220cedbbca499451773d6679f8c4615d pmc_31101830.pdf beed7e29c45981a63e31f8bd47d3887547faa3f1 pmc_31101830.pdf 6a678bacf444d5ef0ede2a292e5a54c7414bbc0b130c7227ca8374d892d5d950 pmc_31101830.pdf Title: Expansion of different subpopulations of CD26-/low T cells in allergic and non-allergic asthmatics Subject: Scientific Reports, doi:10.1038/s41598-019-43622-8 Keywords: Author: Juan Josamp#x000E9; Nieto-Fontarigo Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu May 9 10:23:07 2019 CEST ModDate: Mon May 13 18:03:46 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 4068412 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MinionPro-Regular Type 1C Custom yes no yes 108 0 DRFINI+Corbel-BoldItalic Type 1C WinAnsi yes yes yes 345 0 MinionPro-It Type 1C Custom yes no yes 107 0 JFPAKB+Corbel-Bold2 Type 1C WinAnsi yes yes yes 109 0 XGCIKY+Corbel CID TrueType Identity-H yes yes yes 113 0 PNEVXO+STIXGeneral-Regular Type 1C Custom yes yes yes 146 0 SBSKNT+Corbel2 Type 1C WinAnsi yes yes yes 112 0 EuclidSymbol Type 1C Custom yes no yes 111 0 FTENNI+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 462 0 NHYQAS+Corbel-Bold CID TrueType Identity-H yes yes yes 106 0 EuclidSymbol-Bold Type 1C Custom yes no yes 110 0 STIXGeneral-Bold Type 1C Custom yes no yes 463 0 MyriadPro-It Type 1C WinAnsi yes no yes 114 0 SBSKNT+Corbel2 Type 1C WinAnsi yes yes yes 370 0 MinionPro-Bold Type 1C WinAnsi yes no yes 145 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:42:53 CEST RepresentationInformation: pmc_31101830.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:16:22 CET Size: 4068412 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 5. Woodruff, P. G. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 180, 388–395 (2009). :32' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 1. Wenzel, S. E. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 18, 716–725 (2012). :33' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 6. Stokes, J. R. & Casale, T. B. Characterization of asthma endotypes: implications for therapy. Ann. Allergy Asthma Immunol. 117, 121–125 (2016). :34' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 1. Wenzel, S. E. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 18, 716–725 (2012). :35' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 6. Stokes, J. R. & Casale, T. B. Characterization of asthma endotypes: implications for therapy. Ann. Allergy Asthma Immunol. 117, 121–125 (2016). :36' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 7. Newcomb, D. C. & Peebles, R. S. Jr. Th17-mediated inflammation in asthma. Curr. Opin. Immunol. 25, 755–760 (2013). :37' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 8. Cosmi, L., Liotta, F. & Annunziato, F. Th17 regulating lower airway disease. Curr. Opin. Allergy Clin. Immunol. 16, 1–6 (2016). :38' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 9. Chesné, J. et al. IL-17 in severe asthma. Where do we stand? Am. J. Respir. Crit. Care Med. 190, 1094–1101 (2014). :39' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 11. Bengsch, B. et al. Human Th17 cells express high levels of enzymatically active dipeptidyl peptidase IV (CD26). J. Immunol. 188, 5438–5447 (2012). :42' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: Table 1. Characteristics of the study population. AA, allergic asthmatics; HC, healthy controls; NAA, non-allergic asthmatics; R, rhinitis patients. Data are presented as median value (IQR1–3), unless otherwise expressed.:73' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: Table 1. Characteristics of the study population. AA, allergic asthmatics; HC, healthy controls; NAA, non-allergic asthmatics; R, rhinitis patients. Data are presented as median value (IQR1–3), unless otherwise expressed.:74' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymphocytes:82' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymphocyte:83' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymphocyt:84' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymphocy:85' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymphoc:86' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lympho:87' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymph:88' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lymp:90' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 11. Bengsch, B. et al. Human Th17 cells express high levels of enzymatically active dipeptidyl peptidase IV (CD26). J. Immunol. 188, 5438–5447 (2012). :91' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 2. CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. (a) CD4+ T cells were identified by using the same strategy as in Fig. 1a. Then, CD127 and CD26 markers were used to delimitate three:94' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 2. CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. (a) CD4+ T cells were identified by using the same strategy as in Fig. 1a. Then, CD127 and CD26 markers were used to delimitate thre:95' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 2. CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. (a) CD4+ T cells were identified by using the same strategy as in Fig. 1a. Then, CD127 and CD26 markers were used to delimitate thr:96' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 2. CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. (a) CD4+ T cells were identified by using the same strategy as in Fig. 1a. Then, CD127 and CD26 markers were used to delimitate th:97' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 2. CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. (a) CD4+ T cells were identified by using the same strategy as in Fig. 1a. Then, CD127 and CD26 markers were used to delimitate t:98' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Lym:99' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to identify fiv:102' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to identify fi:104' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to identify f:105' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to identify :106' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to identif:108' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to identi:109' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to ident:110' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 3. CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. (a) CD4− lymphocytes were identified by flow cytometry (left and middle dot plots). Then CD127 and CD26 were used to iden:111' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 1. CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. (a) Gating strategy in flow cytometry assays to identify relevant CD4+ T cell subsets. Ly:101' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 4. Non-allergic asthmatics exhibit augmented proportions of CD26−/low γδ-T lymphocytes compared with allergic asthmatics. (a) Gating strategy for CD3+γδ-TCR+ lymphocytes (γδ-T cells). After gating, expression of CD127 and CD26 wa:112' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 5. siRNA mediated depletion of CD26 mRNA leads to enhanced T-cell proliferation. PBMCs from healthy subjects were isolated and placed in culture for 6 days in 96 round-well plates. To promote T-cell division, Accell culture medium was sup:113' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 5. siRNA mediated depletion of CD26 mRNA leads to enhanced T-cell proliferation. PBMCs from healthy subjects were isolated and placed in culture for 6 days in 96 round-well plates. To promote T-cell division, Accell culture medium was su:114' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 6. Generalised down-modulation of CD126 in leukocytes from patients with moderate-severe asthma. Monocytes (a), neutrophils (b), and lymphocytes (c,d) were gated on a flow cytometry FSC/SSC plot. Afterwards, lymphocytes were furth:116' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 8. Cosmi, L., Liotta, F. & Annunziato, F. Th17 regulating lower airway disease. Curr. Opin. Allergy Clin. Immunol. 16, 1–6 (2016). :121' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 47. Di Mitri, D. et al. Reversible senescence in human CD4⁜琀⬠䌀䐀㐀㔀刀䄠⬠䌀䐀㈀㜀ⴀ 洀攀洀漀爀礀 吀 挀攀氀氀猀⸀⃾＀䨀⸀ 䤀洀洀甀渀漀氀⻾＀⃾＀㄀㠀㟾＀Ⰰ ㈀　㤀㌠ጀ㈀㄀　　 ㈀　㄀㄀⻾＀㨀㄀㈀㜩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐱㜮㠲㤠㈴ㄮ㜶㌠㐲㌮㘰㔠㈲㤮㘲㉝⽈⽎⽁值㰯丠㈶㜠〠刾㸾㸊敮摯扪ਲ㔲‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_43622.indd: 17. Bailey, S. R. et al. Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence. Nat. Commun. 8, 1961 (2017). :128' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 48. Bank, I. & Marcu-Malina, V. Quantitative peripheral blood perturbations of γδ T cells in human disease and their clinical implications. Clin. Rev. Allergy Immunol. 47, 311–333 (2014). :130' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 49. Pang, D. J., Neves, J. F., Sumaria, N. & Pennington, D. J. Understanding the complexity of γδ T-cell subsets in mouse and human. Immunology 136, 283–290 (2012). :131' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 50. Dieli, F. et al. Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites. J. Exp. Med. 198, 391–397 (2003). :132' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 51. Caccamo, N. et al. Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells. Blood 118, 129–138 (2011). :133' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 52. Oberg, H. H., Wesch, D., Grüssel, S., Rose-John, S. & Kabelitz, D. Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4⁜琀⬠䌀䐀㈀㔢ሀ 愀渀搀 䌀䐀㈀㔀栀椀最栀 爀攀最甀氀愀琀漀爀礀 吀 挀攀氀氀猀⸀⃾＀䤀渀琀⸀ 䤀洀洀甀渀漀氀⻾＀⃾＀㄀㣾＀Ⰰ 㔀㔀㔠ጀ㔀㘀㌀ ㈀　　㘀⻾＀㨀㄀㌀㐩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌸㌮㘸㜠ㄳㄮ㜶㌠㌸㤮㌰㌠ㄱ㤮㘲㉝⽈⽎⽁值㰯丠㈷㐠〠刾㸾㸊敮摯扪ਲ㔹‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_43622.indd: Table 1. Characteristics of the study population. AA, allergic asthmatics; HC, healthy controls; NAA, non-allergic asthmatics; R, rhinitis patients. Data are presented as median value (IQR1–3), unless otherwise e:135' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 53. Lamas, J. R. et al. Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. Cytokine 61, 720–723 (2013). :137' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 55. Yan, I. et al. ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ralpha from the cell surface of leukocytes during inflammatory responses. J. Leukoc. Biol. 99, 749–760 (2016). :138' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 53. Lamas, J. R. et al. Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. Cytokine 61, 720–723 (2013). :139' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 56. Wolf, J. et al. A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing. Biochem. Biophys. Res. Commun. 470, 870–876 (2016). :140' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 54. Schumacher, N. et al. Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles. J. Biol. Chem. 29:141' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 57. Hemken, P. M. et al. Development and analytical performance of a new ARCHITECT automated dipeptidyl peptidase-4 immunoassay. Pract. Lab. Med. 9, 58–68 (2017). :143' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 58. Agache, I. et al. Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma. J. Allergy Clin. Immunol. 141, 442–445 (2018). :144' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 59. Hartl, D. et al. Quantitative and functional impairment of pulmonary CD4⁜琀⬠䌀䐀㈀㔀栀椀 爀攀最甀氀愀琀漀爀礀 吀 挀攀氀氀猀 椀渀 瀀攀搀椀愀琀爀椀挀 愀猀琀栀洀愀⸀⃾＀䨀⸀ 䄀氀氀攀爀最礀 䌀氀椀渀⸀ 䤀洀洀甀渀漀氀⻾＀⃾＀㄀㄀㧾＀Ⰰ ㄀㈀㔀㠠ጀ㄀㈀㘀㘀 ㈀　　㜀⻾＀㨀㄀㐀㠩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌸〮㜵㌠㘵㐮㜶㌠㌸㘮㌶㤠㘴㈮㘲㉝⽈⽎⽁值㰯丠㌱㤠〠刾㸾㸊敮摯扪ਲ㤷‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_43622.indd: 12. Salgado, F. J. et al. CD26: a negative selection marker for human Treg cells. Cytometry A 81, 843–855 (2012). :149' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 12. Salgado, F. J. et al. CD26: a negative selection marker for human Treg cells. Cytometry A 81, 843–855 (2012). :149' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 60. Mandapathil, M. et al. CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma. Oncoimmunology 1, 659–669 (2012). :150' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 61. Deaglio, S. et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257–1265 (2007). :151' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 62. De Meester, I. et al. Binding of adenosine deaminase to the lymphocyte surface via CD26. Eur. J. Immunol. 24, 566–570 (1994). :152' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 63. Moreno, E. et al. Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins. Front. Pharmacol. 9, 106 (2018). :153' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 66. Doganci, A. et al. The IL-6R alpha chain controls lung CD4⁜琀⬠䌀䐀㈀㔀⬀ 吀爀攀最 搀攀瘀攀氀漀瀀洀攀渀琀 愀渀搀 昀甀渀挀琀椀漀渀 搀甀爀椀渀最 愀氀氀攀爀最椀挀 愀椀爀眀愀礀 椀渀昀氀愀洀洀愀琀椀漀渀⃾＀椀渀 瘀椀瘀濾＀⸀⃾＀䨀⸀ 䌀氀椀渀⸀ 䤀渀瘀攀猀琀⻾＀⃾＀㄀㄀㗾＀Ⰰ ㌀㄀㌠ጀ㌀㈀㔀 ㈀　　㔀⻾＀㨀㄀㔀㤩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐷㔮㠲㜠㔳㐮㜶㌠㐸ㄮ㐶㈠㔲㈮㘲㉝⽈⽎⽁值㰯丠㌳〠〠刾㸾㸊敮摯扪ਲ਼〸‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_43622.indd: 28. Jones, G. W. et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol. 184, 2130–2139 (2010). :160' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd: 67. Wang, Y. et al. The IL6R gene polymorphisms are associated with sIL-6R, IgE and lung function in Chinese patients with asthma. Gene 585, 51–57 (2016). :161' cannot be found Offset: 3345101 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_43622.indd:Figure 2. CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. (a) CD4+ T cells were identified by using the same strategy as in Fig. 1a. Then, CD127 and CD26 markers were used to delimitate :162' cannot be found Offset: 3345101 MIMEtype: application/pdf PDFMetadata: Objects: 570 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Expansion of different subpopulations of CD26−/low T cells in allergic and non-allergic asthmatics Children: Item: Title: Results Children: Item: Title: Characteristics of study subjects. Item: Title: CD26 and CD126 molecules display a highly correlated expression on lymphocytes, while the expansion of “triple low” (CD25−C ... Item: Title: The CD4+CD26−/low T compartment from allergic asthmatics includes memory cells in an advanced stage of differentiation. Item: Title: Non-allergic asthmatics display increased proportions of CD26−CD127− and CD126−CD127− subpopulations amongst CD4− lymphocyt ... Item: Title: The CD26−/low subpopulation of γδ-T lymphocytes is augmented in non-allergic compared to allergic asthmatics. Item: Title: CD26 could act as a negative regulator of T-cell proliferation. Item: Title: CD126/IL-6Rα down-modulation in neutrophils, monocytes, and lymphocytes is associated to disease severity and asthma contro ... Item: Title: Discussion Item: Title: Material and Methods Children: Item: Title: Subjects. Item: Title: Biochemical determinations. Item: Title: Flow cytometry assays. Item: Title: In vitro proliferation assays and CD26 mRNA silencing. Item: Title: Statistics. Item: Title: Acknowledgements Item: Title: Figure 1 CD26 and CD126/IL-6Rα display a coordinated expression on effector CD4+ T cells, but only CD26/sCD26 levels are altered in asthma. Item: Title: Figure 2 CD26−/low CD4+ T cells contain effector lymphocytes with an advanced differentiation stage. Item: Title: Figure 3 CD4− lymphocytes with a highly differentiated memory phenotype are expanded in non-allergic asthma. Item: Title: Figure 4 Non-allergic asthmatics exhibit augmented proportions of CD26−/low γδ-T lymphocytes compared with allergic asthmatics. Item: Title: Figure 5 siRNA mediated depletion of CD26 mRNA leads to enhanced T-cell proliferation. Item: Title: Figure 6 Generalised down-modulation of CD126 in leukocytes from patients with moderate-severe asthma. Item: Title: Table 1 Characteristics of the study population. 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