947d90940d4260a01b67e5aaab7c7698 pmc_31222137.pdf 718d9f8b1681b46e5f5f588b6d91a277a090b559 pmc_31222137.pdf 1d9446d5a563379b60345555281decc6d451f196bdd9627a27e06da6e9826c4a pmc_31222137.pdf Title: Cholesterol-Lowering Treatment in Chronic Kidney Disease: Multistage Pairwise and Network Meta-Analyses Subject: Scientific Reports, doi:10.1038/s41598-019-45431-5 Keywords: Author: Francisco Herrera-Gamp#x000F3;mez Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Jun 13 13:34:34 2019 CEST ModDate: Fri Jun 14 17:28:14 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2503727 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TTINCW+Corbel-Bold CID TrueType Identity-H yes yes yes 93 0 GKYZCW+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 618 0 MinionPro-Regular Type 1C Custom yes no yes 94 0 QVNAYJ+Corbel-Bold2 Type 1C WinAnsi yes yes yes 95 0 FYBCCK+Corbel2 Type 1C WinAnsi yes yes yes 96 0 IXZEES+Corbel CID TrueType Identity-H yes yes yes 97 0 MyriadPro-It Type 1C WinAnsi yes no yes 98 0 FYBCCK+Corbel2 Type 1C WinAnsi yes yes yes 540 0 MinionPro-Bold Type 1C WinAnsi yes no yes 159 0 EuclidSymbol Type 1C Custom yes no yes 160 0 MinionPro-It Type 1C Custom yes no yes 271 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:39:39 CEST RepresentationInformation: pmc_31222137.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:11:09 CET Size: 2503727 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd:Figure 1. The PRISMA flowcharts presenting the selection processes used in the two systematic reviews. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.:42' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd:Figure 2. The effect of cholesterol-lowering treatment on MACEs when the eGFR is lower than 60⁜琀洀氀⼀洀椀渀⼀㄀⸀㜀㌠淾＀㋾＀ 攀砀挀氀甀搀椀渀最 搀椀愀氀礀猀椀猀 瀀愀琀椀攀渀琀猀⸀ ＀懾＀ 䄀氀氀 琀爀椀愀氀猀⸀ ＀拾＀ 倀爀椀洀愀爀礀 瀀爀攀瘀攀渀琀椀漀渀 琀爀椀愀氀猀⸀ 䌀䤀Ⰰ 挀漀渀昀椀搀攀渀挀攀 椀渀琀攀爀瘀愀氀㬀 攀䜀䘀刀Ⰰ 攀猀琀椀洀愀琀攀搀 最氀漀洀攀爀甀氀愀爀㨀㘀ㄩ⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌷㔮㌵㈠㈰㐮㘴㈠㌹〮㘳㠠ㄹ㈮㔰ㅝ⽈⽎⽁值㰯丠㜵‰⁒㸾㸾੥湤潢樊㌶‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_45431.indd:Figure 3. SUCRA-based ranking of all statins and the combination of simvastatin plus ezetimibe when the eGFR is lower than 60⁜琀洀氀⼀洀椀渀⼀㄀⸀㜀㌠淾＀㋾＀ 攀砀挀氀甀搀椀渀最 搀椀愀氀礀猀椀猀 瀀愀琀椀攀渀琀猀⸀ 攀䜀䘀刀Ⰰ 攀猀琀椀洀愀琀攀搀 最氀漀洀攀爀甀氀愀爀 昀椀氀琀爀愀琀椀漀渀 爀愀琀攀㬀 匀唀䌀刀䄀Ⰰ 猀甀爀昀愀挀攀 甀渀搀攀爀 琀栀攀 挀甀㨀㘀㈩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐹㔮㐴㌠ㄳ㐮㘴㈠㐹㤮㜸ㄠㄲ㈮㔰ㅝ⽈⽎⽁值㰯丠㜶‰⁒㸾㸾੥湤潢樊㌷‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_45431.indd: 40. Salanti, G., Ades, A. E. & Ioannidis, J. P. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J. Clin. Epidemiol. 64, 163–171, https://doi.org/10.1016/j.j:63' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd:Figure 3. SUCRA-based ranking of all statins and the combination of simvastatin plus ezetimibe when the eGFR is lower than 60⁜琀洀氀⼀洀椀渀⼀㄀⸀㜀㌠淾＀㋾＀ 攀砀挀氀甀搀椀渀最 搀椀愀氀礀猀椀猀 瀀愀琀椀攀渀琀猀⸀ 攀䜀䘀刀Ⰰ 攀猀琀椀洀愀琀攀搀 最氀漀洀攀爀甀氀愀爀 昀椀氀琀爀愀琀椀漀渀 爀愀琀攀㬀 匀唀䌀刀䄀Ⰰ 猀甀爀昀愀挀攀 甀渀搀攀爀 琀栀攀 挀甀㨀㘀㈩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐹㔮㐴㌠ㄳ㐮㘴㈠㐹㤮㜸ㄠㄲ㈮㔰ㅝ⽈⽎⽁值㰯丠㜶‰⁒㸾㸾੥湤潢樊㌷‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_45431.indd: 40. Salanti, G., Ades, A. E. & Ioannidis, J. P. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J. Clin. Epidemiol. 64, 163–171, https://doi.org/10.1016/j.j:63' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd:Figure 4. Network diagram for the competing cholesterol-lowering treatment strategies (Markov chain Monte Carlo simulation).:64' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd:Figure 5. Network forest plot of the fixed and random effects of the competing cholesterol-lowering treatment strategies. CrI, credible intervals; OR, odds ratio.:65' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd:Figure 6. Inconsistency plot of the random effects for the competing cholesterol-lowering treatment strategies.:66' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 35. Brouwers, F. P. et al. Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria: Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND:69' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 17. Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181–2192,:76' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 37. Ridker, P. M. et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N. Engl. J. Med. 344, 1959–1965, https://doi.org/10.1056/NEJM200106283442601 (2001:79' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 39. Ridker, P. M. et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 373, 1175–1182, https://doi.org/10.1016/S0:80' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 37. Ridker, P. M. et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N. Engl. J. Med. 344, 1959–1965, https://doi.org/10.1056/NEJM200106283442601 (20:84' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 39. Ridker, P. M. et al. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 373, 1175–1182, https://doi.org/10.1016/:85' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: Table 1. The ranking of the LDLc and CRP treatment objectives based on SUCRA. †In a Bayesian context (Markov chain Monte Carlo simulation), the LDLc and/or CRP treatment objectives were the parameters used for ranking according to:86' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 17. Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181–219:91' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: 10. KDIGO Clinical Practice Guideline for Lipid Management in CKD: summary of recommendation statements and clinical approach to the patient. Kidney Int. 85, 1303–1309, https://doi.org/10.1038/ki.2014.31 (2014). :127' cannot be found Offset: 2128065 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_45431.indd: Table 2. Review questions and study eligibility. §Only statins were studied, and patients treated with chronic dialysis or kidney transplantation were included in the systematic review to support systematic mapping. #Individua:131' cannot be found Offset: 2128065 MIMEtype: application/pdf PDFMetadata: Objects: 698 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Cholesterol-Lowering Treatment in Chronic Kidney Disease: Multistage Pairwise and Network Meta-Analyses Children: Item: Title: Current context and study objective. Item: Title: Results Children: Item: Title: Literature search. Item: Title: Cholesterol-lowering treatment efficacy evaluation. Item: Title: Treatment objectives evaluation. Item: Title: Discussion Children: Item: Title: Key messages. Item: Title: Strengths and limitations. Item: Title: Conclusion and study contribution. Item: Title: Methods Children: Item: Title: Study design, eligibility criteria and systematic searches. Item: Title: Data collection and analyses. Item: Title: Acknowledgements Item: Title: Figure 1 The PRISMA flowcharts presenting the selection processes used in the two systematic reviews. Item: Title: Figure 2 The effect of cholesterol-lowering treatment on MACEs when the eGFR is lower than 60 ml/min/1. Item: Title: Figure 3 SUCRA-based ranking of all statins and the combination of simvastatin plus ezetimibe when the eGFR is lower than 60 ml/min/1. Item: Title: Figure 4 Network diagram for the competing cholesterol-lowering treatment strategies (Markov chain Monte Carlo simulation). Item: Title: Figure 5 Network forest plot of the fixed and random effects of the competing cholesterol-lowering treatment strategies. Item: Title: Figure 6 Inconsistency plot of the random effects for the competing cholesterol-lowering treatment strategies. Item: Title: Table 1 The ranking of the LDLc and CRP treatment objectives based on SUCRA. Item: Title: Table 2 Review questions and study eligibility. Info: Title: Cholesterol-Lowering Treatment in Chronic Kidney Disease: Multistage Pairwise and Network Meta-Analyses Author: Francisco Herrera-Gamp#x000F3;mez Subject: Scientific Reports, doi:10.1038/s41598-019-45431-5 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Jun 13 14:04:34 CEST 2019 ModDate: Fri Jun 14 17:28:14 CEST 2019 ID: 0x88807c730eb5a05e2233a5713874c541, 0x7fb5d9c7ba7998e3116e8061533b0fe2 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1650 ImageHeight: 1441 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1250 ImageHeight: 429 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1650 ImageHeight: 1101 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1250 ImageHeight: 1242 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 598 ImageHeight: 2300 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1000 ImageHeight: 586 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: IXZEES+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: TTINCW+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: FYBCCK+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: FYBCCK+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: GKYZCW+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: GKYZCW+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QVNAYJ+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: QVNAYJ+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: IXZEES+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IXZEES+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: TTINCW+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TTINCW+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-019-45431-5 Springer US Scientific Reports, doi:10.1038/s41598-019-45431-5 Cholesterol-Lowering Treatment in Chronic Kidney Disease: Multistage Pairwise and Network Meta-Analyses Francisco Herrera-Gamp#x000F3;mez M. Montserrat Chimeno Damp#x000E9;bora Martamp#x000ED;n-Garcamp#x000ED;a Frank Lizaraso-Soto amp#x000C1;lvaro Maurtua-Briseamp#x000F1;o-Meiggs Jesamp#x000FA;s Grande-Villoria Juan Bustamante-Munguira Eric Alamartine Miquel Vilardell Carlos Ochoa-Sangrador F. Javier amp#x000C1;lvarez 10.1038/s41598-019-45431-5 http://dx.doi.org/10.1038/s41598-019-45431-5 journal Scientific Reports © 2019, The Author(s) 2045-2322 10.1038/s41598-019-45431-5 Springer 2019-06-14T17:28:14+02:00 2019-06-13T17:04:34+05:30 2019-06-14T17:28:14+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:8068d8e4-e218-4748-bcec-f425b1c5cf61 uuid:831df4ef-a3df-485b-aea2-ac8754f4f78d default 1 converted uuid:e31c187e-c4f2-4379-9bd1-addf332481c9 converted to PDF/A-2b pdfToolbox 2019-06-13T17:05:16+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 265, 508, 274, 496 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 537, 484, 546, 472 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 233, 472, 241, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 497, 266, 499, 254 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 188, 246, 191, 234 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 457, 246, 460, 234 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 549, 236, 552, 224 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 401, 216, 403, 204 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 405, 216, 408, 204 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 282, 206, 285, 194 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 384, 196, 386, 184 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 440, 53, 517, 43 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 375, 734, 378, 722 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 364, 724, 367, 712 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 304, 694, 307, 682 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 229, 634, 235, 622 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 198, 424, 204, 412 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 207, 424, 212, 412 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 243, 424, 248, 412 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 394, 414, 399, 402 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 546, 374, 552, 362 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 472, 364, 478, 352 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 480, 364, 485, 352 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 293, 354, 298, 342 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 300, 354, 305, 342 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 370, 344, 376, 332 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 377, 344, 383, 332 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 182, 294, 188, 282 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 191, 294, 196, 282 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 412, 284, 417, 272 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 420, 284, 426, 272 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 337, 274, 343, 262 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 346, 274, 352, 262 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 210, 264, 216, 252 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 217, 264, 223, 252 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 330, 204, 336, 192 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 339, 204, 345, 192 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 241, 114, 246, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 114, 246, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 114, 246, 102 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 391, 114, 395, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 545, 114, 549, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 317, 104, 321, 92 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 383, 94, 389, 82 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 390, 94, 396, 82 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 399, 94, 405, 82 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 490, 94, 496, 82 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 499, 94, 505, 82 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 392, 54, 397, 42 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 479, 54, 484, 42 Flags: Print AppearanceDictionary: true Destination: 317 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 173, 335, 179, 323 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 287, 335, 293, 323 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 445, 325, 451, 313 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 452, 325, 458, 313 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 461, 325, 467, 313 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 279, 305, 285, 293 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 288, 305, 293, 293 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 317, 275, 323, 263 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 324, 275, 330, 263 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 333, 275, 338, 263 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 478, 265, 483, 253 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 486, 265, 492, 253 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 196, 255, 200, 243 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 203, 255, 208, 243 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 497, 235, 502, 223 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 262, 195, 268, 183 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 271, 195, 277, 183 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 205, 104, 211, 92 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 104, 218, 92 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 221, 104, 227, 92 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 351, 94, 354, 82 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 429, 84, 435, 72 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 261, 54, 266, 42 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 268, 54, 273, 42 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 277, 54, 282, 42 Flags: Print AppearanceDictionary: true Destination: 317 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 231, 230, 236, 218 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 240, 230, 245, 218 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 529, 210, 535, 198 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 515, 130, 518, 118 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 390, 100, 395, 88 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 398, 100, 404, 88 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 224, 80, 229, 68 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 233, 80, 238, 68 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 389, 80, 394, 68 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 397, 80, 403, 68 Flags: Print AppearanceDictionary: true Destination: 438 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 377, 478, 365 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 182, 357, 188, 345 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 393, 337, 398, 325 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 262, 276, 267, 264 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 457, 266, 463, 254 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 348, 216, 353, 204 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 340, 206, 345, 194 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 319, 186, 325, 174 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 328, 186, 333, 174 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 315, 176, 321, 164 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 214, 166, 220, 154 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 278, 156, 281, 144 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 471, 156, 477, 144 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 385, 126, 391, 114 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 336, 96, 342, 84 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 343, 96, 349, 84 Flags: Print AppearanceDictionary: true Destination: 317 Annotation: Subtype: Link Rect: 427, 86, 433, 74 Flags: Print AppearanceDictionary: true Destination: 438 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 283, 85, 288, 73 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 510, 65, 516, 53 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 451, 315, 457, 303 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 251, 285, 256, 273 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 258, 285, 263, 273 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 361, 235, 365, 223 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 546, 84, 552, 72 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 313, 54, 319, 42 Flags: Print AppearanceDictionary: true Destination: 438 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 418, 362, 424, 350 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 442, 292, 447, 280 Flags: Print AppearanceDictionary: true Destination: 438 Annotation: Subtype: Link Rect: 196, 199, 343, 189 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 232, 183, 356, 172 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 532, 166, 554, 155 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 157, 249, 147 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 521, 149, 554, 138 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 140, 281, 130 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 123, 277, 113 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 106, 325, 96 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 89, 381, 79 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 287, 72, 430, 62 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 481, 64, 554, 53 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 55, 201, 45 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 290, 726, 392, 716 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 286, 709, 429, 699 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 250, 692, 398, 682 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 675, 286, 665 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 325, 658, 449, 648 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 641, 290, 631 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 276, 624, 408, 614 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 481, 607, 554, 597 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 598, 239, 588 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 207, 573, 332, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 547, 296, 537 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 522, 554, 512 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 513, 267, 503 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 497, 554, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 488, 249, 478 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 471, 554, 461 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 462, 217, 452 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 519, 446, 554, 435 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 437, 259, 427 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 279, 420, 383, 410 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 207, 403, 332, 393 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 474, 386, 554, 376 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 377, 217, 367 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 385, 361, 532, 350 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 521, 335, 554, 325 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 326, 258, 316 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 300, 310, 436, 299 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 532, 301, 554, 291 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 292, 302, 282 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 267, 296, 257 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 387, 250, 511, 240 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 233, 326, 223 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 218, 216, 378, 206 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 203, 190, 324, 180 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 173, 306, 163 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 286, 157, 431, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 460, 140, 554, 129 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 131, 201, 121 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 361, 114, 504, 104 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 417, 97, 554, 87 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 71, 315, 61 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 233, 718, 356, 707 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 700, 350, 690 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 683, 293, 673 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 666, 303, 656 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 455, 658, 554, 648 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 649, 252, 639 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 196, 624, 339, 614 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 220, 607, 359, 597 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 282, 590, 396, 580 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 431, 573, 554, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 287, 548, 465, 537 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 246, 531, 425, 520 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 276, 514, 413, 503 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 482, 497, 554, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 488, 232, 478 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 434, 454, 554, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 203, 428, 326, 418 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 412, 554, 401 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 403, 225, 393 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 269, 386, 372, 376 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 477, 378, 554, 367 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 369, 240, 359 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 270, 352, 378, 342 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 349, 335, 454, 325 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 522, 326, 554, 316 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 318, 291, 308 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 297, 301, 420, 291 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 249, 284, 380, 274 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 356, 120, 515, 107 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 222, 25, 369, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 664, 504, 652 Flags: Print AppearanceDictionary: true Thumb: true Checksum: bce648db Type: CRC32 Checksum: 947d90940d4260a01b67e5aaab7c7698 Type: MD5 Checksum: 718d9f8b1681b46e5f5f588b6d91a277a090b559 Type: SHA-1