4d92a388d2ff71c9bf6650024db2ca9b pmc_31181663.pdf 70de7b442acad64afd06c6b0cc94bc28805fb86e pmc_31181663.pdf 2431e5b5771f37f05b178b47ad388e2a6954dbd011f7c4e3f599da4e87fd78c8 pmc_31181663.pdf Title: BarkBase: Epigenomic Annotation of Canine Genomes Subject: Dogs are an unparalleled natural model for investigating the genetics of health and disease, particularly for complex diseases like cancer. Comprehensive genomic annotation of regulatory elements active in healthy canine tissues is crucial both for identifying candidate causal variants and for designing functional studies needed to translate genetic associations into disease insight. Currently, canine geneticists rely primarily on annotations of the human or mouse genome that have been remapped to dog, an approach that misses dog-specific features. Here, we describe BarkBase, a canine epigenomic resource available at barkbase.org. BarkBase hosts data for 27 adult tissue types, with biological replicates, and for one sample of up to five tissues sampled at each of four carefully staged embryonic time points. RNA sequencing is complemented with whole genome sequencing and with assay for transposase-accessible chromatin using sequencing (ATAC-seq), which identifies open chromatin regions. By including replicates, we can more confidently discern tissue-specific transcripts and assess differential gene expression between tissues and timepoints. By offering data in easy-to-use file formats, through a visual browser modeled on similar genomic resources for human, BarkBase introduces a powerful new resource to support comparative studies in dogs and humans. Keywords: dog; expression; genome; annotation; ATAC-seq; RNA-seq; epigenomic; canine; comparative Author: Kate Megquier, Diane P. Genereux, Jessica Hekman, Ross Swofford, Jason Turner-Maier, Jeremy Johnson, Jacob Alonso, Xue Li, Kathleen Morrill, Lynne J. Anguish, Michele Koltookian, Brittney Logan, Claire R. Sharp, Lluis Ferrer, Kerstin Lindblad-Toh, Vicki N. Meyers-Wallen, Andrew Hoffman and Elinor K. 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CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こちねばぬづぜ〴ぜ〰ぃはぬぬづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸱ Children: Item: Title: こちねばぬづぜ〴ぜ〰ぃはぬぬづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸱ Children: Item: Title: ぁつふぬぴぜ〴ぜ〰ごどびびふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸱⸲ Item: Title: ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰しとはぬづぜ〴ぜ〰ぇづのはねづぜ〴ぜ〰こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸱ Item: Title: しとはぬづぜ〴ぜ〰ぇづのはねづぜ〴ぜ〰こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸱ Children: Item: Title: こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ざちひどちのぴぜ〴ぜ〰ぃちぬぬどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸲ Item: Title: げづぬちぴづつのづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸲⸳ Item: Title: ぁののはぴちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰げぎぁぜ〴ぜ〰こづぱふづのっどので〬ぜ〴ぜ〰ぎはひねちぬどぺちぴどはの〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Item: Title: げぎぁぜ〴ぜ〰こづぱふづのっどので〬ぜ〴ぜ〰ぎはひねちぬどぺちぴどはの〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸱ Children: Item: Title: こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸲ Item: Title: げづちつぜ〴ぜ〰ぐひづばひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸳ Item: Title: ごききぜ〴ぜ〰ぎはひねちぬどぺちぴどはのぜ〴ぜ〰ぴはぜ〴ぜ〰ぃちぬっふぬちぴづぜ〴ぜ〰ぃはふのぴびぜ〴ぜ〰ぐづひぜ〴ぜ〰きどぬぬどはのぜ〴ぜ〰ぜ〵ぜ〰ぃぐきぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸴ Item: Title: ぃふねふぬちぴどぶづぜ〴ぜ〰ぁぢふのつちのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ごどびびふづ〭こばづっどてどっぜ〴ぜ〰げづちつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸵ Item: Title: えどづひちひっとどっちぬぜ〴ぜ〰ぃぬふびぴづひどのでぜ〴ぜ〰はてぜ〴ぜ〰こちねばぬづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつふぬぴぜ〴ぜ〰いはでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸶ Item: Title: いどててづひづのぴどちぬぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぜ〵ぜ〰いぇぅぜ〵ㅜ〰ぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのひどっとねづのぴぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰いちぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸷ Item: Title: ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰いはでぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸸ Item: Title: ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ごひちのびっひどばぴぜ〴ぜ〰こづぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへどびぴどのでぜ〴ぜ〰ぅのびづねぢぬぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰げづてづひづのっづぜ〴ぜ〰ぁののはぴちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸳⸹ Item: Title: ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰さのちののはぴちぴづつぜ〴ぜ〰ごひちのびっひどばぴびぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰げづてこづぱぜ〴ぜ〰ざづひぴづぢひちぴづぜ〴ぜ〰きちねねちぬどちのぜ〴ぜ〰ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Item: Title: ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸱ Children: Item: Title: こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸲ Item: Title: ぐひはっづびびどのでぜ〴ぜ〰げづちつび〬ぜ〴ぜ〰ぃちぬぬどのでぜ〴ぜ〰ぐづちにび〬ぜ〴ぜ〰ちのつぜ〴ぜ〰けぃぜ〴ぜ〰はてぜ〴ぜ〰がどぢひちひどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸳ Item: Title: ぁびびづびびどのでぜ〴ぜ〰くぶづひぬちばぜ〴ぜ〰はてぜ〴ぜ〰ぐづちにびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸲⸴⸴ Item: Title: いちぴちぜ〴ぜ〰ことちひどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰あちひにあちびづぜ〴ぜ〰しづぢびどぴづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰しとはぬづぜ〴ぜ〰ぇづのはねづぜ〴ぜ〰こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰くぶづひぬちばぜ〴ぜ〰しどぴとぜ〴ぜ〰ぅへどびぴどのでぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぁののはぴちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢどぬどぴべぜ〴ぜ〰ぁねはのでぜ〴ぜ〰ぁつふぬぴぜ〴ぜ〰いはでびぜ〴ぜ〰ちのつぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: あちひにあちびづぜ〴ぜ〰しづぢびどぴづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰しとはぬづぜ〴ぜ〰ぇづのはねづぜ〴ぜ〰こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰くぶづひぬちばぜ〴ぜ〰しどぴとぜ〴ぜ〰ぅへどびぴどのでぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぁののはぴちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢどぬどぴべぜ〴ぜ〰ぁねはのでぜ〴ぜ〰ぁつふぬぴぜ〴ぜ〰いはでびぜ〴ぜ〰ちのつぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: しとはぬづぜ〴ぜ〰ぇづのはねづぜ〴ぜ〰こづぱふづのっどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰くぶづひぬちばぜ〴ぜ〰しどぴとぜ〴ぜ〰ぅへどびぴどのでぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぁののはぴちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢどぬどぴべぜ〴ぜ〰ぁねはのでぜ〴ぜ〰ぁつふぬぴぜ〴ぜ〰いはでびぜ〴ぜ〰ちのつぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: くぶづひぬちばぜ〴ぜ〰しどぴとぜ〴ぜ〰ぅへどびぴどのでぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぁののはぴちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ざちひどちぢどぬどぴべぜ〴ぜ〰ぁねはのでぜ〴ぜ〰ぁつふぬぴぜ〴ぜ〰いはでびぜ〴ぜ〰ちのつぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ざちひどちぢどぬどぴべぜ〴ぜ〰ぁねはのでぜ〴ぜ〰ぁつふぬぴぜ〴ぜ〰いはでびぜ〴ぜ〰ちのつぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのどのづぜ〴ぜ〰ちのつぜ〴ぜ〰えふねちのぜ〴ぜ〰ごどびびふづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げぎぁ〭こづぱふづのっどのでぜ〴ぜ〰はてぜ〴ぜ〰ぅねぢひべはのどっぜ〴ぜ〰ごどびびふづびぜ〴ぜ〰ちぴぜ〴ぜ〰きふぬぴどばぬづぜ〴ぜ〰ごどねづぜ〴ぜ〰ぐはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁごぁぃ〭びづぱぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㠩‾㸊⡜㌷㙜㌷㝜〰ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぎはぶづぬぜ〴ぜ〰ぇづのづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぁごぁぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VSHNAE+Rpcxr FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: VSHNAE+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: WWQLWV+Pxsy FontSubset: true FirstChar: 0 LastChar: 20 FontDescriptor: FontName: WWQLWV+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: WBVKDJ+URWPalladioL-BoldItal FontSubset: true FirstChar: 112 LastChar: 112 FontDescriptor: FontName: WBVKDJ+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XGJLNN+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: XGJLNN+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: 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