370, 371, 377, 384
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 432, 294, 439, 307
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 422, 239, 429, 252
       Destination: 83
    Page: 
     Label: 287
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 134, 129, 218, 142
      Annotation: 
       Subtype: Link
       Rect: 53, 106, 304, 132
      Annotation: 
       Subtype: Link
       Rect: 54, 53, 144, 66
    Page: 
     Label: 288
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 262, 265, 269, 277
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 148, 155, 155, 168
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 204, 111, 211, 124
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 250, 111, 257, 124
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 478, 673, 485, 685
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 544, 662, 551, 674
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 464, 618, 476, 630
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 369, 483, 376, 496
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 536, 483, 543, 496
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 440, 352, 447, 364
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 393, 242, 405, 255
       Destination: 83
      Annotation: 
       Subtype: Link
       Rect: 516, 220, 523, 233
       Destination: 80
  Checksum: 53cc039d
   Type: CRC32
  Checksum: f6be18e37b14e38c63c053cb233040ed
   Type: MD5
  Checksum: 0430697e9163fba9504890a844b33a3bc6a5d5c4
   Type: SHA-1