d2faa5f194458cb85f29b1d57451dc74 pmc_31277226.pdf a40f25545b27f77860f9e643d5a4d301b582e83f pmc_31277226.pdf 7a39f54c75d4746feb4225ab44ce8054e18efac9754de3ffe9b52f50976dbf84 pmc_31277226.pdf Title: Genetic Testing to Predict Weight Loss and Diabetes Remission and Long-Term Sustainability after Bariatric Surgery: A Pilot Study Subject: Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission. Research Design and Methods: A case-control study in which 96 females (47 with type 2 diabetes) underwent Roux-en-Y gastric by-pass were included. The DNA was extracted from saliva samples and SNPs were examined and grouped into 3 GPS. ROC curves were used to calculate sensitivity and specificity. Results: A highly sensitive and specific predictive model of response to BS was obtained by combining the GPS in non-diabetic subjects. This combination was different in diabetic subjects and highly predictive of diabetes remission. Additionally, the model was able to predict the weight regain and type 2 diabetes relapse after 5 years’ follow-up. Conclusions: Genetic testing is a simple, reliable and useful tool for implementing personalized medicine in type 2 diabetic patients requiring BS. Keywords: diabetes; obesity; bariatric surgery Author: Andreea Ciudin, Enzamaria Fidilio, Angel Ortiz, Sara Pich, Eduardo Salas, Jordi Mesa, Cristina Hernández, Olga Simó-Servat, Albert Lecube and Rafael Simó Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Jul 3 08:48:08 2019 CEST ModDate: Wed Jul 3 08:48:08 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1232023 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JPJPBY+URWPalladioL-Ital Type 1 Custom yes yes no 59 0 WVVBPT+URWPalladioL-Bold Type 1 Custom yes yes no 60 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 61 0 ENXZUH+VnURWPalladioL-Bold Type 1 Custom yes yes no 62 0 OMBZCR+URWPalladioL-Roma Type 1 Custom yes yes no 63 0 LWJOET+VnURWPalladioL Type 1 Custom yes yes no 64 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