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Title:          Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials
Keywords:       area at risk, clinical trial, edema, endpoint, infarct size, magnetic resonance imaging, myocardial infarction, STEMI
Author:         Borja Ibanez, Anthony H. Aletras, Andrew E. Arai, Hakan Arheden, Jeroen Bax, Colin Berry, Chiara Bucciarelli-Ducci, Pierre Croisille, Erica Dall’Armellina, Rohan Dharmakumar, Ingo Eitel, Rodrigo Fernández-Jiménez, Matthias G. Friedrich, David García-Dorado, Derek J. Hausenloy, Raymond J. Kim, Sebastian Kozerke, Christopher M. Kramer, Michael Salerno, Javier Sánchez-González, Javier Sanz, Valentin Fuster
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     Item: 
      Title: Abstract
     Item: 
      Title: THE INFARCTED MYOCARDIUMIS NOT STATIC: EVOLVING CHANGES AFTER I/R
      Children: 
       Item: 
        Title: PROGRESSION OF NECROSIS AND ITS BORDERS.
       Item: 
        Title: DYNAMIC CHANGES OF INFARCT SIZE AFTER I/R.
       Item: 
        Title: PATHOPHYSIOLOGY AND SPATIAL DISTRIBUTION OF POST-I/R EDEMA.
       Item: 
        Title: PATHOPHYSIOLOGY OF MICROVASCULAR INJURY: MICROVASCULAR OBSTRUCTION AND INTRAMYOCARDIAL HEMORRHAGE.
     Item: 
      Title: POST-MYOCARDIAL INFARCTION TISSUE CHARACTERIZATION BY CMR
      Children: 
       Item: 
        Title: CMR IMAGING OF INFARCT SIZE.
        Children: 
         Item: 
          Title: Late gadolinium enhancement.
         Item: 
          Title: Effect of infarct size dynamics and partial volume effects on LGE interpretation.
         Item: 
          Title: Pre- and post-contrast T1 mapping for assessment of acute infarct size.
       Item: 
        Title: CMR IMAGING OF EDEMA.
        Children: 
         Item: 
          Title: CMR as a tool to detect myocardial edema.
          Children: 
           Item: 
            Title: T2-weighted pulse sequences.
           Item: 
            Title: T2 mapping.
           Item: 
            Title: T1 mapping.
         Item: 
          Title: Retrospective AAR size estimation by CMR: an evolving controversy.
          Children: 
           Item: 
            Title: The “AAR” concept.
           Item: 
            Title: Dynamic changes in the AAR of the Acutely Infarcted Myocardium.
           Item: 
            Title: Edema-based CMR methodologies for retrospective AAR size estimate.
         Item: 
          Title: Dynamics of post-MI edema: the classic concept of “stable” myocardial edematous reaction revisited.
         Item: 
          Title: Effect of protective therapies on edema: implications for edema-based AAR quantification.
         Item: 
          Title: Salvage index concept and its quantification.
       Item: 
        Title: CMR IMAGING OF MICROVASCULAR INJURY: MVO AND INTRAMYOCARDIAL HEMORRHAGE.
        Children: 
         Item: 
          Title: Microvascular obstruction.
         Item: 
          Title: Intramyocardial hemorrhage.
     Item: 
      Title: CMR ENDPOINTS IN CLINICAL TRIALS AND EXPERIMENTAL STUDIES
     Item: 
      Title: FUTURE DIRECTIONS
     Item: 
      Title: References
     Item: 
      Title: FIGURE 1
     Item: 
      Title: FIGURE 2
     Item: 
      Title: FIGURE 3
     Item: 
      Title: FIGURE 4
     Item: 
      Title: CENTRAL ILLUSTRATION
     Item: 
      Title: TABLE 1
     Item: 
      Title: TABLE 2
     Item: 
      Title: TABLE 3
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