b9c93ae2eaa80ed7efa900017b3d7a2d pmc_31109060.pdf 2480fae2cdd521bb02030f0b0b40cec3677ca63e pmc_31109060.pdf ce669ba55ce911058d59db85fbc79b00e68c9a26270d3d9b225a1370f6f4a6c1 pmc_31109060.pdf Title: Cross-Talk between Inflammatory Mediators and the Epithelial Mesenchymal Transition Process in the Development of Thyroid Carcinoma Subject: There is strong association between inflammatory processes and their main metabolic mediators, such as leptin, adiponectin secretion, and low/high-density lipoproteins, with the cancer risk and aggressive behavior of solid tumors. In this scenario, cancer cells (CCs) and cancer stem cells (CSCs) have important roles. These cellular populations, which come from differentiated cells and progenitor stem cells, have increased metabolic requirements when it comes to maintaining or expanding the tumors, and they serve as links to some inflammatory mediators. Although the molecular mechanisms that are involved in these associations remain unclear, the two following cellular pathways have been suggested: 1) the mesenchymal-epithelial transition (MET) process, which permits the differentiation of adult stem cells throughout the acquisition of cell polarity and the adhesion to epithelia, as well to new cellular lineages (CSCs); and, 2) a reverse process, termed the epithelial-mesenchymal transition (EMT), where, in pathophysiological conditions (tissue injury, inflammatory process, and oxidative stress), the differentiated cells can acquire a multipotent stem cell-like phenotype. The molecular mechanisms that regulate both EMT and MET are complex and poorly understood. Especially, in the thyroid gland, little is known regarding MET/EMT and the role of CCs or CSCs, providing an exciting, new area of knowledge to be investigated. This article reviews the progress to date in research on the role of inflammatory mediators and metabolic reprogramming during the carcinogenesis process of the thyroid gland and the EMT pathways. Keywords: thyroid carcinoma; signaling pathways; MET/EMT; leptin; adiponectin; low-density lipoproteins; high-density lipoproteins Author: Giovanna Revilla, Rosa Corcoy, Antonio Moral, Joan Carles Escolà-Gil and Eugenia Mato Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat May 18 10:55:09 2019 CEST ModDate: Sat May 18 10:55:09 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1919774 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TEUCVT+URWPalladioL-Ital Type 1 Custom yes yes no 91 0 SVLNYF+URWPalladioL-Bold Type 1 Custom yes yes no 92 0 WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes no 93 0 CLFPZP+URWPalladioL-Roma Type 1 Custom yes yes no 94 0 KORLVE+VnURWPalladioL Type 1 Custom yes yes no 95 0 SYXPPI+Rpxr Type 1 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0 BOLCKL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 636 0 BOLDEI+TimesNewRoman CID TrueType Identity-H yes yes yes 637 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 922 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:42:45 CEST RepresentationInformation: pmc_31109060.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 04:12:11 CEST Size: 1919774 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 3 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: くひどでどのぜ〴ぜ〰はてぜ〴ぜ〰ぅばどぴとづぬどちぬぜ〴ぜ〰ごとべひはどつぜ〴ぜ〰ぃちひっどのはねちぜ〴ぜ〰ぜ〵ぜ〰ぅごぃぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰はてぜ〴ぜ〰ぅごぃぜ〴ぜ〰くのっはでづのづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ごとべひはどつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぜ〵ぜ〰ぃぃびぜ〵ㅜ〰ぜ〴ぜ〰ちのつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぜ〵ぜ〰ぃこぃびぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぅきご〯きぅごぜ〴ぜ〰ぐひはっづびびづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰はてぜ〴ぜ〰ぅごぃぜ〴ぜ〰くのっはでづのづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ごとべひはどつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぜ〵ぜ〰ぃぃびぜ〵ㅜ〰ぜ〴ぜ〰ちのつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぜ〵ぜ〰ぃこぃびぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぅきご〯きぅごぜ〴ぜ〰ぐひはっづびびづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごとべひはどつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぜ〵ぜ〰ぃぃびぜ〵ㅜ〰ぜ〴ぜ〰ちのつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰こぴづねぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぜ〵ぜ〰ぃこぃびぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぅきご〯きぅごぜ〴ぜ〰ぐひはっづびびづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅきご〯きぅごぜ〴ぜ〰ぐひはっづびびづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごどびびふづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰きづつどちぴはひびぜ〴ぜ〰どのぜ〴ぜ〰げづぬちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅきごぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰どのぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぁつどばはびづぜ〴ぜ〰ごどびびふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸱ Children: Item: Title: ぁつどばはびづぜ〴ぜ〰ごどびびふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸱ Children: Item: Title: がづばぴどのぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴびぜ〴ぜ〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸲ Item: Title: がづばぴどのぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅきごぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸳ Item: Title: ぁつどばはのづっぴどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸴ Item: Title: ぁつどばはのづっぴどのぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸵ Item: Title: ぁつどばはのづっぴどの〬ぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅきごぜ〴ぜ〰ぐひはっづびびぜ〴ぜ〰ちのつぜ〴ぜ〰ぅごぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぐぬちびねちぜ〴ぜ〰がどばはばひはぴづどのぜ〴ぜ〰ぐちひぴどっぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸱ Item: Title: ぐぬちびねちぜ〴ぜ〰がどばはばひはぴづどのぜ〴ぜ〰ぐちひぴどっぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸱ Children: Item: Title: げはぬづぜ〴ぜ〰はてぜ〴ぜ〰がはぷ〭いづのびどぴべぜ〴ぜ〰がどばはばひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸲ Item: Title: げはぬづぜ〴ぜ〰はてぜ〴ぜ〰えどでと〭いづのびどぴべぜ〴ぜ〰がどばはばひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづてづひづのっづび Filters: 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