7a28326a8946fd4895cd9ecc67bfdf57  pmc_31138531.pdf
6e7ef066882ecb1cb5b157ff8d1ec40d91998cc4  pmc_31138531.pdf
c9b6a39415fcfb94655f135d7190733da2334dbd8f663b46f698726b9bcc83d9  pmc_31138531.pdf

Creator:        Adobe InDesign CS6 (Windows)
Producer:       Adobe PDF Library 10.0.1
CreationDate:   Fri Jun  7 07:24:52 2019 CEST
ModDate:        Fri Jun  7 07:24:53 2019 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          7
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      414058 bytes
Optimized:      yes
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
XJUXJT+ArialMT                       CID TrueType      Identity-H       yes yes yes    293  0
LJQWCR+FrutigerLTPro-LightCn         Type 1C           Custom           yes yes yes    276  0
KFGQOT+FrutigerLTPro-BoldCn          Type 1C           Custom           yes yes yes    277  0
ZMTJLP+FrutigerLTPro-Condensed       Type 1C           Custom           yes yes yes    278  0
KFGQOT+FrutigerLTPro-LightCnIta      Type 1C           Custom           yes yes yes    294  0
VGVLHX+ClassicalGaramondBT-Roman     TrueType          WinAnsi          yes yes yes    301  0
LJQWCR+FrutigerLTPro-LightCn         Type 1C           WinAnsi          yes yes yes    343  0
KFGQOT+FrutigerLTPro-LightCnIta      Type 1C           Custom           yes yes yes    345  0
KFGQOT+FrutigerLTPro-BoldCn          Type 1C           WinAnsi          yes yes yes    347  0
LJQWCR+FrutigerLTPro-LightCn         Type 1C           WinAnsi          yes yes yes    206  0
KFGQOT+FrutigerLTPro-LightCnIta      Type 1C           Custom           yes yes yes    204  0
KFGQOT+FrutigerLTPro-BoldCn          Type 1C           WinAnsi          yes yes yes    202  0
UCGFTZ+FrutigerLTPro-CondensedIta    Type 1C           WinAnsi          yes yes yes    215  0
LJQWCR+FrutigerLTPro-LightCn         Type 1C           WinAnsi          yes yes yes    213  0
KFGQOT+FrutigerLTPro-LightCnIta      Type 1C           Custom           yes yes yes    211  0
KFGQOT+FrutigerLTPro-BoldCn          Type 1C           WinAnsi          yes yes yes    209  0
SZHTRD+FrutigerLTStd-BoldCn          Type 1C           WinAnsi          yes yes yes    219  0
SZHTRD+Symbol                        Type 1C           Custom           yes yes yes    218  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-08-10 12:42:02 CEST
 RepresentationInformation: pmc_31138531.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-03-02 04:15:10 CET
  Size: 414058
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 362
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study population
         Item: 
          Title: Autoantibody testing
         Item: 
          Title: Genotyping
         Item: 
          Title: HLA imputation
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Autoantibody frequencies in the study population
         Item: 
          Title: Strong classical HLA associations are observed in IIM autoantibody subgroups
         Item: 
          Title: Amino acid positions may be more strongly associated than classical HLA alleles
         Item: 
          Title: HLA alleles may differentiate adult-onset and juvenile-onset patients with anti-TIF1 autoantibodies
       Item: 
        Title: Discussion
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign CS6 (Windows)
    Producer: Adobe PDF Library 10.0.1
    CreationDate: Fri Jun 07 07:24:52 CEST 2019
    ModDate: Fri Jun 07 07:24:53 CEST 2019
   ID: 0x72127ee0e8cbcc40acfd093ed4ff4b0b, 0x34b2d0aa2109e34e8c7f4cddb8f08019
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type0: 
     Font: 
      BaseFont: XJUXJT+ArialMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: LJQWCR+FrutigerLTPro-LightCn
      FontSubset: true
      FirstChar: 28
      LastChar: 253
      FontDescriptor: 
       FontName: LJQWCR+FrutigerLTPro-LightCn
       Flags: Nonsymbolic
       FontBBox: -100, -250, 1000, 919
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KFGQOT+FrutigerLTPro-BoldCn
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: KFGQOT+FrutigerLTPro-BoldCn
       Flags: Nonsymbolic
       FontBBox: -112, -250, 1000, 940
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ZMTJLP+FrutigerLTPro-Condensed
      FontSubset: true
      FirstChar: 29
      LastChar: 215
      FontDescriptor: 
       FontName: ZMTJLP+FrutigerLTPro-Condensed
       Flags: Nonsymbolic
       FontBBox: -105, -250, 1000, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KFGQOT+FrutigerLTPro-LightCnIta
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: KFGQOT+FrutigerLTPro-LightCnIta
       Flags: Nonsymbolic
       FontBBox: -161, -250, 991, 919
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UCGFTZ+FrutigerLTPro-CondensedIta
      FontSubset: true
      FirstChar: 48
      LastChar: 58
      FontDescriptor: 
       FontName: UCGFTZ+FrutigerLTPro-CondensedIta
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -250, 992, 929
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SZHTRD+Symbol
      FontSubset: true
      FirstChar: 29
      LastChar: 31
      FontDescriptor: 
       FontName: SZHTRD+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SZHTRD+FrutigerLTStd-BoldCn
      FontSubset: true
      FirstChar: 67
      LastChar: 83
      FontDescriptor: 
       FontName: SZHTRD+FrutigerLTStd-BoldCn
       Flags: Nonsymbolic
       FontBBox: -112, -250, 1000, 940
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: VGVLHX+ClassicalGaramondBT-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 215
      FontDescriptor: 
       FontName: VGVLHX+ClassicalGaramondBT-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -237, 1261, 963
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: XJUXJT+ArialMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: XJUXJT+ArialMT
       Flags: Symbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.3-c011 66.145661, 2012/02/06-14:56:27        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:identifier>doi:annrheumdis-2019-215046</dc:identifier>
         <dc:format>application/pdf</dc:format>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2019-06-07T06:24:52+01:00</xmp:CreateDate>
         <xmp:MetadataDate>2019-06-07T06:24:53+01:00</xmp:MetadataDate>
         <xmp:ModifyDate>2019-06-07T06:24:53+01:00</xmp:ModifyDate>
         <xmp:CreatorTool>Adobe InDesign CS6 (Windows)</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:InstanceID>uuid:6d86b502-bb84-4bd3-8ed9-4a7ed3db9d25</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>xmp.did:B2C59A163194E611BD009A7CB80B8EC7</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:F26BFE92E488E911A5E8D1F0A76C5697</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:F16BFE92E488E911A5E8D1F0A76C5697</stRef:instanceID>
            <stRef:documentID>xmp.did:F55F4D56162068118C14CF26067AF65C</stRef:documentID>
            <stRef:originalDocumentID>xmp.did:B2C59A163194E611BD009A7CB80B8EC7</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign CS6 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2019-06-07T06:24:52+01:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:jobID>f20e7bbe-9143-4417-8e4c-de96bcf7fc7e</pdfx:jobID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Adobe PDF Library 10.0.1</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 996
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 63, 38, 110, 20
      Annotation: 
       Subtype: Link
       Rect: 530, 34, 555, 18
      Annotation: 
       Subtype: Link
       Rect: 221, 657, 227, 642
      Annotation: 
       Subtype: Link
       Rect: 306, 657, 311, 642
      Annotation: 
       Subtype: Link
       Rect: 390, 642, 395, 627
      Annotation: 
       Subtype: Link
       Rect: 500, 642, 506, 627
      Annotation: 
       Subtype: Link
       Rect: 384, 627, 389, 612
      Annotation: 
       Subtype: Link
       Rect: 444, 582, 450, 567
      Annotation: 
       Subtype: Link
       Rect: 44, 452, 119, 443
      Annotation: 
       Subtype: Link
       Rect: 42, 443, 122, 434
      Annotation: 
       Subtype: Link
       Rect: 40, 171, 136, 148
      Annotation: 
       Subtype: Link
       Rect: 469, 54, 477, 43
       ActionDest: 127
    Page: 
     Label: 997
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 736, 226, 725
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 285, 713, 288, 703
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 81, 613, 84, 602
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 90, 579, 93, 568
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 128, 545, 131, 534
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 253, 478, 256, 467
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 89, 444, 102, 434
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 151, 400, 157, 389
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 236, 388, 240, 378
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 187, 332, 194, 321
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 234, 211, 288, 201
      Annotation: 
       Subtype: Link
       Rect: 42, 200, 102, 189
      Annotation: 
       Subtype: Link
       Rect: 108, 200, 111, 189
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 209, 155, 213, 145
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 197, 133, 203, 122
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 168, 110, 172, 100
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 529, 725, 553, 714
      Annotation: 
       Subtype: Link
       Rect: 306, 714, 394, 703
      Annotation: 
       Subtype: Link
       Rect: 529, 714, 553, 703
      Annotation: 
       Subtype: Link
       Rect: 306, 703, 395, 692
      Annotation: 
       Subtype: Link
       Rect: 347, 613, 351, 602
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 471, 556, 477, 545
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 546, 434, 553, 423
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 359, 194, 387, 184
       ActionDest: 54
      Annotation: 
       Subtype: Link
       Rect: 446, 54, 553, 43
    Page: 
     Label: 998
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 496, 47, 485
      Annotation: 
       Subtype: Link
       Rect: 187, 430, 213, 419
       ActionDest: 54
      Annotation: 
       Subtype: Link
       Rect: 234, 265, 288, 254
      Annotation: 
       Subtype: Link
       Rect: 42, 254, 104, 243
      Annotation: 
       Subtype: Link
       Rect: 482, 496, 553, 485
      Annotation: 
       Subtype: Link
       Rect: 306, 485, 366, 474
    Page: 
     Label: 999
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 168, 109, 194, 98
       ActionDest: 72
      Annotation: 
       Subtype: Link
       Rect: 133, 54, 248, 43
      Annotation: 
       Subtype: Link
       Rect: 442, 143, 469, 132
       ActionDest: 54
      Annotation: 
       Subtype: Link
       Rect: 317, 121, 453, 110
    Page: 
     Label: 1000
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 96, 617, 126, 606
       ActionDest: 72
      Annotation: 
       Subtype: Link
       Rect: 44, 329, 72, 318
       ActionDest: 83
      Annotation: 
       Subtype: Link
       Rect: 367, 615, 484, 604
      Annotation: 
       Subtype: Link
       Rect: 355, 430, 492, 419
      Annotation: 
       Subtype: Link
       Rect: 538, 308, 545, 297
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 427, 220, 442, 209
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 404, 209, 411, 198
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 431, 55, 547, 44
    Page: 
     Label: 1001
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 250, 713, 257, 702
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 138, 656, 144, 645
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 134, 611, 141, 600
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 272, 599, 276, 589
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 217, 475, 232, 464
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 271, 452, 277, 441
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 235, 418, 249, 407
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 57, 407, 63, 396
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 103, 407, 110, 396
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 151, 372, 157, 362
       ActionDest: 127
      Annotation: 
       Subtype: Link
       Rect: 107, 293, 121, 282
       ActionDest: 127
    Page: 
     Label: 1002
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 111, 239, 247, 230
      Annotation: 
       Subtype: Link
       Rect: 143, 153, 180, 145
      Annotation: 
       Subtype: Link
       Rect: 136, 135, 170, 127
      Annotation: 
       Subtype: Link
       Rect: 251, 117, 286, 108
      Annotation: 
       Subtype: Link
       Rect: 229, 99, 282, 90
      Annotation: 
       Subtype: Link
       Rect: 125, 63, 168, 54
      Annotation: 
       Subtype: Link
       Rect: 361, 728, 386, 720
      Annotation: 
       Subtype: Link
       Rect: 319, 692, 361, 684
      Annotation: 
       Subtype: Link
       Rect: 362, 656, 387, 648
      Annotation: 
       Subtype: Link
       Rect: 437, 629, 483, 621
      Annotation: 
       Subtype: Link
       Rect: 319, 602, 356, 594
      Annotation: 
       Subtype: Link
       Rect: 319, 575, 354, 567
      Annotation: 
       Subtype: Link
       Rect: 371, 521, 424, 513
      Annotation: 
       Subtype: Link
       Rect: 393, 503, 419, 495
      Annotation: 
       Subtype: Link
       Rect: 500, 486, 533, 476
      Annotation: 
       Subtype: Link
       Rect: 512, 431, 551, 423
      Annotation: 
       Subtype: Link
       Rect: 419, 395, 458, 387
      Annotation: 
       Subtype: Link
       Rect: 366, 368, 409, 360
      Annotation: 
       Subtype: Link
       Rect: 349, 341, 482, 333
      Annotation: 
       Subtype: Link
       Rect: 524, 323, 551, 315
      Annotation: 
       Subtype: Link
       Rect: 319, 314, 335, 306
      Annotation: 
       Subtype: Link
       Rect: 524, 296, 547, 288
      Annotation: 
       Subtype: Link
       Rect: 319, 287, 338, 279
      Annotation: 
       Subtype: Link
       Rect: 421, 260, 463, 252
      Annotation: 
       Subtype: Link
       Rect: 418, 234, 460, 224
      Annotation: 
       Subtype: Link
       Rect: 494, 215, 533, 207
      Annotation: 
       Subtype: Link
       Rect: 461, 188, 500, 180
      Annotation: 
       Subtype: Link
       Rect: 495, 161, 538, 153
      Annotation: 
       Subtype: Link
       Rect: 520, 134, 544, 126
      Annotation: 
       Subtype: Link
       Rect: 319, 125, 338, 117
      Annotation: 
       Subtype: Link
       Rect: 319, 107, 372, 99
      Annotation: 
       Subtype: Link
       Rect: 502, 71, 542, 63
  Checksum: ddfd36c7
   Type: CRC32
  Checksum: 7a28326a8946fd4895cd9ecc67bfdf57
   Type: MD5
  Checksum: 6e7ef066882ecb1cb5b157ff8d1ec40d91998cc4
   Type: SHA-1